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    • 1. 发明授权
    • Composition pulse time-of-flight mass flow sensor
    • 组成脉冲飞行时间质量流量传感器
    • US07225683B2
    • 2007-06-05
    • US10661401
    • 2003-09-11
    • Cindy K. HarnettRobert W. CrockerBruce P. MosierPamela F. CatonJames F. Stamps
    • Cindy K. HarnettRobert W. CrockerBruce P. MosierPamela F. CatonJames F. Stamps
    • G01F1/58
    • G01F1/7088
    • A device for measuring fluid flow rates over a wide range of flow rates ( 10 μL/min) and at pressures at least as great as 2,000 psi. The invention is particularly adapted for use in microfluidic systems. The device operates by producing compositional variations in the fluid, or pulses, that are subsequently detected downstream from the point of creation to derive a flow rate. Each pulse, comprising a small fluid volume, whose composition is different from the mean composition of the fluid, can be created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species. Measurements of the conductivity of the fluid can be used to detect the arrival time of the pulses, from which the fluid flow rate can be determined. A pair of spaced apart electrodes can be used to produce the electrochemical pulse. In those instances where it is desired to measure a wide range of fluid flow rates a three electrode configuration in which the electrodes are spaced at unequal distances has been found to be desirable.
    • 用于在宽的流量范围(<1nL / min至>10μL/ min)和至少高达2,000psi的压力下测量流体流速的装置。 本发明特别适用于微流体系统。 该装置通过产生流体或脉冲中的组成变化来操作,随后从创建点下游检测出流体或脉冲以导出流量。 可以通过电化学方法,例如通过溶剂的电解,溶解的物质的电解或溶解的离子物质的电渗析来产生包含小的流体体积的每个脉冲,其组成不同于流体的平均组成。 可以使用流体的电导率的测量来检测脉冲的到达时间,从而可以确定流体流速。 可以使用一对间隔开的电极来产生电化学脉冲。 在需要测量各种流体流速的情况下,已经发现其中电极以不等距离间隔开的三电极配置是期望的。