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1. 发明申请

US20130303522A1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 有权
标题翻译： 11-羟基脱氢酶脱氢酶1型抑制剂化合物
公开(公告)号：US20130303522A1
公开(公告)日：2013-11-14
申请号：US13947808
申请日：2013-07-22
申请人： Juan Lorenzo CATENA RUIZ , Carme SERRA COMAS , Oscar REY PUIGGROS , Albert ANTOLIN HERNANDEZ , Esther MONLLEO MAS
发明人： Juan Lorenzo CATENA RUIZ , Carme SERRA COMAS , Oscar REY PUIGGROS , Albert ANTOLIN HERNANDEZ , Esther MONLLEO MAS
IPC分类号： C07D217/16 , C07D215/14 , C07D409/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D401/06 , C07D413/06
CPC分类号： C07D217/16 , A61K31/47 , A61K31/4709 , A61K31/472 , C07D215/08 , C07D215/14 , C07D215/20 , C07D215/58 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.
摘要翻译：式（I）化合物衍生自全氢喹啉和全氢异喹啉，可用作预防或治疗由11-β-羟基类固醇脱氢酶1型（11-β-HSD1）酶相关疾病引起的疾病的活性药物成分，例如青光眼，眼压升高，代谢紊乱，肥胖，代谢综合征，血脂异常，高血压，糖尿病，动脉粥样硬化，库兴综合征，牛皮癣，类风湿性关节炎，认知障碍，阿尔茨海默病或神经变性。

2. 发明申请

US20120253377A1 MODIFIABLE OCCLUSION DEVICE 审中-公开
标题翻译：可修改的装置
公开(公告)号：US20120253377A1
公开(公告)日：2012-10-04
申请号：US13076474
申请日：2011-03-31
申请人： Robert Slazas , Juan Lorenzo , Peter Forsythe
发明人： Robert Slazas , Juan Lorenzo , Peter Forsythe
IPC分类号： A61M29/00
CPC分类号： A61B17/12045 , A61B17/12118
摘要： An occlusive device suitable for endovascular treatment of an aneurysm in a region of a parent vessel in a patient, including a structure having a fixed porosity and having dimensions suitable for insertion into vasculature of the patient to reach the region of the aneurysm in the parent vessel. The device further includes a frangible material supported by the structure which initially provides a substantial barrier to flow through the frangible material and is capable of at least one of localized rupturing and localized eroding, in the presence of a pressure differential arising at an ostium of a perforator vessel communicating with the parent vessel, within an acute time period to minimize ischemia downstream of the perforator vessel.
摘要翻译：一种闭塞装置，适用于在患者的母体血管的区域内血管内治疗动脉瘤，包括具有固定孔隙度并具有适于插入患者血管的尺寸的结构，以到达母体血管的动脉瘤区域。该装置还包括由结构支撑的易碎材料，其最初提供流过易碎材料的实质屏障，并且能够在存在压力差异的情况下产生局部破裂和局部侵蚀中的至少一种穿孔器容器在急性期间与母体血管连通，以最小化穿孔器下游的缺血。

3. 发明申请

US20090088438A1 NEW TYROSINE DERIVATIVES AS PPARy MODULATORS 审中-公开
标题翻译：新型酪氨酸衍生物作为PPARY调节剂
公开(公告)号：US20090088438A1
公开(公告)日：2009-04-02
申请号：US12146145
申请日：2008-06-25
申请人： Carmen SERRA COMAS , Anna FERNANDEZ SERRAT , Dolors BALSA LOPEZ , Isabel MASIP MASIP , Juan Lorenzo CATENA RUIZ , Jose HIDALGO RODRIGUEZ , Carmen LAGUNAS ARNAL , Carolina SALCEDO ROCA , Andres FERNANDEZ GARCIA
发明人： Carmen SERRA COMAS , Anna FERNANDEZ SERRAT , Dolors BALSA LOPEZ , Isabel MASIP MASIP , Juan Lorenzo CATENA RUIZ , Jose HIDALGO RODRIGUEZ , Carmen LAGUNAS ARNAL , Carolina SALCEDO ROCA , Andres FERNANDEZ GARCIA
IPC分类号： A61K31/195 , A61P3/10 , A61P3/04 , A61P9/00 , A61P29/00 , A61K31/381 , A61K31/47 , A61K31/498 , A61K31/341 , A61K31/472 , A61K31/215 , A61K31/44 , A61P35/00 , A61P19/00 , A61P17/02
CPC分类号： C07D213/81 , C07C229/36 , C07C233/20 , C07C233/24 , C07C233/60 , C07C233/69 , C07C233/88 , C07C2601/02 , C07C2601/04 , C07D213/56 , C07D213/82 , C07D215/48 , C07D217/26 , C07D241/24 , C07D241/44 , C07D307/52 , C07D307/54 , C07D307/68 , C07D333/20 , C07D333/24 , C07D333/38
摘要： Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH2)s—N(COR3)-A-J-T or —(CH2)s—N(R4)-B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed herein. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
摘要翻译：通式I的化合物及其盐和溶剂合物，其中R1表示2-苯甲酰基苯基; R2表示 - （CH2）s-N（COR3）-A-J-T或 - （CH2）s-N（R4）-B-J-T; 并且s，R 3，R 4，A，B，J和T具有本文公开的含义。这些化合物是PPARγ调节剂，因此可用于治疗或预防由这些受体介导的疾病或疾病。

4. 发明申请

US20060276827A1 Stretch resistant embolic coil delivery system with mechanical release mechanism 审中-公开
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US20060276827A1
公开(公告)日：2006-12-07
申请号：US11172198
申请日：2005-06-30
申请人： Vladimir Mitelberg , Donald Jones , Juan Lorenzo
发明人： Vladimir Mitelberg , Donald Jones , Juan Lorenzo
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12154 , A61B2017/00292 , A61B2017/00477 , A61B2017/00867 , A61B2017/12054 , A61M25/00
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. A stretch resistant embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is slidably disposed within the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the engagement member. The engagement member engages a retaining ring on the embolic device. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.
摘要翻译：一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。弹性阻塞栓塞装置通过机械互锁机构保持在输送导管内，该联动机构包括可滑动地设置在推动器构件内并且延伸穿过栓塞装置的近端处的保持环的接合构件。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定在接合构件上。接合构件接合栓塞装置上的保持环。当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

5. 发明申请

US20060276826A1 Stretch resistant embolic coil delivery system with mechanical release mechanism 审中-公开
公开(公告)号：US20060276826A1
公开(公告)日：2006-12-07
申请号：US11172195
申请日：2005-06-30
申请人： Vladimir Mitelberg , Donald Jones , Juan Lorenzo , Darren Sherman
发明人： Vladimir Mitelberg , Donald Jones , Juan Lorenzo , Darren Sherman
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12154 , A61B2017/00292 , A61B2017/00477 , A61B2017/00867 , A61B2017/12054 , A61M25/00
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. A stretch resistant embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. The engagement member engages a retaining ring on the embolic device. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.

6. 外观设计

USD711538S1 Dermatological treatment system 有权
标题翻译：皮肤病治疗系统
公开(公告)号：USD711538S1
公开(公告)日：2014-08-19
申请号：US29427126
申请日：2012-07-13
申请人： David Youngquist , John Philip Stoddard , Jay M. Vahlensieck , Juan-Lorenzo G. Rubi , Harvey I-Heng Liu , Tobin Island
设计人： David Youngquist , John Philip Stoddard , Jay M. Vahlensieck , Juan-Lorenzo G. Rubi , Harvey I-Heng Liu , Tobin Island

7. 发明申请

US20120071466A1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 有权
标题翻译： 11-羟基脱氢酶脱氢酶1型抑制剂化合物
公开(公告)号：US20120071466A1
公开(公告)日：2012-03-22
申请号：US13375389
申请日：2010-06-04
申请人： Juan Lorenzo Catena Ruiz , Carme Serra Comas , Oscar Rey Puiggros , Albert Antolin Hernandez , Esther Monlleomas
发明人： Juan Lorenzo Catena Ruiz , Carme Serra Comas , Oscar Rey Puiggros , Albert Antolin Hernandez , Esther Monlleomas
IPC分类号： A61K31/55 , A61K31/496 , A61K31/472 , A61K31/4725 , A61K31/4709 , C07D413/06 , C07D217/08 , C07D217/04 , C07D401/12 , C07D401/06 , A61P25/28 , C07D215/14 , C07D217/06 , C07D405/12 , C07D409/14 , C07D409/12 , A61P27/06 , A61P27/02 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/12 , A61P3/10 , A61P9/10 , A61P17/06 , A61P29/00 , A61P25/00 , A61K31/5377
CPC分类号： C07D217/16 , A61K31/47 , A61K31/4709 , A61K31/472 , C07D215/08 , C07D215/14 , C07D215/20 , C07D215/58 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type I (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.
摘要翻译：式（I）化合物衍生自全氢喹啉和全氢异喹啉，并且可用作预防或治疗由11-β-羟基类固醇脱氢酶I型（11-β-HSD1）酶相关病症引起的疾病的活性药物成分，例如青光眼，眼压升高，代谢紊乱，肥胖，代谢综合征，血脂异常，高血压，糖尿病，动脉粥样硬化，库兴综合征，牛皮癣，类风湿性关节炎，认知障碍，阿尔茨海默病或神经变性。

8. 发明授权

US07423172B2 Tyrosine derivatives as PPAR-γ-modulators 失效
标题翻译：酪氨酸衍生物作为PPAR-γ调节剂
公开(公告)号：US07423172B2
公开(公告)日：2008-09-09
申请号：US11658856
申请日：2005-07-29
申请人： Carmen Serra Comas , Anna Fernández Serrat , Dolors Balsa López , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , José Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andrés Fernández García
发明人： Carmen Serra Comas , Anna Fernández Serrat , Dolors Balsa López , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , José Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andrés Fernández García
IPC分类号： C07C233/88 , C07C229/36 , C07C233/20 , C07C233/69
CPC分类号： C07D213/81 , C07C229/36 , C07C233/20 , C07C233/24 , C07C233/60 , C07C233/69 , C07C233/88 , C07C2601/02 , C07C2601/04 , C07D213/56 , C07D213/82 , C07D215/48 , C07D217/26 , C07D241/24 , C07D241/44 , C07D307/52 , C07D307/54 , C07D307/68 , C07D333/20 , C07D333/24 , C07D333/38
摘要： Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH2)s—N(COR3)-A-J-T or —(CH2)s—N(R4)—B-J-T; and s. R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
摘要翻译：通式I的化合物及其盐和溶剂合物，其中R1表示2-苯甲酰基苯基; R 2表示 - （CH 2 CH 2）n -N（COR 3） - ， - 或 - （CH 2 2） -N（R 4） - BJT; 和s。 R3，R4，A，B，J和T具有说明书中公开的含义。这些化合物是PPARγ调节剂，因此可用于治疗或预防由这些受体介导的疾病或疾病。

9. 发明申请

US20070276043A1 Tyrosine Derivatives As Ppar-Gamma-Modulators 失效
标题翻译：酪氨酸衍生物作为P-gamma调节剂
公开(公告)号：US20070276043A1
公开(公告)日：2007-11-29
申请号：US11658856
申请日：2005-07-29
申请人： Carmen Serra Comas , Anna Fernandez Serrat , Dolors Balsa Lopez , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , Jose Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andres Fernandez Garcia
发明人： Carmen Serra Comas , Anna Fernandez Serrat , Dolors Balsa Lopez , Isabel Masip Masip , Juan Lorenzo Catena Ruiz , Jose Hidalgo Rodriguez , Carmen Lagunas Arnal , Carolina Salcedo Roca , Andres Fernandez Garcia
IPC分类号： A61K31/19 , A61P19/08 , A61P29/00 , A61P3/04 , A61P3/10 , A61P35/00 , A61P9/00 , C07C61/00
CPC分类号： C07D213/81 , C07C229/36 , C07C233/20 , C07C233/24 , C07C233/60 , C07C233/69 , C07C233/88 , C07C2601/02 , C07C2601/04 , C07D213/56 , C07D213/82 , C07D215/48 , C07D217/26 , C07D241/24 , C07D241/44 , C07D307/52 , C07D307/54 , C07D307/68 , C07D333/20 , C07D333/24 , C07D333/38
摘要： Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH2)s—N(COR3)-A-J-T or —(CH2)S—N(R4)—B-J-T; and s, R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPARγ modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors.
摘要翻译：通式I的化合物及其盐和溶剂合物，其中R1表示2-苯甲酰基苯基; R 2表示 - （CH 2 CH 2）n -N（COR 3） - ， - 或 - （CH 2 2） N（R 4） - BJT; s，R3，R4，A，B，J和T具有说明书中公开的含义。这些化合物是PPARγ调节剂，因此可用于治疗或预防由这些受体介导的疾病或疾病。

10. 发明申请

US20070255253A1 Activatable bioactive vascular occlusive device and method of use 审中-公开
标题翻译：可活化生物活性血管闭塞装置及其使用方法
公开(公告)号：US20070255253A1
公开(公告)日：2007-11-01
申请号：US11821340
申请日：2007-06-22
申请人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
发明人： Donald Jones , Juan Lorenzo , Mark Pomeranz , Darren Sherman
IPC分类号： A61M31/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1215 , A61B17/12186 , A61B2017/00004 , A61B2017/00831
摘要： A vascular occlusive device which includes a vascular occlusive embolic coil, a bioactive coating disposed onto the embolic coil, and an outer barrier coating which serves to prevent a reaction between the bioactive agent in the bioactive coating and bodily fluids, until the outer barrier is activated by applying an external agent to the outer barrier.
摘要翻译：一种血管闭塞装置，其包括血管闭塞栓塞线圈，设置在栓塞线圈上的生物活性涂层和用于防止生物活性涂层中的生物活性剂与体液之间的反应的外部阻隔涂层，直到外部屏障被激活通过将外部剂施加到外部屏障。

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