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1. 发明申请

US20100268072A1 METHOD AND APPARATUS FOR POSITIONAL TRACKING OF THERAPEUTIC ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于治疗超声波传感器的位置跟踪的方法和装置
公开(公告)号：US20100268072A1
公开(公告)日：2010-10-21
申请号：US12741831
申请日：2008-11-13
申请人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
发明人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
IPC分类号： A61B5/05 , A61N7/00
CPC分类号： A61N7/02 , A61B34/20 , A61B34/25 , A61B2017/00123 , A61B2090/372 , A61M37/0092 , A61N2007/0008
摘要： A therapeutic ultrasound tracking system (10) includes a first and second plurality of tracking elements ((14, 16, 18),(20,22,24)), a tracking generator (26), and a system controller (28). The first plurality of tracking elements (14, 16, 18) is disposed in a first position and orientation with respect to each another and with respect to an energy emission surface (30) of a therapeutic ultrasound probe (12). The second plurality of tracking elements (20,22,24) is adapted to be coupled to a patient (42) in a second position and orientation with respect to each other and with respect to a target region of the patient which is to receive a therapeutic treatment. The tracking generator (26) emits tracking energy for use in connection with the first and second plurality of tracking elements. The system controller (28) detects whether the probe (12) is positioned within an allowable position and orientation with respect to the target region, and (i) responsive to detecting the probe being within the allowable position and orientation, the system controller enables an energization of the probe to perform one of (i)(a) commence the therapeutic treatment and (i)(b) continue the therapeutic treatment, and (ii) responsive to not detecting the probe being within the allowable position and orientation, the system controller disables the energization of the probe for the therapeutic treatment.
摘要翻译：治疗性超声跟踪系统（10）包括第一和第二多个跟踪元件（（14,16,18），（20,22,24）），跟踪发生器（26）和系统控制器（28）。第一组多个跟踪元件（14,16,18）相对于彼此并且相对于治疗性超声波探头（12）的能量发射表面（30）设置在第一位置和方向上。第二组多个跟踪元件（20,22,24）适于以相对于彼此并且相对于要接收患者的目标区域的第二位置和取向联接到患者（42）治疗方法。跟踪发生器（26）发射用于与第一和第二多个跟踪元件结合使用的跟踪能量。系统控制器（28）检测探头（12）是否位于相对于目标区域的允许位置和方位之内，以及（i）响应于探测器在允许的位置和方向上的检测，系统控制器（i）（a）中的一个的通电开始治疗处理，（i）（b）继续治疗，以及（ii）响应于不检测探针在允许的位置和方向内，系统控制器禁用用于治疗治疗的探针通电。

2. 发明申请

US20110125080A1 ULTRASOUND MEDIATED DRUG DELIVERY 审中-公开
标题翻译：超声介质药物递送
公开(公告)号：US20110125080A1
公开(公告)日：2011-05-26
申请号：US13054584
申请日：2009-06-09
申请人： William Tao Shi , Chien Ting Chin , Christopher S. Hall , Balasundara Raju , Marcel Rene Bohmer
发明人： William Tao Shi , Chien Ting Chin , Christopher S. Hall , Balasundara Raju , Marcel Rene Bohmer
IPC分类号： A61M5/00
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/0019 , A61K49/223 , A61M37/0092
摘要： Described is a method for the delivery of a therapeutic agent to a mammal, particularly a human person, comprising (i) the administration of ultrasound particles that undergo a physical change when subjected to ultrasound; (ii) the administration of the therapeutic agent in an ultrasound dosage form allowing release of the therapeutic agent to be affected by the application of ultrasound, (iii) the application of ultrasound so as to affect a physical change in at least some of the ultrasound particles, and (iv) the application of ultrasound so as to stimulate release of the therapeutic agent. According to the invention the ultrasound particles are subjected to detection of their acoustic responses via echoes and/or emissions. The information thus obtained is processed and the processed information is used to adapt or adjust the ultrasound-mediated delivery of the therapeutic agent. This can be carried out using a single set of particles (that serve both as ultrasound imaging tracers and as drug delivery vehicles) or by applying separate sets of particles.
摘要翻译：描述了将哺乳动物，特别是人类的治疗剂递送的方法，包括（i）施用经受超声的物理变化的超声波颗粒; （ii）以超声波剂量形式施用治疗剂，允许释放待施用超声波的治疗剂，（iii）施加超声波以影响至少一些超声波的物理变化颗粒，以及（iv）超声波的应用，以刺激治疗剂的释放。根据本发明，超声波颗粒经由回声和/或发射来检测其声响应。处理如此获得的信息，并且使用处理的信息来适应或调整超声介导的治疗剂的递送。这可以使用单组颗粒（既用作超声成像示踪剂又作为药物递送载体）或通过应用单独的颗粒组来进行。

3. 发明授权

US08764665B2 Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
标题翻译：具有可调节流体透镜的微波成像的方法和装置
公开(公告)号：US08764665B2
公开(公告)日：2014-07-01
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

4. 发明申请

US20100087735A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 失效
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：US20100087735A1
公开(公告)日：2010-04-08
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00 , G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

5. 发明申请

US20120029397A1 TUMOR TREATMENT USING ULTRASOUND CAVITATION 审中-公开
标题翻译：使用超声波治疗肿瘤治疗
公开(公告)号：US20120029397A1
公开(公告)日：2012-02-02
申请号：US13262924
申请日：2010-04-02
申请人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
发明人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/481 , A61B2017/22008 , A61N2007/0039
摘要： Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.
摘要翻译：身体组织的增长减慢，被阻止或逆转。在一个方面，这是通过提供气泡（S315）和递送，以引起生理学的暂时改变，使至少一个延迟，阻止和逆转所述生长，将一系列一个或多个能量脉冲（206）分配到相应的联络点（213）在现场的增长。另一方面，通过由脉冲引起的流体空化的机械非热效应来诱导生理学的暂时性变化，例如肿瘤脉管系统中的瞬时血管痉挛（216）。在一些实施方案中，用于促进气蚀的气泡通过向主体施用微泡剂来提供。

6. 发明申请

US20100069754A1 APPARATUS FOR 3D ULTRASOUND IMAGING AND THERAPY 有权
标题翻译： 3D超声成像和治疗设备
公开(公告)号：US20100069754A1
公开(公告)日：2010-03-18
申请号：US12516598
申请日：2007-11-06
申请人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
发明人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61B8/08 , A61B8/0808 , A61B8/0833 , A61B8/4483 , A61B8/463 , A61B8/483 , A61B2090/378 , A61M37/0092 , A61N7/02 , B06B1/0625 , B06B1/0637
摘要： An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two-dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume. Also disclosed is a method of delivering ultrasound therapy to a biological tissue in a three-dimensional moving or stationary spatial volume utilizing the apparatus.
摘要翻译：一种用于应用三维超声成像和治疗的装置，包括具有图像信号发射器和接收器的换能器元件的二维超声成像阵列，所述图像信号发射器和接收器形成，控制和选择性地将超声波束聚焦到三维移动或固定空间体积; 换能器元件的一个或多个二维超声治疗阵列，每个阵列具有治疗信号发射器，其形成，转向和选择性地聚焦并将超声治疗递送到所述体积; 其中成像和治疗换能器元件阵列的位置相对于彼此是已知的; 以及控制器，其控制所述图像发射器和接收器以提供所述体积的三维图像，并且同时独立地控制所述一个或多个治疗发射器中的每一个以向所述体积传递治疗。还公开了利用该装置在三维移动或静止空间体积中向生物组织递送超声治疗的方法。

7. 发明授权

US08500641B2 Apparatus and method for 3D ultrasound imaging and therapy 有权
标题翻译： 3D超声成像和治疗的装置和方法
公开(公告)号：US08500641B2
公开(公告)日：2013-08-06
申请号：US12516598
申请日：2007-11-06
申请人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
发明人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61B8/08 , A61B8/0808 , A61B8/0833 , A61B8/4483 , A61B8/463 , A61B8/483 , A61B2090/378 , A61M37/0092 , A61N7/02 , B06B1/0625 , B06B1/0637
摘要： An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two-dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume. Also disclosed is a method of delivering ultrasound therapy to a biological tissue in a three-dimensional moving or stationary spatial volume utilizing the apparatus.
摘要翻译：一种用于应用三维超声成像和治疗的装置，包括具有图像信号发射器和接收器的换能器元件的二维超声成像阵列，所述图像信号发射器和接收器形成，控制和选择性地将超声波束聚焦到三维移动或固定空间体积; 换能器元件的一个或多个二维超声治疗阵列，每个阵列具有治疗信号发射器，其形成，转向和选择性地聚焦并将超声治疗递送到所述体积; 其中成像和治疗换能器元件阵列的位置相对于彼此是已知的; 以及控制器，其控制所述图像发射器和接收器以提供所述体积的三维图像，并且同时独立地控制所述一个或多个治疗发射器中的每一个以向所述体积传递治疗。还公开了利用该装置在三维移动或静止空间体积中向生物组织递送超声治疗的方法。

8. 发明申请

US20080208059A1 Microbubble Generating Technique For Phase Aberration Correction 有权
标题翻译：微波发生技术用于相位畸变校正
公开(公告)号：US20080208059A1
公开(公告)日：2008-08-28
申请号：US11908199
申请日：2006-03-02
申请人： Christopher Hall , Shunmugavelu Sokka , David Louis Marie Savery , Chien Ting Chin
发明人： Christopher Hall , Shunmugavelu Sokka , David Louis Marie Savery , Chien Ting Chin
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/4281
摘要： Method and system for ultrasound imaging of body tissue in which a focused ultrasound (FUS) transducer (20) is oriented relative to the body such that ultrasonic waves generated by the FUS transducer (20) are directed toward the tissue being imaged. The FUS transducer (20) is operated to cause the formation of microbubbles (28) in the tissue and an ultrasound image of the tissue with the microbubbles (28) is acquired. Phase aberration in the acquired ultrasound image may be corrected, if necessary, using each microbubble (28) as a point source or point-like scatterer. Microbubble (28) formation can therefore be obtained in a non-invasive manner since FUS-induced microbubble (28) formation does not require the insertion of interventional tools into the body.
摘要翻译：其中聚焦超声（FUS）换能器（20）相对于身体定向的身体组织的超声成像的方法和系统，使得由FUS换能器（20）产生的超声波指向被成像的组织。操作FUS换能器（20）以在组织中形成微泡（28），并且获取具有微泡（28）的组织的超声图像。如果需要，可以使用每个微泡（28）作为点源或点状散射体来校正所获取的超声图像中的相位差。因此，由于FUS诱导的微泡（28）形成不需要将介入工具插入体内，因此可以非侵入性方式获得微泡（28）形成。

9. 发明授权

US07957219B2 Method and apparatus for elevation focus control of acoustic waves 有权
标题翻译：用于声波高程聚焦控制的方法和装置
公开(公告)号：US07957219B2
公开(公告)日：2011-06-07
申请号：US12297902
申请日：2007-04-27
申请人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher S. Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe includes an acoustic transducer having acoustic transducer elements arranged in a one-dimensional array; and a variably-refracting acoustic lens coupled to the acoustic transducer. The variably-refracting acoustic lens has a pair of electrodes configured to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探头包括具有以一维阵列布置的声换能器元件的声换能器; 以及耦合到声换能器的可变折射声透镜。可变折射声透镜具有一对电极，其被配置为响应于跨过电极施加的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

10. 发明申请

US20090122639A1 METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 有权
标题翻译：用于高音重点控制声波的方法和装置
公开(公告)号：US20090122639A1
公开(公告)日：2009-05-14
申请号：US12297902
申请日：2007-04-27
申请人： Christopher Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

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