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1. 发明申请

US20120029397A1 TUMOR TREATMENT USING ULTRASOUND CAVITATION 审中-公开
标题翻译：使用超声波治疗肿瘤治疗
公开(公告)号：US20120029397A1
公开(公告)日：2012-02-02
申请号：US13262924
申请日：2010-04-02
申请人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
发明人： Chien Ting Chin , Christopher Stephen Hall , Alexander L. Klibanov
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/481 , A61B2017/22008 , A61N2007/0039
摘要： Growth in body tissue is slowed, arrested or reversed. In one aspect, this is accomplished by providing bubbles (S315), and delivering, to cause temporary change in physiology that at least one of retards, arrests and reverses said growth, a series of one or more pulses (206) of energy to respective focal points (213) at the site of the growth. In another aspect, temporary change in physiology, such as transient vasospasm (216) in vasculature of a neoplasm, is induced via the mechanical, non-thermal effects of fluid cavitation caused by the pulses. The bubbles, for facilitating the cavitation, in some embodiments, are afforded by administration of a microbubble agent to the host.
摘要翻译：身体组织的增长减慢，被阻止或逆转。在一个方面，这是通过提供气泡（S315）和递送，以引起生理学的暂时改变，使至少一个延迟，阻止和逆转所述生长，将一系列一个或多个能量脉冲（206）分配到相应的联络点（213）在现场的增长。另一方面，通过由脉冲引起的流体空化的机械非热效应来诱导生理学的暂时性变化，例如肿瘤脉管系统中的瞬时血管痉挛（216）。在一些实施方案中，用于促进气蚀的气泡通过向主体施用微泡剂来提供。

2. 发明申请

US20100268072A1 METHOD AND APPARATUS FOR POSITIONAL TRACKING OF THERAPEUTIC ULTRASOUND TRANSDUCER 审中-公开
标题翻译：用于治疗超声波传感器的位置跟踪的方法和装置
公开(公告)号：US20100268072A1
公开(公告)日：2010-10-21
申请号：US12741831
申请日：2008-11-13
申请人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
发明人： Christopher Stephen Hall , Chien Ting Chin , Balasundara I. Raju , William Tao Shi , Guy Shechter
IPC分类号： A61B5/05 , A61N7/00
CPC分类号： A61N7/02 , A61B34/20 , A61B34/25 , A61B2017/00123 , A61B2090/372 , A61M37/0092 , A61N2007/0008
摘要： A therapeutic ultrasound tracking system (10) includes a first and second plurality of tracking elements ((14, 16, 18),(20,22,24)), a tracking generator (26), and a system controller (28). The first plurality of tracking elements (14, 16, 18) is disposed in a first position and orientation with respect to each another and with respect to an energy emission surface (30) of a therapeutic ultrasound probe (12). The second plurality of tracking elements (20,22,24) is adapted to be coupled to a patient (42) in a second position and orientation with respect to each other and with respect to a target region of the patient which is to receive a therapeutic treatment. The tracking generator (26) emits tracking energy for use in connection with the first and second plurality of tracking elements. The system controller (28) detects whether the probe (12) is positioned within an allowable position and orientation with respect to the target region, and (i) responsive to detecting the probe being within the allowable position and orientation, the system controller enables an energization of the probe to perform one of (i)(a) commence the therapeutic treatment and (i)(b) continue the therapeutic treatment, and (ii) responsive to not detecting the probe being within the allowable position and orientation, the system controller disables the energization of the probe for the therapeutic treatment.
摘要翻译：治疗性超声跟踪系统（10）包括第一和第二多个跟踪元件（（14,16,18），（20,22,24）），跟踪发生器（26）和系统控制器（28）。第一组多个跟踪元件（14,16,18）相对于彼此并且相对于治疗性超声波探头（12）的能量发射表面（30）设置在第一位置和方向上。第二组多个跟踪元件（20,22,24）适于以相对于彼此并且相对于要接收患者的目标区域的第二位置和取向联接到患者（42）治疗方法。跟踪发生器（26）发射用于与第一和第二多个跟踪元件结合使用的跟踪能量。系统控制器（28）检测探头（12）是否位于相对于目标区域的允许位置和方位之内，以及（i）响应于探测器在允许的位置和方向上的检测，系统控制器（i）（a）中的一个的通电开始治疗处理，（i）（b）继续治疗，以及（ii）响应于不检测探针在允许的位置和方向内，系统控制器禁用用于治疗治疗的探针通电。

3. 发明授权

US08764665B2 Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
标题翻译：具有可调节流体透镜的微波成像的方法和装置
公开(公告)号：US08764665B2
公开(公告)日：2014-07-01
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

4. 发明申请

US20100087735A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 失效
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：US20100087735A1
公开(公告)日：2010-04-08
申请号：US12596841
申请日：2008-04-30
申请人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
发明人： Christopher Stephen Hall , Chien Ting Chin , Jan Frederik Suijver , Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper
IPC分类号： A61B8/00 , G03B42/06
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

5. 发明授权

US08475442B2 Ultrasonic assembly with adjustable fluid lens 失效
标题翻译：超声波组件带可调节液晶镜头
公开(公告)号：US08475442B2
公开(公告)日：2013-07-02
申请号：US12663307
申请日：2008-07-07
申请人： Christopher Stephen Hall , Anna Teresa Fernandez , Jan Frederik Suijver
发明人： Christopher Stephen Hall , Anna Teresa Fernandez , Jan Frederik Suijver
IPC分类号： A61B18/04
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0056 , G10K11/30
摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the center of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.
摘要翻译：适于附接到导管的超声波组件，例如用于治疗。超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如，当向电极施加电压时，界面的曲率。在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。这是例如适用于人体组织的消融或凝血坏死治疗，例如用于心房颤动治疗。在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

6. 发明申请

US20100280390A1 CATHETER FOR THREE-DIMENSIONAL INTRACARDIAC ECHOCARDIOGRAPHY AND SYSTEM INCLUDING THE SAME 有权
标题翻译：三维入侵物理学及其系统的导管
公开(公告)号：US20100280390A1
公开(公告)日：2010-11-04
申请号：US12522037
申请日：2008-01-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Stein Kuiper , Jan Frederik Suijver , Ronald Tabaksblat , Nijs Cornelis Van Der Vaart , Christopher Stephen Hall , Anna Teresa Fernandez
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B8/0883 , A61B8/445 , A61B8/483 , G10K11/30
摘要： A catheter apparatus (100, 2000, 3000, 4000, 540) includes an elongated body (110) having proximal (112) and distal (114) ends, an acoustic transducer (130, 2300, 5 3300, 4300, 544), disposed proximate the distal end (114) of the elongated body (110), and a variably-refracting acoustic lens (140, 2200, 3200, 4200, 542) adapted to dynamically adjust a direction associated with an acoustic wave coupled to the acoustic transducer in response to one or more control signals provided thereto.
摘要翻译：导管装置（100,2000,3000,4000,540）包括具有近端（112）和远端端（114）的细长体（110），设置有声变换器（130,2300,5300,4300,544）靠近所述细长体（110）的远端（114），以及可变折射声透镜（140,2200,3200,4200,542），其适于动态地调节与耦合到所述声换能器的声波相关联的方向响应于提供给其的一个或多个控制信号。

7. 发明授权

US09757034B2 Flexible tether with integrated sensors for dynamic instrument tracking 有权
公开(公告)号：US09757034B2
公开(公告)日：2017-09-12
申请号：US13877343
申请日：2011-10-06
申请人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
发明人： Adrien Emmanuel Desjardins , Gert Wim 'T Hooft , Raymond Chan , Robert Manzke , Guy Shechter , Christopher Stephen Hall
IPC分类号： A61B6/00 , A61B5/00 , A61B34/20 , A61B90/98 , A61B17/34 , A61B90/00
CPC分类号： A61B5/0033 , A61B6/4494 , A61B17/3478 , A61B34/20 , A61B90/98 , A61B2034/2061 , A61B2090/3764
摘要： A system and method are provided for tracking a functional part of an instrument during an interventional procedure and displaying dynamic imaging corresponding to a functional part of the instrument. The system comprises: at least one instrument; a system for acquiring anatomical images relevant to guiding the instrument; a tether connected to the imaging system at a fixed end and connected to the instrument at a distal end, the tether comprising at least one longitudinal optical fiber with a plurality of optical shape sensors; an optical console that interrogates the sensors and detects reflected light; and a processor that calculates local curvature at each sensor location to determine the three-dimensional shape of the tether and determines the location and orientation of the instrument relative to the images using the local curvatures of the tether and the location of the fixed end of the tether.

8. 发明授权

US08932239B2 Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids 有权
标题翻译：用于超声药物输送和具有相变流体的热疗法的方法和装置
公开(公告)号：US08932239B2
公开(公告)日：2015-01-13
申请号：US11914777
申请日：2006-05-25
申请人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
发明人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
IPC分类号： A61B8/00 , A61M37/00 , A61K41/00 , A61K49/22 , A61B8/12 , A61N7/00 , A61N7/02 , A61B17/22
CPC分类号： A61M37/0092 , A61B8/12 , A61B8/546 , A61B2017/22008 , A61K41/0033 , A61K49/223 , A61N7/00 , A61N7/02
摘要： An ultrasound treatment includes applying ultrasound at a first energy level to a region of interest in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle. Ultrasound at a second energy level is applied to the region of interest during a second portion of the treatment cycle for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.
摘要翻译：超声处理包括在处理周期的第一部分期间将超声波以第一能级应用于受试者中感兴趣的区域，以激活空化成核剂。在治疗周期的第二部分期间，将第二能量级的超声波施加到感兴趣区域，以在存在在治疗周期的第一部分期间激活的空化成核剂的情况下实施期望的热疗法。第二能级处于与第一能级不同的能级。

9. 发明申请

US20100259832A1 ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 失效
标题翻译：可调镜头系统实时应用
公开(公告)号：US20100259832A1
公开(公告)日：2010-10-14
申请号：US12742658
申请日：2008-12-10
申请人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
发明人： Jan Frederik Suijver , Christopher Stephen Hall , Anna Teresa Fernandez , Stein Kuiper , Yan Shi
IPC分类号： G02B3/14
CPC分类号： G02B3/14
摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
摘要翻译：提供了一种可调节流体型透镜系统，超声波成像通过透镜在调整镜片期间。透镜包括容纳两个不混溶流体的容器，例如水和油在界面处彼此接触。然后在这个界面折射出来的波。通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。选择两种流体使得它们一起显示出关键或近临界的机械阻尼。控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射界面以连续的方式。这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。透镜系统具有许多应用，例如，在医疗领域内。用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

10. 发明申请

US20080200845A1 Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids 有权
标题翻译：用于超声药物递送和相可转换液体治疗的方法和装置
公开(公告)号：US20080200845A1
公开(公告)日：2008-08-21
申请号：US11914777
申请日：2006-05-25
申请人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
发明人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
IPC分类号： A61N7/02 , A61M37/00
CPC分类号： A61M37/0092 , A61B8/12 , A61B8/546 , A61B2017/22008 , A61K41/0033 , A61K49/223 , A61N7/00 , A61N7/02
摘要： An ultrasound treatment comprises applying ultrasound at a first energy level (32) to a region of interest (20) in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle (t1-t2). Ultrasound at a second energy level (34) is applied to the region of interest (20) during a second portion of the treatment cycle (t2-t3) for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.
摘要翻译：超声处理包括将第一能级（32）的超声波施用于受试者的感兴趣区域（20），以在治疗周期（t 1 -t 2）的第一部分期间激活空化成核剂。在治疗周期（t 2 -t 3）的第二部分期间，在第二能量水平（34）处的超声被施加到感兴趣区域（20），以在存在激活的空化成核剂的情况下实现期望的热疗法治疗周期的第一部分。第二能级处于与第一能级不同的能级。

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