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1. 发明授权

US09765067B2 Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators 有权
公开(公告)号：US09765067B2
公开(公告)日：2017-09-19
申请号：US15320813
申请日：2015-07-02
申请人： Christopher M. Adams , David B. Belanger , Doug Bevan , Takeru Ehara , Luciana Ferrara , Nan Ji , Donglei Liu , Erik Meredith , Muneto Mogi , James Powers , Ganesh Prasanna , Mitsunori Kato
发明人： Christopher M. Adams , David B. Belanger , Doug Bevan , Takeru Ehara , Luciana Ferrara , Nan Ji , Donglei Liu , Erik Meredith , Muneto Mogi , James Powers , Ganesh Prasanna , Mitsunori Kato
IPC分类号： A61K31/4545 , A61K31/4725 , A61K31/4439 , C07D409/14 , A61K9/00
CPC分类号： C07D409/14 , A61K9/0048 , A61K31/4439 , A61K31/4545 , A61K31/4725
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

2. 发明授权

US09957254B2 Cyclohexen-1-yl-pyridin-2-yl-1h-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate cyclase activators 有权
公开(公告)号：US09957254B2
公开(公告)日：2018-05-01
申请号：US15320815
申请日：2015-07-02
申请人： Christopher M. Adams , David B. Belanger , Doug Bevan , Philippe Bolduc , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
发明人： Christopher M. Adams , David B. Belanger , Doug Bevan , Philippe Bolduc , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
IPC分类号： C07D401/14 , C07D401/04
CPC分类号： C07D401/14 , A61K31/4545 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , A61K2300/00
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

3. 发明授权

US10208018B2 Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators 有权
公开(公告)号：US10208018B2
公开(公告)日：2019-02-19
申请号：US15320810
申请日：2015-07-02
申请人： Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
发明人： Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , A61K9/00 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , C07D405/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

4. 发明申请

US20160175327A1 TOMATIDINE, ANALOGS THEREOF, COMPOSITIONS COMPRISING SAME, AND USES FOR SAME 有权
公开(公告)号：US20160175327A1
公开(公告)日：2016-06-23
申请号：US14978886
申请日：2015-12-22
申请人： Christopher M. Adams , Michael C. Dyle , Michael Welsh
发明人： Christopher M. Adams , Michael C. Dyle , Michael Welsh
IPC分类号： A61K31/58 , C12Q1/68 , A61K45/06
CPC分类号： A61K31/58 , A23K20/121 , A23L33/10 , A23V2002/00 , A61K45/06 , C07J53/00 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

5. 发明申请

US20120071512A1 5-PYRIDIN-3-YL-1, 3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 失效
标题翻译： 5-吡啶-3-YL-1,3-二氢吲哚-2-酮衍生物及其作为阿托品酮合成酶和/或CYP11B1的调节剂的用途
公开(公告)号：US20120071512A1
公开(公告)日：2012-03-22
申请号：US13319786
申请日：2010-05-12
申请人： Qi-Ying Hu , Sylvie Chamoin , Christopher M. Adams , Chun Zhang
发明人： Qi-Ying Hu , Sylvie Chamoin , Christopher M. Adams , Chun Zhang
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/10 , C07D417/10 , A61K31/444 , A61P9/12 , A61P13/12 , A61P9/10 , A61P3/04 , A61P9/00 , A61P1/16 , A61P25/06 , A61P9/04 , A61P9/06 , C07D401/10
CPC分类号： C07D417/04 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

6. 发明授权

US06290586B1 Abrasive attachment for use with reciprocating saw 失效
标题翻译：用于往复锯的磨料附件
公开(公告)号：US06290586B1
公开(公告)日：2001-09-18
申请号：US09629249
申请日：2000-07-27
申请人： Christopher M. Adams
发明人： Christopher M. Adams
IPC分类号： B24B2300
CPC分类号： B24D99/00 , B23D49/007 , B23D51/14 , Y10T83/9457 , Y10T83/9481
摘要： This invention relates to reciprocating saws, and to abrasive sanding attachments and blades for such saws, to facilitate the oscillating, the reciprocating sanding, and the shaping of straight, curved, concave or convex surfaces, with abrasive cutting surfaces. The invention described herein fits and mounts in blade holders currently in use on scroll saws, and is designed to take advantage of pin-end and plain pinless-end saw blade mounting methods as applied to holding an abrasive member. This invention increases the versatility and use of the scroll saw and related C-shaped saws, as tools for use in intricate, delicate, and controlled woodworking, metalworking, and finishing. Methods for making abrasive member holders 40, 68, 74, 84, 104, 112, 124, 142, and 160 are disclosed. The holders can be mounted on pin-end blade or pin-less blade scroll saws using abrasive member head, extenders and pivot heads.
摘要翻译：本发明涉及往复锯，以及用于这种锯的磨料砂磨附件和刀片，以便于具有研磨切割表面的直的，弯曲的，凹形的或凸形的表面的摆动，往复砂磨和成型。本文所述的本发明适合和安装在目前在涡旋锯上使用的刀片保持器中，并且被设计为利用用于保持研磨构件的销端和平纹无端锯片安装方法。本发明增加了卷锯和相关C形锯的通用性和用途，作为用于复杂，精细和受控的木工，金属加工和精加工的工具。公开了用于制造研磨部件保持件40,68,74,84,104,112,124,142和160的方法。保持器可以使用研磨件头，延伸器和枢轴头安装在销端刀片或无销刀片滚动锯上。

7. 发明申请

US20130054455A1 System for Allocating and Managing Contributions to Account Categories 审中-公开
标题翻译：分配和管理账户类别分配的系统
公开(公告)号：US20130054455A1
公开(公告)日：2013-02-28
申请号：US13221166
申请日：2011-08-30
申请人： Carrie Anne Hanson , Brad J. Kirchenbaum , Kimberly B. Summerrow , Christopher M. Adams , Jason Typrin , Erik S. Ross , Jacqueline A. Corr , Deshaun G. Hunter , Susan S. Thomas
发明人： Carrie Anne Hanson , Brad J. Kirchenbaum , Kimberly B. Summerrow , Christopher M. Adams , Jason Typrin , Erik S. Ross , Jacqueline A. Corr , Deshaun G. Hunter , Susan S. Thomas
IPC分类号： G06Q40/00
CPC分类号： G06Q40/02
摘要： According to some embodiments, a deposit system for receiving funds into an account held for an account beneficiary, the account being identifiable by an account number, comprises a management module, a contributor module, and an allocation module. The management module is operable to register a plurality of contributors. The contributor module is operable to receive information identifying a first contributor, determine whether the first contributor is one of the plurality of registered contributors, and if the first contributor is a registered contributor, receive, from the first contributor, a deposit of funds, the deposit comprising a first set of funds associated by the first contributor for deposit into the account without identifying the account by the account number. The allocation module operable to deposit the first set of funds into the account without informing the first contributor of the account number.
摘要翻译：根据一些实施例，一种用于将资金接收到为帐户受益人持有的账户的存款系统，该帐户可由帐号识别，包括管理模块，贡献者模块和分配模块。管理模块可操作以注册多个贡献者。贡献者模块可操作地接收识别第一贡献者的信息，确定第一贡献者是否是多个注册贡献者中的一个，并且如果第一贡献者是注册贡献者，则从第一贡献者接收资金存款，存款包括由第一供稿人相关的第一组资金存入帐户，而不用帐号识别帐户。所述分配模块可操作以将所述第一组资金存入所述账户而不通知所述第一贡献者账号。

8. 发明授权

US6129617A Abrasive member holder for reciprocating saw 失效
标题翻译：用于往复锯的研磨件支架
公开(公告)号：US6129617A
公开(公告)日：2000-10-10
申请号：US804275
申请日：1997-03-03
申请人： Christopher M. Adams
发明人： Christopher M. Adams
IPC分类号： B23D49/00 , B23D51/14 , B24D99/00 , B24B23/00 , B24B27/08
CPC分类号： B24D99/00 , B23D49/007 , B23D51/14
摘要： This invention relates to reciprocating saws, and to abrasive sanding attachments and blades for such saws, to facilitate the oscillating, the reciprocating sanding, and the shaping of straight, curved, concave or convex surfaces, with abrasive cutting surfaces. The invention described herein fits and mounts in blade holders currently in use on scroll saws, and is designed to take advantage of pin-end and plain pinless-end saw blade mounting methods as applied to holding an abrasive member. This invention increases the versatility and use of the scroll saw and related C-shaped saws, as tools for use in intricate, delicate, and controlled woodworking, metalworking, and finishing. Methods for making abrasive member holders 40, 68, 74, 84, 104, 112, 124, 142, and 160 are disclosed. The holders can be mounted on pin-end blade or pin-less blade scroll saws using abrasive member head, extenders and pivot heads.
摘要翻译：本发明涉及往复锯，以及用于这种锯的磨料砂磨附件和刀片，以便于具有研磨切割表面的直的，弯曲的，凹形的或凸形的表面的摆动，往复砂磨和成型。本文所述的本发明适合和安装在目前在涡旋锯上使用的刀片保持器中，并且被设计为利用用于保持研磨构件的销端和平纹无端锯片安装方法。本发明增加了卷锯和相关C形锯的通用性和用途，作为用于复杂，精细和受控的木工，金属加工和精加工的工具。公开了用于制造研磨部件保持件40,68,74,84,104,112,124,142和160的方法。保持器可以使用研磨件头，延伸器和枢轴头安装在销端刀片或无销刀片滚动锯上。

9. 发明授权

US09856204B2 Methods for inhibiting muscle atrophy 有权
公开(公告)号：US09856204B2
公开(公告)日：2018-01-02
申请号：US13698645
申请日：2011-05-19
申请人： Christopher M. Adams , Steven D. Kunkel , Manish Suneja , Michael Welsh
发明人： Christopher M. Adams , Steven D. Kunkel , Manish Suneja , Michael Welsh
IPC分类号： C07C61/29 , A61K31/19 , A61K31/191 , A61K31/198 , A61K31/215 , C07C69/12 , C07C69/757 , C07C235/82 , C07D265/30 , C07J53/00
CPC分类号： C07C61/29 , A61K31/19 , A61K31/191 , A61K31/198 , A61K31/215 , C07C69/12 , C07C69/757 , C07C235/82 , C07D265/30 , C07J53/002
摘要： In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

10. 发明授权

US09295664B2 Methods for lowering blood glucose 有权
标题翻译：降低血糖的方法
公开(公告)号：US09295664B2
公开(公告)日：2016-03-29
申请号：US14124582
申请日：2012-06-06
申请人： Christopher M. Adams , Steven D. Kunkel , Michael Welsh
发明人： Christopher M. Adams , Steven D. Kunkel , Michael Welsh
IPC分类号： A61K31/58 , A61K31/565 , A61K31/353 , A61K31/435 , A61K31/4166 , A61K31/473 , A61K31/407 , C12Q1/68 , A61K31/436 , A61K31/215 , A61K31/352 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/4164 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/56 , G01N33/50
CPC分类号： A61K31/58 , A61K31/215 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/382 , A61K31/404 , A61K31/407 , A61K31/4164 , A61K31/4166 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4706 , A61K31/473 , A61K31/56 , A61K31/565 , C12Q1/6809 , C12Q2600/136 , G01N33/5023 , G01N2800/10 , G01N2800/52 , A61K2300/00
摘要： In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及通过向有需要的动物提供有效量的化合物来治疗肌肉萎缩的方法。该化合物可以调节肌肉萎缩特征的多个mRNA的表达水平。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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