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1. 发明申请

US20100215691A1 RECOMBINANT VIRAL VECTORS 审中-公开
标题翻译：重组病毒载体
公开(公告)号：US20100215691A1
公开(公告)日：2010-08-26
申请号：US12708940
申请日：2010-02-19
申请人： Christopher L. PARKS , Ivo Lorenz , Sanjay K. Phogat , Timothy J. Zamb
发明人： Christopher L. PARKS , Ivo Lorenz , Sanjay K. Phogat , Timothy J. Zamb
IPC分类号： A61K39/12 , C12N15/63 , C12N7/08 , A61P31/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , C12N7/00 , C12N2740/16051 , C12N2740/16134 , C12N2760/20234 , C12N2760/20243 , C12N2760/20251 , G01N33/6854 , G01N2333/162
摘要： The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
摘要翻译：本发明涉及重组水泡性口炎病毒，用作艾滋病感染性疾病的预防和治疗疫苗。本发明包括配制成本发明疫苗的免疫原性组合物的制备和纯化。

2. 发明授权

US07485415B2 Sequence analysis of the tetravalent rotavirus vaccine 失效
标题翻译：四价轮状病毒疫苗的序列分析
公开(公告)号：US07485415B2
公开(公告)日：2009-02-03
申请号：US10505818
申请日：2003-02-19
申请人： Deborah A. Buonagurio , Alice F. Georgiu , Robert A. Lerch , Bruce B. Mason , Shridhara C. Murthy , Ruth S. Rappaport , Mohinder S. Sidhu , Stephen A. Udem , Timothy J. Zamb
发明人： Deborah A. Buonagurio , Alice F. Georgiu , Robert A. Lerch , Bruce B. Mason , Shridhara C. Murthy , Ruth S. Rappaport , Mohinder S. Sidhu , Stephen A. Udem , Timothy J. Zamb
IPC分类号： C12Q1/70 , C12N15/46 , C12N15/63 , C12N1/21 , C12N5/10 , A61K39/15
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N2720/12322 , C12N2720/12362 , C12Q1/701
摘要： Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus: human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules.
摘要翻译：公开了分离的核酸分子，其包含来自恒河猴轮状病毒（RRV）的基因片段或三种恒河猴中的一种：人重配病毒，包括具有选自以下的序列的分离的核酸分子：SEQ ID NO：1-14 和包含编码具有选自SEQ ID NO：15-28的序列的蛋白质的分离的核酸分子，以及分离的核酸分子的变体。

3. 发明授权

US5521084A Bovine heat shock promoter and uses thereof 失效
公开(公告)号：US5521084A
公开(公告)日：1996-05-28
申请号：US975719
申请日：1992-11-10
申请人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
发明人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
IPC分类号： C12N15/09 , A61K39/00 , C07K14/03 , C12N1/21 , C12N5/10 , C12N15/38 , C12N15/40 , C12N15/85 , C12P21/00 , C12N15/11
CPC分类号： C07K14/005 , C12N15/85 , A61K39/00 , C07K2319/02 , C12N2710/16722 , C12N2830/002 , C12N2830/85
摘要： A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure, authentic protein, substantially free of infectious viral and cellular protein contaminants.

4. 发明申请

US20090246829A1 SEQUENCE ANALYSIS OF THE TETRAVALENT ROTAVIRUS VACCINE 审中-公开
标题翻译：四川流感疫苗的序列分析
公开(公告)号：US20090246829A1
公开(公告)日：2009-10-01
申请号：US12365122
申请日：2009-02-03
申请人： Deborah A. Buonagurio , Alice F. Georgiu , Robert A. Lerch , Bruce B. Mason , Shridhara C. Murthy , Ruth S. Rappaport , Mohinder S. Sidhu , Stephen A. Udem , Timothy J. Zamb
发明人： Deborah A. Buonagurio , Alice F. Georgiu , Robert A. Lerch , Bruce B. Mason , Shridhara C. Murthy , Ruth S. Rappaport , Mohinder S. Sidhu , Stephen A. Udem , Timothy J. Zamb
IPC分类号： C12P21/02 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/00 , C12N1/19 , C12N5/06
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N2720/12322 , C12N2720/12362 , C12Q1/701
摘要： Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus:human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules.
摘要翻译：公开了分离的核酸分子，其包含来自恒河猴轮状病毒（RRV）的基因片段或三种恒河猴中的一种：人重配病毒，包括具有选自以下的序列的分离的核酸分子：SEQ ID NO：1-14 和包含编码具有选自SEQ ID NO：15-28的序列的蛋白质的分离的核酸分子，以及分离的核酸分子的变体。

5. 发明授权

US06716431B1 Differential cytotoxicity of alternative forms of rotavirus nonstructural protein 4 失效
标题翻译：轮状病毒非结构蛋白的替代形式的差异细胞毒性4
公开(公告)号：US06716431B1
公开(公告)日：2004-04-06
申请号：US10048540
申请日：2001-12-07
申请人： Peng Tian , Timothy J. Zamb , Stephen A. Udem
发明人： Peng Tian , Timothy J. Zamb , Stephen A. Udem
IPC分类号： A61K3915
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/14143 , C12N2720/12322
摘要： The nonstructural protein 4 (NSP4) in the SA11 ATCC rotavirus strain has a histidine at amino acid position 47. This substituted form is more cytotoxic than the NSP4 of the Australia rotavirus strain, which has an asparagine at amino acid position 47. The histidine at amino acid position 47 is mutagenized to another amino acid to produce an alternative form of NSP4 which has reduced toxicity, while retaining its antigenicity and immunogenicity. NSP4 having a glutamic acid at amino acid position 48 is more cytotoxic than NSP4 having a lysine at amino acid position 48. The lysine at amino acid position 48 is mutagenized to another amino acid other than glutamic acid to produce an alternative form of NSP4 which has reduced toxicity, while retaining its antigenicity and immunogenicity.
摘要翻译： SA11 ATCC轮状病毒株中的非结构蛋白4（NSP4）在氨基酸位置47具有组氨酸。该取代形式比澳大利亚轮状病毒株的NSP4更具细胞毒性，其在氨基酸位置47具有天冬酰胺。组氨酸在氨基酸位置47被诱变成另一种氨基酸以产生另一形式的NSP4，其具有降低的毒性，同时保持其抗原性和免疫原性。在氨基酸位置48具有谷氨酸的NSP4比在氨基酸位置48具有赖氨酸的NSP4更具细胞毒性。氨基酸位置48处的赖氨酸被诱变成除谷氨酸以外的另一种氨基酸，以产生NSP4的替代形式，其具有降低毒性，同时保持其抗原性和免疫原性。

6. 发明授权

US5981224A Bovine heat shock promoter and uses thereof 失效
标题翻译：牛热休克启动子及其用途
公开(公告)号：US5981224A
公开(公告)日：1999-11-09
申请号：US48488
申请日：1998-03-26
申请人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
发明人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
IPC分类号： C12N15/09 , A61K39/00 , C07K14/03 , C12N1/21 , C12N5/10 , C12N15/38 , C12N15/40 , C12N15/85 , C12P21/00 , C12N15/11
CPC分类号： C07K14/005 , C12N15/85 , A61K39/00 , C07K2319/02 , C12N2710/16722 , C12N2830/002 , C12N2830/85
摘要： A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure, authentic protein, substantially free of infectious viral and cellular protein contaminants.
摘要翻译：公开了一种使用热诱导型牛hsp70A启动子和相关顺式作用元件的新型表达系统。该系统提供连续生产基本上不含感染性病毒和细胞蛋白质污染物的高纯度，可靠的蛋白质。

7. 发明授权

US5733745A Bovine heat shock promoter and uses thereof 失效
公开(公告)号：US5733745A
公开(公告)日：1998-03-31
申请号：US599825
申请日：1996-02-12
申请人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
发明人： Jacek Kowalski , Scott Gilbert , Timothy J. Zamb
IPC分类号： C12N15/09 , A61K39/00 , C07K14/03 , C12N1/21 , C12N5/10 , C12N15/38 , C12N15/40 , C12N15/85 , C12P21/00 , C12N15/11
CPC分类号： C07K14/005 , C12N15/85 , A61K39/00 , C07K2319/02 , C12N2710/16722 , C12N2830/002 , C12N2830/85
摘要： A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure, authentic protein, substantially free of infectious viral and cellular protein contaminants.

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