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1. 发明授权

US06639211B1 Contrast-enhanced MRA including an effective zero-latency method of bolus detection 失效
标题翻译：对比增强MRA，包括有效的零延迟方法的推注检测
公开(公告)号：US06639211B1
公开(公告)日：2003-10-28
申请号：US09718746
申请日：2000-11-22
申请人： Christopher K. Anand , Paul M. Margosian , Michael R. Thompson
发明人： Christopher K. Anand , Paul M. Margosian , Michael R. Thompson
IPC分类号： B01D5944
CPC分类号： G01R33/561 , G01R33/281 , G01R33/5619
摘要： To generate a magnetic resonance angiograph, a patient is injected with a contrast-enhancing agent (210). An ellipsoidal central portion of k-space (300) and a first surrounding region (310) are continuously sampled (220). A portion of each central data set (300, 310) is reconstructed (230) into a low-resolution volume and maximum-intensity-projected (240) onto a line. The maximum intensity projection (240) is processed (250) in order to detect the arrival of the contrast enhancing bolus within a volume of interest. Upon detection of the arrival of the bolus, the acquisition of a high-resolution magnetic resonance angiograph is triggered (260) in which higher phase encode portions (310, 420) of k-space are sampled. The central data set (300) along with the higher phase encode views (310, 420) are reconstructed (290) into a high-resolution magnetic resonance angiogram. The present technique allows for substantially zero latency between the detection of the contrast-enhancing agent bolus and the acquisition of the magnetic resonance angiogram.
摘要翻译：为了产生磁共振血管造影仪，向患者注射造影剂（210）。连续采样k空间（300）和第一周围区域（310）的椭圆形中心部分（220）。将每个中央数据集（300,310）的一部分重建（230）成一行的低分辨率体积和最大强度投影（240）。处理最大强度投影（240）（250），以便检测增强感光剂在感兴趣体积内的到达。在检测到推注的到来之后，触发采集高分辨率磁共振血管造影仪（260），其中对k空间的较高相位编码部分（310,420）进行采样。中央数据集（300）以及较高相位编码视图（310,420）被重建（290）成高分辨率磁共振血管造影图。本技术允许在对比增强剂推注的检测和磁共振血管造影图的获取之间基本上为零的等待时间。

2. 发明授权

US06804546B1 Multiple contrast echo-planar imaging for contrast-enhanced imaging 失效
标题翻译：用于对比度增强成像的多重对比回波平面成像
公开(公告)号：US06804546B1
公开(公告)日：2004-10-12
申请号：US09885884
申请日：2001-06-20
申请人： Michael R. Thompson , Dee H. Wu , Wayne R. Dannels , Christopher K. Anand
发明人： Michael R. Thompson , Dee H. Wu , Wayne R. Dannels , Christopher K. Anand
IPC分类号： A61B5055
CPC分类号： G01R33/56 , A61B5/055 , G01R33/281
摘要： A dose of a contrast agent (44) is administered to the patient (42). A magnetic resonance is excited by an RF pulse (200) in a region of interest of the patient (42). An echo-planar imaging (EPI) readout waveform is implemented a preselected duration after the excitation to generate T2 or T2* weighted data. During the preselected duration, another echo planar readout waveform is implemented to generate T1 or proton density weighted data. The data is reconstructed (56) to generate a T2 or T2* weighted image and a T1 weighted image. The T1 and T2 or T2* weighted images are combined (62) to generate a contrast enhanced image.
摘要翻译：向患者（42）施用剂量的造影剂（44）。在患者（42）的感兴趣区域中的RF脉冲（200）激发磁共振。回波平面成像（EPI）读出波形在激励之后被预先设定的持续时间，以产生T2或T2 *加权数据。在预选持续时间期间，实现另一个回波平面读出波形以产生T1或质子密度加权数据。重建数据（56）以产生T2或T2 *加权图像和T1加权图像。组合T1和T2或T2 *加权图像以产生对比度增强图像。

3. 发明授权

US06549008B1 Steady-state imaging sequence 失效
标题翻译：稳态成像序列
公开(公告)号：US06549008B1
公开(公告)日：2003-04-15
申请号：US09712402
申请日：2000-11-14
申请人： Christopher K. Anand , Michael R. Thompson , Dee H. Wu
发明人： Christopher K. Anand , Michael R. Thompson , Dee H. Wu
IPC分类号： G01V300
CPC分类号： G01R33/54
摘要： A subject is disposed in an imaging region (10) of a magnetic resonance imaging apparatus. An operator designates a steady-state imaging sequence and a sequence controller (42) coordinates a gradient field controller (30) and an RF pulse controller (38) to generate the desired sequence. The gradient controller applies gradients that define a closed trajectory through k-space that starts at an origin point and follows a closed path to an end point. An analyzer (112) analyzes data sampled at the beginning and end points. A gradient offset processor (114) signals the sequence controller to apply additional gradients until the analyzer determines that the end point coincides with the origin point. A scaling circuit (84) scales data sampled between the origin and end points for various anomalies in the steady-state magnetization, reconstructing scaled data into at least one image representation.
摘要翻译：受试者设置在磁共振成像装置的成像区域（10）中。操作员指定稳态成像序列，并且序列控制器（42）协调梯度场控制器（30）和RF脉冲控制器（38）以产生所需的序列。梯度控制器通过从原点开始的k空间来应用定义闭合轨迹的梯度，并遵循到终点的封闭路径。分析器（112）分析在开始和结束点采样的数据。梯度偏移处理器（114）向序列控制器发信号以施加附加梯度，直到分析仪确定终点与原点一致。缩放电路（84）对在稳态磁化中的各种异常进行原点和终点之间采样的数据进行缩放，将缩放后的数据重建成至少一个图像表示。

4. 发明授权

US06566877B1 Band-limited gradient waveforms 有权
标题翻译：带限制梯度波形
公开(公告)号：US06566877B1
公开(公告)日：2003-05-20
申请号：US09748499
申请日：2000-12-26
申请人： Christopher K. Anand , Michael R. Thompson
发明人： Christopher K. Anand , Michael R. Thompson
IPC分类号： G01V300
CPC分类号： G01R33/385
摘要： A subject is disposed in an imaging region (10) of a magnetic resonance imaging apparatus. An operator submits a series of user preferences to the apparatus. A gradient optimizer (82) generates a gradient waveform that is optimal for the imaging procedure based on the user submitted specifications and the apparatus hardware specifications. The optimizer (82) accesses a memory that stores ideal gradient waveform models. The model that best fits the user specifications is selected and digitized (84). The digitized waveform is then convolved (86) with a band-limited kernel (88) that represents a frequency spectrum (89) of a gradient amplifier (28), producing a gradient waveform (90) that is smooth and does not exceed the capabilities of the amplifier. This optimized waveform is used in an imaging process including a collected data reconstruction portion of the process.
摘要翻译：受试者设置在磁共振成像装置的成像区域（10）中。操作员向设备提交一系列用户偏好。梯度优化器（82）基于用户提交的规格和设备硬件规格生成对于成像过程最佳的梯度波形。优化器（82）访问存储理想梯度波形模型的存储器。选择和数字化最适合用户规格的型号（84）。然后，数字化波形与表示梯度放大器（28）的频谱（89）的带限制内核（88）卷积（86），产生平滑且不超过能力的梯度波形（90）的放大器。该优化的波形用于包括处理的收集的数据重建部分的成像处理。

5. 发明授权

US06476607B1 MRI method and apparatus for rapid acquisition of multiple views through a volume 失效
标题翻译：用于通过体积快速获取多个视图的MRI方法和装置
公开(公告)号：US06476607B1
公开(公告)日：2002-11-05
申请号：US09732815
申请日：2000-12-08
申请人： Wayne R. Dannels , Michael R. Thompson
发明人： Wayne R. Dannels , Michael R. Thompson
IPC分类号： G01V300
CPC分类号： G01R33/4824 , G01R33/4833 , G01R33/561
摘要： A magnetic resonance imaging apparatus and method employ a magnet system (12) creating a temporally constant magnetic field through an examination region (14) in which at least a portion of an object to be imaged is placed. A radio frequency (RF) excitation system (24, 26) applies an RF excitation to a volume of interest of the object to be imaged, and a receiver system (32) detects and demodulates magnetic resonance data from the volume of interest. A magnetic field encoding system (20, 22, 40) applies encoding magnetic fields to provide spatial discrimination of magnetic resonance data from the volume of interest within a single radio frequency excitation period. The spatial encoding of the magnetic resonance signal data is performed and collected along a preselected k-space trajectory, the k-space trajectory covering a plurality of intersecting. planes or partial planes of k-space data.
摘要翻译：一种磁共振成像装置和方法采用磁体系统（12），通过检查区域（14）产生时间上恒定的磁场，其中放置待成像物体的至少一部分。射频（RF）激励系统（24,26）对待成像对象的感兴趣体积应用RF激励，并且接收机系统（32）从感兴趣的体积检测和解调磁共振数据。磁场编码系统（20,22,40）施加编码磁场以在单个射频激发周期内提供来自感兴趣体积的磁共振数据的空间辨别。磁共振信号数据的空间编码沿预选的k空间轨迹执行和采集，k空间轨迹覆盖多个相交。平面或k空间数据的部分平面。

6. 发明授权

US06522139B1 Calibration of timing delays using alternating/repeating waveforms and EPI 失效
标题翻译：使用交替/重复波形和EPI校准定时延迟
公开(公告)号：US06522139B1
公开(公告)日：2003-02-18
申请号：US09712404
申请日：2000-11-14
申请人： Michael R. Thompson , Wayne R. Dannels
发明人： Michael R. Thompson , Wayne R. Dannels
IPC分类号： G01V300
CPC分类号： G01R33/5615 , G01R33/5616 , G01R33/56554
摘要： A magnetic resonance imaging system includes a gradient hardware subsystem (36), a radio frequency transmission hardware subsystem (30), and a data sampling and digitization hardware subsystem (40) A sequence control processor (20) applies control signals or pulses to the hardware subsystems to cause the implementation of a selected EPI imaging sequence. Due to inductive loads, analog filters, and other circuit constructions within the hardware subsystems, each of the hardware subsystems has a different inherent delay between receipt of a control signal and actually achieving the controlled function such as applying a gradient or RF pulse or sampling data. Due to these different inherent delays, the imaging sequence occurs with timing variations from the intended sequence. Echo planar imaging sequences are very sensitive to phase errors caused by these relative delays, which phase errors manifest themselves in the form of Nyquist ghosts. A calibration processor (60) analyzes resultant EPI images for Nyquist ghosts and adjusts a relative delay in the control signals from the signal processor until ghosting is minimized.
摘要翻译：磁共振成像系统包括梯度硬件子系统（36），射频传输硬件子系统（30）以及数据采样和数字化硬件子系统（40）。序列控制处理器（20）将控制信号或脉冲施加到硬件子系统，以实现选定的EPI成像序列。由于硬件子系统内的感性负载，模拟滤波器和其他电路结构，每个硬件子系统在接收到控制信号和实际实现受控功能之间具有不同的固有延迟，例如应用梯度或RF脉冲或采样数据。由于这些不同的固有延迟，成像序列随着来自预期序列的定时变化而发生。回波平面成像序列对由这些相对延迟引起的相位误差非常敏感，这些相位误差以奈奎斯特幽灵的形式表现出来。校准处理器（60）分析奈奎斯特重影的所得EPI图像，并调整来自信号处理器的控制信号中的相对延迟，直到重影最小化。

7. 发明授权

US5269459A Thermally responsive expansion valve 失效
标题翻译：热响应膨胀阀
公开(公告)号：US5269459A
公开(公告)日：1993-12-14
申请号：US900621
申请日：1992-06-18
申请人： Michael R. Thompson , Peter G. Malone , Peter J. Malone
发明人： Michael R. Thompson , Peter G. Malone , Peter J. Malone
IPC分类号： F25B41/06 , F25B41/04
CPC分类号： F25B41/062 , F25B2341/0683 , F25B2500/15
摘要： A refrigerant expansion valve has a pressure-responsive diaphragm forming a wall of a fluid filled chamber. The diaphragm is connected to one end of an actuator rod incorporating a hollow with a closed end opposite and operative to move a valve member for controlling flow between an inlet and outlet. The actuator member has the hollow communicating with the fluid filled chamber and its external surface exposed to return refrigerant flow. Fluid communications between the hollow of the actuator member and the fluid filled chamber is restricted by an orifice in a plug in the open end of the hollow to dampen the effects of sudden temperature changes of the return flow over the hollow. Preferably, the actuator member, plug, and diaphragm are commonly clamped, sealed, and welded together.
摘要翻译：制冷剂膨胀阀具有形成流体填充室的壁的压力响应膜片。隔膜连接到一个致动器杆的一端，该致动器杆具有一个中空孔，该空心具有一个相对的封闭端，并且可操作地移动一个阀构件，以控制入口和出口之间的流动。致动器构件具有与流体填充室连通的中空部，其外表面暴露于返回制冷剂流动。致动器构件的中空部分和流体填充腔之间的流体连通通过中空开口端中的塞子中的孔口来限制，以抑制回流在空心上的突然的温度变化的影响。优选地，致动器构件，插头和隔膜通常被夹紧，密封并焊接在一起。

8. 发明申请

US20090116761A1 Method of Motion Correction for Dynamic Volume Alignment Without Timing Restrictions 有权
标题翻译：不带时序限制的动态体积校准的运动校正方法
公开(公告)号：US20090116761A1
公开(公告)日：2009-05-07
申请号：US12296939
申请日：2007-04-03
申请人： Andrew J. Wheaton , Deepak V. Bhat , Michael R. Thompson , Wayne R. Dannels , Ad L. Moerland
发明人： Andrew J. Wheaton , Deepak V. Bhat , Michael R. Thompson , Wayne R. Dannels , Ad L. Moerland
IPC分类号： G06K9/40
CPC分类号： G01R33/56509 , A61B5/055 , A61B5/7207 , A61B5/7292 , G01R33/5673 , G06F19/00 , G06T7/20 , G06T7/30 , G06T2207/30016
摘要： When performing repetitive scans of a patient using a magnetic resonance imaging machine or the like, patients often tend to move as they relax during a lengthy scanning session, causing movement in the volume or portion of the patient being scanned. A prospective motion correction component (64) accounts for patient movement by calculating transformation data representative of patient movement in multiple planes, as well as rotational movement, and a host (38, 122) evaluates the change in position relative to a most recent scanning geometry of the patient or dynamic volume. In this manner, correction or adjustment to the scanning geometry employed by an associated scanner (10) is made only for the differential between the current geometry and the most recent geometry, to mitigate redundant adjustment that can result in oscillatory over- and under-compensation during adjustments.
摘要翻译：当使用磁共振成像机等进行患者的重复扫描时，患者经常倾向于在长时间的扫描会话期间放松时移动，导致被扫描的患者的体积或部分的运动。预期运动校正组件（64）通过计算表示多平面中的患者运动以及旋转运动的变换数据来计算患者运动，并且主机（38,122）评估相对于最近的扫描几何形状的位置变化的患者或动态体积。以这种方式，由相关联的扫描器（10）采用的扫描几何形状的校正或调整仅用于当前几何形状和最近几何形状之间的差异，以减轻可能导致振荡过度和欠补偿的冗余调整在调整期间。

9. 发明授权

US07375524B2 Mr imaging with sensitivity encoding in the readout direction 失效
标题翻译：在读出方向进行灵敏度编码的成像
公开(公告)号：US07375524B2
公开(公告)日：2008-05-20
申请号：US10560872
申请日：2004-06-01
申请人： Ulrich Katscher , Mark J. Loncar , Michael R. Thompson
发明人： Ulrich Katscher , Mark J. Loncar , Michael R. Thompson
IPC分类号： G01V3/00
CPC分类号： G01R33/5611
摘要： A magnetic resonance imaging system acquires a final image of a selected field of view with a selected spatial resolution. A magnetic resonance imaging scanner (10) encodes and receives magnetic resonance samples in phase encode and readout directions using a plurality of receive coils (14). The encoding and receiving undersamples in the readout direction. A reconstruction processor (30) reconstructs magnetic resonance samples acquired by each of the plurality of receive coils (14) into a corresponding plurality of intermediate reconstructed images. Each intermediate reconstructed image has aliasing and in some aspects degraded high spatial frequency characteristics due to the reduced sampling in the readout direction. A combining processor (40) combines the plurality of intermediate reconstructed images based on coil sensitivity factors (42) to produce the final reconstructed image with the selected field of view and the selected spatial resolution in the readout direction.
摘要翻译：磁共振成像系统以所选择的空间分辨率获取所选视场的最终图像。磁共振成像扫描器（10）使用多个接收线圈（14）对相位编码和读出方向的磁共振样本进行编码和接收。在读出方向编码和接收欠采样。重建处理器（30）将由多个接收线圈（14）中的每一个获取的磁共振样本重建成相应的多个中间重建图像。每个中间重建图像具有混叠，并且在一些方面由于在读出方向上的采样减少而导致高空间频率特性降低。组合处理器（40）基于线圈灵敏度因子（42）组合多个中间重建图像，以产生具有所选视场的最终重建图像，并且在读出方向上产生所选择的空间分辨率。

10. 发明授权

US06668253B1 Enterprise information management system and methods 有权
标题翻译：企业信息管理系统和方法
公开(公告)号：US06668253B1
公开(公告)日：2003-12-23
申请号：US09651203
申请日：2000-08-30
申请人： Michael R. Thompson , Tal D. Burkhart , Lisa D. Smith , Gregory P. Niehoff , Jamie A. Ward , Julie L. Horan , Mark A. Jung , Rayapa S. Datla , Safdar R. Syed , Satya S. Sunkara , Carol M. Hergenrather , Mary J. Matthews , Teresa J. Johnston , Elizabeth E. Campbell-Kaminski
发明人： Michael R. Thompson , Tal D. Burkhart , Lisa D. Smith , Gregory P. Niehoff , Jamie A. Ward , Julie L. Horan , Mark A. Jung , Rayapa S. Datla , Safdar R. Syed , Satya S. Sunkara , Carol M. Hergenrather , Mary J. Matthews , Teresa J. Johnston , Elizabeth E. Campbell-Kaminski
IPC分类号： G06F1730
CPC分类号： G06Q10/06
摘要： A system for enterprise information management includes a data warehouse server; a transformation and staging server connected to the data warehouse server for providing transformed and cleansed data to the data warehouse server; a data source application connected to the transformation and staging server to provide data to the transformation and staging server, wherein the transformation and staging server obtains data from the data source application via requests and places the data into temporary staging tables to prepare for the transformation and cleansing process prior to movement of the data to the data warehouse server; a financial consolidation application connected to the transformation and staging server for performing consolidation and reporting of financial data; a web server connected to the data warehouse server; and a plurality of clients connectable to the web server for accessing data from the data warehouse server via the web server.
摘要翻译：企业信息管理系统包括数据仓库服务器; 连接到数据仓库服务器的转换和分段服务器，用于向数据仓库服务器提供变换和清理的数据; 连接到转换和暂存服务器的数据源应用程序向转换和分段服务器提供数据，其中转换和分段服务器通过请求从数据源应用程序获取数据，并将数据放入临时分段表以准备转换，在将数据移动到数据仓库服务器之前的清洁过程; 与转型和分期服务器连接的财务整合应用程序，用于执行财务数据的合并和报告; 连接到数据仓库服务器的Web服务器; 以及可连接到web服务器的多个客户机，用于经由web服务器访问来自数据仓库服务器的数据。

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