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1. 发明授权

US06411089B1 Two-dimensional phase-conjugate symmetry reconstruction for 3d spin-warp, echo-planar and echo-volume magnetic resonance imaging 失效
标题翻译：用于3d自旋扭曲，回波平面和回波体积磁共振成像的二维相位共轭对称重建
公开(公告)号：US06411089B1
公开(公告)日：2002-06-25
申请号：US09718747
申请日：2000-11-22
申请人： Christopher K. Anand , Paul M. Margosian , Francis H. Bearden
发明人： Christopher K. Anand , Paul M. Margosian , Francis H. Bearden
IPC分类号： G01V300
CPC分类号： G01R33/54
摘要： A non-rectangular central kernel (200, 400, 500) of magnetic resonance image data is collected and stored in an acquired data memory (44). A non-rectangular peripheral portion (210, 410, 510) of magnetic resonance image data adjacent the central kernel (200) is collected and stored in the acquired data memory (44). A phase correction data value set (54) is generated from at least a portion of the central and peripheral data value sets. A synthetic conjugately symmetric data set (220, 420, 520) is generated (60) from the peripheral data set and phase corrected (60) using the phase correction data value set (54). Unsampled corners of k-space are zero filled. The central, peripheral, and conjugately symmetric data sets are combined (80) to form a combined data set. The combined data'set is Fourier transformed (82) to form an intermediate image representation (84), which may be exported for display (90) or used for a further iteration. In this manner, a significant amount of data in a central region of k-space that contributes most strongly to the resultant image is collected while significantly reducing data acquisition time.
摘要翻译：将磁共振图像数据的非矩形中心核心（200,400,500）收集并存储在获取的数据存储器（44）中。与中央核（200）相邻的磁共振图像数据的非矩形周边部分（210,410,510）被收集并存储在获取的数据存储器（44）中。从中央和外围数据值集合的至少一部分生成相位校正数据值集合（54）。使用相位校正数据值集合（54）从外围数据集（60）生成合成对称数据集（220,420,520）并进行相位校正（60）。 k空间的未采样角是零填充。组合中央，外围和共同对称的数据集（80）以形成组合数据集。组合数据集被傅立叶变换（82）以形成中间图像表示（84），其可以被输出用于显示（90）或用于进一步的迭代。以这种方式，在显着减少数据采集时间的同时，收集对结果图像贡献最大的k空间的中心区域中的大量数据。

2. 发明授权

US5786693A Batch multi-volume angiography using magnetic resonance imaging 失效
标题翻译：使用磁共振成像进行批量多体积血管造影
公开(公告)号：US5786693A
公开(公告)日：1998-07-28
申请号：US638641
申请日：1996-04-26
申请人： Rao P. Gullapalli , Mark J. Loncar , Paul M. Margosian
发明人： Rao P. Gullapalli , Mark J. Loncar , Paul M. Margosian
IPC分类号： G01R33/48 , A61B5/055 , G01R33/54 , G01R33/563 , G06T1/00 , G01V3/00
CPC分类号： G01R33/4835 , G01R33/5605
摘要： A sequence controller (40) controls the pulses applied by the radio transmitter (24) and the gradient amplifiers (20) and gradient coils (22) such that each repetition includes a prepreparation sequence segment, such as a presaturation sequence segment and a magnetization transfer contrast correction (MTC) segment, and a plurality of image sequence segments. More specifically, each of the image sequence segments induce resonance, phase and frequency-encode the resonance, and generate one or more views of data, all within a corresponding one of a plurality of slabs or sub-regions (74.sub.1, 74.sub.2, . . .) of an image volume (72). More precisely to the preferred embodiment, the imaging sequence segments interleave the slabs such that resonance is not excited concurrently in adjacent slabs, without exciting resonance and collecting a view in a non-adjacent slab. The views are sorted (80) by slab and stored in corresponding slab data memories (82). The data in each slab data memory is reconstructed (84) into a corresponding slab image stored in corresponding slab image memories (86). The slab images are stacked or combined (88) into a volumetric image representation of the region of interest and stored in a volume image memory (90).
摘要翻译：序列控制器（40）控制由无线电发射器（24）和梯度放大器（20）和梯度线圈（22）施加的脉冲，使得每个重复包括预制准序列片段，例如预饱和序列片段和磁化转移对比度校正（MTC）段和多个图像序列段。更具体地，每个图像序列段引起谐振，相位和频率编码谐振，并且产生数据的一个或多个视图，全部在多个板或子区域（741,742，...）中的相应一个之内。。）图像体积（72）。更准确地说，优选实施例中，成像序列段交错板坯，使得在相邻的板坯中不会同时激发共振，而不刺激共振并且收集在非相邻板坯中的视野。视图通过平板排序（80）并存储在相应的平板数据存储器（82）中。将每个平板数据存储器中的数据重建（84）到存储在对应的平板图像存储器（86）中的对应的平板图像。将平板图像堆叠或组合（88）成感兴趣区域的体积图像表示并存储在体积图像存储器（90）中。

3. 发明授权

US06639211B1 Contrast-enhanced MRA including an effective zero-latency method of bolus detection 失效
标题翻译：对比增强MRA，包括有效的零延迟方法的推注检测
公开(公告)号：US06639211B1
公开(公告)日：2003-10-28
申请号：US09718746
申请日：2000-11-22
申请人： Christopher K. Anand , Paul M. Margosian , Michael R. Thompson
发明人： Christopher K. Anand , Paul M. Margosian , Michael R. Thompson
IPC分类号： B01D5944
CPC分类号： G01R33/561 , G01R33/281 , G01R33/5619
摘要： To generate a magnetic resonance angiograph, a patient is injected with a contrast-enhancing agent (210). An ellipsoidal central portion of k-space (300) and a first surrounding region (310) are continuously sampled (220). A portion of each central data set (300, 310) is reconstructed (230) into a low-resolution volume and maximum-intensity-projected (240) onto a line. The maximum intensity projection (240) is processed (250) in order to detect the arrival of the contrast enhancing bolus within a volume of interest. Upon detection of the arrival of the bolus, the acquisition of a high-resolution magnetic resonance angiograph is triggered (260) in which higher phase encode portions (310, 420) of k-space are sampled. The central data set (300) along with the higher phase encode views (310, 420) are reconstructed (290) into a high-resolution magnetic resonance angiogram. The present technique allows for substantially zero latency between the detection of the contrast-enhancing agent bolus and the acquisition of the magnetic resonance angiogram.
摘要翻译：为了产生磁共振血管造影仪，向患者注射造影剂（210）。连续采样k空间（300）和第一周围区域（310）的椭圆形中心部分（220）。将每个中央数据集（300,310）的一部分重建（230）成一行的低分辨率体积和最大强度投影（240）。处理最大强度投影（240）（250），以便检测增强感光剂在感兴趣体积内的到达。在检测到推注的到来之后，触发采集高分辨率磁共振血管造影仪（260），其中对k空间的较高相位编码部分（310,420）进行采样。中央数据集（300）以及较高相位编码视图（310,420）被重建（290）成高分辨率磁共振血管造影图。本技术允许在对比增强剂推注的检测和磁共振血管造影图的获取之间基本上为零的等待时间。

4. 发明授权

US06505064B1 Diagnostic imaging systems and methods employing temporally resolved intensity tracing 有权
标题翻译：诊断成像系统和采用时间分辨强度追踪的方法
公开(公告)号：US06505064B1
公开(公告)日：2003-01-07
申请号：US09644034
申请日：2000-08-22
申请人： Kecheng Liu , Paul M. Margosian
发明人： Kecheng Liu , Paul M. Margosian
IPC分类号： A61B5055
CPC分类号： G06T11/206
摘要： A diagnostic imaging system (100, 200) and method generates a plurality of temporally resolved volume image representations (130, 132, . . . , 134). A time course projection processor (140, 240) temporally collapses the volume image representations. A spatial projection processor (146, 246) performs a maximum or minimum intensity process along rays through voxels of a three-dimensional image representation. By sequentially temporally collapsing and maximum or minimum intensity projecting, in either order, the plurality of temporally resolved volume image representations is reduced to a two-dimensional temporally collapsed and spatially projected image representation (148, 248). In preferred embodiments, the present invention is directed to angiography, and more preferably to magnetic resonance angiography. In certain embodiments, time course information, such as blood flow rate information, vessel wall dynamics, contrast agent propagation, contrast agent peak arrival time, and the like, is logged in a database (142), providing additional diagnostic information or timing information for future reference. In this manner, more accurate images of vessel lumina, as well as blood flow time variant effects, are obtained.
摘要翻译：诊断成像系统（100,200）和方法产生多个时间分辨的体积图像表示（130,132，...，134）。时间投影处理器（140,240）在时间上折叠卷图像表示。空间投影处理器（146,246）通过三维图像表示的体素沿着光线执行最大或最小强度处理。通过顺序地时间折叠和最大或最小强度投影，以任何顺序，多个时间分辨的体积图像表示被减少到二维时间折叠和空间投影的图像表示（148,248）。在优选实施例中，本发明涉及血管造影术，更优选磁共振血管造影术。在某些实施例中，在数据库（142）中记录诸如血液流量信息，血管壁动力学，造影剂传播，造影剂峰值到达时间等的时间过程信息，提供附加诊断信息或定时信息以后的参考。以这种方式，获得血管腔的更准确的图像，以及血流时间变化效应。

5. 发明授权

US5297551A Weighted ray projection imaging for MR angiography 失效
标题翻译：用于MR血管造影的加权射线投影成像
公开(公告)号：US5297551A
公开(公告)日：1994-03-29
申请号：US925999
申请日：1992-08-06
申请人： Paul M. Margosian , Haiying Liu
发明人： Paul M. Margosian , Haiying Liu
IPC分类号： G01R33/56 , G01R33/563 , A61B5/055
CPC分类号： G01R33/563 , G01R33/56
摘要： A magnetic resonance imaging apparatus (A) applies appropriate magnetic fields, magnetic field gradients, and radio frequency pulses across an examination region to generate magnetic resonance signals or views indicative of the properties of a volume of a subject examined in the examination region. The views are reconstructed (B) into voxel values V(x,y,z) and stored in a volumetric image memory (C). A relative angle and position of a viewing plane (10) relative to the image volume are selected. A plurality of rays (14), each corresponding to a pixel P(i,j) of a resultant projection image, are projected from the viewing plane into the volumetric image data. Each ray retrieves a corresponding vector of voxel values V.sub.1, V.sub.2, V.sub.3, . . . V.sub.n. Bright voxel values indicate blood. Dark pixel values indicate non-blood tissue. Intermediate voxel values have a greater uncertainty whether the pixel value represents blood or non-blood tissue. Probability ranges are determined (30) and used to select powers or exponents N which are used to expand the dynamic range of the voxel values non-linearly. The normalized partial sums of each ray are weightedly averaged (56 ) to produce the corresponding angiographic projection pixel value for storage in an image memory (F).
摘要翻译：磁共振成像装置（A）在检查区域中施加适当的磁场，磁场梯度和射频脉冲，以产生指示检查区域中检查的被检体体积的特性的磁共振信号或视图。视图被重建（B）到体素值V（x，y，z）中并存储在体积图像存储器（C）中。选择相对于图像体积的观察平面（10）的相对角度和位置。将从结果投影图像的像素P（i，j）对应的多个光线（14）从观察平面投影到体积图像数据中。每个射线检索体素值V1，V2，V3的相应矢量。。。 Vn。明亮的体素值表示血液。暗像素值表示非血液组织。像素值是否表示血液或非血液组织，中间体素值具有更大的不确定性。概率范围被确定（30），并用于选择用于非线性地扩展体素值的动态范围的幂或指数N. 每个射线的归一化部分和被加权平均（56）以产生用于存储在图像存储器（F）中的相应的血管造影投影像素值。

6. 发明授权

US5652513A Phase sensitive magnetic resonance technique with integrated gradient profile and continuous tunable flow 失效
标题翻译：具有积分梯度曲线和连续可调流量的相敏磁共振技术
公开(公告)号：US5652513A
公开(公告)日：1997-07-29
申请号：US690850
申请日：1996-08-01
申请人： Haiying Liu , Paul M. Margosian , Yansun Xu
发明人： Haiying Liu , Paul M. Margosian , Yansun Xu
IPC分类号： G01R33/48 , A61B5/055 , G01R33/563 , G01V3/00
CPC分类号： G01R33/563
摘要： When a magnetic resonance imaging sequence is retrieved from memory (58), one of the slice select, phase-encode to read gradient profiles are retrieved for one of the slice select, phase-encode, read gradients. The two gradient profiles have a common field of view if a read gradient or slice thickness if a slice select gradient, but have different motion sensitizations. The reference gradient profile G.sub.1 stored in a memory (52) and the motion sensitized gradient profile G.sub.2 stored in a memory (56) are weighted (60, 62) by weighting functions .alpha..sub.1, .alpha..sub.2 which are selected in accordance with the selected motion sensitivity and a selected one of the field of view or slice thickness. The weighted profiles are combined (64) to generate a motion sensitized gradient with the selected motion sensitivity, field of view or slice thickness. The combined weighted gradient profile and the reference gradient profile are used in imaging sequences to generate reference and motion sensitized data lines (82, 84) which are reconstructed (86) into a reference image representation and a motion sensitized image representation. A moving tissue only image representation can be obtained (88) as well.
摘要翻译：当从存储器（58）检索磁共振成像序列时，检索片选，相位编码，读梯度中的一个片选，相位编码读取梯度分布。如果读取梯度或切片厚度，如果切片选择梯度，但具有不同的运动敏感度，则两个梯度轮廓具有公共视场。存储在存储器（52）中的参考梯度曲线G1和存储在存储器（56）中的运动敏化梯度轮廓G2通过根据所选运动选择的加权函数α1，α2加权（60,62）灵敏度和选择的视野或切片厚度之一。加权轮廓被组合（64）以产生具有选择的运动灵敏度，视场或切片厚度的运动敏化梯度。组合的加权梯度分布和参考梯度分布用于成像序列以产生被重建（86）成参考图像表示和运动敏化图像表示的参考和运动敏化数据线（82,84）。也可以获得移动的仅组织图像表示（88）。

7. 发明授权

US5297550A Background darkening of magnetic resonance angiographic images 失效
标题翻译：磁共振血管造影图像的背景变暗
公开(公告)号：US5297550A
公开(公告)日：1994-03-29
申请号：US925993
申请日：1992-08-06
申请人： Paul M. Margosian
发明人： Paul M. Margosian
IPC分类号： G01R33/56 , G01R33/563 , G06T5/50 , A61B5/055
CPC分类号： G01R33/5607 , G01R33/56 , G01R33/563 , G06T5/50
摘要： A magnetic resonance imaging system (A) examines a region of a patient and generates a plurality of views which are reconstructed (B) into a volumetric image representation and stored in a volume image memory (C). A ray projector (D) projects a plurality of rays (14) from a selectable viewing plane (10) into the volume data and retrieves a plurality of data values that lie along each ray. A maximum intensity projection system (E) selects the brightest pixel along each ray to become the corresponding pixel value of an uncorrected projection angiographic image which is stored in an image memory (F). The uncorrected angiographic image represents blood as bright or white values and non-blood tissues as dark or black values. Noise, some tissue types, regions with fine capillaries, and the like, cause the background non-blood regions of the image to appear hazy or gray rather than black. Each pixel value from the uncorrected angiographic image is processed by a transfer function (30) to generate corresponding pixel values of a background darkened angiographic image. The transfer function is linear (32) above a threshold brightness value (34) such that the bright or blood pixels have the same brightness in both the uncorrected and background darkened images. Pixels below the threshold (34) are lowered in brightness along a parabolic curve segment (36) such that the background appears darker.
摘要翻译：磁共振成像系统（A）检查患者的区域，并且生成被重建为（B）的多个视图成为体积图像表示并存储在体积图像存储器（C）中。射线投射器（D）将多个光线（14）从可选择的观看平面（10）投射到体积数据中并检索沿着每个射线的多个数据值。最大强度投影系统（E）选择沿着每条光线的最亮像素，成为存储在图像存储器（F）中的未校正的投影血管造影图像的相应像素值。未校正的血管造影图像表示血液为亮或白色值，非血液组织为黑色或黑色值。噪音，一些组织类型，细毛细血管的区域等导致图像的背景非血液区域出现模糊或灰色，而不是黑色。来自未校正的血管造影图像的每个像素值由传递函数（30）处理以产生背景变暗的血管造影图像的相应像素值。传递函数在阈值亮度值（34）之上是线性（32），使得亮度或血液像素在未校正和背景变暗的图像中具有相同的亮度。低于阈值（34）的像素沿着抛物线曲线段（36）的亮度降低，使得背景显得更暗。

8. 发明授权

US06397096B1 Methods of rendering vascular morphology in MRI with multiple contrast acquisition for black-blood angiography 失效
标题翻译：在血管造影术中进行血管造影的方法，采用多重对比采集进行黑血管造影
公开(公告)号：US06397096B1
公开(公告)日：2002-05-28
申请号：US09540341
申请日：2000-03-31
申请人： Kecheng Liu , Paul M. Margosian , Jian Lin
发明人： Kecheng Liu , Paul M. Margosian , Jian Lin
IPC分类号： A61B5055
CPC分类号： G01R33/563 , G01R33/5608 , G01R33/5617
摘要： A black blood magnetic resonance angiogram is produced by exciting dipoles (52) and repeatedly inverting the resonance (541, 542, . . . ) to produce a series of magnetic resonance echoes (561, 562, . . . ). Early echoes (e.g., (561, . . . , 568)) are more heavily proton density weighted than later echoes (e.g., (569, . . . , 5616)), which are more heavily T2 weighted. The magnetic resonance echoes are received and demodulated (38) into a series of data lines. The data lines are sorted (60) between the more heavily proton density weighted data lines and T2 weighted data lines which are reconstructed into a proton density weighted image representation and a T2 weighted image representation. The proton density weighted and T2 weighted image representations are combined (90) to emphasize the black blood from the T2 weighted images and the static tissue from the proton density weighted image. The combination processor (90) scales (92) the PDW and T2W images to a common maximum intensity level. The PDW and T2W image representations are then combined, e.g. averaged, together (94) to form a combined or averaged image. An edge image (96) is computed from the T2W image and a threshold mask (98) is applied. The edge image (96) is combined (100) with the combined image (94) to form an edge enhanced image. Optionally, a minimum projection intensity algorithm (102) is applied to the enhanced image. Preferably, the enhanced image is a black blood magnetic resonance angiogram with emphasized blood vessel edges.
摘要翻译：通过激发偶极子（52）并重复地反转谐振（541,542 ...）来产生黑色血液磁共振血管造影图，以产生一系列磁共振回波（561,562 ......）。早期的回波（例如，（561，...，568））比后来的回波（例如，（569，...，5616））加权的质子密度更重，T2加权更重。磁共振回波被接收和解调（38）成一系列数据线。数据线在重质子密度加权数据线和被重建为质子密度加权图像表示和T2加权图像表示的T2加权数据线之间被排序（60）。将质子密度加权和T2加权图像表示组合（90）以强调来自T2加权图像的黑血和来自质子密度加权图像的静态组织。组合处理器（90）将PDW和T2W图像缩放（92）到共同的最大强度水平。然后组合PDW和T2W图像表示。平均，一起（94）以形成组合或平均图像。从T2W图像计算边缘图像（96），并应用阈值掩码（98）。边缘图像（96）与组合图像（94）组合（100）以形成边缘增强图像。可选地，将最小投影强度算法（102）应用于增强图像。优选地，增强图像是具有强调的血管边缘的黑色血液磁共振血管造影。

9. 发明授权

US06340887B1 Multiple contrast FSE approach to black blood angiography with redundant and supplementary vascular information 失效
标题翻译：多重对比FSE方法进行黑血管造影与冗余和补充血管信息
公开(公告)号：US06340887B1
公开(公告)日：2002-01-22
申请号：US09400228
申请日：1999-09-21
申请人： Kecheng Liu , Jian Lin , Paul M. Margosian
发明人： Kecheng Liu , Jian Lin , Paul M. Margosian
IPC分类号： G01V300
CPC分类号： G01R33/563 , G01R33/5608 , G01R33/5617
摘要： A black blood magnetic resonance angiogram is produced by exciting dipoles (52) and repeatedly inverting the resonance (541, 542, . . . ) to produce a series of magnetic resonance echoes (561, 562, . . . ). Early echoes (e.g., (561, . . . , 568)) are more heavily proton density weighted than later echoes (e.g., (569, . . . , 5616)) which are more heavily T2 weighted. The magnetic resonance echoes are received and demodulated (38) into a series of data lines. The data lines are sorted (60) between the more heavily proton density weighted data lines and T2 weighted data lines which are reconstructed into a proton density weighted image representation and a T2 weighted image representation. The proton density weighted and T2 weighted image representations are combined (90) to emphasize the black blood from the T2 weighted images and the static tissue from the proton density weighted image. The combined image is a black blood magnetic resonance angiogram. The production of the angiogram is time efficient and displays enhanced vessel depiction.
摘要翻译：通过激发偶极子（52）并重复地反转谐振（541,542 ...）来产生黑色血液磁共振血管造影图，以产生一系列磁共振回波（561,562 ......）。早期的回波（例如，（561，...，568））比重于T2加权的后期回波（例如（569，...，5616））更重的质子密度。磁共振回波被接收和解调（38）成一系列数据线。数据线在重质子密度加权数据线和被重建为质子密度加权图像表示和T2加权图像表示的T2加权数据线之间被排序（60）。将质子密度加权和T2加权图像表示组合（90）以强调来自T2加权图像的黑血和来自质子密度加权图像的静态组织。组合的图像是黑色血液磁共振血管造影。血管造影术的生产是时间有效的并显示增强的血管描述。

10. 发明授权

US5525905A Patient handling system for use on multiple imaging systems 失效
标题翻译：用于多个成像系统的患者处理系统
公开(公告)号：US5525905A
公开(公告)日：1996-06-11
申请号：US342584
申请日：1994-11-21
申请人： Surya N. Mohapatra , Paul M. Margosian , Fredrick F. Awig
发明人： Surya N. Mohapatra , Paul M. Margosian , Fredrick F. Awig
IPC分类号： A61B6/00 , A61B5/055 , A61B6/03 , A61B6/04 , G01V3/00
CPC分类号： A61B6/0457
摘要： A object handling system is moveable between various diagnostic imaging apparatus for imaging thereby. The handling system has an object handling computer 34 for storing object identification data and imaging data. Selectively linking the object handling computer 34 with a first imaging system provides the first imaging system with access to the object identification data and imaging data for use in the production of diagnostic images thereby. Similarly, the object identification data and imaging data are available to a second imaging system for use in the production of diagnostic images thereby when the object handling computer 34 is selectively linked thereto. The object identification data is associated with the diagnostic images produced by various imaging system for subsequent correlation of the object with the diagnostic images of the object. The object handling computer 34 also modifies various automated table movement apparatus as a function of the imaging system to which the handling system is selectively linked.
摘要翻译：物体处理系统可在用于成像的各种诊断成像装置之间移动。处理系统具有用于存储对象识别数据和成像数据的对象处理计算机34。将对象处理计算机34与第一成像系统选择性地链接，使得第一成像系统能够访问对象识别数据和成像数据，从而在生产诊断图像中使用。类似地，对象识别数据和成像数据可用于第二成像系统，以用于生产诊断图像，从而当对象处理计算机34选择性地链接到其上时。对象识别数据与由各种成像系统产生的诊断图像相关联，用于随后对象与对象的诊断图像的相关性。对象处理计算机34还可以将各种自动台移动装置修改为选择性地链接处理系统的成像系统的功能。

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