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1. 发明申请

US20130190697A1 DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE 有权
标题翻译：用于药物递送装置的驱动机构
公开(公告)号：US20130190697A1
公开(公告)日：2013-07-25
申请号：US13702808
申请日：2011-06-09
申请人： Steffen Raab , Christopher James Smith , Mark Philip Horlock , Stephen David Butler
发明人： Steffen Raab , Christopher James Smith , Mark Philip Horlock , Stephen David Butler
IPC分类号： A61M5/315
CPC分类号： A61M5/31543 , A61M5/24 , A61M5/3155 , A61M5/31551 , A61M5/31553 , A61M5/31555 , A61M5/3158 , A61M5/31583 , A61M5/31585
摘要： A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation member being adapted to move the stop member and the drive member in the distal direction with respect to the housing when the normal operation state is switched to the reset state, thereby decoupling the stop member and the drive member and decoupling the drive member and the rotation member.
摘要翻译：用于可在正常操作状态和复位状态之间切换的药物输送装置的驱动机构包括具有近端和远端的壳体，适于沿第一方向旋转的旋转构件方向相对于壳体，驱动构件，其中在正常操作状态下，旋转构件与驱动构件联接，使得驱动构件沿第二方向旋转构件的旋转运动，活塞杆，其中在当驱动构件相对于壳体沿第二方向旋转时，活塞杆相对于壳体在远端方向上移位，其中在正常操作状态下，止动构件与驱动器联接使得止动构件防止驱动构件相对于壳体沿第一方向的旋转运动，以及用于切换操作的分离构件 n状态，当正常操作状态切换到复位状态时，分离构件适于在远端方向上相对于壳体移动止动构件和驱动构件，从而使止动构件和驱动构件分离，驱动构件和旋转构件。

2. 发明授权

US08882723B2 Drive mechanism for a drug delivery device and drug delivery device 有权
标题翻译：用于药物递送装置和药物递送装置的驱动机构
公开(公告)号：US08882723B2
公开(公告)日：2014-11-11
申请号：US13702812
申请日：2011-06-09
申请人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
发明人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
IPC分类号： A61M5/00 , A61M5/315
CPC分类号： A61M5/31528 , A61M5/31543 , A61M5/31555 , A61M5/31585
摘要： A drive member and a rotation member are rotatable with respect to a housing. A stop member is rotationally locked with the housing. Clutches unidirectionally rotationally engage the drive member with the rotation member and with the stop member when a unit is attached to the housing. A separating member is disposed between the rotation member and the stop member. The separating member causes a separation of the rotation member, the drive member and the stop member when the unit is removed. A coupling feature of the separating member is provided to engage the unit and to move the separating member when the unit is being attached to the housing or is being removed.
摘要翻译：驱动构件和旋转构件可相对于壳体旋转。止动构件与壳体旋转地锁定。当单元附接到壳体时，离合器单向地旋转地与驱动构件旋转地接合旋转构件和止动构件。分离构件设置在旋转构件和止动构件之间。当单元被移除时，分离构件导致旋转构件，驱动构件和止动构件的分离。提供分离构件的联接特征以接合单元并且当单元附接到壳体或正在移除时移动分离构件。

3. 发明申请

US20130190719A1 DRUG DELIVERY DEVICE WITH DRIVE MEMBER HAVING INDICATION ELEMENTS 审中-公开
标题翻译：具有指示元件的驱动器的药物递送装置
公开(公告)号：US20130190719A1
公开(公告)日：2013-07-25
申请号：US13702816
申请日：2011-06-09
申请人： Christopher James Smith , Mark Philip Horlock , Stephen David Butler
发明人： Christopher James Smith , Mark Philip Horlock , Stephen David Butler
IPC分类号： A61M5/315
CPC分类号： A61M5/31568 , A61M5/24 , A61M5/31543 , A61M5/31555 , A61M5/31585 , A61M2005/3125 , A61M2005/3126
摘要： A drug delivery device is proposed, which comprises a housing, a drive member which is movably retained within the housing, a piston rod which is operatively coupled to the drive member, wherein the drug delivery device is configured to convert movement of the drive member with respect to the housing into movement of the piston rod with respect to the drive member, wherein a surface of the drive member is provided with one or a plurality of indication elements, and wherein the drug delivery device is adapted to display at least one of the indication elements through the housing. Furthermore it is proposed to use a single member in a drug delivery device for driving movement of a piston rod of the device and for displaying dose related information to a user of the device.
摘要翻译：提出了一种药物输送装置，其包括壳体，可移动地保持在壳体内的驱动构件，可操作地联接到驱动构件的活塞杆，其中药物输送装置构造成将驱动构件的运动转换为相对于驱动构件，活塞杆相对于驱动构件的运动相对于壳体，其中驱动构件的表面设置有一个或多个指示元件，并且其中药物输送装置适于显示至少一个指示元素通过住房。此外，建议在药物输送装置中使用单个构件来驱动装置的活塞杆的运动并向用户显示剂量相关信息。

4. 发明申请

US20130211331A1 DRIVE ASSEMBLY, DRIVE COMPONENT AND DRUG DELIVERY DEVICE 有权
标题翻译：驱动组件，驱动组件和药物传送装置
公开(公告)号：US20130211331A1
公开(公告)日：2013-08-15
申请号：US13701995
申请日：2011-06-09
申请人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
发明人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
IPC分类号： F16H19/02 , A61M5/142
CPC分类号： A61M5/31551 , A61M5/142 , A61M5/31536 , A61M5/31555 , A61M5/31585 , A61M2205/581 , A61M2205/582 , F16H19/02 , Y10T74/18568
摘要： A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.
摘要翻译：用于药物递送装置的驱动组件包括旋转构件，其构造成在药物剂量的设定期间沿第一方向旋转并且在剂量递送期间沿第二方向旋转，驱动部件被配置为跟随在剂量输送期间旋转构件在第二方向上的旋转运动，以及止动构件被构造成防止驱动构件在第一方向上的旋转运动。驱动部件包括彼此连接的第一驱动部分和第二驱动部分，从而防止第一和第二驱动部件的相对旋转运动并允许相对的轴向移动。

5. 发明申请

US20130184652A1 DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE 有权
标题翻译：用于药物递送装置和药物递送装置的驱动机构
公开(公告)号：US20130184652A1
公开(公告)日：2013-07-18
申请号：US13702812
申请日：2011-06-09
申请人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
发明人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
IPC分类号： A61M5/315
CPC分类号： A61M5/31528 , A61M5/31543 , A61M5/31555 , A61M5/31585
摘要： A drive member and a rotation member are rotatable with respect to a housing. A stop member is rotationally locked with the housing. Clutches unidirectionally rotationally engage the drive member with the rotation member and with the stop member when a unit is attached to the housing. A separating member is disposed between the rotation member and the stop member. The separating member causes a separation of the rotation member, the drive member and the stop member when the unit is removed. A coupling feature of the separating member is provided to engage the unit and to move the separating member when the unit is being attached to the housing or is being removed.
摘要翻译：驱动构件和旋转构件可相对于壳体旋转。止动构件与壳体旋转地锁定。当单元附接到壳体时，离合器单向地旋转地与驱动构件旋转地接合旋转构件和止动构件。分离构件设置在旋转构件和止动构件之间。当单元被移除时，分离构件导致旋转构件，驱动构件和止动构件的分离。提供分离构件的联接特征以接合单元并且当单元附接到壳体或正在移除时移动分离构件。

6. 再颁专利

USRE46814E1 Medication delivery device 有权
公开(公告)号：USRE46814E1
公开(公告)日：2018-05-01
申请号：US14677006
申请日：2015-04-02
申请人： Christopher James Smith , Michael Heald , Stephen David Butler , Mark Philip Horlock
发明人： Christopher James Smith , Michael Heald , Stephen David Butler , Mark Philip Horlock
IPC分类号： A61M5/315
CPC分类号： A61M5/315
摘要： A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing. In the resetting state of the device the coupling means is disengaged from the conversion element under force of the resilient member, the conversion element thereby being allowed to rotate with respect to the housing and thereby allowing a resetting of the device.

7. 发明授权

US09555195B2 Drive assembly, drive component and drug delivery device 有权
标题翻译：驱动组件，驱动部件和药物输送装置
公开(公告)号：US09555195B2
公开(公告)日：2017-01-31
申请号：US13701995
申请日：2011-06-09
申请人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
发明人： Christopher James Smith , Stephen David Butler , Mark Philip Horlock
IPC分类号： A61M5/142 , A61M5/315 , F16H19/02
CPC分类号： A61M5/31551 , A61M5/142 , A61M5/31536 , A61M5/31555 , A61M5/31585 , A61M2205/581 , A61M2205/582 , F16H19/02 , Y10T74/18568
摘要： A drive assembly for a drug delivery device comprises a rotation member being configured to be rotated in a first direction during setting of a dose of a drug and to be rotated in a second direction during delivery of the dose, a drive component being configured to follow rotational movement of the rotation member in the second direction during delivery of the dose and a stop member being configured to prevent rotational movement of the drive component in the first direction. The drive component comprises a first drive part and a second drive part, coupled to each other such that relative rotational movement of the first and second drive parts is prevented and relative axial movement is permitted.
摘要翻译：用于药物递送装置的驱动组件包括旋转构件，其构造成在药物剂量的设定期间沿第一方向旋转并且在剂量递送期间沿第二方向旋转，驱动部件被配置为跟随在剂量输送期间旋转构件在第二方向上的旋转运动，以及止动构件被构造成防止驱动构件在第一方向上的旋转运动。驱动部件包括彼此连接的第一驱动部分和第二驱动部分，从而防止第一和第二驱动部件的相对旋转运动并允许相对的轴向移动。

8. 发明授权

US09498576B2 Drive mechanism for a drug delivery device 有权
标题翻译：药物输送装置的驱动机构
公开(公告)号：US09498576B2
公开(公告)日：2016-11-22
申请号：US13702808
申请日：2011-06-09
申请人： Steffen Raab , Christopher James Smith , Mark Philip Horlock , Stephen David Butler
发明人： Steffen Raab , Christopher James Smith , Mark Philip Horlock , Stephen David Butler
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31543 , A61M5/24 , A61M5/3155 , A61M5/31551 , A61M5/31553 , A61M5/31555 , A61M5/3158 , A61M5/31583 , A61M5/31585
摘要： A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation member being adapted to move the stop member and the drive member in the distal direction with respect to the housing when the normal operation state is switched to the reset state, thereby decoupling the stop member and the drive member and decoupling the drive member and the rotation member.
摘要翻译：用于可在正常操作状态和复位状态之间切换的药物输送装置的驱动机构包括具有近端和远端的壳体，适于沿第一方向旋转的旋转构件方向相对于壳体，驱动构件，其中在正常操作状态下，旋转构件与驱动构件联接，使得驱动构件沿第二方向旋转构件的旋转运动，活塞杆，其中在当驱动构件相对于壳体沿第二方向旋转时，活塞杆相对于壳体在远端方向上移位，其中在正常操作状态下，止动构件与驱动器联接使得止动构件防止驱动构件相对于壳体沿第一方向的旋转运动，以及用于切换操作的分离构件 n状态，当正常操作状态切换到复位状态时，分离构件适于在远端方向上相对于壳体移动止动构件和驱动构件，从而使止动构件和驱动构件分离，驱动构件和旋转构件。

9. 发明授权

US09669170B2 Safety device and injection device 有权
公开(公告)号：US09669170B2
公开(公告)日：2017-06-06
申请号：US14241842
申请日：2012-09-11
申请人： Matthew Ekman , Christopher James Smith , Troy Baker , Graham Wilson , Gareth Roberts , Carl Tucker
发明人： Matthew Ekman , Christopher James Smith , Troy Baker , Graham Wilson , Gareth Roberts , Carl Tucker
IPC分类号： A61M5/32 , A61M5/28
CPC分类号： A61M5/326 , A61M5/28 , A61M2005/3247
摘要： A safety device suitable for a pre-filled syringe containing a medicament includes a chassis adapted to be affixed to the pre-filled syringe, a deformable flexible outer structure made from a material with a shape memory, and a substantially cylindrical needle shield affixed or integral to the outer structure. The deformed flexible outer structure is capable of advancing the needle shield with respect to the chassis in a distal direction into a position in which the needle shield projects from the chassis in the distal direction. A biasing force for advancing the needle shield originates from a shape memory effect that causes the deformed flexible outer structure to substantially return to its unstressed shape.

10. 发明申请

US20140213983A1 Safety Device and Injection Device 有权
标题翻译：安全装置和注射装置
公开(公告)号：US20140213983A1
公开(公告)日：2014-07-31
申请号：US14241842
申请日：2012-09-11
申请人： Matthew Ekman , Christopher James Smith , Troy Baker , Graham Wilson , Gareth Roberts , Carl Tucker
发明人： Matthew Ekman , Christopher James Smith , Troy Baker , Graham Wilson , Gareth Roberts , Carl Tucker
IPC分类号： A61M5/32
CPC分类号： A61M5/326 , A61M5/28 , A61M2005/3247
摘要： According to the invention, a safety device suitable (S) for a pre-filled syringe containing a medicament comprises a chassis adapted to be affixed to the pre-filled syringe, a deformable flexible outer structure made from a material with a shape memory and a substantially cylindrical needle shield affixed or integral to the outer structure. The deformed flexible outer structure is capable of advancing the needle shield with respect to the chassis in a distal direction (D) into a position in which the needle shield projects from the chassis in the distal direction (D). A biasing force for advancing the needle shield originates from a shape memory effect that causes the deformed flexible outer structure to substantially return to its unstressed shape.
摘要翻译：根据本发明，一种用于装有药物的预装注射器的适于（S）的安全装置包括适于固定到预填充注射器的底盘，由具有形状记忆的材料制成的可变形柔性外部结构，基本上圆柱形的针护罩固定或与外部结构一体。变形的柔性外部结构能够使针护罩相对于底盘沿远端方向（D）推进到针护罩在远端方向（D）处从底盘突出的位置。用于推进针护罩的偏置力源自形状记忆效应，其使得变形的柔性外部结构基本上返回到其不受应力的形状。

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