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1. 发明申请

US20110151534A1 INDUSTRIAL PRODUCTION OF ORGANIC COMPOUNDS USING RECOMBINANT ORGANISMS EXPRESSING METHYL HALIDE TRANSFERASE 审中-公开
标题翻译：使用表达甲基卤化物转移酶的重组体进行工业化生产有机化合物
公开(公告)号：US20110151534A1
公开(公告)日：2011-06-23
申请号：US12745538
申请日：2008-11-26
申请人： Christopher A. Voigt , Daniel V. Santi , Travis S. Bayer
发明人： Christopher A. Voigt , Daniel V. Santi , Travis S. Bayer
IPC分类号： C12P1/02 , C12N1/13 , C12N1/15 , C12N1/21 , C12N1/19
CPC分类号： C12N9/10 , C12P5/00 , Y02E50/16
摘要： The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules.
摘要翻译：本发明涉及使用表达S-腺苷甲硫氨酸（SAM） - 依赖性甲基卤转移酶的遗传工程生物生产有机化合物的方法，并且任选地在通过SAM代谢途径影响通过或影响细胞内卤化物水平的位点处修饰。在一种方法中，生物体，卤化物（氯，溴和/或碘）; 并将碳源在培养基中在产生甲基卤的条件下培养。甲基卤可以被收集并转化成非卤化的有机分子。

2. 发明申请

US20110165618A1 BIOLOGICAL SYSTEMS FOR PRODUCTION OF COMMERCIALLY VALUABLE COMPOUNDS 有权
标题翻译：用于生产商业有价值化合物的生物系统
公开(公告)号：US20110165618A1
公开(公告)日：2011-07-07
申请号：US12745539
申请日：2008-11-26
申请人： Christopher A. Voigt , Travis S. Bayer
发明人： Christopher A. Voigt , Travis S. Bayer
IPC分类号： C12P39/00 , C12N1/20
CPC分类号： C12N9/10 , C12P5/00 , Y02E50/16
摘要： The invention relates to systems and methods for production of compounds by yeast and other organisms. In one approach yeast engineered for production of a compound of commercial value is cultured together with a cellulosic bacteria, and the yeast uses a metabolic product produced by the bacteria as a carbon source. Methyl halides are an example of compounds that may be produced by this process. The invention also relates to production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase. In one approach the organism, halides and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules.
摘要翻译：本发明涉及由酵母和其他生物体生产化合物的系统和方法。在一种方法中，用于生产商业价值化合物的酵母菌与纤维素细菌一起培养，酵母使用由细菌产生的代谢产物作为碳源。甲基卤化物是可以通过该方法生产的化合物的实例。本发明还涉及使用表达S-腺苷甲硫氨酸（SAM） - 依赖性甲基卤转移酶的遗传工程生物体生产有机化合物。在一种方法中，生物体，卤化物和碳源在培养基中在产生甲基卤的条件下孵育。甲基卤可以被收集并转化成非卤化的有机分子。

3. 发明授权

US09657279B2 Biological systems for production of commercially valuable compounds 有权
公开(公告)号：US09657279B2
公开(公告)日：2017-05-23
申请号：US12745539
申请日：2008-11-26
申请人： Christopher A. Voigt , Travis S. Bayer
发明人： Christopher A. Voigt , Travis S. Bayer
IPC分类号： C12P39/00 , C12N1/20 , A01N63/00 , A61K48/00 , C12N9/10 , C12P5/00
CPC分类号： C12N9/10 , C12P5/00 , Y02E50/16
摘要： The invention relates to systems and methods for production of compounds by yeast and other organisms. In one approach yeast engineered for production of a compound of commercial value is cultured together with a cellulosic bacteria, and the yeast uses a metabolic product produced by the bacteria as a carbon source. Methyl halides are an example of compounds that may be produced by this process. The invention also relates to production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase. In one approach the organism, halides and a carbon source are incubated in a cultivation medium under conditions in which methyl halide is produced. The methyl halide may be collected and converted into non-halogenated organic molecules.

4. 发明申请

US20120258506A1 CELL-BASED SYSTEMS FOR PRODUCTION OF METHYL FORMATE 有权
标题翻译：用于生产甲基纤维素的基于细胞的系统
公开(公告)号：US20120258506A1
公开(公告)日：2012-10-11
申请号：US13386205
申请日：2010-07-22
申请人： Christopher A. Voigt , Travis S. Bayer
发明人： Christopher A. Voigt , Travis S. Bayer
IPC分类号： C12P7/62 , C12N1/19 , C12N1/20 , C12P7/04
CPC分类号： C12N9/1007 , C12P1/02 , C12P7/62 , C12P39/00 , C12Y201/01165
摘要： Disclosed is a process in which a recombinant organism, such as a yeast, expressing a heterologous S-adenosylmethionme (SAM)-dependent methyl halide transferase (MHT) protein is combined with a halide and a carbon source in a cultivation medium under conditions in which methyl formate is produced. The cell may genetically modified to express methyl formate synthase, methanol dehydrogenase and/or hydrolytic dehalogenase at levels higher than a cell of the same species that is not genetically modified. The methyl formate may be collected and used in a variety of applications. The halide may be chlorine, bromine or iodine.
摘要翻译：公开了一种方法，其中将表达异源S-腺苷甲硫氨酸（SAM） - 依赖性甲基卤转移酶（MHT））蛋白的重组生物体如酵母与培养基中的卤化物和碳源组合，产生甲酸甲酯。所述细胞可以在高于未经遗传修饰的相同物种的细胞的水平上进行基因修饰以表达甲酸甲酯合酶，甲醇脱氢酶和/或水解脱卤素酶。可以收集甲酸甲酯并将其用于各种应用中。卤化物可以是氯，溴或碘。

5. 发明授权

US09040266B2 Cell-based systems for production of methyl formate 有权
标题翻译：用于生产甲酸甲酯的基于细胞的系统
公开(公告)号：US09040266B2
公开(公告)日：2015-05-26
申请号：US13386205
申请日：2010-07-22
申请人： Christopher A. Voigt , Travis S. Bayer
发明人： Christopher A. Voigt , Travis S. Bayer
IPC分类号： C12P7/62 , C12P1/02 , C12N9/10 , C12P39/00
CPC分类号： C12N9/1007 , C12P1/02 , C12P7/62 , C12P39/00 , C12Y201/01165
摘要： Disclosed is a process in which a recombinant organism, such as a yeast, expressing a heterologous S-adenosylmethionine (SAM)-dependent methyl halide transferase (MHT) protein is combined with a halide and a carbon source in a cultivation medium under conditions in which methyl formate is produced. The cell may genetically modified to express methyl formate synthase, methanol dehydrogenase and/or hydrolytic dehalogenase at levels higher than a cell of the same species that is not genetically modified. The methyl formate may be collected and used in a variety of applications. The halide may be chlorine, bromine or iodine.
摘要翻译：公开了一种方法，其中将表达异源S-腺苷甲硫氨酸（SAM） - 依赖性甲基卤转移酶（MHT）蛋白的酵母的重组生物体与培养基中的卤化物和碳源组合，产生甲酸甲酯。所述细胞可以在高于未经遗传修饰的相同物种的细胞的水平上进行基因修饰以表达甲酸甲酯合酶，甲醇脱氢酶和/或水解脱卤素酶。可以收集甲酸甲酯并将其用于各种应用中。卤化物可以是氯，溴或碘。

6. 发明授权

US08828658B2 Spatio-temporal control of protein interactions using phytochromes 有权
标题翻译：使用植物色素进行蛋白质相互作用的时空控制
公开(公告)号：US08828658B2
公开(公告)日：2014-09-09
申请号：US12993702
申请日：2009-05-26
申请人： Christopher A. Voigt , Anselm Levskaya , Wendell Lim
发明人： Christopher A. Voigt , Anselm Levskaya , Wendell Lim
IPC分类号： C12Q1/68 , C12N5/00
CPC分类号： C12N5/00 , C12N2529/10
摘要： The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome-interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain-interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain.
摘要翻译：本发明提供了使用光调节感兴趣的蛋白质之间的关联的方法，材料和系统。在一方面，本发明利用植物色素在暴露于合适的光条件下改变构象的能力，并以构象依赖性方式结合称为植物色素相互作用因子的同源蛋白质。本发明包括通过光调节细胞内第一种目的蛋白质和第二种蛋白质之间的相互作用的方法。这种方法任选地包括在细胞（1）中提供包含第一蛋白质，植物色素结构域（PHD）的第一蛋白质构建体，和（2）在细胞中提供包含第二蛋白质和植物色素结构域的第二蛋白质构建体 - 相互作用肽（PIP），其可以选择性地结合植物色素结构域的Pfr状态但不结合Pr状态。

7. 发明授权

US09512431B2 Synthetic gene clusters 有权
标题翻译：合成基因簇
公开(公告)号：US09512431B2
公开(公告)日：2016-12-06
申请号：US14126307
申请日：2012-06-14
申请人： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
发明人： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
IPC分类号： C12N15/63 , C07K14/255 , C07K14/26 , C12N15/52 , C12N15/67 , C12N15/74 , G06F19/22
CPC分类号： C12N15/635 , C07K14/255 , C07K14/26 , C12N9/0095 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/74 , C12Y118/06001 , G06F19/20 , G06F19/22
摘要： Methods for making synthetic gene clusters are described.
摘要翻译：描述制备合成基因簇的方法。

8. 发明申请

US20140329326A1 SYNTHETIC GENE CLUSTERS 有权
标题翻译：合成基因组
公开(公告)号：US20140329326A1
公开(公告)日：2014-11-06
申请号：US14126307
申请日：2012-06-14
申请人： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
发明人： Ethan Mirsky , Karsten Temme , Christopher A. Voigt , Dehua Zhao
IPC分类号： C12N15/63
CPC分类号： C12N15/635 , C07K14/255 , C07K14/26 , C12N9/0095 , C12N15/52 , C12N15/63 , C12N15/67 , C12N15/74 , C12Y118/06001 , G06F19/20 , G06F19/22
摘要： Methods for making synthetic gene clusters are described.
摘要翻译：描述制备合成基因簇的方法。

9. 发明申请

US20110207116A1 SPATIO-TEMPORAL CONTROL OF PROTEIN INTERACTIONS USING PHYTOCHROMES 有权
标题翻译：使用生物色素蛋白质相互作用的时空控制
公开(公告)号：US20110207116A1
公开(公告)日：2011-08-25
申请号：US12993702
申请日：2009-05-26
申请人： Christopher A. Voigt , Anselm Levskaya
发明人： Christopher A. Voigt , Anselm Levskaya
IPC分类号： C12Q1/68 , C12Q1/02 , C12N5/071 , C12N5/10 , C07H21/00
CPC分类号： C12N5/00 , C12N2529/10
摘要： The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome-interacting factors. The invention comprises a method of regulating interaction between a first protein of interest and second protein within a cell by light. Such a method optionally comprises providing in the cell (1) a first protein construct which comprises the first protein, a phytochrome domain (PHD), and (2) providing in the cell a second protein construct which comprises the second protein and a phytochrome domain-interacting peptide (PIP) that can bind selectively to the Pfr state, but not to the Pr state, of the phytochrome domain.
摘要翻译：本发明提供了使用光调节感兴趣的蛋白质之间的关联的方法，材料和系统。在一方面，本发明利用植物色素在暴露于合适的光条件下改变构象的能力，并以构象依赖性方式结合称为植物色素相互作用因子的同源蛋白质。本发明包括通过光调节细胞内第一种目的蛋白质和第二种蛋白质之间的相互作用的方法。这种方法任选地包括在细胞（1）中提供包含第一蛋白质，植物色素结构域（PHD）的第一蛋白质构建体，和（2）在细胞中提供包含第二蛋白质和植物色素结构域的第二蛋白质构建体 - 相互作用肽（PIP），其可以选择性地结合植物色素结构域的Pfr状态但不结合Pr状态。

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