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1. 发明授权

US07400409B2 Coherence microscope using interference of time incoherent light to achieve depth resolution in a measurement specimen 有权
标题翻译：相干显微镜使用时间非相干光的干涉来实现测量样本中的深度分辨率
公开(公告)号：US07400409B2
公开(公告)日：2008-07-15
申请号：US10538587
申请日：2003-12-16
申请人： Christoph Hauger , Hans-Joachim Miesner , Ludwin Monz
发明人： Christoph Hauger , Hans-Joachim Miesner , Ludwin Monz
IPC分类号： G01B9/02
CPC分类号： G02B21/0004 , G01B9/02091 , G01B2290/65
摘要： A coherence microscope has a divider (3) that divides light emitted by a light source (1) into measurement light, which is supplied to and reflected by a specimen (13), and reference light. A superimposition device (25, 31) superimposes the measurement light reflected by the specimen (13) with the reference light. A short sensor array (41) detects the light resulting from the superimposition and permits a read-out rate of at least about 60 kHz. The superimposition device has an emission device (25, 31) for emitting the measurement light and the reference light arranged to effect extensive irradiation of the sensor array (41) with superimposed light. The ratio of distances covered by the measurement light and the reference light from the emission device (25, 31) to impingement points on the sensor array (41) varies in the portion of the sensor array (41) that is irradiated with superimposed light.
摘要翻译：相干显微镜具有将由光源（1）发射的光分离成被供给到试样（13）并被反射的测量光和参考光的分割器（3）。叠加装置（25,31）将由试样（13）反射的测量光与参考光重叠。短传感器阵列（41）检测由叠加产生的光，并允许至少约60kHz的读出速率。叠加装置具有用于发射测量光的发射装置（25,31）和布置成以叠加的光来广泛照射传感器阵列（41）的参考光。测量光所覆盖的距离与来自发射装置（25,31）的参考光与传感器阵列（41）上的撞击点的比率在用叠加的光照射的传感器阵列（41）的部分中变化。

2. 发明申请

US20060056784A1 Coherence microscope 有权
标题翻译：相干显微镜
公开(公告)号：US20060056784A1
公开(公告)日：2006-03-16
申请号：US10538587
申请日：2003-12-16
申请人： Christoph Hauger , Hans-Joachim Miesner , Ludwin Monz
发明人： Christoph Hauger , Hans-Joachim Miesner , Ludwin Monz
IPC分类号： G02B6/04
CPC分类号： G02B21/0004 , G01B9/02091 , G01B2290/65
摘要： A coherence microscope has a divider (3) that divides light emitted by a light source (1) into measurement light, which is supplied to and reflected by a specimen (13), and reference light. A superimposition device (25, 31) superimposes the measurement light reflected by the specimen (13) with the reference light. A short sensor array (41) detects the light resulting from the superimposition and permits a read-out rate of at least about 60 kHz. The superimposition device has an emission device (25, 31) for emitting the measurement light and the reference light arranged to effect extensive irradiation of the sensor array (41) with superimposed light. The ratio of distances covered by the measurement light and the reference light from the emission device (25, 31) to impingement points on the sensor array (41) varies in the portion of the sensor array (41) that is irradiated with superimposed light.
摘要翻译：相干显微镜具有将由光源（1）发射的光分离成被供给到试样（13）并被反射的测量光和参考光的分割器（3）。叠加装置（25,31）将由试样（13）反射的测量光与参考光重叠。短传感器阵列（41）检测由叠加产生的光，并允许至少约60kHz的读出速率。叠加装置具有用于发射测量光的发射装置（25,31）和布置成以叠加的光来广泛照射传感器阵列（41）的参考光。测量光所覆盖的距离与来自发射装置（25,31）的参考光与传感器阵列（41）上的撞击点的比率在用叠加的光照射的传感器阵列（41）的部分中变化。

3. 发明申请

US20110166420A1 IMAGING METHOD AND APPARATUS 审中-公开
标题翻译：成像方法和装置
公开(公告)号：US20110166420A1
公开(公告)日：2011-07-07
申请号：US12756692
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
IPC分类号： A61B1/06
CPC分类号： A61B1/00078 , A61B1/00009 , A61B1/00041 , A61B1/00045 , A61B1/0005 , A61B1/0008 , A61B1/00172 , A61B1/042 , A61B1/06 , A61B1/227 , A61B1/233 , A61B1/267 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/064 , A61B5/065 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B7/02 , A61B8/12 , A61B90/90 , A61B90/92 , A61B90/94 , G02B21/0028 , G02B23/2476
摘要： An imaging apparatus and method are provided. The probe for an imaging apparatus includes a manually manipulable proximal portion; a straight distal portion with a distal tip for locating at a site to define an observational field; and a curved portion between the proximal portion and the distal portion. The imaging method includes the steps of locating a distal tip of an imaging probe at a site to define an observational field; irradiating the observational field from the distal tip; and collecting a return signal at the distal tip; wherein the probe comprises a manually manipulable proximal portion. The apparatus and method provided herein are useful for various applications including but not limited to endomicroscopy and other microsurgical procedures performed under optical stereoscopic magnified visualization, such as neurosurgery, ENT/facial surgery and spinal surgery.
摘要翻译：提供了一种成像装置和方法。用于成像装置的探针包括手动可操纵的近端部分; 具有远端的直的远端部分，用于定位在现场以限定观察场; 以及在近端部分和远端部分之间的弯曲部分。该成像方法包括以下步骤：将成像探针的远侧末端定位在位置以限定观察场; 从远端照射观察场; 并在远端收集返回信号; 其中所述探针包括可手动操作的近端部分。本文提供的装置和方法可用于各种应用，包括但不限于在光学立体放大显微镜（例如神经外科手术，ENT /面部手术和脊柱手术）下执行的内窥镜和其他显微外科手术。

4. 发明申请

US20070090985A1 Microscopy system and recording method for visualizing fluorescence 有权
标题翻译：显微镜系统和荧光显像的记录方法
公开(公告)号：US20070090985A1
公开(公告)日：2007-04-26
申请号：US11544269
申请日：2006-10-06
申请人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
发明人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
IPC分类号： H03M1/12
CPC分类号： G02B21/0076 , G01N21/6428 , G01N21/6458
摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.
摘要翻译：图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。电路的增益可调。在记录过程开始时，增益被设置为合适的最大值。如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。

5. 发明申请

US20110178395A1 IMAGING METHOD AND SYSTEM 审中-公开
标题翻译：成像方法与系统
公开(公告)号：US20110178395A1
公开(公告)日：2011-07-21
申请号：US12756765
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
IPC分类号： A61B6/00
CPC分类号： A61B5/064 , A61B1/00041 , A61B1/0005 , A61B1/0008 , A61B1/00096 , A61B1/00149 , A61B1/00172 , A61B1/042 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/065 , A61B5/445 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B8/12 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B90/20 , A61B90/36 , A61B2090/364 , A61B2562/0242 , G02B21/0012 , G02B21/0024
摘要： Imaging systems and methods are provided herein. An imaging system for imaging a surgical site, may include a macroscopic visualization system; and an imaging apparatus with a probe, the imaging apparatus being adapted to image the observational field and generate second image data; wherein the system is operable to control the macroscopic visualization system and the imaging apparatus to image the site and the observational field respectively at substantially the same time, and to associate the first image data and the second image data. Imaging methods provided herein may include the steps of: imaging the site with a macroscopic visualization system and generating first image data; imaging at substantially the same time an observational field with an imaging apparatus and generating second image data; and associating the first image data and the second image data.
摘要翻译：本文提供成像系统和方法。用于成像外科手术部位的成像系统可以包括宏观可视化系统; 以及具有探针的成像装置，所述成像装置适于对所述观察场进行成像并生成第二图像数据; 其中所述系统可操作以控制所述宏观可视化系统和所述成像装置，以在基本相同的时间分别对所述场地和所述观测场进行成像，并且将所述第一图像数据和所述第二图像数据相关联。本文提供的成像方法可以包括以下步骤：用宏观可视化系统对站点进行成像并产生第一图像数据; 在大体上相同的时间成像具有成像装置的观察场并产生第二图像数据; 以及将所述第一图像数据和所述第二图像数据相关联。

6. 发明授权

US07369073B2 Microscopy system and recording method for visualizing fluorescence 有权
标题翻译：显微镜系统和荧光显像的记录方法
公开(公告)号：US07369073B2
公开(公告)日：2008-05-06
申请号：US11544269
申请日：2006-10-06
申请人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
发明人： Helge Jess , Petra Weinschenk , Martin Schneider , Christoph Hauger , Hans-Joachim Miesner
IPC分类号： H03M1/00
CPC分类号： G02B21/0076 , G01N21/6428 , G01N21/6458
摘要： An image sensor and a circuitry associated with the image sensor is used for recording a series of fluorescence images. The image sensor comprises a plurality of pixels for accumulating charges generated by incident radiation, and the circuitry converts the charges accumulated in the pixels into binary numbers. A gain of the circuitry is adjustable. The gain is set to a suitable maximum value at the beginning of a recording procedure. The gain is reduced if it is determined during the recording procedure that one or more brightness values of the recorded image exceed a suitably chosen maximum brightness value.
摘要翻译：图像传感器和与图像传感器相关联的电路用于记录一系列荧光图像。图像传感器包括用于累积由入射辐射产生的电荷的多个像素，并且电路将在像素中累积的电荷转换为二进制数。电路的增益可调。在记录过程开始时，增益被设置为合适的最大值。如果在记录过程中确定记录图像的一个或多个亮度值超过适当选择的最大亮度值，则增益减小。

7. 发明申请

US20110028850A1 Process for quantitative display of blood flow 审中-公开
标题翻译：定量显示血流量的过程
公开(公告)号：US20110028850A1
公开(公告)日：2011-02-03
申请号：US12462038
申请日：2009-07-28
申请人： Thomas Schuhrke , Guenter Meckes , Joachim Steffen , Hans-Joachim Miesner , Frank Rudolph , Werner Nahm
发明人： Thomas Schuhrke , Guenter Meckes , Joachim Steffen , Hans-Joachim Miesner , Frank Rudolph , Werner Nahm
IPC分类号： A61B6/00 , A61B5/02
CPC分类号： A61B5/0261 , A61B5/0059 , A61B5/0275 , G06T7/0016 , G06T11/00 , G06T2207/10016 , G06T2207/10048 , G06T2207/30104
摘要： A method for the quantitative representation of the blood flow in a tissue or vascular region is based on the signal of a contrast agent injected into the blood. In the method, several individual images of the signal emitted by the tissue or vascular region are recorded at successive points in time and are stored. Based on the respective signal, a quantity characteristic for the blood flow and a quantity characteristic for the position of the blood vessels are determined for image areas of individual images. These quantities are represented superimposed for the respective image areas such that both the blood flow quantity and the position of the fine blood vessels become clearly visible in the representation and can be differentiated from the tissue.
摘要翻译：用于定量表示组织或血管区域中的血液流动的方法基于注射到血液中的造影剂的信号。在该方法中，在连续的时间点记录由组织或血管区域发射的信号的几个单独的图像，并被存储。基于各信号，针对各图像的图像区域确定血流的量特性和血管位置的量特征。这些量对于各个图像区域被叠加，使得血液流量和细小血管的位置在表示中变得清晰可见，并且可以与组织区分开。

8. 发明申请

US20100069759A1 Method for the quantitative display of blood flow 审中-公开
标题翻译：定量显示血流量的方法
公开(公告)号：US20100069759A1
公开(公告)日：2010-03-18
申请号：US12462036
申请日：2009-07-28
申请人： Thomas Schuhrke , Guenter Meckes , Joachim Steffen , Hans-Joachim Miesner , Frank Rudolph , Werner Nahm
发明人： Thomas Schuhrke , Guenter Meckes , Joachim Steffen , Hans-Joachim Miesner , Frank Rudolph , Werner Nahm
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B5/0275 , A61B5/0261 , A61B5/7207 , G06T5/50 , G06T7/33 , G06T2207/10056 , G06T2207/10064 , G06T2207/30104
摘要： A method for the quantitative representation of the blood flow in a tissue or vascular region is based on the signal of a contrast agent injected into the blood. Several individual images of the signal emitted by the tissue or vascular region are recorded and stored at successive points in time. For image areas of the individual images, the respective intensities of different points in time are compared and the maximum intensities of the signals are determined for these image areas. The maximum intensities are represented for these image areas.
摘要翻译：用于定量表示组织或血管区域中的血液流动的方法基于注射到血液中的造影剂的信号。由组织或血管区域发射的信号的几个单独图像在连续的时间点被记录并存储。对于各个图像的图像区域，比较不同时间点的相应强度，并且为这些图像区域确定信号的最大强度。对于这些图像区域表示最大强度。

9. 发明申请

US20070165302A1 Mouth switch arrangement and microscopy system having a mouth switch 有权
标题翻译：口开关布置和显微镜系统具有开口
公开(公告)号：US20070165302A1
公开(公告)日：2007-07-19
申请号：US11588125
申请日：2006-10-26
申请人： Robert Spetzler , Hans-Joachim Miesner , Frank Rudolph
发明人： Robert Spetzler , Hans-Joachim Miesner , Frank Rudolph
IPC分类号： G02B21/00
CPC分类号： G02B21/0012
摘要： A microscopy assembly comprises a stand, a stereo microscope supported by the stand, and a mouth switch assembly mounted to a holder, the mouth switch assembly including a mouth piece grippable by a user's teeth, and with a force sensor actuatable by the exertion of pressure by a user's lip while the mouth piece is held by the user's teeth, the force sensor including an actuating element arranged at a side of the mouth piece, wherein an actuating area of the actuating element located next to a front end of the mouth piece is spaced apart from the front end of the mouth piece by a distance larger than 4 mm and smaller than 35 mm.
摘要翻译：显微镜组件包括支架，由支架支撑的立体显微镜和安装到保持器的口开关组件，嘴开关组件包括可由使用者的牙齿夹持的口部件，以及通过施加压力可致动的力传感器当使用者的嘴部被使用者的牙齿保持时，用户的唇部，力传感器包括布置在口部件侧面的致动元件，其中位于口部件前端的致动元件的致动区域是与嘴部的前端间隔开大于4mm且小于35mm的距离。

10. 发明申请

US20050041308A1 Optical imaging system having an expand depth of field 有权
标题翻译：具有扩大景深的光学成像系统
公开(公告)号：US20050041308A1
公开(公告)日：2005-02-24
申请号：US10923004
申请日：2004-08-23
申请人： Gerhard Gaida , Hans-Joachim Miesner
发明人： Gerhard Gaida , Hans-Joachim Miesner
IPC分类号： G02B21/00 , G02B21/02 , G02B27/58 , G02B9/00
CPC分类号： G02B27/0075 , G02B21/02 , G02B27/58
摘要： An optical imaging system, for example, for a surgical microscope (100) has a beam deflecting unit in order to cast light rays out of an object region (112) into an image plane (104) with an optical beam path. An optical phase plate (107) is mounted in the optical beam path. In the optical imaging system, a unit for generating a geometric image of the image plane is provided, for example, an ocular unit (105). The optical phase plate (107) is arranged on the end of the object lens (101) facing away from the object or is arranged in a region of the optical imaging system in which the beam path is parallel.
摘要翻译：例如，用于手术显微镜（100）的光学成像系统具有光束偏转单元，以便用光束路径将光线从对象区域（112）投射到图像平面（104）中。光学相位板（107）安装在光束路径中。在光学成像系统中，提供了用于生成图像平面的几何图像的单元，例如，眼单元（105）。光学相位板107配置在远离物体的物镜101的端部，或配置在光路平行的光学摄像系统的区域。

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