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1. 发明授权

US07122320B2 Method for detecting acid-resistant microorganisms in the stool 有权
标题翻译：方法检测粪便中的耐酸微生物
公开(公告)号：US07122320B2
公开(公告)日：2006-10-17
申请号：US09842776
申请日：2001-04-27
申请人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
发明人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
IPC分类号： G01N33/53 , G01N33/537 , G01N33/554 , G01N33/567 , G01N33/569
CPC分类号： G01N33/56922 , C07K16/121 , G01N2333/205
摘要： The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the second aptamer specifically binds an epitope of a second antigen differing from the epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide, wherein the parts of the mammals may overlap according to (aa) and (ab) and in total essentially make up the overall number of infected mammals; and (b) the formation of at least one antigen-antibody complex or antigen-aptamer complex according to (aa) or (ab) is detected.
摘要翻译：本发明涉及一种用耐酸微生物检测哺乳动物的感染的方法，其中（a）将哺乳动物的粪便样品与至少两种不同的单克隆抗体，其片段或衍生物或适体在允许用抗体，其片段或衍生物或适配体复合形成抗酸微生物的抗原，并且其中（aa）第一单克隆抗体或其片段或其衍生物或第一适体特异性结合第一抗原的表位，其至少与一些哺乳动物一起显示出肠道通过后的结构，该结构对应于哺乳动物产生针对抗酸微生物或其提取物或裂解物或蛋白质的免疫后的抗原的天然结构或结构，或其片段或合成肽; （ab）第二单克隆抗体或其片段或其衍生物或第二适体特异性结合不同于第一抗原表位的第二抗原的表位，其至少显示出一些哺乳动物在肠道通过后对应的结构哺乳动物产生抗体的抗原结构或结构，用抗酸微生物或其提取物或裂解物或其蛋白质或其片段或合成肽进行感染或免疫之后产生抗体，其中哺乳动物的部分可以根据（aa）和（ab）重叠，总共基本上构成感染哺乳动物的总数; 和（b）检测根据（aa）或（ab）形成至少一种抗原 - 抗体复合物或抗原 - 适配子复合物。

2. 发明授权

US07736859B2 Method for detecting acid-resistant microorganisms in the stool 失效
标题翻译：方法检测粪便中的耐酸微生物
公开(公告)号：US07736859B2
公开(公告)日：2010-06-15
申请号：US11513129
申请日：2006-08-31
申请人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
发明人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
IPC分类号： G01N33/53 , G01N33/537 , G01N33/554 , G01N33/567 , G01N33/569
CPC分类号： G01N33/56922 , C07K16/121 , G01N2333/205
摘要： The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the second aptamer specifically binds an epitope of a second antigen differing from the epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide, wherein the parts of the mammals may overlap according to (aa) and (ab) and in total essentially make up the overall number of infected mammals; and (b) the formation of at least one antigen-antibody complex or antigen-aptamer complex according to (aa) or (ab) is detected.
摘要翻译：本发明涉及一种用耐酸微生物检测哺乳动物的感染的方法，其中（a）将哺乳动物的粪便样品与至少两种不同的单克隆抗体，其片段或衍生物或适体在允许用抗体，其片段或衍生物或适配体复合形成抗酸微生物的抗原，并且其中（aa）第一单克隆抗体或其片段或其衍生物或第一适体特异性结合第一抗原的表位，其至少与一些哺乳动物一起显示出肠道通过后的结构，该结构对应于哺乳动物产生针对抗酸微生物或其提取物或裂解物或蛋白质的免疫后的抗原的天然结构或结构，或其片段或合成肽; （ab）第二单克隆抗体或其片段或其衍生物或第二适体特异性结合不同于第一抗原表位的第二抗原的表位，其至少显示出一些哺乳动物在肠道通过后对应的结构哺乳动物产生抗体的抗原结构或结构，用抗酸微生物或其提取物或裂解物或其蛋白质或其片段或合成肽进行感染或免疫之后产生抗体，其中哺乳动物的部分可以根据（aa）和（ab）重叠，总共基本上构成感染哺乳动物的总数; 和（b）检测根据（aa）或（ab）形成至少一种抗原 - 抗体复合物或抗原 - 适配子复合物。

3. 发明申请

US20070009975A1 Method for detecting acid-resistant microorganisms in the stool 失效
标题翻译：方法检测粪便中的耐酸微生物
公开(公告)号：US20070009975A1
公开(公告)日：2007-01-11
申请号：US11513129
申请日：2006-08-31
申请人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
发明人： Christian Reiter , Gerhard Cullman , Ulrike Friedrichs , Petra Heppner , Meret Lakner , Achim Ringeis
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/56922 , C07K16/121 , G01N2333/205
摘要： The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the acid-resistant microorganism with antibodies, fragments or derivatives thereof or the aptamers, and wherein (aa) the first monoclonal antibody or the fragment or the derivative thereof or the first aptamer specifically binds an epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide; (ab) the second monoclonal antibody or the fragment or the derivative thereof or the second aptamer specifically binds an epitope of a second antigen differing from the epitope of the first antigen, which shows at least with some mammals a structure after the intestinal passage that corresponds to the native structure or the structure which a mammal produces antibodies against after being infected or immunised with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide, wherein the parts of the mammals may overlap according to (aa) and (ab) and in total essentially make up the overall number of infected mammals; and (b) the formation of at least one antigen-antibody complex or antigen-aptamer complex according to (aa) or (ab) is detected.
摘要翻译：本发明涉及一种用耐酸微生物检测哺乳动物的感染的方法，其中（a）将哺乳动物的粪便样品与至少两种不同的单克隆抗体，其片段或衍生物或适体在允许用抗体，其片段或衍生物或适配体复合形成抗酸微生物的抗原，并且其中（aa）第一单克隆抗体或其片段或其衍生物或第一适体特异性结合第一抗原的表位，其至少与一些哺乳动物一起显示出肠道通过后的结构，该结构对应于哺乳动物产生针对抗酸微生物或其提取物或裂解物或蛋白质的免疫后的抗原的天然结构或结构，或其片段或合成肽; （ab）第二单克隆抗体或其片段或其衍生物或第二适体特异性结合不同于第一抗原表位的第二抗原的表位，其至少显示出一些哺乳动物在肠道通过后对应的结构哺乳动物产生抗体的抗原结构或结构，用抗酸微生物或其提取物或裂解物或其蛋白质或其片段或合成肽进行感染或免疫之后产生抗体，其中哺乳动物的部分可以根据（aa）和（ab）重叠，总共基本上构成感染哺乳动物的总数; 和（b）检测根据（aa）或（ab）形成至少一种抗原 - 抗体复合物或抗原 - 适配子复合物。

4. 发明申请

US20050042675A1 Solution for preparing stool specimens for diagnostic purposes 审中-公开
标题翻译：为诊断目的准备粪便标本的解决方案
公开(公告)号：US20050042675A1
公开(公告)日：2005-02-24
申请号：US10362976
申请日：2001-08-31
申请人： Meret Lakner , Andreas True , Sonja Dehnert , Christian Reiter , Gerhard Cullmann , Petra Heppner , Eva Haindl , Andreas Finck , Helmut Benesch , Achim Ringeis
发明人： Meret Lakner , Andreas True , Sonja Dehnert , Christian Reiter , Gerhard Cullmann , Petra Heppner , Eva Haindl , Andreas Finck , Helmut Benesch , Achim Ringeis
IPC分类号： G01N1/38 , G01N1/40 , G01N33/53
CPC分类号： G01N1/38 , G01N1/40
摘要： The present invention relates to a new solution for the preparation of stool samples for diagnostic tests. The solution allows samples to be prepared simply before use in an immunological detection process and also provides a high level of sensitivity, specificity and reproducibility of the tests. The solution must contain at least one buffer substance, one detergent and one blocking reagent. The Invention also relates to a process for the analysis of a stool sample for diagnostic purposes using the solution according to the invention.
摘要翻译：本发明涉及用于诊断测试的粪便样品的制备的新解决方案。该溶液允许在免疫检测过程中简单地制备样品，并且还提供测试的高水平的灵敏度，特异性和可重复性。该溶液必须含有至少一种缓冲物质，一种洗涤剂和一种封闭剂。本发明还涉及使用根据本发明的溶液来诊断粪便样品的方法。

5. 发明授权

US07129053B1 Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool 有权
标题翻译：免疫色谱快速检测法检测粪便中的耐酸微生物
公开(公告)号：US07129053B1
公开(公告)日：2006-10-31
申请号：US10110410
申请日：2000-10-12
申请人： Christian Reiter , Gerhard Cullman , Meret Lakner , Andreas Trüe , Sonja Dehnert , Georg Schwartz
发明人： Christian Reiter , Gerhard Cullman , Meret Lakner , Andreas Trüe , Sonja Dehnert , Georg Schwartz
IPC分类号： G01N1/30 , G01N33/53 , G01N33/567 , G01N33/569
CPC分类号： C07K16/121 , C07K16/40 , C07K2317/565 , G01N33/558 , G01N33/56911 , G01N33/56922 , G01N33/5695 , G01N33/573 , G01N2333/908 , G01N2333/96486 , G01N2333/98 , Y10S435/975
摘要： The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism comprising the following steps: (a) provision of an immunochromatographic test with a sample application area for the application of a stool sample of the mammal with an antigen and application of the stool sample, (b) incubation of the stool sample using (i) a first receptor under conditions permitting a complex formation of the antigen from the acid resistant microorganism with the receptor; or (ii) at least two different first receptors under conditions permitting a complex formation of the antigen from the acid-resistant microorganism with the at least two first receptors and wherein the first receptor according to (i) or the first receptors according to (ii) specifically bind(s) an antigen which shows, at least with some mammals, a structure after passage through the intestine that corresponds to the native structure or the structure against which a mammal produces antibodies against after being infected or immunized with the acid-resistant microorganism or an extract or lysate thereof or a protein therefrom or a fragment thereof or a synthetic peptide produces antibodies; and (c) provision of a second receptor immobilized at an analysis region, wherein the second receptor binds an antigen receptor complex according to (b) and (d) transport and detection of the formation of at least one antigen receptor complex according to (b) by accumulation of the antigen receptor complex at the second receptor in the analysis area. The invention further relates to an immunochromatographic test which is particularly suitable and designed to carry out the method of the invention.
摘要翻译：本发明涉及一种用耐酸微生物检测哺乳动物感染的方法，包括以下步骤：（a）提供具有样品施用区域的免疫层析试验，以用于将哺乳动物的粪便样品与抗原和粪便样品的施用，（b）使用（i）第一受体在允许来自抗酸微生物的抗原与受体复合形成的条件下温育粪便样品; 或（ii）至少两种不同的第一受体，其条件是允许具有至少两个第一受体的抗酸微生物的抗原复合形成，并且其中根据（i）的第一受体或根据（ii）的第一受体）特异性结合至少与一些哺乳动物通过肠道的结构，该结构对应于天然结构或结构，其中哺乳动物产生针对感染后的抗体或用耐酸性免疫的结构微生物或其提取物或裂解物或其蛋白质或其片段或合成肽产生抗体; （c）提供固定在分析区域的第二受体，其中所述第二受体根据（b）和（d）结合抗原受体复合物，根据（b）的转运和检测至少一种抗原受体复合物的形成）通过在分析区域中的第二受体处的抗原受体复合物的积累。本发明还涉及一种特别适合和设计用于实施本发明方法的免疫层析试验。

6. 发明授权

US08113058B2 Piezoelectric pressure transducer 有权
标题翻译：压电式压力传感器
公开(公告)号：US08113058B2
公开(公告)日：2012-02-14
申请号：US12585305
申请日：2009-09-10
申请人： Martin Baumgartner , Christian Reiter , Friedrich Anton Holzinger , Alexander Schricker
发明人： Martin Baumgartner , Christian Reiter , Friedrich Anton Holzinger , Alexander Schricker
IPC分类号： G01L9/00
CPC分类号： G01L9/008
摘要： To render possible a high-quality, yet cost-effective provision suitable for mass production of a piezoelectric pressure transducer (1) with at least one piezoelectric measuring element (3, 3′, 3″) arranged on a housing base part (2), which measuring element is connected on the opposite side to a diaphragm (4), the measuring element (3, 3′, 3″) is fixed on an electrode sheet (5, 5′, 5″, 5″′) or directly on the base part 2 or the diaphragm 4, wherein the electrode sheet (5, 5′, 5″, 5″′) wraps conductively and positively as well as in a manner fixing the layers around a contact pin (7) insulated with respect to the base part (2) and projecting outwards.
摘要翻译：为了使可能的高质量但成本有效的设备适合于大量生产具有布置在壳体基部（2）上的至少一个压电测量元件（3,3'，3“）的压电压力传感器（1）测量元件（3,3'，3“）固定在电极片（5,5'，5”，5“）上或直接固定在测量元件在基部2或隔膜4上，其中电极片5,5'，5“，5”'）电导和积极地包裹，并且以使得层围绕绝缘的接触销（7）的方式到基部（2）并向外突出。

7. 发明申请

US20090104188A1 ANTI-HEPATITIS C VIRUS ANTIBODY AND USES THEREOF 审中-公开
标题翻译：抗生素C病毒抗体及其用途
公开(公告)号：US20090104188A1
公开(公告)日：2009-04-23
申请号：US12207460
申请日：2008-09-09
申请人： Christian Reiter , Francois Habersetzer , Anne Fournillier , Christian Trepo , Claude Desgranges , Genevieve Inchauspe
发明人： Christian Reiter , Francois Habersetzer , Anne Fournillier , Christian Trepo , Claude Desgranges , Genevieve Inchauspe
IPC分类号： A61K39/395
CPC分类号： G01N33/5767 , A61K2039/505 , C07K16/109 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable of neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.
摘要翻译：描述了特异性识别HCV糖蛋白E2的构象依赖性表位并能够中和E2蛋白与敏感细胞的结合的新型抗体。此外，提供了由上述抗体识别的抗原和表位以及编码所述抗体的多核苷酸。还提供了包含所述多核苷酸的载体以及转化的宿主细胞及其在所述抗体的产生中的用途。此外，提供药物和诊断组合物，其包含任何上述抗体，抗原，表位，多核苷酸，载体或细胞。进一步描述了上述抗体，抗原，多核苷酸和载体在过继性免疫治疗中的用途，优选用于治疗或预防肝移植期间的HCV感染。

8. 发明授权

US06972841B2 Method and apparatus for determining the non-volatile component of aerosol particles in a gas sample 失效
标题翻译：用于测定气体样品中气溶胶颗粒的非挥发性成分的方法和装置
公开(公告)号：US06972841B2
公开(公告)日：2005-12-06
申请号：US10302980
申请日：2002-11-25
申请人： Peter W. Krempl , Christian Reiter , Wolfgang Schindler , Wolfgang Singer
发明人： Peter W. Krempl , Christian Reiter , Wolfgang Schindler , Wolfgang Singer
IPC分类号： G01N1/22 , G01N27/00 , G01N15/02
CPC分类号： G01N29/036 , G01N1/2202 , G01N1/2252 , G01N2001/2223 , G01N2001/2264 , G01N2291/0217 , G01N2291/0256 , G01N2291/0422
摘要： The invention relates to a method for determining the non-volatile component of aerosol particles in a gas sample, especially in the exhaust gas of internal combustion engines, where the aerosol particles are deposited on an oscillating sensor (2) of at least one crystal microbalance (3), and the change in at least one oscillation parameter of the oscillating sensor is employed as measurement variable. According to the invention the oscillating sensor (2) of at least one crystal microbalance (3) is maintained at a temperature of more than 200° C. during deposition of the aerosol particles, and preferably between 250° C. and 350° C.
摘要翻译：本发明涉及一种用于确定气体样品中的气溶胶颗粒的非挥发性组分的方法，特别是在内燃机的废气中，其中气溶胶颗粒沉积在至少一个晶体微量天平的振荡传感器（2）上（3），并且使用振荡传感器的至少一个振荡参数的变化作为测量变量。根据本发明，至少一种晶体微量天平（3）的振荡传感器（2）在气溶胶颗粒沉积期间保持在大于200℃的温度，优选在250℃和350℃之间。

9. 发明申请

US20070289354A1 Method And Apparatus For Feeding Fasteners To A Processing Device 审中-公开
标题翻译：用于将紧固件送入处理装置的方法和装置
公开(公告)号：US20070289354A1
公开(公告)日：2007-12-20
申请号：US11835496
申请日：2007-08-08
申请人： Christian Reiter
发明人： Christian Reiter
IPC分类号： B21D43/20
CPC分类号： B23P19/005 , B21J15/32
摘要： A method and apparatus for feeding fasteners with at least two parallel boundary surfaces to a processing device includes lining up the fasteners in the same orientation by a feeder. The fasteners move through a conveying duct to a loading device arranged on a processing device. Individual conveying steps are separated from one another in time. At each conveying step a column of multiple fasteners in the same orientation, with their parallel boundary surfaces resting on one another, is conveyed by the feeder to the loading device by introducing air into the conveying duct. The loading device has, adjoining a magazine output end, a loading duct extending perpendicular to a magazine longitudinal axis, terminating in a processing device working duct. The loading duct has a conveying mechanism which conveys individual fasteners emerging from the magazine into the working duct one at a time.
摘要翻译：用于将具有至少两个平行的边界表面的紧固件供给到处理装置的方法和装置包括通过进给器以相同取向对齐紧固件。紧固件通过输送管道移动到布置在处理装置上的装载装置。个别输送步骤在时间上彼此分离。在每个输送步骤中，将相同取向的多个紧固件的一列以及它们的平行的边界表面彼此搁置，通过将空气引入输送管道中而由进料器输送到装载装置。该装载装置具有邻近一个料仓输出端的一个垂直于料仓纵向轴线延伸的装载管道，终止于处理装置工作管道。装载管道具有一个输送机构，其将从料盒出来的各个紧固件一次一个地输送到工作管道中。

10. 发明授权

US06951646B1 Anti hepatitis C virus antibody and uses thereof 失效
标题翻译：抗丙型肝炎病毒抗体及其用途
公开(公告)号：US06951646B1
公开(公告)日：2005-10-04
申请号：US09744176
申请日：1999-07-20
申请人： Christian Reiter , Francois Habersetzer , Anne Fournillier , Christian Trepo , Claude Desgranges , Genevieve Inchauspe
发明人： Christian Reiter , Francois Habersetzer , Anne Fournillier , Christian Trepo , Claude Desgranges , Genevieve Inchauspe
IPC分类号： G01N33/53 , A61K39/29 , A61K39/395 , A61P31/12 , C07K14/18 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/10 , C12P21/08 , C12R1/91 , G01N33/569 , G01N33/576 , G01N33/577 , A61K39/12 , A61K39/42 , C12Q1/70
CPC分类号： G01N33/5767 , A61K2039/505 , C07K16/109 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.
摘要翻译：描述了特异性识别HCV糖蛋白E2的构象依赖性表位的新型抗体，并且能够中和E2蛋白与敏感细胞的结合。此外，提供了由上述抗体识别的抗原和表位以及编码所述抗体的多核苷酸。还提供了包含所述多核苷酸的载体以及转化的宿主细胞及其在所述抗体的产生中的用途。此外，提供药物和诊断组合物，其包含任何上述抗体，抗原，表位，多核苷酸，载体或细胞。进一步描述了上述抗体，抗原，多核苷酸和载体在过继性免疫治疗中的用途，优选用于治疗或预防肝移植期间的HCV感染。

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