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1. 发明申请

US20050149104A1 Expandable guide sheath and apparatus and methods for making them 有权
标题翻译：可扩展导套及其制造方法
公开(公告)号：US20050149104A1
公开(公告)日：2005-07-07
申请号：US10958034
申请日：2004-10-04
申请人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas , Christopher Loew
发明人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas , Christopher Loew
IPC分类号： A61F2/958 , A61B17/22 , A61B17/34 , A61M25/00 , A61M25/06 , A61M29/00 , A61N1/05
CPC分类号： A61M25/0662 , A61B17/3439 , A61M25/003 , A61M2025/0024 , A61M2025/0035 , A61N1/056
摘要： Apparatus and methods are provided for providing access to a body lumen. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending between the proximal and distal ends. A pushable stiffening member extends from the distal end of the tubular member, the elongate member terminating in a distal tip. An expandable sheath extends along at least a portion of the stiffening member, the sheath being expandable from a contracted condition to minimize a profile of the sheath to allow insertion along with the stiffening member into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. In one embodiment, the sheath includes an outer lumen and an inner lumen floating within the outer lumen, and the stiffening member is carried in the inner lumen.
摘要翻译：提供了用于提供对体腔的接近的装置和方法。该装置包括管状构件，其包括近端，尺寸适于插入体腔的远端以及在近端和远端之间延伸的内腔。可推动加强构件从管状构件的远端延伸，细长构件终止于远端。可扩张护套沿着加强构件的至少一部分延伸，护套可以从收缩状态扩展，以最小化护套的轮廓，以允许将加强构件插入体腔内，并且扩大状态，其中护套至少部分地限定与所述管状构件内腔连通的管腔。在一个实施例中，护套包括外腔和漂浮在外腔内的内腔，并且加强构件承载在内腔中。

2. 发明申请

US20070293845A1 SLITTABLE OR REMOVABLE VALVES AND APPARATUS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：可变的或可拆卸的阀门，以及用于制造和使用它们的装置和方法
公开(公告)号：US20070293845A1
公开(公告)日：2007-12-20
申请号：US11687653
申请日：2007-03-18
申请人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas
发明人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas
IPC分类号： A61M25/00
CPC分类号： A61M39/22 , A61M25/0668 , A61M39/06 , A61M39/0606
摘要： Valves for medical devices and methods for making them are provided. In one embodiment, a valve is injection molded as a single piece that includes a tubular body and a flap. The tubular body includes an open first end, a closed second end, and a passage extending between the first and second ends defining a central longitudinal axis. The second end includes an end wall including a hole therein communicating with the passage. The flap is formed in the end wall over the hole and is movable away from the second end when an elongate device is introduced through the passage and the hole. Apparatus are also provided for delivering a medical device into a patient's body that includes an elongate tubular member including proximal and distal ends, a lumen extending between the proximal and distal ends; and a valve attached to the proximal end.
摘要翻译：提供用于医疗设备的阀门及其制造方法。在一个实施例中，阀被注塑成单件，其包括管状主体和折翼。管状体包括敞开的第一端，闭合的第二端和在第一和第二端之间延伸的通道，限定中心纵向轴线。第二端包括端壁，其包括与通道连通的孔。翼片形成在洞上方的端壁中，并且当细长装置通过通道和孔引入时，翼片可移动离开第二端。还提供了用于将医疗装置输送到患者体内的装置，其包括细长管状构件，其包括近端和远端，在近端和远端之间延伸的内腔; 以及附接到近端的阀。

3. 发明申请

US20070083187A1 APPARATUS AND METHODS FOR DELIVERING STEM CELLS AND OTHER AGENTS INTO CARDIAC TISSUE 有权
标题翻译：将干细胞和其他药物递送到心脏组织的装置和方法
公开(公告)号：US20070083187A1
公开(公告)日：2007-04-12
申请号：US11465109
申请日：2006-08-16
申请人： Christian Eversull , Stephen Leeflang , Christine Ventura , Nicholas Mourlas
发明人： Christian Eversull , Stephen Leeflang , Christine Ventura , Nicholas Mourlas
IPC分类号： A61M31/00 , A61M25/00 , A61M5/00
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Apparatus, systems, and methods are provided for delivering stem cells or other agents to cardiac tissue surrounding a cardiac vessel or to tissue adjacent other body lumens. The apparatus includes an expandable member and a source of one or more agents communicating with a lumen extending between proximal and distal ends of the apparatus. The distal end of the apparatus is advanced through one or more body lumens until the distal end is disposed within or adjacent the target body lumen. The target body lumen is sealed, e.g., by expanding the expandable member, thereby isolating the target body lumen. One or more agents are delivered into the target body lumen with sufficient pressure to extravasate the one or more agents into tissue surrounding the target body lumen.
摘要翻译：提供了装置，系统和方法，用于将干细胞或其它药剂递送到围绕心脏血管的心脏组织或邻近其他体腔的组织。该装置包括可扩张构件和一个或多个试剂的源，其与在装置的近端和远端之间延伸的内腔连通。装置的远端通过一个或多个体腔前进直到远端设置在目标体腔内或邻近靶体腔。目标体腔被密封，例如通过膨胀可扩张构件，从而隔离目标体腔。一个或多个药剂以足够的压力被递送到目标体腔内，以将一种或多种药剂外渗到靶体周围的组织中。

4. 发明申请

US20070075452A1 Catheters with lubricious linings and methods for making and using them 有权
公开(公告)号：US20070075452A1
公开(公告)日：2007-04-05
申请号：US11340944
申请日：2006-01-26
申请人： Stephen Leeflang , Christian Eversull , Nicholas Mourlas , Christine Ventura
发明人： Stephen Leeflang , Christian Eversull , Nicholas Mourlas , Christine Ventura
IPC分类号： B29C59/00
CPC分类号： B29C61/006 , A61L29/085 , A61L29/14 , A61M25/0009 , A61M25/0045 , A61M2025/0046 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/021 , B29C47/065 , B29C53/40 , B29C66/1122 , B29C66/1142 , B29C66/131 , B29C66/432 , B29C66/4322 , B29C66/49 , B29C66/52272 , B29C67/0018 , B29C69/001 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/028 , B32B27/08 , B32B27/12 , B32B27/285 , B32B27/32 , B32B27/34 , B32B27/40 , B32B2255/10 , B32B2255/24 , B32B2255/26 , B32B2535/00 , Y10T156/1038 , C08L75/04
摘要： Coated devices for introduction into bodies and methods for making and using them are provided, such as delivery sheaths, guidewire lumen cores, and elongate leads. In one embodiment, a tubular device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes a relatively thin inner polyurethane liner including a coating on an inner surface thereof, e.g., providing a lubricious and/or hydrophilic lumen, and an outer layer surrounding the liner. In another embodiment, a lead is provided that includes a proximal end, a distal end, and at least one electrode on the distal end. A polyurethane cover surrounds at least a portion of an outer surface of the lead that include a coating, e.g., including a lubricious and/or hydrophilic material. Optionally, the cover may be removable from around the lead body.

5. 发明申请

US20050149105A1 Expandable guide sheath and apparatus and methods for making them 审中-公开
公开(公告)号：US20050149105A1
公开(公告)日：2005-07-07
申请号：US10958035
申请日：2004-10-04
申请人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas , Christopher Loew
发明人： Stephen Leeflang , Christine Ventura , Christian Eversull , Nicholas Mourlas , Christopher Loew
IPC分类号： A61F2/958 , A61B17/22 , A61B17/34 , A61M25/00 , A61M25/06 , A61M29/00 , A61N1/05
CPC分类号： A61M25/0662 , A61B17/3439 , A61M25/003 , A61M2025/0024 , A61M2025/0035 , A61N1/056
摘要： Apparatus and methods are provided for providing access to a body lumen. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending between the proximal and distal ends. A pushable stiffening member extends from the distal end of the tubular member, the elongate member terminating in a distal tip. An expandable sheath extends along at least a portion of the stiffening member, the sheath being expandable from a contracted condition to minimize a profile of the sheath to allow insertion along with the stiffening member into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. In one embodiment, the sheath includes an outer lumen and an inner lumen floating within the outer lumen, and the stiffening member is carried in the inner lumen.

6. 发明申请

US20060217755A1 Expandable guide sheath with steerable backbone and methods for making and using them 有权
标题翻译：具有可转向骨架的可扩展导向护套及其制造和使用方法
公开(公告)号：US20060217755A1
公开(公告)日：2006-09-28
申请号：US11347361
申请日：2006-02-03
申请人： Christian Eversull , Stephen Leeflang , Nicholas Mourlas , Christine Ventura
发明人： Christian Eversull , Stephen Leeflang , Nicholas Mourlas , Christine Ventura
IPC分类号： A61M29/00
CPC分类号： A61M25/0662 , A61B17/3439 , A61M2025/0024
摘要： Apparatus and methods are provided for providing access to a body lumen. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending therebetween. A pushable stiffening member extends from the distal end of the tubular member. An expandable sheath extends along at least a portion of the stiffening member, the sheath being expandable from a contracted condition to facilitate insertion into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. A distal portion of the sheath is steerable, e.g., using a pull wire disposed within a lumen of the sheath or within the stiffening member. In addition or alternatively, the stiffening member may be biased to a predetermined shape to facilitate introduction.
摘要翻译：提供了用于提供对体腔的接近的装置和方法。该装置包括管状构件，该管状构件包括近端，尺寸适于插入体腔的远端和在其间延伸的内腔。推动加强构件从管状构件的远端延伸。可扩张护套沿着加强构件的至少一部分延伸，护套可从收缩状态扩展以便于插入体腔，以及扩大状态，其中护套至少部分地限定与管状构件腔连通的内腔。护套的远端部分是可操纵的，例如使用设置在鞘的内腔内或加强构件内的拉线。另外或替代地，加强构件可被偏压到预定形状以便于引入。

7. 发明申请

US20080015625A1 SHAPEABLE FOR STEERABLE GUIDE SHEATHS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：适用于可导向指南的形式及其制作和使用方法
公开(公告)号：US20080015625A1
公开(公告)日：2008-01-17
申请号：US11746639
申请日：2007-05-09
申请人： Christine Ventura , Alfonso Pulido , Stephen Leeflang
发明人： Christine Ventura , Alfonso Pulido , Stephen Leeflang
IPC分类号： A61M29/00
CPC分类号： A61M25/0097 , A61B17/3439 , A61M25/0147 , A61M25/0152 , A61M25/0662 , A61M2025/0024 , A61N1/056 , A61N2001/0585
摘要： Apparatus and methods are provided for providing access to a body lumen, e.g., to deliver a pacing lead within a patient's heart. The apparatus includes a tubular member including a proximal end, a distal end sized for insertion into a body lumen, and a lumen extending therebetween. An elongate member extends from the distal end of the tubular member. An expandable sheath extends along at least a portion of the elongate member, the sheath being expandable from a contracted condition to facilitate insertion into a body lumen, and an enlarged condition wherein the sheath at least partially defines a lumen communicating with the tubular member lumen. A stylet or other shaped element is insertable into the elongate member for changing a shape of at least a distal tip of the elongate member, e.g., for accessing side branches extending from a body lumen, e.g., within a patient's coronary venous system.
摘要翻译：提供了用于提供对体腔的接近的装置和方法，例如将患者心脏内的起搏引线输送。该装置包括管状构件，该管状构件包括近端，尺寸适于插入体腔的远端和在其间延伸的内腔。细长构件从管状构件的远端延伸。可扩张护套沿着细长构件的至少一部分延伸，护套可以从收缩状态扩展以便于插入体腔，以及扩大状态，其中护套至少部分地限定与管状构件腔连通的内腔。探针或其他形状的元件可插入到细长构件中，用于改变细长构件的至少远侧末端的形状，例如用于进入从体腔延伸的侧分支，例如在病人的冠状静脉系统内。

8. 发明申请

US20060030846A1 Tissue localizing and separating assembly 失效
标题翻译：组织定位和分离装配
公开(公告)号：US20060030846A1
公开(公告)日：2006-02-09
申请号：US11245625
申请日：2005-10-07
申请人： Eric Buehlmann , Lisanne Eng , Christine Ventura , Robert Laird , Frank Ingle
发明人： Eric Buehlmann , Lisanne Eng , Christine Ventura , Robert Laird , Frank Ingle
IPC分类号： A61B18/14
CPC分类号： A61B18/148 , A61B18/1477 , A61B90/39 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/144 , A61B2090/3908
摘要： A tissue separator assembly has an elongate tubular member and a tissue separator device located at a distal end of the elongate tubular member. An elongate coupler extends through the lumen of the elongate tubular member and has a distal coupler end. A tissue localization assembly has an elongate member and a localization device located at the distal end of the elongate member. The localization device may be movable from a first, radially-contracted state to a second, radially-expandable state. The distal coupler end of the elongate coupler and the proximal end of the elongate tubular member of the localization assembly are joinable to one another to permit docking of the tissue localization assembly to the tissue separator assembly. Methods of use of this device are also described.
摘要翻译：组织分离器组件具有细长的管状构件和位于细长管状构件的远端处的组织分离器装置。细长联接器延伸穿过细长管状构件的内腔并且具有远端联接器端部。组织定位组件具有细长构件和位于细长构件的远端处的定位装置。定位装置可以从第一径向收缩状态移动到第二径向可扩张状态。细长联接器的远端联接器端和定位组件的细长管状构件的近端可彼此连接，以允许组织定位组件对接组织分离器组件。还描述了该装置的使用方法。

9. 发明申请

US20060293654A1 Tissue separating and localizing catheter assembly 有权
公开(公告)号：US20060293654A1
公开(公告)日：2006-12-28
申请号：US11434632
申请日：2006-05-15
申请人： George Morrison , Robert Laird , Eric Buehlmann , Christine Ventura
发明人： George Morrison , Robert Laird , Eric Buehlmann , Christine Ventura
IPC分类号： A61B18/14
CPC分类号： A61B18/148 , A61B17/221 , A61B2018/00601 , A61B2018/1475 , A61B2090/3908
摘要： A tissue-separating catheter assembly comprises a rotatable shaft, having a distal shaft portion, and a tissue separator device extending along the shaft. The tissue separator device has a distal separator part at the distal shaft portion movable between a retracted state, towards the distal shaft portion, and an outwardly extending, operational state, away from the distal shaft portion. A localization device is movable to a radially expanded state. An expandable tubular element is movable so that its outer end is generally axially aligned with the localization device so to capture a separated tissue section therebetween to aid removal of the separated tissue section from the patient.

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