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1. 发明申请

US20070243999A1 Method of Forming a Carbon-Heteroatom Bond 失效
标题翻译：形成碳杂原子键的方法
公开(公告)号：US20070243999A1
公开(公告)日：2007-10-18
申请号：US10556849
申请日：2004-05-12
申请人： Christelle Mauger , Gerard Mignani
发明人： Christelle Mauger , Gerard Mignani
IPC分类号： B01J21/00
CPC分类号： C07C249/16 , C07C251/86
摘要： The present invention relates to a method of creating a carbon-heteroatom bond, and preferably a carbon-nitrogen bond, by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound. In particular, the invention relates to the creation of a carbon-nitrogen bond, using a method involving the arylation of nitrogenous organic derivatives; the inventive method consists in creating a carbon-heteroatom bond by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound introducing a heteroatom which can be substituted for the leaving group, thereby creating a carbon-heteroatom bond, in the presence of a palladium-based catalyst, optionally a ligand. The invention is characterized in that the reaction takes place in the presence of an effective quantity of a metal hydroxide or ammonium hydroxide which is associated with an alcohol-type solvent.
摘要翻译：本发明涉及通过使含离去基团的不饱和化合物与亲核性化合物反应而产生碳 - 杂原子键，优选碳 - 氮键的方法。特别地，本发明涉及使用涉及含氮有机衍生物的芳基化的方法产生碳 - 氮键; 本发明的方法包括通过使带有离去基团的不饱和化合物和引入可被取代离去基团的杂原子的亲核化合物反应产生碳 - 杂原子键，从而在钯的存在下产生碳 - 杂原子键的催化剂，任选的配体。本发明的特征在于反应在有效量的与醇型溶剂相关的金属氢氧化物或氢氧化铵存在下进行。

2. 发明申请

US20100113800A1 Formation of Carbon-nitrogen bond 审中-公开
标题翻译：形成碳 - 氮键
公开(公告)号：US20100113800A1
公开(公告)日：2010-05-06
申请号：US11990012
申请日：2006-08-04
申请人： Christelle Mauger , Gerard Mignani , Roland Jacquot
发明人： Christelle Mauger , Gerard Mignani , Roland Jacquot
IPC分类号： C07D233/00
CPC分类号： C07D233/56
摘要： The present invention relates to a process to create a carbon-nitrogen bond by the reaction of an aromatic compound carrying at least one electro attractive group with one nitrogenous heterocyclic type nucleophile compound. The invention aims, in particular, at a link reaction between an aromatic compound carrying at least one electro attractive group and an imidazole heterocycle type. The invention process, consisting of the reaction of an aromatic compound carrying one leaving group and at least one electro attractive group and a nitrogenous heterocyclic type nucleophile compound comprising a N—H pattern likely to substitute the leaving group, thereby creating a carbon-nitrogen bond in the presence of a copper catalyst, of a base in an organic solvent, is characterized by the fact that the said nitrogenous heterocycle reacts with an aromatic type electrophile compound carrying one leaving group (Y) chosen from bromine, chlorine or sulfonic ester and at least one electro attractive group (Z1), in the presence of a copper catalyst, of a mineral or organic base, of an extracting agent selected from aliphatic diamines, aliphatic amino alcohols and diols in a polar aprotic organic solvent with a dielectric constant less than about 20 and a basicity such that its “donor number” is less than about 25.
摘要翻译：本发明涉及通过携带至少一个电吸引基团的芳族化合物与一种含氮杂环型亲核化合物的反应产生碳 - 氮键的方法。本发明特别涉及携带至少一个电吸引基团的芳族化合物和咪唑杂环类型之间的连接反应。本发明方法由携带一个离去基团的芳族化合物和至少一个电吸引基团和含氮杂环型亲核化合物的反应组成，该化合物包含可能代替离去基团的N-H型，从而产生碳 - 氮键在铜催化剂存在下，在有机溶剂中存在碱，其特征在于所述含氮杂环与携带选自溴，氯或磺酸酯的一个离去基团（Y）的芳香族亲电子试剂反应，并且在在铜催化剂存在下，在介电常数小于或等于的极性非质子有机溶剂中的选自脂族二胺，脂族氨基醇和二醇的萃取剂的至少一个电吸引组（Z1）大约20岁，并且其“捐赠人数”小于约25的碱度。

3. 发明授权

US07557248B2 Method of forming a carbon-heteroatom bond 失效
标题翻译：形成碳 - 杂原子键的方法
公开(公告)号：US07557248B2
公开(公告)日：2009-07-07
申请号：US10556849
申请日：2004-05-12
申请人： Christelle Mauger , Gérard Mignani
发明人： Christelle Mauger , Gérard Mignani
IPC分类号： C07C241/00
CPC分类号： C07C249/16 , C07C251/86
摘要： The present invention relates to a method of creating a carbon-heteroatom bond, and preferably a carbon-nitrogen bond, by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound. In particular, the invention relates to the creation of a carbon-nitrogen bond, using a method involving the arylation of nitrogenous organic derivatives; the inventive method consists in creating a carbon-heteroatom bond by reacting a leaving group-bearing unsaturated compound and a nucleophilic compound introducing a heteroatom which can be substituted for the leaving group, thereby creating a carbon-heteroatom bond, in the presence of a palladium-based catalyst, optionally a ligand. The invention is characterized in that the reaction takes place in the presence of an effective quantity of a metal hydroxide or ammonium hydroxide which is associated with an alcohol-type solvent.
摘要翻译：本发明涉及通过使含离去基团的不饱和化合物与亲核性化合物反应而产生碳 - 杂原子键，优选碳 - 氮键的方法。特别地，本发明涉及使用涉及含氮有机衍生物的芳基化的方法产生碳 - 氮键; 本发明的方法包括通过使带有离去基团的不饱和化合物和引入可被取代离去基团的杂原子的亲核化合物反应产生碳 - 杂原子键，从而在钯的存在下产生碳 - 杂原子键的催化剂，任选的配体。本发明的特征在于反应在有效量的与醇型溶剂相关的金属氢氧化物或氢氧化铵的存在下进行。

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