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1. 发明授权

US5734047A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US5734047A
公开(公告)日：1998-03-31
申请号：US761738
申请日：1996-12-05
申请人： Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco , John A. Wichtowski
发明人： Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco , John A. Wichtowski
IPC分类号： C07D501/00 , C07D501/36 , A61K31/545
CPC分类号： C07D501/00
摘要： Novel cephem derivatives represented by the general formula ##STR1## wherein Ar is an optionally substituted lipophilic phenyl, naphthyl, benzthiazolyl or pyridyl group; R.sup.1 represents a group of the formula ##STR2## in which R.sup.8 and R.sup.9 are each independently hydrogen, C.sub.1 -C.sub.6 alkyl or (C.sub.1 -C.sub.6)alkoxycarbonyl, said C.sub.1 -C.sub.6 alkyl group being optionally substituted by 1-5 hydroxy or C.sub.1 -C.sub.6 alkoxy groups; m is either 0 or 1; A is a C.sub.2 -C.sub.10 alkyl group optionally substituted by 1-5 hydroxy groups; and R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.
摘要翻译：由通式 + TR 表示的新型头孢烯衍生物，其中Ar是任选取代的亲脂性苯基，萘基，苯并噻唑基或吡啶基; R 1表示式（VIII）的基团，其中R 8和R 9各自独立地为氢，C 1 -C 6烷基或（C 1 -C 6）烷氧基羰基，所述C 1 -C 6烷基任选被1-5个羟基或C 1 -C 6 烷氧基 m为0或1; A是任选被1-5个羟基取代的C 2 -C 10烷基; 且R 2和R 3各自独立地为氢或C 1 -C 6烷基。衍生物是革兰氏阳性抗菌剂，特别适用于治疗耐甲氧西林金黄色葡萄球菌引起的疾病。

2. 发明授权

US5306722A Thymidine derivatives and therapeutic method of use 失效
标题翻译：胸苷衍生物及其治疗方法
公开(公告)号：US5306722A
公开(公告)日：1994-04-26
申请号：US939232
申请日：1992-09-02
申请人： Choung U. Kim , Bing Y. Luh , Peter F. Misco
发明人： Choung U. Kim , Bing Y. Luh , Peter F. Misco
IPC分类号： A61K31/505 , A61P31/12 , C07D405/04 , C07H19/06 , C07D403/04
CPC分类号： C07H19/06
摘要： Thymidine kinase inhibitor of formula I ##STR1## in which R is C.sub.1-6 alkyl or AR(CH.sub.2).sub.n --, wherein Ar represents phenyl optionally substituted with one to five same or different halogen, C.sub.1-6 alkyl or C.sub.1-6 alkyloxy; and n equals one to six.A further aspect of the present invention provides a method of inhibiting viral thymidine kinase. Yet another aspect of the invention relates to treating herpes simplex viral infections in mammals. Yet another aspect of the invention provides a pharmaceutical formulation.
摘要翻译：式I的胸苷激酶抑制剂（*化学结构*）I其中R是C 1-6烷基或AR（CH 2）n - ，其中Ar表示任选被1至5个相同或不同的卤素，C 1-6烷基或C 1 -C 6烷基取代的苯基， 6烷氧基; n等于1到6。本发明的另一方面提供了抑制病毒胸苷激酶的方法。本发明的另一方面涉及治疗哺乳动物中的单纯疱疹病毒感染。本发明的另一方面提供一种药物制剂。

3. 发明授权

US5208221A Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives 失效
标题翻译：抗病毒（磷酸二氢吡喃）甲氧基嘌呤/吡嗪衍生物
公开(公告)号：US5208221A
公开(公告)日：1993-05-04
申请号：US619856
申请日：1990-11-29
申请人： Choung U. Kim , John C. Martin , Bing Y. Luh , Peter F. Misco
发明人： Choung U. Kim , John C. Martin , Bing Y. Luh , Peter F. Misco
IPC分类号： A61K31/675 , A61P31/12 , A61P31/18 , C07F9/40 , C07F9/6512 , C07F9/6561
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.

4. 发明授权

US5386030A Antiviral (phosphonomethoxy)methoxy purine/pyrimidine derivatives 失效
标题翻译：抗病毒（膦酰基甲氧基）甲氧基嘌呤/嘧啶衍生物
公开(公告)号：US5386030A
公开(公告)日：1995-01-31
申请号：US16401
申请日：1993-02-11
申请人： Choung U. Kim , John C. Martin , Bing Y. Luh , Peter F. Misco
发明人： Choung U. Kim , John C. Martin , Bing Y. Luh , Peter F. Misco
IPC分类号： A61K31/675 , A61P31/12 , A61P31/18 , C07F9/40 , C07F9/6512 , C07F9/6561 , C07F9/02
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
摘要： The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.
摘要翻译：本发明涉及核苷酸类似物及其组合物和用途。特别涉及新型（膦酰基甲氧基）甲氧基嘌呤/嘧啶衍生物。

5. 发明授权

US5696265A Vinyl ethers of nucleoside analogs 失效
标题翻译：核苷类似物的乙烯基醚
公开(公告)号：US5696265A
公开(公告)日：1997-12-09
申请号：US488340
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , A61K31/52 , C07D473/18 , C07D473/34 , C07D473/30
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR2## wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base. A compound of the formula (V) ##STR3## wherein B is cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil, 5-vinyluracil, hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, or 2-acetamido-6-diphenylcarbamoylpurine; and the pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基，B为嘌呤或嘧啶碱基。其中X和X'相同或不同且为氢或烷基，Y和Z相同或不同，为氢，羟基或烷基的4'-膦基甲氧基四氢呋喃基-1'-嘌呤嘧啶， Y + Z是烯基，环氧化物或环丙基，B是嘌呤或嘧啶碱基。式（V）化合物其中B为胞嘧啶，5-乙基胞嘧啶，5-甲基胞嘧啶，胸腺嘧啶，尿嘧啶，5-氯尿嘧啶，5-溴尿嘧啶，5-乙基尿嘧啶，5-碘尿嘧啶，5-丙基尿嘧啶， 5-乙酰尿嘧啶，次黄嘌呤，黄嘌呤，鸟嘌呤，8-溴鸟嘌呤，8-氯鸟嘌呤，8-甲基鸟嘌呤，8-硫鸟嘌呤，3-脱氮鸟嘌呤，嘌呤，2-氨基嘌呤，2,6-二氨基嘌呤，腺嘌呤，3-脱氮腺嘌呤，8-氨基鸟嘌呤， 8-肼基鸟嘌呤，8-羟基鸟嘌呤或2-乙酰氨基-6-二苯基氨基甲酰基嘌呤; 及其药学上可接受的盐。

6. 发明授权

US5693798A Phosphonate nucleoside analogs 失效
标题翻译：膦酸核苷类似物
公开(公告)号：US5693798A
公开(公告)日：1997-12-02
申请号：US488337
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , C07D473/18 , C07D473/34
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR2## wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基，B为嘌呤或嘧啶碱基。其中X和X'相同或不同且为氢或烷基，Y和Z相同或不同，为氢，羟基或烷基的4'-膦基甲氧基四氢呋喃基-1'-嘌呤 - 嘧啶， Y + Z是烯基，环氧化物或环丙基，B是嘌呤或嘧啶碱基。

7. 发明授权

US5688778A Nucleoside analogs 失效
标题翻译：核苷类似物
公开(公告)号：US5688778A
公开(公告)日：1997-11-18
申请号：US391312
申请日：1995-02-17
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , A61K31/675 , C07D473/18
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl; B is a purine or pyrimidine base. optionally R is taken together with X' to complete a cyclic phosphonate having the formula ##STR2## A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR3## wherein X and X' are the same or different and are hydrogen or alkyl, the dashed line is an optional bond, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z are taken together to form an epoxide or cyclopropyl, and B is a purine or pyrimidine base.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基; B是嘌呤或嘧啶碱基。任选地R与X'一起形成具有下式的具有下式的化合物的下式的膦酸膦：其中X和X'相同或不同，并且是氢的式4'-膦基甲氧基四氢呋喃基-1'-嘌呤 - 嘧啶或烷基，虚线是任选键，Y和Z相同或不同，为氢，羟基或烷基或Y + Z一起形成环氧化物或环丙基，B为嘌呤或嘧啶碱基。

8. 发明授权

US5837871A Nucleoside analogs 失效
标题翻译：核苷类似物
公开(公告)号：US5837871A
公开(公告)日：1998-11-17
申请号：US486991
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , A61K31/675 , C07D473/18
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (II) or (VIII) ##STR2## wherein the broken line is an optional bond; X, R and X' are the same or different and are H or alkyl with 1 to 6 carbon atoms; and B is cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil or 5-vinyluracil, any one of which is substituted at the 1-position; wherein in the compound of formula (II), Y and Z are the same or different and are H; OH; alkyl having 1 to 6 carbon atoms; alkyl having 1 to 6 carbon atoms which is substituted with halogen, hydroxy, amino or azido; or are taken together to form an oxygen atom or a methylene group; or are taken together with X' to complete a cyclic phosphonate having the structure of formula (III) ##STR3## wherein R.sup.b is H or OH; wherein in the compound of formula (VIII), Y is halogen, phenylthio or phenylseleno; and the pharmaceutically acceptable salts thereof. B is a purine or pyrimidine base.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，烷基或烷酰基，B为嘌呤或嘧啶碱基。（II）或（VIII）化合物其中虚线是任选的键; X，R和X'相同或不同，为H或具有1至6个碳原子的烷基; B是胞嘧啶，5-乙基胞嘧啶，5-甲基胞嘧啶，胸腺嘧啶，尿嘧啶，5-氯尿嘧啶，5-溴尿嘧啶，5-乙基尿嘧啶，5-碘尿嘧啶，5-丙基尿嘧啶或5-乙烯基尿嘧啶，其中任何一个在1 -位置; 其中在式（II）化合物中，Y和Z相同或不同，为H; 哦; 具有1至6个碳原子的烷基; 被卤素，羟基，氨基或叠氮基取代的具有1至6个碳原子的烷基; 或者一起形成氧原子或亚甲基; 或与X'一起，以完成具有式（III）结构的环状膦酸酯，其中R b是H或OH; 其中在式（Ⅷ）化合物中，Y是卤素，苯硫基或苯基硒; 及其药学上可接受的盐。 B是嘌呤或嘧啶碱基。

9. 发明授权

US5726174A Nucleoside analogs 失效
标题翻译：核苷类似物
公开(公告)号：US5726174A
公开(公告)日：1998-03-10
申请号：US488338
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , A61K31/675
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyridimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (II) or (VIII) ##STR2## wherein the broken line is an optional bond; X, R and X' are the same or different and are H or alkyl with 1 to 6 carbon atoms; wherein in the compound of formula (II), Y and Z are the same or different and are H; OH; alkyl having 1 to 6 carbon atoms; alkyl having 1 to 6 carbon atoms which is substituted with halogen, hydroxy, amino or azido; or Y and Z are taken together to form an oxygen atom or a methylene group; or Y is taken together with X' to complete a cyclic phosphonate having the structure of formula (III) ##STR3## wherein R.sup.b is H or OH; wherein in the compound of formula (VIII), Y is halogen, phenylthio or phenylseleno; wherein in the compound of formula (II), B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine or 3-deazaadenine, any one of which is substituted at the 9-position; and, wherein in the compound of formula (III) or (VIII), B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine or 8-hydroxyguanine, any one of which is substituted at the 9-position; and the pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/吡啶并吡啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基，B为嘌呤或嘧啶碱基。（II）或（VIII）化合物其中虚线是任选的键; X，R和X'相同或不同，为H或具有1至6个碳原子的烷基; 其中在式（II）化合物中，Y和Z相同或不同，为H; 哦; 具有1至6个碳原子的烷基; 被卤素，羟基，氨基或叠氮基取代的具有1至6个碳原子的烷基; 或Y和Z一起形成氧原子或亚甲基; 或Y与X'一起形成具有式（III）结构的环状膦酸酯，其中R b是H或OH; 其中在式（Ⅷ）化合物中，Y是卤素，苯硫基或苯基硒; 其中在式（II）化合物中，B是次黄嘌呤，黄嘌呤，鸟嘌呤，8-溴鸟嘌呤，8-氯胍，8-甲基鸟嘌呤，8-硫鸟嘌呤，3-脱氮鸟嘌呤，嘌呤，2-氨基嘌呤，2,6-二氨基嘌呤，腺嘌呤或3-脱氮腺嘌呤，其中任何一个在9位被取代; 其中在式（III）或（VIII）的化合物中，B是次黄嘌呤，黄嘌呤，鸟嘌呤，8-溴鸟嘌呤，8-氯鸟嘌呤，8-甲基鸟嘌呤，8-硫鸟嘌呤，3-脱氮鸟嘌呤，嘌呤，2-氨基嘌呤， 6-二氨基嘌呤，腺嘌呤，3-脱氮腺嘌呤，8-氨基胍，8-肼基鸟嘌呤或8-羟基鸟嘌呤，其中任何一个在9位被取代; 及其药学上可接受的盐。

10. 发明授权

US5686611A Nucleoside analogs 失效
标题翻译：核苷类似物
公开(公告)号：US5686611A
公开(公告)日：1997-11-11
申请号：US488339
申请日：1995-06-07
申请人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
发明人： Choung Un Kim , John C. Martin , Bing Uh Luh , Peter F. Misco
IPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/6512 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07H19/04 , C07H19/10 , C07H19/20 , C07D473/18 , C07D473/34 , C07D473/24
CPC分类号： C07D239/54 , C07D405/04 , C07D473/00 , C07D473/32 , C07D473/40 , C07F9/65121 , C07F9/65586 , C07F9/65616 , C07F9/657181 , C07H19/04 , C07H19/10 , C07H19/20
摘要： Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (VI) ##STR2## wherein X is halogen, Y is S-phenyl, Se-phenyl or halogen and B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil or 5-vinyluracil, 2-acetamido-6-diphenylcarbamoylpurine, 6-N-dimethylamino-methyladenine or 6-N-pivaloyladenine. A compound of formula (VII) ##STR3## wherein B is guanine, 8-guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, cytosine, 5-ethylcytosine, or 5-methylcytosine.
摘要翻译：本发明提供下式的化合物：下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物，其中X和X'相同或不同，为氢或烷基。 R和R'相同或不同，为氢，烷基，羟基烷基或烷酰基，B为嘌呤或嘧啶碱基。式（VI）的化合物其中X是卤素，Y是S-苯基，Se-苯基或卤素，B是次黄嘌呤，黄嘌呤，鸟嘌呤，8-溴鸟嘌呤，8-氯鸟嘌呤，8-甲基鸟嘌呤， 8-硫鸟嘌呤，3-脱氮鸟嘌呤，嘌呤，2-氨基嘌呤，2,6-二氨基嘌呤，腺嘌呤，3-脱氮腺嘌呤，8-氨基胍，8-肼基鸟嘌呤，8-羟基鸟嘌呤，胞嘧啶，5-乙基胞嘧啶，5-甲基胞嘧啶，胸腺嘧啶，尿嘧啶，5-氯尿嘧啶，5-溴尿嘧啶，5-乙基尿嘧啶，5-碘尿嘧啶，5-丙基尿嘧啶或5-乙烯基尿嘧啶，2-乙酰氨基-6-二苯基氨基甲酰基嘌呤，6-N-二甲基氨基 - 甲基腺嘌呤或6-N-新戊酰基腺嘌呤。式（VII）化合物其中B是鸟嘌呤，8-鸟嘌呤，8-溴鸟嘌呤，8-氯鸟嘌呤，8-甲基鸟嘌呤，8-硫鸟嘌呤，3-脱氮鸟嘌呤，8-氨基胍，8-肼基鸟嘌呤， 5-羟基鸟嘌呤，胞嘧啶，5-乙基胞嘧啶或5-甲基胞嘧啶。

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