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    • 3. 发明授权
    • Vinyl ethers of nucleoside analogs
    • 核苷类似物的乙烯基醚
    • US5696265A
    • 1997-12-09
    • US488340
    • 1995-06-07
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/6512C07F9/6558C07F9/6561C07F9/6571C07H19/04C07H19/10C07H19/20A61K31/52C07D473/18C07D473/34C07D473/30
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/65121C07F9/65586C07F9/65616C07F9/657181C07H19/04C07H19/10C07H19/20
    • Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR2## wherein X and X' are the same or different and are hydrogen or alkyl, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z is an alkenyl, an epoxide or cyclopropyl, and B is a purine or pyrimidine base. A compound of the formula (V) ##STR3## wherein B is cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil, 5-vinyluracil, hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, or 2-acetamido-6-diphenylcarbamoylpurine; and the pharmaceutically acceptable salts thereof.
    • 本发明提供下式的化合物:下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物,其中X和X'相同或不同,为氢或烷基。 R和R'相同或不同,为氢,烷基,羟基烷基或烷酰基,B为嘌呤或嘧啶碱基。 其中X和X'相同或不同且为氢或烷基,Y和Z相同或不同,为氢,羟基或烷基的4'-膦基甲氧基四氢呋喃基-1'-嘌呤嘧啶, Y + Z是烯基,环氧化物或环丙基,B是嘌呤或嘧啶碱基。 式(V)化合物其中B为胞嘧啶,5-乙基胞嘧啶,5-甲基胞嘧啶,胸腺嘧啶,尿嘧啶,5-氯尿嘧啶,5-溴尿嘧啶,5-乙基尿嘧啶,5-碘尿嘧啶,5-丙基尿嘧啶, 5-乙酰尿嘧啶,次黄嘌呤,黄嘌呤,鸟嘌呤,8-溴鸟嘌呤,8-氯鸟嘌呤,8-甲基鸟嘌呤,8-硫鸟嘌呤,3-脱氮鸟嘌呤,嘌呤,2-氨基嘌呤,2,6-二氨基嘌呤,腺嘌呤,3-脱氮腺嘌呤,8-氨基鸟嘌呤, 8-肼基鸟嘌呤,8-羟基鸟嘌呤或2-乙酰氨基-6-二苯基氨基甲酰基嘌呤; 及其药学上可接受的盐。
    • 7. 发明授权
    • Nucleoside analogs
    • 核苷类似物
    • US5837871A
    • 1998-11-17
    • US486991
    • 1995-06-07
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/6512C07F9/6558C07F9/6561C07F9/6571C07H19/04C07H19/10C07H19/20A61K31/675C07D473/18
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/65121C07F9/65586C07F9/65616C07F9/657181C07H19/04C07H19/10C07H19/20
    • Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (II) or (VIII) ##STR2## wherein the broken line is an optional bond; X, R and X' are the same or different and are H or alkyl with 1 to 6 carbon atoms; and B is cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil or 5-vinyluracil, any one of which is substituted at the 1-position; wherein in the compound of formula (II), Y and Z are the same or different and are H; OH; alkyl having 1 to 6 carbon atoms; alkyl having 1 to 6 carbon atoms which is substituted with halogen, hydroxy, amino or azido; or are taken together to form an oxygen atom or a methylene group; or are taken together with X' to complete a cyclic phosphonate having the structure of formula (III) ##STR3## wherein R.sup.b is H or OH; wherein in the compound of formula (VIII), Y is halogen, phenylthio or phenylseleno; and the pharmaceutically acceptable salts thereof. B is a purine or pyrimidine base.
    • 本发明提供下式的化合物:下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物,其中X和X'相同或不同,为氢或烷基。 R和R'相同或不同,为氢,烷基,烷基或烷酰基,B为嘌呤或嘧啶碱基。 (II)或(VIII)化合物其中虚线是任选的键; X,R和X'相同或不同,为H或具有1至6个碳原子的烷基; B是胞嘧啶,5-乙基胞嘧啶,5-甲基胞嘧啶,胸腺嘧啶,尿嘧啶,5-氯尿嘧啶,5-溴尿嘧啶,5-乙基尿嘧啶,5-碘尿嘧啶,5-丙基尿嘧啶或5-乙烯基尿嘧啶,其中任何一个在1 -位置; 其中在式(II)化合物中,Y和Z相同或不同,为H; 哦; 具有1至6个碳原子的烷基; 被卤素,羟基,氨基或叠氮基取代的具有1至6个碳原子的烷基; 或者一起形成氧原子或亚甲基; 或与X'一起,以完成具有式(III)结构的环状膦酸酯,其中R b是H或OH; 其中在式(Ⅷ)化合物中,Y是卤素,苯硫基或苯基硒; 及其药学上可接受的盐。 B是嘌呤或嘧啶碱基。
    • 8. 发明授权
    • Nucleoside analogs
    • 核苷类似物
    • US5726174A
    • 1998-03-10
    • US488338
    • 1995-06-07
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/6512C07F9/6558C07F9/6561C07F9/6571C07H19/04C07H19/10C07H19/20A61K31/675
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/65121C07F9/65586C07F9/65616C07F9/657181C07H19/04C07H19/10C07H19/20
    • Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyridimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (II) or (VIII) ##STR2## wherein the broken line is an optional bond; X, R and X' are the same or different and are H or alkyl with 1 to 6 carbon atoms; wherein in the compound of formula (II), Y and Z are the same or different and are H; OH; alkyl having 1 to 6 carbon atoms; alkyl having 1 to 6 carbon atoms which is substituted with halogen, hydroxy, amino or azido; or Y and Z are taken together to form an oxygen atom or a methylene group; or Y is taken together with X' to complete a cyclic phosphonate having the structure of formula (III) ##STR3## wherein R.sup.b is H or OH; wherein in the compound of formula (VIII), Y is halogen, phenylthio or phenylseleno; wherein in the compound of formula (II), B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine or 3-deazaadenine, any one of which is substituted at the 9-position; and, wherein in the compound of formula (III) or (VIII), B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine or 8-hydroxyguanine, any one of which is substituted at the 9-position; and the pharmaceutically acceptable salts thereof.
    • 本发明提供下式的化合物:下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/吡啶并吡啶衍生物,其中X和X'相同或不同,为氢或烷基。 R和R'相同或不同,为氢,烷基,羟基烷基或烷酰基,B为嘌呤或嘧啶碱基。 (II)或(VIII)化合物其中虚线是任选的键; X,R和X'相同或不同,为H或具有1至6个碳原子的烷基; 其中在式(II)化合物中,Y和Z相同或不同,为H; 哦; 具有1至6个碳原子的烷基; 被卤素,羟基,氨基或叠氮基取代的具有1至6个碳原子的烷基; 或Y和Z一起形成氧原子或亚甲基; 或Y与X'一起形成具有式(III)结构的环状膦酸酯,其中R b是H或OH; 其中在式(Ⅷ)化合物中,Y是卤素,苯硫基或苯基硒; 其中在式(II)化合物中,B是次黄嘌呤,黄嘌呤,鸟嘌呤,8-溴鸟嘌呤,8-氯胍,8-甲基鸟嘌呤,8-硫鸟嘌呤,3-脱氮鸟嘌呤,嘌呤,2-氨基嘌呤,2,6-二氨基嘌呤, 腺嘌呤或3-脱氮腺嘌呤,其中任何一个在9位被取代; 其中在式(III)或(VIII)的化合物中,B是次黄嘌呤,黄嘌呤,鸟嘌呤,8-溴鸟嘌呤,8-氯鸟嘌呤,8-甲基鸟嘌呤,8-硫鸟嘌呤,3-脱氮鸟嘌呤,嘌呤,2-氨基嘌呤, 6-二氨基嘌呤,腺嘌呤,3-脱氮腺嘌呤,8-氨基胍,8-肼基鸟嘌呤或8-羟基鸟嘌呤,其中任何一个在9位被取代; 及其药学上可接受的盐。
    • 9. 发明授权
    • Nucleoside analogs
    • 核苷类似物
    • US5686611A
    • 1997-11-11
    • US488339
    • 1995-06-07
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • Choung Un KimJohn C. MartinBing Uh LuhPeter F. Misco
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/6512C07F9/6558C07F9/6561C07F9/6571C07H19/04C07H19/10C07H19/20C07D473/18C07D473/34C07D473/24
    • C07D239/54C07D405/04C07D473/00C07D473/32C07D473/40C07F9/65121C07F9/65586C07F9/65616C07F9/657181C07H19/04C07H19/10C07H19/20
    • Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl and B is a purine or pyrimidine base. A compound of formula (VI) ##STR2## wherein X is halogen, Y is S-phenyl, Se-phenyl or halogen and B is hypoxanthine, xanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, purine, 2-aminopurine, 2,6-diaminopurine, adenine, 3-deazaadenine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-chlorouracil, 5-bromouracil, 5-ethyluracil, 5-iodouracil, 5-propyluracil or 5-vinyluracil, 2-acetamido-6-diphenylcarbamoylpurine, 6-N-dimethylamino-methyladenine or 6-N-pivaloyladenine. A compound of formula (VII) ##STR3## wherein B is guanine, 8-guanine, 8-bromoguanine, 8-chloroguanine, 8-methylguanine, 8-thioguanine, 3-deazaguanine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, cytosine, 5-ethylcytosine, or 5-methylcytosine.
    • 本发明提供下式的化合物:下式的膦酰甲氧基甲氧基甲氧基甲基嘌呤/嘧啶衍生物,其中X和X'相同或不同,为氢或烷基。 R和R'相同或不同,为氢,烷基,羟基烷基或烷酰基,B为嘌呤或嘧啶碱基。 式(VI)的化合物其中X是卤素,Y是S-苯基,Se-苯基或卤素,B是次黄嘌呤,黄嘌呤,鸟嘌呤,8-溴鸟嘌呤,8-氯鸟嘌呤,8-甲基鸟嘌呤, 8-硫鸟嘌呤,3-脱氮鸟嘌呤,嘌呤,2-氨基嘌呤,2,6-二氨基嘌呤,腺嘌呤,3-脱氮腺嘌呤,8-氨基胍,8-肼基鸟嘌呤,8-羟基鸟嘌呤,胞嘧啶,5-乙基胞嘧啶,5-甲基胞嘧啶,胸腺嘧啶, 尿嘧啶,5-氯尿嘧啶,5-溴尿嘧啶,5-乙基尿嘧啶,5-碘尿嘧啶,5-丙基尿嘧啶或5-乙烯基尿嘧啶,2-乙酰氨基-6-二苯基氨基甲酰基嘌呤,6-N-二甲基氨基 - 甲基腺嘌呤或6-N-新戊酰基腺嘌呤。 式(VII)化合物其中B是鸟嘌呤,8-鸟嘌呤,8-溴鸟嘌呤,8-氯鸟嘌呤,8-甲基鸟嘌呤,8-硫鸟嘌呤,3-脱氮鸟嘌呤,8-氨基胍,8-肼基鸟嘌呤, 5-羟基鸟嘌呤,胞嘧啶,5-乙基胞嘧啶或5-甲基胞嘧啶。
    • 10. 发明授权
    • Arrow launched media reservoir
    • 箭推出媒体库
    • US07731612B2
    • 2010-06-08
    • US11956023
    • 2007-12-13
    • John C. Martin
    • John C. Martin
    • F42B6/04
    • F42B6/08F41J3/0004F42B6/02F42B12/362F42B12/40
    • An arrow having an arrowhead assembly attached thereto is provided for marking a remote location with a marking media. The marking media is preferably in the form of a paint ball or a scent ball. The arrowhead assembly includes a media reservoir defining a cavity and a plurality of supports extending outward from the media reservoir along a longitudinal axis. The supports secure the marking media within the cavity in a press-fit connection. In one embodiment, a cap and a resilient nose cone are attached to the media reservoir, surrounding the marking media, to prevent damage to a target upon impacting the target.
    • 提供了具有附接到其上的箭头组件的箭头,用于用标记介质标记远程位置。 标记介质优选为油漆球或气味球的形式。 箭头组件包括限定空腔的介质储存器和沿着纵向轴线从介质储存器向外延伸的多个支撑件。 支撑件将压痕连接中的标记介质固定在空腔内。 在一个实施例中,盖和弹性鼻锥连接到介质储存器,围绕标记介质,以防止在撞击目标时损坏目标物。