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1. 发明申请

US20050014935A1 Methods and compositions for determination of glycated proteins 有权
标题翻译：测定糖基化蛋白质的方法和组合物
公开(公告)号：US20050014935A1
公开(公告)日：2005-01-20
申请号：US10622893
申请日：2003-07-17
申请人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
发明人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
IPC分类号： C12N1/21 , C12N9/06 , C12Q1/26 , C12Q1/37 , G01N33/68 , G01N33/72 , C07K14/245 , C07H21/04 , C12N9/48
CPC分类号： G01N33/723 , C07K2319/40 , C07K2319/50 , C12N9/0032 , C12Q1/26 , C12Q1/37 , G01N33/6893 , G01N2400/00 , G01N2800/042
摘要： This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase.
摘要翻译：本发明一般涉及糖基化蛋白检测领域。特别地，本发明提供嵌合蛋白质，编码嵌合蛋白的核酸，用于使用特别是阿马道里酶测定样品中糖基化蛋白质的方法和试剂盒。

2. 发明申请

US20080241880A1 Methods and compositions for determination of glycated proteins 审中-公开
标题翻译：测定糖基化蛋白质的方法和组合物
公开(公告)号：US20080241880A1
公开(公告)日：2008-10-02
申请号：US11595209
申请日：2006-11-08
申请人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
发明人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
IPC分类号： C12P21/04 , C07H21/04 , C12N1/20
CPC分类号： G01N33/723 , C07K2319/40 , C07K2319/50 , C12N9/0032 , C12Q1/26 , C12Q1/37 , G01N33/6893 , G01N2400/00 , G01N2800/042
摘要： This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase.
摘要翻译：本发明一般涉及糖基化蛋白检测领域。特别地，本发明提供嵌合蛋白质，编码嵌合蛋白的核酸，用于使用特别是阿马道里酶测定样品中糖基化蛋白质的方法和试剂盒。

3. 发明授权

US07153666B2 Methods and compositions for determination of glycated proteins 有权
标题翻译：测定糖基化蛋白质的方法和组合物
公开(公告)号：US07153666B2
公开(公告)日：2006-12-26
申请号：US10622893
申请日：2003-07-17
申请人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
发明人： Chong-Sheng Yuan , Abhijit Datta , Yuping Wang
IPC分类号： C12Q1/37 , C12Q1/26 , C12Q1/28 , C12Q1/54 , C12N9/02
CPC分类号： G01N33/723 , C07K2319/40 , C07K2319/50 , C12N9/0032 , C12Q1/26 , C12Q1/37 , G01N33/6893 , G01N2400/00 , G01N2800/042
摘要： This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase.
摘要翻译：本发明一般涉及糖基化蛋白检测领域。特别地，本发明提供嵌合蛋白质，编码嵌合蛋白的核酸，用于使用特别是阿马道里酶测定样品中糖基化蛋白质的方法和试剂盒。

4. 发明申请

US20050009128A1 Methods and compositions for assaying homocysteine 有权
标题翻译：用于测定同型半胱氨酸的方法和组合物
公开(公告)号：US20050009128A1
公开(公告)日：2005-01-13
申请号：US10801623
申请日：2004-03-15
申请人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
发明人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
IPC分类号： C12Q1/34 , C12Q1/48 , G01N33/68
CPC分类号： C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6815
摘要： This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. A kit for assaying homocysteine based on the same principle is also provided.
摘要翻译：本发明一般涉及同型半胱氨酸检测领域。特别地，本发明提供了一种测定样品中同型半胱氨酸存在或浓度的方法，该方法包括：在Hcy转化反应中使包含或怀疑含有Hcy的样品与Hcy共底物和Hcy转化酶接触以形成Hcy 转化产物和Hcy共底物转化产物; 并评估Hcy共底物转化产物以确定样品中Hcy的存在，不存在和/或量。还提供了用于基于相同原理测定同型半胱氨酸的试剂盒。

5. 发明授权

US08338184B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US08338184B2
公开(公告)日：2012-12-25
申请号：US13083357
申请日：2011-04-08
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

6. 发明授权

US07943385B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US07943385B2
公开(公告)日：2011-05-17
申请号：US12120122
申请日：2008-05-13
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

7. 发明授权

US07855079B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US07855079B2
公开(公告)日：2010-12-21
申请号：US11881179
申请日：2007-07-25
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： G01N33/723 , Y10T436/104998 , Y10T436/105831 , Y10T436/107497 , Y10T436/25375
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶和过氧化物酶催化的酶反应。本发明提供了用于实施本发明方法的试剂盒。

8. 发明申请

US20100025264A1 ELECTROCHEMICAL BIOSENSOR FOR DIRECT DETERMINATION OF PERCENTAGE OF GLYCATED HEMOGLOBIN 失效
标题翻译：用于直接测定糖化血红蛋白百分比的电化学生物传感器
公开(公告)号：US20100025264A1
公开(公告)日：2010-02-04
申请号：US12465143
申请日：2009-05-13
申请人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
发明人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N33/723 , C12Q1/005 , G01N33/5438 , G01N2333/906
摘要： The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的电化学生物传感器，而不需要分离测量血液样品中的总血红蛋白含量。本发明提供了使用电化学生物传感器的方法。

9. 发明授权

US07097968B2 Methods and compositions for assaying homocysteine 有权
标题翻译：用于测定同型半胱氨酸的方法和组合物
公开(公告)号：US07097968B2
公开(公告)日：2006-08-29
申请号：US10801623
申请日：2004-03-15
申请人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
发明人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
IPC分类号： C12Q1/00
CPC分类号： C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6815
摘要： This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. A kit for assaying homocysteine based on the same principle is also provided.
摘要翻译：本发明一般涉及同型半胱氨酸检测领域。特别地，本发明提供了一种测定样品中同型半胱氨酸存在或浓度的方法，该方法包括：在Hcy转化反应中使包含或怀疑含有Hcy的样品与Hcy共底物和Hcy转化酶接触以形成Hcy 转化产物和Hcy共底物转化产物; 并评估Hcy共底物转化产物以确定样品中Hcy的存在，不存在和/或量。还提供了用于基于相同原理测定同型半胱氨酸的试剂盒。

10. 发明申请

US20060172362A1 Methods and compositions for assaying homocysteine 审中-公开
公开(公告)号：US20060172362A1
公开(公告)日：2006-08-03
申请号：US11394457
申请日：2006-03-31
申请人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
发明人： Chong-Sheng Yuan , Abhijit Datta , Chao Dou
IPC分类号： C12Q1/48 , C12Q1/37
CPC分类号： C12Q1/34 , C12Q1/48 , C12Q1/485 , G01N33/6815
摘要： This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. A kit for assaying homocysteine based on the same principle is also provided.

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