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1. 发明申请

US20110250627A1 METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US20110250627A1
公开(公告)日：2011-10-13
申请号：US13083357
申请日：2011-04-08
申请人： Chong-Sheng YUAN , Abhijit DATTA , Limin Liu
发明人： Chong-Sheng YUAN , Abhijit DATTA , Limin Liu
IPC分类号： C12Q1/28 , C12Q1/26
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

2. 发明授权

US07855079B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US07855079B2
公开(公告)日：2010-12-21
申请号：US11881179
申请日：2007-07-25
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： G01N33/723 , Y10T436/104998 , Y10T436/105831 , Y10T436/107497 , Y10T436/25375
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶和过氧化物酶催化的酶反应。本发明提供了用于实施本发明方法的试剂盒。

3. 发明申请

US20100025264A1 ELECTROCHEMICAL BIOSENSOR FOR DIRECT DETERMINATION OF PERCENTAGE OF GLYCATED HEMOGLOBIN 失效
标题翻译：用于直接测定糖化血红蛋白百分比的电化学生物传感器
公开(公告)号：US20100025264A1
公开(公告)日：2010-02-04
申请号：US12465143
申请日：2009-05-13
申请人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
发明人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N33/723 , C12Q1/005 , G01N33/5438 , G01N2333/906
摘要： The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的电化学生物传感器，而不需要分离测量血液样品中的总血红蛋白含量。本发明提供了使用电化学生物传感器的方法。

4. 发明授权

US08673646B2 Electrochemical biosensor for direct determination of percentage of glycated hemoglobin 失效
标题翻译：用于直接测定糖化血红蛋白百分比的电化学生物传感器
公开(公告)号：US08673646B2
公开(公告)日：2014-03-18
申请号：US12465143
申请日：2009-05-13
申请人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
发明人： Chong-Sheng Yuan , Neal K. Blue , Abhijit Datta , Limin Liu , Lei Fang
IPC分类号： G01N33/72
CPC分类号： G01N33/723 , C12Q1/005 , G01N33/5438 , G01N2333/906
摘要： The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的电化学生物传感器，而不需要分离测量血液样品中的总血红蛋白含量。本发明提供了使用电化学生物传感器的方法。

5. 发明申请

US20110189712A1 METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US20110189712A1
公开(公告)日：2011-08-04
申请号：US12944586
申请日：2010-11-11
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： C12Q1/37
CPC分类号： G01N33/723 , Y10T436/104998 , Y10T436/105831 , Y10T436/107497 , Y10T436/25375
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶和过氧化物酶催化的酶反应。本发明提供了用于实施本发明方法的试剂盒。

6. 发明申请

US20080299597A1 METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US20080299597A1
公开(公告)日：2008-12-04
申请号：US12120122
申请日：2008-05-13
申请人： Chong-Sheng YUAN , Abhijit Datta , Limin Liu
发明人： Chong-Sheng YUAN , Abhijit Datta , Limin Liu
IPC分类号： C12Q1/37
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

7. 发明授权

US08338184B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US08338184B2
公开(公告)日：2012-12-25
申请号：US13083357
申请日：2011-04-08
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

8. 发明授权

US07943385B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US07943385B2
公开(公告)日：2011-05-17
申请号：US12120122
申请日：2008-05-13
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： C12Q1/28 , G01N33/723
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶催化的酶反应。测定反应中产生的过氧化氢的量，以测定血液样品中糖化血红蛋白的百分比。本发明提供了用于实施本发明方法的试剂盒。

9. 发明授权

US08318501B2 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US08318501B2
公开(公告)日：2012-11-27
申请号：US12944586
申请日：2010-11-11
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/72 , G01N33/00
CPC分类号： G01N33/723 , Y10T436/104998 , Y10T436/105831 , Y10T436/107497 , Y10T436/25375
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶和过氧化物酶催化的酶反应。本发明提供了用于实施本发明方法的试剂盒。

10. 发明申请

US20080096230A1 Methods for assaying percentage of glycated hemoglobin 有权
标题翻译：测定糖化血红蛋白百分比的方法
公开(公告)号：US20080096230A1
公开(公告)日：2008-04-24
申请号：US11881179
申请日：2007-07-25
申请人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
发明人： Chong-Sheng Yuan , Abhijit Datta , Limin Liu
IPC分类号： G01N33/53
CPC分类号： G01N33/723 , Y10T436/104998 , Y10T436/105831 , Y10T436/107497 , Y10T436/25375
摘要： The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
摘要翻译：本发明提供用于直接测定血液样品中糖化血红蛋白百分比的酶法，而不需要分离测量血液样品中的总血红蛋白含量。该方法使用一种或两种不同类型的氧化剂，其选择性地氧化血液样品中的低分子量还原物质和高分子量（主要是血红蛋白）还原物质，加上由蛋白酶，果糖基氨基酸氧化酶和过氧化物酶催化的酶反应。本发明提供了用于实施本发明方法的试剂盒。

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