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1. 发明授权

US5596014A Hydroxymethyl-polythiophene derivatives 失效
标题翻译：羟甲基 - 聚噻吩衍生物
公开(公告)号：US5596014A
公开(公告)日：1997-01-21
申请号：US461176
申请日：1995-06-05
申请人： Ching-Te Chang , Rong-Tsun Wu
发明人： Ching-Te Chang , Rong-Tsun Wu
IPC分类号： C07D333/16 , C07D333/18 , C07D333/22 , A61K31/38 , C07D409/14
CPC分类号： C07D333/16 , C07D333/18 , C07D333/22
摘要： A pharmaceutical composition containing a compound and an excipient, the compound having the formula: ##STR1## in which n is 2, 3 or 4; R is H, --CH(R.sup.1).cndot.OR.sup.2, --CH(O--Z).sub.2, or --COR.sup.3 ; R.sup.1 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; R.sup.2 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, tetrahydropyranyl, phenyl, benzoyl, C.sub.1-6 acyl, tosyl, or --CO--Y--COOH; and R.sup.3 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; wherein Z is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.1-6 acyl; and Y is C.sub.1-6 alkylidene, C.sub.2-6 alkenylidene, phenylene, or deleted; or an ester or a salt thereof.
摘要翻译：含有化合物和赋形剂的药物组合物，具有下式的化合物：其中n为2,3或4; R为H，-CH（R 1），OR 2，-CH（O-Z）2或-COR 3; R1是H，C1-6烷基，C2-6烯基，OH，C1-6羟基烷基或COOH; R2是H，C1-6烷基，C2-6烯基，四氢吡喃基，苯基，苯甲酰基，C1-6酰基，甲苯磺酰基或-CO-Y-COOH; 和R 3是H，C 1-6烷基，C 2-6烯基，OH，C 1-6羟基烷基或COOH; 其中Z为C 1-6烷基，C 2-6烯基或C 1-6酰基; Y为C1-6亚烷基，C2-6亚烯基，亚苯基或缺失; 或其酯或其盐。

2. 发明授权

US5753692A Medicinal thiophene compounds 失效
标题翻译：药用噻吩化合物
公开(公告)号：US5753692A
公开(公告)日：1998-05-19
申请号：US468522
申请日：1995-06-06
申请人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
发明人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： A method of augmenting the immune system including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH.dbd.NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 .dbd.CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently, is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 halogenated alkyl; OR.sup.1, or NHR.sup.7 ; each of R.sup.5 and R.sup.6, independently, is H, CHO, COR.sup.1, COOH, COOR.sup.9, CN, or halogen; R.sup.7 is H, C.sub.1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R.sup.8 is COOR.sup.2, CO.CHO, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R.sup.9 is H, C.sub.1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2-thienyl.
摘要翻译：一种增强免疫系统的方法，包括向受试者施用有效量的下式化合物：其中m为1-4; A和B各自独立地为H，C 1-7烷基，C 2-7烯基，C 2-7炔基，（CH 2）n CHO，（CH 2）o COOH，C 1-7烷氧基，C 2-7烷氧基烷基，C 1-7 羟基烷基，CN，NO 2，卤素，CH（OR 1）2，CO.R 1，NR 2 R 3或其酸式盐，CO.NR 2 R 3，CHRRNR 2 R 3或其酸式盐CH = NR 2，C 3 D 4 CR 4，CR 1 = CR 5 R 6，CO.CH = CHR7，CH = CHR8或COOR9; 其中n和o各自独立地为0-4; R1是C1-4烷基或C1-4酰基; R 2和R 3各自独立地是H，C 1-4烷基或C 1-4羟基烷基; R4是H，C1-4烷基，C2-4烯基，COR2，COOR10，C1-4羟烷基或其酸酯或2-四氢吡喃基醚，C1-4二羟基烷基或其酸酯或2-四氢吡喃基醚，C1-4卤代烷基; OR1或NHR7; R 5和R 6各自独立地是H，CHO，COR1，COOH，COOR9，CN或卤素; R 7是H，C 1-4烷基，2-噻吩基，苯基，单取代的苯基或二取代的苯基; R8是COOR2，CO.CHO，C1-4羟烷基或其酸酯或2-四氢吡喃基醚; 且R 9为H，C 1-4烷基，苯基，单取代苯基，二取代苯基或2-噻吩基。

3. 发明授权

US5747525A Medicinal thiophene compounds 失效
标题翻译：药用噻吩化合物
公开(公告)号：US5747525A
公开(公告)日：1998-05-05
申请号：US468253
申请日：1995-06-06
申请人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
发明人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： A method of treating tumor including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH.dbd.NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 .dbd.CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently, is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 halogenated alkyl; OR.sup.1, or NHR.sup.7 ; each of R.sup.5 and R.sup.6, independently, is H, CHO, COR.sup.1, COOH, COOR.sup.9, CN, or halogen; R.sup.7 is H, C.sub.1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R.sup.8 is COOR.sup.2, CO.CHO, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R.sup.9 is H, C.sub.1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2-thienyl.
摘要翻译：一种治疗肿瘤的方法，包括向受试者施用有效量的下式化合物：其中m为1-4; A和B各自独立地为H，C 1-7烷基，C 2-7烯基，C 2-7炔基，（CH 2）n CHO，（CH 2）o COOH，C 1-7烷氧基，C 2-7烷氧基烷基，C 1-7 羟基烷基，CN，NO 2，卤素，CH（OR 1）2，CO.R 1，NR 2 R 3或其酸式盐，CO.NR 2 R 3，CHRRNR 2 R 3或其酸式盐CH = NR 2，C 3 D 4 CR 4，CR 1 = CR 5 R 6，CO.CH = CHR7，CH = CHR8或COOR9; 其中n和o各自独立地为0-4; R1是C1-4烷基或C1-4酰基; R 2和R 3各自独立地是H，C 1-4烷基或C 1-4羟基烷基; R4是H，C1-4烷基，C2-4烯基，COR2，COOR10，C1-4羟烷基或其酸酯或2-四氢吡喃基醚，C1-4二羟基烷基或其酸酯或2-四氢吡喃基醚，C1-4卤代烷基; OR1或NHR7; R 5和R 6各自独立地是H，CHO，COR1，COOH，COOR9，CN或卤素; R 7是H，C 1-4烷基，2-噻吩基，苯基，单取代的苯基或二取代的苯基; R8是COOR2，CO.CHO，C1-4羟烷基或其酸酯或2-四氢吡喃基醚; 且R 9为H，C 1-4烷基，苯基，单取代苯基，二取代苯基或2-噻吩基。

4. 发明授权

US5602170A Medicinal thiophene compounds 失效
标题翻译：药用噻吩化合物
公开(公告)号：US5602170A
公开(公告)日：1997-02-11
申请号：US302278
申请日：1994-09-08
申请人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
发明人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH=NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 =CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 halogenated alkyl; OR.sup.1, NHR.sup.7 ; each of R.sup.5 R.sup.6, independently, is H, CHO, COR.sup.1, COOH, COOR.sup.9, CN, or halogen; R.sup.7 is H, C.sub.1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R.sup.8 is COOR.sup.2, CO.CHO, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R.sup.9 is H, C.sub.1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2 -thienyl.
摘要翻译：一种治疗炎症的方法，包括向受试者施用有效量的下式化合物：其中m为1-4; A和B各自独立地为H，C 1-7烷基，C 2-7烯基，C 2-7炔基，（CH 2）n CHO，（CH 2）o COOH，C 1-7烷氧基，C 2-7烷氧基烷基，C 1-7 羟基烷基，CN，NO 2，卤素，CH（OR 1）2，CO.R 1，NR 2 R 3或其酸式盐，CO.NR 2 R 3，CHRRNR 2 R 3或其酸式盐CH = NR 2，C 3 D 4 CR 4，CR 1 = CR 5 R 6，CO.CH = CHR7，CH = CHR8或COOR9; 其中n和o各自独立地为0-4; R1是C1-4烷基或C1-4酰基; R 2和R 3各自独立地是H，C 1-4烷基或C 1-4羟基烷基; R4是H，C1-4烷基，C2-4烯基，COR2，COOR10，C1-4羟烷基或其酸酯或2-四氢吡喃基醚，C1-4二羟基烷基或其酸酯或2-四氢吡喃基醚，C1-4卤代烷基; OR1，NHR7; R5 R6各自独立地为H，CHO，COR1，COOH，COOR9，CN或卤素; R 7是H，C 1-4烷基，2-噻吩基，苯基，单取代的苯基或二取代的苯基; R8是COOR2，CO.CHO，C1-4羟烷基或其酸酯或2-四氢吡喃基醚; 且R 9为H，C 1-4烷基，苯基，单取代苯基，二取代苯基或2-噻吩基。

5. 发明授权

US08668908B2 Method for alleviating chemotherapy side effects using extract of Dioscorea sp 有权
标题翻译：薯using提取物缓解化疗副作用的方法
公开(公告)号：US08668908B2
公开(公告)日：2014-03-11
申请号：US12327162
申请日：2008-12-03
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K36/8945 , A61K39/395
CPC分类号： A61K36/8945
摘要： Extract fractions of Dioscorea sp. and methods of preparing the extract fractions are disclosed. The extract fractions enhance the proliferation and differentiation of bone marrow cells. Also described are a method for treatment of osteoporosis and a method for alleviation of side effects caused by chemotherapy by using the extract fractions of Dioscorea sp.
摘要翻译：薯a提取物并且公开了制备提取物组分的方法。提取物部分增强骨髓细胞的增殖和分化。还描述了用于治疗骨质疏松症的方法和通过使用薯the皂甙提取物部分来缓解由化学疗法引起的副作用的方法。

6. 发明授权

US08628809B2 Method of inducing mucosal immune response to antigen with Dioscorea polysaccharides adjuvant 有权
标题翻译：用薯a多糖佐剂诱导抗原的粘膜免疫应答的方法
公开(公告)号：US08628809B2
公开(公告)日：2014-01-14
申请号：US12430353
申请日：2009-04-27
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K36/00 , A61K39/12 , A61K39/02 , A61K45/00 , A61K47/00
CPC分类号： A61K31/715 , A61K36/8945
摘要： A method for inducing mucosal immune responses in a subject in need thereof to an antigen includes administering to the subject a vaccine composition including the antigen and a Dioscorea polysaccharides as an adjuvant. Because of the immuomodulatory effect of the Dioscorea polysaccharides, the vaccine composition is further capable of breaking immunological tolerance in the subject.
摘要翻译：将有此需要的受试者诱导粘膜免疫应答的方法包括向受试者施用包含抗原和薯a皂苷多糖作为佐剂的疫苗组合物。由于薯a皂苷多糖的免疫调节作用，疫苗组合物进一步能够破坏受试者的免疫耐受性。

7. 发明申请

US20090208595A1 Extract of plant Dendrobii caulis and preparing process thereof 有权
标题翻译：植物植物提取物及其制备方法
公开(公告)号：US20090208595A1
公开(公告)日：2009-08-20
申请号：US12316216
申请日：2008-12-10
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K36/8984
CPC分类号： A61K36/8984
摘要： An extract of plant Dendrobii Caulis and preparing process thereof are provided. A physiologically active extract of a plant Dendrobii Caulis and the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.
摘要翻译：提供了植物Dendrobii Caulis的提取物及其制备方法。本发明提供了植物Dendrobii Caulis的生理活性提取物及其方法。提取物通过用水混溶性有机溶剂或其与水的混合物萃取植物或其部分而获得。

8. 发明授权

US07101577B2 Extract of plant Dendrobii caulis and preparing process thereof 有权
公开(公告)号：US07101577B2
公开(公告)日：2006-09-05
申请号：US10648651
申请日：2003-08-25
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K35/78
CPC分类号： A61K36/8984
摘要： An extract of plant Dendrobii Caulis and preparing process thereof are provided. A physiologically active extract of a plant Dendrobii Caulis and the method thereof are provided in the present invention. The extract is obtained by an extraction of the plant or parts thereof with a water miscible organic solvent or a mixture thereof with water.

9. 发明授权

US09089585B2 Extracts of Polygonum multiflorum thunb, and preparation process and uses of the same 有权
标题翻译：茯苓提取物及其制备方法及用途相同
公开(公告)号：US09089585B2
公开(公告)日：2015-07-28
申请号：US11893551
申请日：2007-08-15
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K36/704 , A61K36/70
CPC分类号： A61K36/704 , Y10S514/838
摘要： Disclosed herein are processes for preparing extract products from the root of Polygonum multiflorum Thunb. and the extract products thus obtained, which are biologically active in promoting the proliferation, growth and/or differentiation of hematocytes and bone marrow cells in vitro and in vivo.
摘要翻译：本文公开了从Poly属根中提取产物的方法。以及由此获得的提取物产物，其在体外和体内促进血细胞和骨髓细胞的增殖，生长和/或分化具有生物活性。

10. 发明授权

US08883230B2 Use of black soybean for treating ophthalmic diseases 有权
标题翻译：使用黑豆治疗眼科疾病
公开(公告)号：US08883230B2
公开(公告)日：2014-11-11
申请号：US12036565
申请日：2008-02-25
申请人： Rong-Tsun Wu
发明人： Rong-Tsun Wu
IPC分类号： A61K36/00 , A61K36/48
CPC分类号： A61K36/48
摘要： A method for treating a disease or disorder associated with retinal pigment epithelium (RPE) disturbance, comprising administering to a human in need thereof an effective amount of a black soybean (Glycine max (L.) Merr) product is provided, wherein the black soybean product is the seed coats of black soybean or an alcoholic extract of black soybean or seed coats thereof.
摘要翻译：一种用于治疗与视网膜色素上皮（RPE）障碍相关的疾病或病症的方法，包括向有需要的人施用有效量的黑豆（Glycine max（L.）Merr）产品，其中黑大豆产品是黑大豆的种皮或黑豆或其种皮的酒精提取物。

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