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1. 发明授权

US5596107A Hydroxymethypolythiophene derivatives 失效
标题翻译：羟甲基聚噻吩衍生物
公开(公告)号：US5596107A
公开(公告)日：1997-01-21
申请号：US460075
申请日：1995-06-02
申请人： Ching-Te Chang , Chen-Tao Lee , Fueng-Lan Lin
发明人： Ching-Te Chang , Chen-Tao Lee , Fueng-Lan Lin
IPC分类号： C07D333/16 , C07D333/18 , C07D333/22 , C07D409/14 , A61K31/38
CPC分类号： C07D333/16 , C07D333/18 , C07D333/22
摘要： Novel hydroxymethylthiophene derivatives and their medical use in treating or preventing inflammation and edema.
摘要翻译：新型羟甲基噻吩衍生物及其在治疗或预防炎症和水肿中的用途。

2. 发明授权

US4508654A Preparation of bis-carboxy ethyl germanium sesquioxide and its propionic acid derivatives 失效
标题翻译：双羧基乙二氧化锗及其丙酸衍生物的制备
公开(公告)号：US4508654A
公开(公告)日：1985-04-02
申请号：US344377
申请日：1982-02-01
申请人： Ching-Te Chang , Lian-Tze Lee , Hsueh-Ling Su
发明人： Ching-Te Chang , Lian-Tze Lee , Hsueh-Ling Su
IPC分类号： C01G17/04 , C07F7/30
CPC分类号： C01G17/04 , C07F7/30
摘要： Reaction mixture of germanium dioxide and hypophosphorous acid or its salts in hydrochloric acid is extracted with organic solvent. This resultant is then reacted with acrylic acid or its derivatives, and further hydrolyzed to provide bis-carboxy ethyl germanium sesquioxide or its propionic acid derivatives.
摘要翻译：二氧化碳和次磷酸或其盐在盐酸中的反应混合物用有机溶剂萃取。然后将该产物与丙烯酸或其衍生物反应，并进一步水解以提供双羧基乙基锗倍半氧化物或其丙酸衍生物。

3. 发明申请

US20060234956A1 Dicarboxylic acid ester derivatives of ginsenoside, pharmaceutical preparations containing the same, and preparation thereof 审中-公开
标题翻译：人参皂苷的二羧酸酯衍生物，含有它们的药物制剂及其制备方法
公开(公告)号：US20060234956A1
公开(公告)日：2006-10-19
申请号：US11404303
申请日：2006-04-14
申请人： Hui-Ling Chen , Ying-Ming Huang , Ching-Te Chang , Wen-Yi Chuang
发明人： Hui-Ling Chen , Ying-Ming Huang , Ching-Te Chang , Wen-Yi Chuang
IPC分类号： C07J17/00 , C07J9/00 , A61K31/704 , A61K31/56
CPC分类号： C07J9/00 , C07J9/005 , C07J17/00 , C07J17/005
摘要： The present invention relates to a series of dicarboxylic acid ester derivatives of ginsenosides such as succinate and glutarate derivatives of 20-O-β-D-glucopyranosyl-protopanaxadiol (compound K, abbreviated as CK), preparation thereof and pharmaceutical uses thereof. The dicarboxylic acid ester derivatives of ginsenosides of the present invention can be used to form pharmaceutical acceptable salts thereof having a high water solubility or can be directly dissolved in an aqueous solution of metal salt, and retain the pharmaceutical activities of ginsenosides such as tumor growth inhibition and cancer preventive cytotoxicity. The dicarboxylic acid ester derivatives of ginsenosides of the present invention are thus suitable for use in the manufactures of various pharmaceutically and cosmetically acceptable dosage forms of preparations, such as peripheral, oral, and topical dosage forms.
摘要翻译：本发明涉及一系列人参皂甙二羧酸酯衍生物，如琥珀酸酯和20-O-β-D-吡喃葡萄糖基 - 原人参二醇（化合物K，缩写为CK）的戊二酸酯衍生物，其制备方法及其药物用途。本发明的人参皂甙的二羧酸酯衍生物可用于形成具有高水溶性的药学上可接受的盐，或可直接溶于金属盐水溶液中，并保留人参皂苷的药物活性，如肿瘤生长抑制和癌症预防细胞毒性。因此，本发明的人参皂苷的二羧酸酯衍生物适用于制备各种药学上和化妆品上可接受的制剂例如外周剂，口服剂和局部剂型的剂型。

4. 发明授权

US6046229A Polyaryl antitumor agents 失效
标题翻译：聚芳基抗肿瘤剂
公开(公告)号：US6046229A
公开(公告)日：2000-04-04
申请号：US3317
申请日：1998-01-06
申请人： Ching Te Chang , Yuh-Lin Yang
发明人： Ching Te Chang , Yuh-Lin Yang
IPC分类号： C07D333/16 , C07D333/20 , C07D333/22 , A01N43/10 , C07D333/32 , C07D333/36 , C07D49/10
CPC分类号： C07D333/20 , C07D333/16 , C07D333/22
摘要： A compound of the formula:Ar.sub.1 --B--Ar.sub.2wherein Ar.sub.1 is unsubstituted or substituted phenyl, thienyl, furanyl, or pyrrolyl, in which each substituent of the substituted phenyl, substituted thienyl, substituted furanyl, and substituted pyrrolyl, independently, is aldehyde, acyl, ester, carboxyl, amido, nitrile, nitro, cyano, acetal, ketal, oxoalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, iminoalkyl, acid halide, aminoalkylaminoalkyl, aminoalkylaminoalkylamino, hydroxyalkylaminoalkyl, or hydroxyalkylaminoalkylaminoalkyl; B is, --CH.dbd.CH--, or --C C--, in which R is H, alkyl, hydroxyl, alkoxy, ester, aldehyde, hydroxyalkyl, aminoalkyl, carboxyl, --CH(OR.sub.1).sub.2, or NR.sub.2 R.sub.3, where each R.sub.1, independently, is H, alkyl, or acyl; and each of R.sub.2 and R.sub.3, independently, is H, alkyl, hydroxyalkyl, or aminoalkyl; and Ar.sub.2 is substituted phenyl, substituted thienyl, substituted furanyl, or substituted pyrrolyl, in which each substituent of the substituted phenyl, substituted thienyl, substituted furanyl, and substituted pyrrolyl, independently, is amido, nitrile, nitro, cyano, acetal, ketal, oxoalkyl, aminoalkyl, haloalkyl, iminoalkyl, acid halide, aminoalkylaminoalkyl, aminoalkylaminoalkylamino, hydroxyalkylaminoalkyl, or hydroxyalkylaminoalkylaminoalkyl; or a salt thereof. Also disclosed is a composition which contains a pharmaceutical acceptable carrier and an effective amount of a compound of the above formula.
摘要翻译：式中Ar1-B-Ar2的化合物是未取代或取代的苯基，噻吩基，呋喃基或吡咯基，其中取代的苯基，取代的噻吩基，取代的呋喃基和取代的吡咯基的各取代基独立地为醛，酰基，酯，羧基，酰氨基，腈，硝基，氰基，缩醛，缩酮，氧代烷基，氨基烷基，羟基烷基，卤代烷基，亚氨基烷基，酰卤，氨基烷基氨基烷基，氨基烷基氨基烷基氨基，羟基烷基氨基烷基或羟烷基氨基烷基氨基烷基。 B是-CH = CH-或-C≡C，其中R是H，烷基，羟基，烷氧基，酯，醛，羟基烷基，氨基烷基，羧基，-CH（OR 1）2或NR 2 R 3，独立地是H，烷基或酰基; R 2和R 3各自独立地为H，烷基，羟基烷基或氨基烷基; 并且Ar 2是取代的苯基，取代的噻吩基，取代的呋喃基或取代的吡咯基，其中取代的苯基，取代的噻吩基，取代的呋喃基和取代的吡咯基的各取代基独立地是酰氨基，腈，硝基，氰基，缩醛，缩酮，氧代烷基，氨基烷基，卤代烷基，亚氨基烷基，酰卤，氨基烷基氨基烷基，氨基烷基氨基烷基氨基，羟基烷基氨基烷基或羟烷基氨基烷基氨基烷基; 或其盐。还公开了含有药学上可接受的载体和有效量的上式化合物的组合物。

5. 发明授权

US5741811A Polythiophene anti-tumor agents 失效
公开(公告)号：US5741811A
公开(公告)日：1998-04-21
申请号：US712854
申请日：1996-09-12
申请人： Ching Te Chang , Ching-Jer Chang , Chen-Tao Lee , Fen-Lan Lin , Jih-Dar Tsai , Curtis L. Ashendel , Thomas C. K. Chan , Robert L. Geahlen , David J. Waters
发明人： Ching Te Chang , Ching-Jer Chang , Chen-Tao Lee , Fen-Lan Lin , Jih-Dar Tsai , Curtis L. Ashendel , Thomas C. K. Chan , Robert L. Geahlen , David J. Waters
IPC分类号： A61K31/381 , C07D333/16 , C07D333/22 , C07D333/24 , A61K31/38 , C07D409/02
CPC分类号： A61K31/381 , C07D333/16 , C07D333/22 , C07D333/24
摘要： Novel polythiophene compounds useful as anti-tumor agents are described. Preferred compounds of the formula: ##STR1## wherein n is 0-2 and R.sub.2 and R.sub.3 are optionally substituted 2-thienyl or 3-thienyl have been found to exhibit selective cytotoxic activity against transformed human cells. Pharmaceutical compositions containing the described polythiophene compounds are expected to exhibit good chemotherapeutic activity against slow growing tumors based on tumor cell line assays. A method for treating patients having tumors utilizing the disclosed polythiophene compounds is also described.

6. 发明授权

US5608081A Hydroxymethylpolythiophene derivatives 失效
标题翻译：羟甲基聚噻吩衍生物
公开(公告)号：US5608081A
公开(公告)日：1997-03-04
申请号：US459844
申请日：1995-06-02
申请人： Ching-Te Chang , Chen-Tao Lee , Fueng-Lan Lin
发明人： Ching-Te Chang , Chen-Tao Lee , Fueng-Lan Lin
IPC分类号： C07D333/16 , C07D333/18 , C07D333/22 , C07D409/04
CPC分类号： C07D333/16 , C07D333/18 , C07D333/22
摘要： Novel hydroxymethylthiophene derivatives and their medical use in treating or preventing inflammation and edema.
摘要翻译：新型羟甲基噻吩衍生物及其在治疗或预防炎症和水肿中的用途。

7. 发明授权

US5596014A Hydroxymethyl-polythiophene derivatives 失效
标题翻译：羟甲基 - 聚噻吩衍生物
公开(公告)号：US5596014A
公开(公告)日：1997-01-21
申请号：US461176
申请日：1995-06-05
申请人： Ching-Te Chang , Rong-Tsun Wu
发明人： Ching-Te Chang , Rong-Tsun Wu
IPC分类号： C07D333/16 , C07D333/18 , C07D333/22 , A61K31/38 , C07D409/14
CPC分类号： C07D333/16 , C07D333/18 , C07D333/22
摘要： A pharmaceutical composition containing a compound and an excipient, the compound having the formula: ##STR1## in which n is 2, 3 or 4; R is H, --CH(R.sup.1).cndot.OR.sup.2, --CH(O--Z).sub.2, or --COR.sup.3 ; R.sup.1 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; R.sup.2 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, tetrahydropyranyl, phenyl, benzoyl, C.sub.1-6 acyl, tosyl, or --CO--Y--COOH; and R.sup.3 is H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, OH, C.sub.1-6 hydroxyalkyl, or COOH; wherein Z is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.1-6 acyl; and Y is C.sub.1-6 alkylidene, C.sub.2-6 alkenylidene, phenylene, or deleted; or an ester or a salt thereof.
摘要翻译：含有化合物和赋形剂的药物组合物，具有下式的化合物：其中n为2,3或4; R为H，-CH（R 1），OR 2，-CH（O-Z）2或-COR 3; R1是H，C1-6烷基，C2-6烯基，OH，C1-6羟基烷基或COOH; R2是H，C1-6烷基，C2-6烯基，四氢吡喃基，苯基，苯甲酰基，C1-6酰基，甲苯磺酰基或-CO-Y-COOH; 和R 3是H，C 1-6烷基，C 2-6烯基，OH，C 1-6羟基烷基或COOH; 其中Z为C 1-6烷基，C 2-6烯基或C 1-6酰基; Y为C1-6亚烷基，C2-6亚烯基，亚苯基或缺失; 或其酯或其盐。

8. 发明授权

US4298603A O-Aminoalkylsalicylates 失效
标题翻译： O-氨基烷基水杨酸酯
公开(公告)号：US4298603A
公开(公告)日：1981-11-03
申请号：US100891
申请日：1979-12-06
申请人： Ching-Te Chang , Tsung-Tsan Su
发明人： Ching-Te Chang , Tsung-Tsan Su
IPC分类号： C07D295/092 , A61K31/615 , C07C101/42
CPC分类号： C07D295/088
摘要： Compounds of the formula ##STR1## or pharmaceutically acceptable acid addition salts thereof (for example, a chloride) are useful as local anesthetics. In the compound of the formula (I), R is hydrogen or C.sub.1 -C.sub.14 alkyl, ALK is C.sub.1 -C.sub.4 alkylene, R.sub.1 and R.sub.2 may be the same or different and are hydrogen or C.sub.1 -C.sub.6 alkyl or R.sub.1 and R.sub.2 taken together form a 5 to 7 atom ring which contains 1 to 2 nitrogen atoms.
摘要翻译：式（I）化合物或其药学上可接受的酸加成盐（例如氯化物）可用作局部麻醉剂。在式（I）的化合物中，R为氢或C 1 -C 14烷基，ALK为C 1 -C 4亚烷基，R 1和R 2可以相同或不同，为氢或C 1 -C 6烷基或R 1和R 2一起形成含有1至2个氮原子的5至7个原子环。

9. 发明授权

US5747525A Medicinal thiophene compounds 失效
标题翻译：药用噻吩化合物
公开(公告)号：US5747525A
公开(公告)日：1998-05-05
申请号：US468253
申请日：1995-06-06
申请人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
发明人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： A method of treating tumor including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH.dbd.NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 .dbd.CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently, is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 halogenated alkyl; OR.sup.1, or NHR.sup.7 ; each of R.sup.5 and R.sup.6, independently, is H, CHO, COR.sup.1, COOH, COOR.sup.9, CN, or halogen; R.sup.7 is H, C.sub.1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R.sup.8 is COOR.sup.2, CO.CHO, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R.sup.9 is H, C.sub.1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2-thienyl.
摘要翻译：一种治疗肿瘤的方法，包括向受试者施用有效量的下式化合物：其中m为1-4; A和B各自独立地为H，C 1-7烷基，C 2-7烯基，C 2-7炔基，（CH 2）n CHO，（CH 2）o COOH，C 1-7烷氧基，C 2-7烷氧基烷基，C 1-7 羟基烷基，CN，NO 2，卤素，CH（OR 1）2，CO.R 1，NR 2 R 3或其酸式盐，CO.NR 2 R 3，CHRRNR 2 R 3或其酸式盐CH = NR 2，C 3 D 4 CR 4，CR 1 = CR 5 R 6，CO.CH = CHR7，CH = CHR8或COOR9; 其中n和o各自独立地为0-4; R1是C1-4烷基或C1-4酰基; R 2和R 3各自独立地是H，C 1-4烷基或C 1-4羟基烷基; R4是H，C1-4烷基，C2-4烯基，COR2，COOR10，C1-4羟烷基或其酸酯或2-四氢吡喃基醚，C1-4二羟基烷基或其酸酯或2-四氢吡喃基醚，C1-4卤代烷基; OR1或NHR7; R 5和R 6各自独立地是H，CHO，COR1，COOH，COOR9，CN或卤素; R 7是H，C 1-4烷基，2-噻吩基，苯基，单取代的苯基或二取代的苯基; R8是COOR2，CO.CHO，C1-4羟烷基或其酸酯或2-四氢吡喃基醚; 且R 9为H，C 1-4烷基，苯基，单取代苯基，二取代苯基或2-噻吩基。

10. 发明授权

US5602170A Medicinal thiophene compounds 失效
标题翻译：药用噻吩化合物
公开(公告)号：US5602170A
公开(公告)日：1997-02-11
申请号：US302278
申请日：1994-09-08
申请人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
发明人： Ching-Te Chang , Kuo-Mou Chen , Wann-Huang Liu , Fen-Lan Lin , Rong-Tsun Wu
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C.sub.1-7 alkyl, C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, (CH.sub.2).sub.n CHO, (CH.sub.2).sub.o COOH, C.sub.1-7 alkoxy, C.sub.2-7 alkoxyalkyl, C.sub.1-7 hydroxyalkyl, CN, NO.sub.2, halogen, CH(OR.sup.1).sub.2, CO.R.sup.1, NR.sup.2 R.sup.3 or its acid salt, CO.NR.sup.2 R.sup.3, CHR.sup.1 NR.sup.2 R.sup.3 or its acid salt, CH=NR.sup.2, C.tbd.CR.sup.4, CR.sup.1 =CR.sup.5 R.sup.6, CO.CH.dbd.CHR.sup.7, CH.dbd.CHR.sup.8, or COOR.sup.9 ; in which each of n and o, independently, is 0-4; R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 acyl; each of R.sup.2 and R.sup.3, independently is H, C.sub.1-4 alkyl, or C.sub.1-4 hydroxyalkyl; R.sup.4 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, COR.sup.2, COOR.sup.10, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 dihydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether, C.sub.1-4 halogenated alkyl; OR.sup.1, NHR.sup.7 ; each of R.sup.5 R.sup.6, independently, is H, CHO, COR.sup.1, COOH, COOR.sup.9, CN, or halogen; R.sup.7 is H, C.sub.1-4 alkyl, 2-thienyl, phenyl, mono-substituted phenyl, or di-substituted phenyl; R.sup.8 is COOR.sup.2, CO.CHO, C.sub.1-4 hydroxyalkyl or its acid ester or 2-tetrahydropyranyl ether; and R.sup.9 is H, C.sub.1-4 alkyl, phenyl, mono-substituted phenyl, di-substituted phenyl, or 2 -thienyl.
摘要翻译：一种治疗炎症的方法，包括向受试者施用有效量的下式化合物：其中m为1-4; A和B各自独立地为H，C 1-7烷基，C 2-7烯基，C 2-7炔基，（CH 2）n CHO，（CH 2）o COOH，C 1-7烷氧基，C 2-7烷氧基烷基，C 1-7 羟基烷基，CN，NO 2，卤素，CH（OR 1）2，CO.R 1，NR 2 R 3或其酸式盐，CO.NR 2 R 3，CHRRNR 2 R 3或其酸式盐CH = NR 2，C 3 D 4 CR 4，CR 1 = CR 5 R 6，CO.CH = CHR7，CH = CHR8或COOR9; 其中n和o各自独立地为0-4; R1是C1-4烷基或C1-4酰基; R 2和R 3各自独立地是H，C 1-4烷基或C 1-4羟基烷基; R4是H，C1-4烷基，C2-4烯基，COR2，COOR10，C1-4羟烷基或其酸酯或2-四氢吡喃基醚，C1-4二羟基烷基或其酸酯或2-四氢吡喃基醚，C1-4卤代烷基; OR1，NHR7; R5 R6各自独立地为H，CHO，COR1，COOH，COOR9，CN或卤素; R 7是H，C 1-4烷基，2-噻吩基，苯基，单取代的苯基或二取代的苯基; R8是COOR2，CO.CHO，C1-4羟烷基或其酸酯或2-四氢吡喃基醚; 且R 9为H，C 1-4烷基，苯基，单取代苯基，二取代苯基或2-噻吩基。

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