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1. 发明申请

US20080193916A1 Method of Detecting Hepatitis B Virus S Antigen 有权
标题翻译：检测乙型肝炎病毒S抗原的方法
公开(公告)号：US20080193916A1
公开(公告)日：2008-08-14
申请号：US11663517
申请日：2005-09-21
申请人： Noboru Maki , Yasuyuki Fukuda , Tatsuji Kimura , Yoko Oda , Chiharu Ohue , Osamu Kusano
发明人： Noboru Maki , Yasuyuki Fukuda , Tatsuji Kimura , Yoko Oda , Chiharu Ohue , Osamu Kusano
IPC分类号： C12Q1/70 , C07H21/04
CPC分类号： G01N33/5761 , C07K14/005 , C07K16/082 , C12N2730/10122
摘要： [PROBLEMS] To provide a probe useful in the detection of HBV or HBs antigen by which an escape mutant of hepatitis B virus (HBV) possibly occurring in a specimen can be detected; and a method of using the same.[MEANS FOR SOLVING PROBLEMS]A probe capable of recognizing an epitope located on a peptide comprising the amino acid sequence of SEQ ID NO:1; and a method of detecting hepatitis B virus or hepatitis B virus s antigen by using this probe.
摘要翻译： [问题]提供可用于检测HBV或HBs抗原的探针，通过该探针可以检测可能发生在样品中的乙型肝炎病毒（HBV）的逃逸突变体; 及其使用方法。解决问题的手段能够识别位于包含SEQ ID NO：1的氨基酸序列的肽的表位的探针; 以及通过使用该探针检测乙型肝炎病毒或乙型肝炎病毒抗原的方法。

2. 发明授权

US08679762B2 Method of detecting hepatitis B virus s antigen 有权
标题翻译：检测乙型肝炎病毒抗原的方法
公开(公告)号：US08679762B2
公开(公告)日：2014-03-25
申请号：US11663517
申请日：2005-09-21
申请人： Noboru Maki , Yasuyuki Fukuda , Tatsuji Kimura , Yoko Oda , Chiharu Ohue , Osamu Kusano
发明人： Noboru Maki , Yasuyuki Fukuda , Tatsuji Kimura , Yoko Oda , Chiharu Ohue , Osamu Kusano
IPC分类号： C12Q1/70 , C07H21/04 , A61K39/395
CPC分类号： G01N33/5761 , C07K14/005 , C07K16/082 , C12N2730/10122
摘要： [PROBLEMS] To provide a probe useful in the detection of HBV or HBs antigen by which an escape mutant of hepatitis B virus (HBV) possibly occurring in a specimen can be detected; and a method of using the same.[MEANS FOR SOLVING PROBLEMS] A probe capable of recognizing an epitope located on a peptide comprising the amino acid sequence of SEQ ID NO:1; and a method of detecting hepatitis B virus or hepatitis B virus s antigen by using this probe.
摘要翻译： [问题]提供可用于检测HBV或HBs抗原的探针，通过该探针可以检测可能发生在样品中的乙型肝炎病毒（HBV）的逃逸突变体; 及其使用方法。解决问题的手段能够识别位于包含SEQ ID NO：1的氨基酸序列的肽的表位的探针; 以及通过使用该探针检测乙型肝炎病毒或乙型肝炎病毒抗原的方法。

3. 发明申请

US20090017443A1 Method for Detection of Hepatitus B Virus 审中-公开
标题翻译：乙肝病毒检测方法
公开(公告)号：US20090017443A1
公开(公告)日：2009-01-15
申请号：US11596663
申请日：2005-05-19
申请人： Chiharu Ohue , Noboru Maki , Tatsuji Kimura
发明人： Chiharu Ohue , Noboru Maki , Tatsuji Kimura
IPC分类号： C12Q1/70
CPC分类号： G01N33/5761
摘要： To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that release of HBV antigens and disruption of antibodies that bind to HBV antigens are carried out by treating a sample containing HBV with a treatment agent containing (1) an acidifying agent and (2) a protein denaturant or an amphoteric surfactant or cationic surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt within a molecule.
摘要翻译：提供血清中乙型肝炎病毒（HBV）抗原的检测或定量的方法，以及用于检测或定量的用于样品处理的简单且高度用户友好的方法。用于治疗含有乙型肝炎病毒（HBV）的样品的方法的特征在于通过用含有（1）酸化的处理剂处理含有HBV的样品来进行HBV抗原的释放和与HBV抗原结合的抗体的破坏试剂和（2）分子内具有烷基和叔胺或季铵盐的蛋白质变性剂或两性表面活性剂或阳离子表面活性剂。

4. 发明申请

US20100291546A1 METHOD FOR DETECTION OF HEPATITIS B VIRUS 审中-公开
标题翻译：检测乙型肝炎病毒的方法
公开(公告)号：US20100291546A1
公开(公告)日：2010-11-18
申请号：US12828209
申请日：2010-06-30
申请人： Chiharu Ohue , Noboru Maki , Tatsuji Kimura
发明人： Chiharu Ohue , Noboru Maki , Tatsuji Kimura
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： G01N33/5761
摘要： To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that release of HBV antigens and disruption of antibodies that bind to HBV antigens are carried out by treating a sample containing HBV with a treatment agent containing (1) an acidifying agent and (2) a protein denaturant or an amphoteric surfactant or cationic surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt within a molecule.
摘要翻译：提供血清中乙型肝炎病毒（HBV）抗原的检测或定量的方法，以及用于检测或定量的用于样品处理的简单且高度用户友好的方法。用于治疗含有乙型肝炎病毒（HBV）的样品的方法的特征在于通过用含有（1）酸化的处理剂处理含有HBV的样品来进行HBV抗原的释放和与HBV抗原结合的抗体的破坏试剂和（2）分子内具有烷基和叔胺或季铵盐的蛋白质变性剂或两性表面活性剂或阳离子表面活性剂。

5. 发明申请

US20100173298A1 HCV GENE 审中-公开
标题翻译： HCV基因
公开(公告)号：US20100173298A1
公开(公告)日：2010-07-08
申请号：US12597692
申请日：2008-04-28
申请人： Kenichi Mori , Noboru Maki , Hiromi Fukai , Chiharu Ohue
发明人： Kenichi Mori , Noboru Maki , Hiromi Fukai , Chiharu Ohue
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/005 , C07H21/02 , C12N15/63 , C12N5/071 , C12N7/00
CPC分类号： G01N33/5008 , C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24243 , C12Q1/707 , G01N33/5767 , G01N2333/186 , G01N2500/00
摘要： The present invention provides a hepatitis C virus gene, a replicon RNA derived from the gene, a replicon-replicating cell into which the replicon RNA is introduced, and a method for screening a drug using the replicon-replicating cell. By introducing a replicon RNA comprising (A) a polynucleotide having the nucleic acid sequence shown in SEQ ID NO: 5; (B) a polynucleotide having the nucleic acid sequence shown in SEQ ID NO: 7; (C) a polynucleotide coding for a polypeptide having the amino acid sequence shown in SEQ ID NO: 6; (D) a polynucleotide coding for a polypeptide having the amino acid sequence shown in SEQ ID NO: 8; or (E) a polynucleotide having a nucleic acid sequence having a homology of not less than 90% with the nucleic acid sequence shown in SEQ ID NO: 5 or SEQ ID NO: 7; or a replicon RNA of the genotype 1b comprising nucleotides coding for the 1804th amino acid leucine and the 1966th amino acid lysine in the amino acid sequence of a hepatitis C virus polyprotein and a polynucleotide coding for an NS4B protein, into a cell, the replicon-replicating cell can be prepared. By using the replicon-replicating cell, the screening for the drug can be carried out.
摘要翻译：本发明提供丙型肝炎病毒基因，来源于该基因的复制子RNA，引入复制子RNA的复制子复制细胞和使用复制子复制细胞筛选药物的方法。通过引入包含（A）具有SEQ ID NO：5所示核酸序列的多核苷酸的复制子RNA; （B）具有SEQ ID NO：7所示核酸序列的多核苷酸; （C）编码具有SEQ ID NO：6所示氨基酸序列的多肽的多核苷酸; （D）编码具有SEQ ID NO：8所示氨基酸序列的多肽的多核苷酸; 或（E）具有与SEQ ID NO：5或SEQ ID NO：7所示核酸序列同源性不低于90％的核酸序列的多核苷酸; 或基因型1b的复制子RNA，其包含编码丙型肝炎病毒多蛋白的氨基酸序列中的第1804位氨基酸亮氨酸和第1966位氨基酸赖氨酸的核苷酸和编码NS4B蛋白的多核苷酸的复制子RNA，可以制备复制细胞。通过使用复制子复制细胞，可以进行药物的筛选。

6. 发明申请

US20070264646A1 Hbv Particles Containing Hbv-Rna 审中-公开
标题翻译：含有Hbv-Rna的Hbv颗粒
公开(公告)号：US20070264646A1
公开(公告)日：2007-11-15
申请号：US11630254
申请日：2004-06-22
申请人： Noboru Maki , Tatsuji Kimura , Akihiro Matsumoto , Akinori Rokuhara , Eiji Tanaka , Kendo Kiyosawa
发明人： Noboru Maki , Tatsuji Kimura , Akihiro Matsumoto , Akinori Rokuhara , Eiji Tanaka , Kendo Kiyosawa
IPC分类号： C12Q1/68 , C07H21/04 , C12N7/00
CPC分类号： C12N7/00 , C12N2730/10123 , C12Q1/706
摘要： Hepatitis B virus (HBV) particles that contain HBV-RNA but do not contain HBV-DNA in a body fluid sample; A method of measuring the particles according to claim 1 by measuring HBV-RNA; A method of judging the therapeutic effect of the treatment of HBV infections by a drug having an effect of inhibiting RNA-dependent DNA polymerase, which method comprises performing the measurement on a body fluid of a patient who received said treatment; A method of predicting the risk of developing hepatic carcinoma or selecting risk groups of developing hepatic carcinoma by the above measurement.
摘要翻译：在体液样品中含有HBV-RNA但不含有HBV-DNA的乙型肝炎病毒（HBV）颗粒; 一种通过测量HBV-RNA测量根据权利要求1的颗粒的方法; 一种判断通过具有抑制RNA依赖性DNA聚合酶作用的药物治疗HBV感染的治疗效果的方法，该方法包括对接受所述治疗的患者的体液进行测定; 通过上述测量预测肝癌发展风险或选择发展成肝癌风险组的方法。

7. 发明授权

US08383333B2 HBV precore protein capable of forming particles 有权
标题翻译： HBV前蛋白能够形成颗粒
公开(公告)号：US08383333B2
公开(公告)日：2013-02-26
申请号：US12654280
申请日：2009-12-16
申请人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , G01N33/5761
摘要： There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.
摘要翻译：提供了具有形成颗粒的能力的HBV前核蛋白，以及用于确定它的手段。鉴定出形成HBV病毒（如）颗粒的新型HBV前核蛋白。本发明提供了这种新型HBV前核蛋白。此外，还提供了由该HBV前核蛋白形成的核心状颗粒和病毒样颗粒。这些病毒样颗粒可用于疫苗和治疗剂。本发明还提供了确定HBV前核蛋白的方法以及确定抗HBV前蛋白抗体的方法。

8. 发明申请

US20100285444A1 HBV precore protein capable of forming particles 有权
公开(公告)号：US20100285444A1
公开(公告)日：2010-11-11
申请号：US12654280
申请日：2009-12-16
申请人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , G01N33/5761
摘要： There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.

9. 发明授权

US07323331B2 Method for detecting or assaying HBV 有权
标题翻译： HBV检测方法
公开(公告)号：US07323331B2
公开(公告)日：2008-01-29
申请号：US10343324
申请日：2001-08-10
申请人： Noboru Maki , Tatsuji Kimura , Yoko Oda , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Yoko Oda , Shintaro Yagi
IPC分类号： C12N5/00 , C12N5/06 , C12N5/12 , C12N5/18 , C12N5/20 , C12Q1/00 , C12Q1/70 , G01N33/53 , C07K16/08
CPC分类号： G01N33/5762 , C07K16/082
摘要： A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.
摘要翻译：一种检测乙型肝炎病毒的方法以及试剂盒及其试剂，其包括使用特异性结合乙型肝炎病毒的磷酸盐缓冲液，例如特异性结合乙型肝炎核心相关蛋白质的特定位点的单克隆抗体病毒。

10. 发明授权

US07713532B2 HBV precore protein capable of forming particles 有权
标题翻译： HBV前蛋白能够形成颗粒
公开(公告)号：US07713532B2
公开(公告)日：2010-05-11
申请号：US10526744
申请日：2003-09-05
申请人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
IPC分类号： A61K38/00
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , G01N33/5761
摘要： There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.
摘要翻译：提供了具有形成颗粒的能力的HBV前核蛋白，以及用于确定它的手段。鉴定出形成HBV病毒（如）颗粒的新型HBV前核蛋白。本发明提供了这种新型HBV前核蛋白。此外，还提供了由该HBV前核蛋白形成的核心状颗粒和病毒样颗粒。这些病毒样颗粒可用于疫苗和治疗剂。本发明还提供了确定HBV前核蛋白的方法以及确定抗HBV前蛋白抗体的方法。

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