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1. 发明授权

US6096340A Omeprazole formulation 失效
公开(公告)号：US6096340A
公开(公告)日：2000-08-01
申请号：US970489
申请日：1997-11-14
申请人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
发明人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
IPC分类号： A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/50 , A61K31/4439 , A61K47/02 , A61K47/38 , A61P1/00 , A61P1/04
CPC分类号： A61K9/5078
摘要： A pharmaceutical composition of omeprazole for oral administration is described which consists essentially of:(a) a pellet comprising an inert core component, a therapeutically effective amount of omeprazole, a surface active agent, a filler, a pharmaceutically acceptable alkaline agent and a binder; and(b) a single layer of coating on said pellet which comprises a layer of an enteric coating agent.

2. 发明授权

US6077541A Omeprazole formulation 有权
公开(公告)号：US6077541A
公开(公告)日：2000-06-20
申请号：US335575
申请日：1999-06-18
申请人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
发明人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
IPC分类号： A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/50 , A61K31/4439 , A61K47/02 , A61K47/38 , A61P1/00 , A61P1/04
CPC分类号： A61K9/5078
摘要： A pharmaceutical composition of omeprazole for oral administration is described which consists essentially of:(a) a pellet comprising an inert core component, a therapeutically effective amount of omeprazole, a surface active agent, a filler, a pharmaceutically acceptable alkaline agent and a binder; and(b) a single layer of coating on said pellet which comprises a layer of an enteric coating agent.

3. 发明授权

US06780435B2 Omeprazole formulation 有权
标题翻译：奥美拉唑制剂
公开(公告)号：US06780435B2
公开(公告)日：2004-08-24
申请号：US10279622
申请日：2002-10-23
申请人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
发明人： Chih-Ming Chen , Joseph C. H. Chou , Timothy Weng
IPC分类号： A61K914
CPC分类号： A61K9/5078
摘要： A pharmaceutical composition of omeprazole for oral administration is described which consists essentially of: (a) a pellet comprising an inert core component, a therapeutically effective amount of omeprazole, a surface active agent, a filler, a pharmaceutically acceptable alkaline agent and a binder; and (b) a single layer of coating on said pellet which comprises a layer of an enteric coating agent.
摘要翻译：描述了用于口服给药的奥美拉唑的药物组合物，其基本上由以下组成：（a）包含惰性核心组分，治疗有效量的奥美拉唑，表面活性剂，填充剂，药学上可接受的碱性剂和粘合剂的丸剂; 和（b）所述颗粒上的单层涂层，其包含一层肠溶包衣剂。

4. 发明授权

US06485748B1 Once daily pharmaceutical tablet having a unitary core 失效
标题翻译：每日一次药片具有单一核心
公开(公告)号：US06485748B1
公开(公告)日：2002-11-26
申请号：US08990129
申请日：1997-12-12
申请人： Chih-Ming Chen , Joseph C. H. Chou
发明人： Chih-Ming Chen , Joseph C. H. Chou
IPC分类号： A61K920
CPC分类号： A61K9/0004 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/2886
摘要： A controlled release tablet is disclosed which comprises: (a) a homogeneous compressed core which comprises: (i) a medicament which is very slightly soluble to practically insoluble in water at 25° C.; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of a: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) a pH dependent polymer such as an enteric coating polymer, the weight ratio of the pH dependent polymer to the water insoluble pharmaceutically acceptable polymer being 0.1:1 to 0.75:1. A controlled release tablet which comprises: (a) a medicament (a) a homogeneous compressed core which comprises: (i) a medicament; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) an enteric polymer.
摘要翻译：公开了一种控释片剂，其包括：（a）均质压缩核心，其包含：（i）在25℃下几乎不溶于几乎不溶于水的药物;（ii）水溶性渗透化合物（iii））一种或多种渗透聚合物; 和（b）完全覆盖所述芯片的膜包衣，其包含以下物质的混合物：（i）水不溶性药学上可接受的聚合物; 和（ii）pH依赖性聚合物如肠溶衣聚合物，pH依赖性聚合物与水不溶性药学上可接受的聚合物的重量比为0.1:1至0.75:1。1.一种控释片剂，其包含：（a）药物（a）均质压缩核心，其包含：（i）药物;（ii）水溶性渗透化合物（iii）一种或多种渗透性聚合物; 和（b）完全覆盖所述芯片的膜包衣，其包含以下混合物：（i）水不溶性药学上可接受的聚合物; 和（ii）肠溶性聚合物。

5. 发明授权

US5837379A Once daily pharmaceutical tablet having a unitary core 失效
标题翻译：每日一次药片具有单一核心
公开(公告)号：US5837379A
公开(公告)日：1998-11-17
申请号：US791999
申请日：1997-01-31
申请人： Chih-Ming Chen , Joseph C. H. Chou
发明人： Chih-Ming Chen , Joseph C. H. Chou
IPC分类号： A61K9/00 , A61K9/32 , A61K9/20
CPC分类号： A61K9/0004
摘要： A controlled release nifedipine tablet which comprises: (a) a homogeneous compressed core which comprises: (i) a medicament; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) an enteric polymer.
摘要翻译：一种控释硝苯地平片剂，其包含：（a）均质压缩核心，其包含：（i）药物; （ii）水溶性渗透化合物（iii）一种或多种渗透性聚合物; 和（b）完全覆盖所述芯片的膜包衣，其包含以下混合物：（i）水不溶性药学上可接受的聚合物; 和（ii）肠溶性聚合物。

6. 发明授权

US5478572A Gepirone dosage form 失效
标题翻译：吉非隆剂型
公开(公告)号：US5478572A
公开(公告)日：1995-12-26
申请号：US301281
申请日：1994-09-06
申请人： Stephen T. David , Claude E. Gallian , Joseph C. H. Chou
发明人： Stephen T. David , Claude E. Gallian , Joseph C. H. Chou
IPC分类号： A61K9/22 , A61K9/00 , A61K9/20 , A61K9/26 , A61K9/50 , A61K9/52 , A61K31/505 , A61K31/506 , A61K47/02 , A61K47/12 , A61K47/38 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26
CPC分类号： A61K9/2054 , A61K31/506 , Y10S514/963 , Y10S514/964 , Y10S514/965
摘要： Gepirone compositions having extended release properties contain a gepirone salt, a cellulosic polymer matrix and suitable quantities of pharmaceutical excipients. Dosage forms based thereon require 18 to 24 hours for release of 90 to 95% of gepirone.
摘要翻译：具有延长释放性质的吉哌隆组合物含有吉非隆盐，纤维素聚合物基质和适量的药物赋形剂。基于此的剂型需要18至24小时以释放90至95％的吉哌隆。

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