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    • 5. 发明授权
    • Once daily pharmaceutical tablet having a unitary core
    • 每日一次药片具有单一核心
    • US06485748B1
    • 2002-11-26
    • US08990129
    • 1997-12-12
    • Chih-Ming ChenJoseph C. H. Chou
    • Chih-Ming ChenJoseph C. H. Chou
    • A61K920
    • A61K9/0004A61K9/2826A61K9/2846A61K9/2866A61K9/2886
    • A controlled release tablet is disclosed which comprises: (a) a homogeneous compressed core which comprises: (i) a medicament which is very slightly soluble to practically insoluble in water at 25° C.; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of a: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) a pH dependent polymer such as an enteric coating polymer, the weight ratio of the pH dependent polymer to the water insoluble pharmaceutically acceptable polymer being 0.1:1 to 0.75:1. A controlled release tablet which comprises: (a) a medicament (a) a homogeneous compressed core which comprises: (i) a medicament; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) an enteric polymer.
    • 公开了一种控释片剂,其包括:(a)均质压缩核心,其包含:(i)在25℃下几乎不溶于几乎不溶于水的药物;(ii)水溶性渗透化合物(iii) )一种或多种渗透聚合物; 和(b)完全覆盖所述芯片的膜包衣,其包含以下物质的混合物:(i)水不溶性药学上可接受的聚合物; 和(ii)pH依赖性聚合物如肠溶衣聚合物,pH依赖性聚合物与水不溶性药学上可接受的聚合物的重量比为0.1:1至0.75:1。1.一种控释片剂,其包含:(a) 药物(a)均质压缩核心,其包含:(i)药物;(ii)水溶性渗透化合物(iii)一种或多种渗透性聚合物; 和(b)完全覆盖所述芯片的膜包衣,其包含以下混合物:(i)水不溶性药学上可接受的聚合物; 和(ii)肠溶性聚合物。