专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08097703B2 CD19 antibodies and their uses 有权
标题翻译： CD19抗体及其用途
公开(公告)号：US08097703B2
公开(公告)日：2012-01-17
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
IPC分类号： C07K16/00 , C07K17/00 , C12P21/08 , C07K14/00
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

2. 发明申请

US20090142349A1 CD19 Antibodies And Their uses 有权
标题翻译： CD19抗体及其用途
公开(公告)号：US20090142349A1
公开(公告)日：2009-06-04
申请号：US11917750
申请日：2006-06-20
申请人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
发明人： Chetana Rao-Naik , David John King , Jie Liu , Haichun Huang , David B. Passmore , Alasdair Fraser Bell , Josephine M. Cardarelli , Chin Pan , To Uyen Thi Do , Sharline Chen , Dawn M. Tanamachi
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/08 , A61P35/00 , A61P19/02
CPC分类号： C07K16/2803 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/732 , C07K2317/77 , Y02A50/412
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

3. 发明授权

US10386490B2 Reduced sampling low power GPS 有权
公开(公告)号：US10386490B2
公开(公告)日：2019-08-20
申请号：US13550454
申请日：2012-07-16
申请人： Jie Liu , Yuzhe Jin , Nissanka Arachchige Bodhi Priyantha , Edward Hart , Amanda Souza de Paula
发明人： Jie Liu , Yuzhe Jin , Nissanka Arachchige Bodhi Priyantha , Edward Hart , Amanda Souza de Paula
IPC分类号： G01S19/09 , G01S19/25 , G01S19/34 , G01S19/42 , G01S5/00
摘要： Some implementations provide low power reduced sampling of global positioning system (GPS) locations. A server may be configured to assist a mobile device in determining a location from a plurality of GPS signal samples and corresponding time stamps provided by the mobile device, such as by identifying a set of possible reference locations, which may be used to calculate a location of the mobile device. In another example, the mobile device may sample GPS signals using a GPS receiver, compress the samples, and provide the compressed samples to the server for processing.

4. 发明申请

US20190211859A1 FURNITURE CONNECTING PIECE 审中-公开
公开(公告)号：US20190211859A1
公开(公告)日：2019-07-11
申请号：US15862649
申请日：2018-01-05
申请人： Jie Liu , Lei Cao
发明人： Jie Liu , Minsheng Liu
IPC分类号： F16B12/12 , F16B19/10 , F16B12/14 , F16B12/24 , F16B12/26
CPC分类号： F16B12/125 , F16B12/14 , F16B12/24 , F16B12/26 , F16B19/1081
摘要： The present invention relates to a connecting piece, and more particularly to a furniture connecting piece for connecting a pair of furniture plates. The furniture connecting piece includes a base, at least one tenon and at least two columns; the tenon is arranged on the top of the base, the columns are arranged at the bottom of the tenon. The furniture connecting piece can be used alone to join two plates or used with the other furniture connecting piece in pairs to connect a pair of furniture plates. It can be easily assembled and disassembled, it is worth of promotion and use.

5. 发明授权

US09805956B2 Lead frame and a method of fabrication thereof 有权
公开(公告)号：US09805956B2
公开(公告)日：2017-10-31
申请号：US13747774
申请日：2013-01-23
申请人： Dawei Xing , Jie Liu , Hong Wei Guan , Yue Gen Yu , Seow Kiang Khoo
发明人： Dawei Xing , Jie Liu , Hong Wei Guan , Yue Gen Yu , Seow Kiang Khoo
IPC分类号： H01L21/48 , H01L21/56 , H01L23/31 , H01L23/495 , H01L23/498 , H05K1/02
CPC分类号： H01L21/4828 , H01L21/561 , H01L23/3121 , H01L23/49558 , H01L23/49582 , H01L23/49861 , H01L2224/32245 , H01L2224/45144 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H05K1/02 , H01L2924/00014 , H01L2924/00
摘要： Disclosed is a method of manufacturing a lead frame, which comprises the steps of: providing an electrically-conductive base material having first and second planar sides; forming a plurality of conductive contact points on the first planar side of the base material; providing a non-conductive filling material over the first planar side of the base material so that the filling material fills spaces in-between the plurality of contact points to a form a layer comprising the filling material and the plurality of contact points; and etching the second planar side of the base material to expose a pattern of the filling material from the second planar side of the base material and to thereby form a plurality of isolated conductive regions on the second planar side of the base material, each isolated conductive region being connected with at least a respective one of the plurality of contact points on the first planar side of the base material. A lead frame structure is also disclosed.

6. 发明授权

US09772406B2 Estimating and predicting structures proximate to a mobile device 有权
公开(公告)号：US09772406B2
公开(公告)日：2017-09-26
申请号：US13606029
申请日：2012-09-07
申请人： Jie Liu , Lin Zhong , David Chu , Gursharan Sidhu , Nissanka Arachchige Bodhi Priyantha , Sharad Agarwal
发明人： Jie Liu , Lin Zhong , David Chu , Gursharan Sidhu , Nissanka Arachchige Bodhi Priyantha , Sharad Agarwal
IPC分类号： G01S19/22 , G01S19/42 , G01S19/34
摘要： The description relates to mobile device location. One example can identify global navigation satellite system (GNSS) satellites expected to be in line-of-sight of a mobile device. This example can detect differences between received GNSS data signals and expected GNSS data signals from the expected GNSS satellites. The example can also determine a direction from the mobile device of an obstruction that is causing at least some of the detected differences.

7. 发明授权

US09202712B2 Lead frame and a method of manufacturing thereof 有权
标题翻译：引线框及其制造方法
公开(公告)号：US09202712B2
公开(公告)日：2015-12-01
申请号：US14158321
申请日：2014-01-17
申请人： Dawei Xing , Jie Liu , Hong Wei Guan , Yue Gen Yu , Seow Kiang Khoo
发明人： Dawei Xing , Jie Liu , Hong Wei Guan , Yue Gen Yu , Seow Kiang Khoo
IPC分类号： H01L21/00 , H01L21/48 , H01L23/495 , H01L23/498 , H01L23/00 , H01L23/31 , H01L21/56
CPC分类号： H01L21/4828 , H01L21/561 , H01L23/3121 , H01L23/49548 , H01L23/49582 , H01L23/49861 , H01L24/97 , H01L2224/32245 , H01L2224/48091 , H01L2224/48247 , H01L2224/73265 , H01L2224/97 , H01L2924/181 , H01L2924/00014 , H01L2924/00 , H01L2224/85 , H01L2224/83 , H01L2924/00012
摘要： A method of manufacturing a lead frame, comprising the steps of: providing an electrically-conductive base material having first and second planar sides; forming a patterned conductive layer on the first planar side of the base material; etching the second planar side of the base material at portions with respect to exposed portions on the first planar side of the base material comprising the patterned conductive layer, to form partially-etched portions on the second planar side of the base material; providing a non-conductive filling material over the second planar side of the base material, wherein the filling material fills spaces inside the partially-etched portions on the second planar side of the base material to form adjacent portions of the filling material and a plurality of conductive portions on the second planar side of the base material; and etching the exposed portions of the first planar side of the base material comprising the patterned conductive layer to form partially-etched portions on the first planar side of the base material that combine with the partially-etched portions on the second planar side of the base material to thereby form a plurality of separate conductive regions on the first planar side of the base material, each conductive region being electrically conductive with at least a respective one of the plurality of conductive portions on the second planar side of the base material.
摘要翻译：一种制造引线框架的方法，包括以下步骤：提供具有第一和第二平面侧面的导电基材; 在基材的第一平面侧上形成图案化的导电层; 在相对于包括图案化导电层的基材的第一平面侧上的暴露部分的部分处蚀刻基材的第二平面侧，以在基材的第二平面侧上形成部分蚀刻部分; 在所述基材的所述第二平面侧上设置不导电的填充材料，其中所述填充材料填充所述基材的所述第二平面侧上的部分蚀刻部分内的空间，以形成所述填充材料的相邻部分，在基材的第二平面侧的导电部分; 并且蚀刻包括图案化导电层的基材的第一平面侧的暴露部分，以在基材的第一平面侧上形成部分蚀刻部分，其与基底的第二平面侧上的部分蚀刻部分组合从而在基材的第一平面侧上形成多个单独的导电区域，每个导电区域与基材的第二平面侧上的多个导电部分中的至少一个导电部分导电。

8. 发明授权

US09152726B2 Real-time personalized recommendation of location-related entities 有权
标题翻译：定位相关实体的实时个性化推荐
公开(公告)号：US09152726B2
公开(公告)日：2015-10-06
申请号：US12958320
申请日：2010-12-01
申请人： Dimitrios Lymperopoulos , Jie Liu , Melissa Wood Dunn , Ashwini K. Varma , Fang Wang , Jen-Hsien Kenny Chien
发明人： Dimitrios Lymperopoulos , Jie Liu , Melissa Wood Dunn , Ashwini K. Varma , Fang Wang , Jen-Hsien Kenny Chien
IPC分类号： G06F9/44 , G06F17/30
CPC分类号： G06F17/3087
摘要： A location-related entity ranking technique is described that allows a user see the ranking of location-related entities near a desired location in response to a query. The technique can leverage the searches performed by a community of mobile device users at a given location and at a given time to infer the location-related entities that are popular at this specific location and time window. The technique can also filter out or re-rank these location-related entities based on the personal preferences of the person that submits the query and group preferences of a group to which the user belongs. The personal preferences can also be context specific (i.e. different restaurant preferences for lunch and dinner times).
摘要翻译：描述了位置相关的实体排序技术，其允许用户响应于查询来查看在期望位置附近的位置相关实体的排名。该技术可以利用在给定位置处和在给定时间由移动设备用户的社区执行的搜索来推断在该特定位置和时间窗口中流行的位置相关实体。该技术还可以基于提交用户所属的组的查询和组偏好的个人偏好来过滤掉或重新排列这些位置相关实体。个人偏好也可以是上下文特定的（即午餐和晚餐时间的不同餐厅偏好）。

9. 发明授权

US08984520B2 Resource modeling and scheduling for extensible computing platforms 有权
标题翻译：可扩展计算平台的资源建模和调度
公开(公告)号：US08984520B2
公开(公告)日：2015-03-17
申请号：US11763397
申请日：2007-06-14
申请人： Jie Liu , Feng Zhao , Michel Goraczko , Slobodan Matic , Dimitrios Lymberopoulos , Nissanka Priyantha
发明人： Jie Liu , Feng Zhao , Michel Goraczko , Slobodan Matic , Dimitrios Lymberopoulos , Nissanka Priyantha
IPC分类号： G06F9/46 , G06F1/00 , G06F1/32 , G06F9/48
CPC分类号： G06F1/3203 , G06F1/329 , G06F9/4893 , G06F2209/484 , Y02D10/24
摘要： Energy management modeling and scheduling techniques are described for reducing the power consumed to execute an application on a multi-processor computing platform within a certain time period. In one embodiment, a sophisticated resource model which accounts for discrete operating modes for computing components/resources on a computing platform and transition costs for transitioning between each of the discrete modes is described. This resource model provides information for a specific heterogeneous multi-processor computing platform and an application being implemented on the platform in a form that can be processed by a selection module, typically utilizing an integer linear programming (ILP) solver or algorithm, to select a task schedule and operating configuration(s) for executing the application within a given time.
摘要翻译：描述了能量管理建模和调度技术，以在一定时间段内减少在多处理器计算平台上执行应用程序所消耗的功耗。在一个实施例中，描述了考虑用于在计算平台上计算组件/资源的离散操作模式的复杂资源模型以及在每个离散模式之间转换的转换成本。该资源模型提供用于特定异构多处理器计算平台和正在平台上实现的应用程序的信息，该应用程序可以由通常利用整数线性规划（ILP）解算器或算法的选择模块来处理的形式来选择任务计划和在给定时间内执行应用程序的操作配置。

10. 发明授权

US08865875B2 Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions 有权
标题翻译：药物或其他药物与具有C末端延伸的工程抗体的位点特异性连接
公开(公告)号：US08865875B2
公开(公告)日：2014-10-21
申请号：US12674503
申请日：2008-08-19
申请人： Jie Liu , David King
发明人： Jie Liu , David King
IPC分类号： C07K16/00 , C07K16/46 , A61K47/48 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2875 , A61K47/6803 , A61K47/6805 , A61K47/6819 , A61K47/6869 , A61K47/6889 , C07K16/3069 , C07K2317/21
摘要： The present invention provides antibodies (e.g., IgG antibodies) having C-terminal cysteine-containing extensions that facilitate antibody conjugation to a partner molecule (e.g. a drug, toxin, marker molecule, protein, radioisotope, or other therapeutic agent). Methods of making, screening and selecting the antibodies of the invention are provided.
摘要翻译：本发明提供了具有C末端半胱氨酸延伸的抗体（例如，IgG抗体），其有助于抗体与配偶体分子（例如药物，毒素，标记分子，蛋白质，放射性同位素或其它治疗剂）缀合。提供制备，筛选和选择本发明抗体的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式