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1. 发明授权

US06636623B2 Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease 有权
公开(公告)号：US06636623B2
公开(公告)日：2003-10-21
申请号：US10145982
申请日：2002-05-14
申请人： Alan C. Nelson , Robert W. Webster , Chee-Wui Chu
发明人： Alan C. Nelson , Robert W. Webster , Chee-Wui Chu
IPC分类号： G06K900
CPC分类号： G01N33/5091 , G01N15/1475 , G01N23/046 , G01N33/574 , G01N2015/1006 , G01N2223/419 , G06K9/00127 , G06T7/0012 , G06T2207/10152 , G06T2207/30024
摘要： A system and method for rapidly detecting cells associated with malignancy and disease using molecular marker compartmentalization includes an optical tomography (OT) or a flow optical tomography (FOT) instrument capable of producing various optical projection images (or shadowgrams) containing accurate density information from a cell or cells labeled with tagged molecular probes or stains, a computer and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using cells from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping, and the system can be used to detect rare cells in specimens including blood.

2. 发明授权

US06591003B2 Optical tomography of small moving objects using time delay and integration imaging 有权
公开(公告)号：US06591003B2
公开(公告)日：2003-07-08
申请号：US10260908
申请日：2002-09-30
申请人： Chee-Wui Chu , Alan C. Nelson
发明人： Chee-Wui Chu , Alan C. Nelson
IPC分类号： G06K900
CPC分类号： G01N23/046 , G01N15/147 , G01N21/05 , G01N21/4795 , G01N2223/419 , G06T11/006
摘要： Three dimensional reconstruction of an object of interest moving at a constant velocity. The object of interest is centered. The object of interest is imaged with optical point sources located at multiple projection angles around the object of interest, in cooperation with opposing time delay and integration (TDI) image sensors located at a distance from the objects of interest such that there is no focal plane within the objects of interest during imaging. Each of the TDI sensors has a line transfer rate synchronized to the constant velocity of the objects of interest.

3. 发明申请

US20120145926A1 3D IMAGING OF LIVE CELLS WITH ULTRAVIOLET RADIATION 有权
标题翻译：具有超紫外线辐射的真实细胞的3D成像
公开(公告)号：US20120145926A1
公开(公告)日：2012-06-14
申请号：US13402149
申请日：2012-02-22
申请人： Eric J. Seibel , Alan C. Nelson , Mark E. Fauver , J. Richard Rahn
发明人： Eric J. Seibel , Alan C. Nelson , Mark E. Fauver , J. Richard Rahn
IPC分类号： G01N21/64
CPC分类号： G01N21/4795 , G01N15/1436 , G01N2015/1445 , G01N2021/1787 , G06T11/006
摘要： A method for 3D imaging of cells in an optical tomography system includes moving a biological object relatively to a microscope objective to present varying angles of view. The biological object is illuminated with radiation having a spectral bandwidth limited to wavelengths between 150 nm and 390 nm. Radiation transmitted through the biological object and the microscope objective is sensed with a camera from a plurality of differing view angles. A plurality of pseudoprojections of the biological object from the sensed radiation is formed and the plurality of pseudoprojections is reconstructed to form a 3D image of the cell.
摘要翻译：用于光学断层摄影系统中的细胞的3D成像的方法包括相对于显微镜物镜移动生物体以呈现不同的视角。用具有限制在150nm和390nm之间的波长的光谱带宽的辐射照射该生物物体。利用摄像机从多个不同的视角检测透过生物物体和显微镜物镜的辐射。形成来自感测辐射的生物物体的多个伪投影，并重建多个伪投影以形成该细胞的3D图像。

4. 发明授权

US07811825B2 System and method for processing specimens and images for optical tomography 有权
标题翻译：用于光学层析成像的标本和图像处理系统和方法
公开(公告)号：US07811825B2
公开(公告)日：2010-10-12
申请号：US10964508
申请日：2004-10-13
申请人： Mark E. Fauver , J. Richard Rahn , Eric J. Seibel , Alan C. Nelson
发明人： Mark E. Fauver , J. Richard Rahn , Eric J. Seibel , Alan C. Nelson
IPC分类号： G01N33/48
CPC分类号： G02B21/002 , G02B21/365
摘要： A scanning method for scanning samples of biological cells using optical tomography includes preparing, acquiring, reconstructing and viewing three-dimensional images of cell samples. Concentration and enrichment of the cell sample follows. The cell sample is stained. Cells are isolated from the cell sample and purified. A cell/solvent mixture is injected into a gel by centrifugation. A cell/gel mixture is injected into a capillary tube until a cell appears centered in a field of view using a stopped-flow method. An optical imaging system, such as a fixed or variable motion optical tomography system acquires a projection image. The sample is rotated about a tube axis to generate additional projections. Once image acquisition is completed, the acquired image projections are corrected for errors. A computer or other equivalent processor is used to compute filtered backprojection information for 3D reconstruction.
摘要翻译：使用光学断层摄影扫描生物细胞样本的扫描方法包括准备，获取，重建和观察细胞样品的三维图像。细胞样品的浓缩和浓缩如下。细胞样品染色。细胞从细胞样品中分离并纯化。通过离心将细胞/溶剂混合物注入凝胶。将细胞/凝胶混合物注入毛细管中，直到细胞以视野停止流出中心为止。诸如固定或可变运动光学断层摄影系统的光学成像系统获取投影图像。样品围绕管轴旋转以产生额外的突起。一旦图像获取完成，就获得的图像投影被校正以用于错误。计算机或其他等效处理器用于计算用于3D重建的滤波反投影信息。

5. 发明授权

US07738945B2 Method and apparatus for pseudo-projection formation for optical tomography 有权
标题翻译：用于光学层析成像的伪投影形成的方法和装置
公开(公告)号：US07738945B2
公开(公告)日：2010-06-15
申请号：US10716744
申请日：2003-11-18
申请人： Mark E. Fauver , J. Richard Rahn , Eric J. Seibel , Alan C. Nelson
发明人： Mark E. Fauver , J. Richard Rahn , Eric J. Seibel , Alan C. Nelson
IPC分类号： A61B5/05
CPC分类号： G01N15/1475 , G01N15/1468 , G01N15/147 , G01N21/05 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2015/1447 , G01N2021/0346 , G01N2021/1787 , G01N2201/0813 , G01N2223/612 , G06T11/006 , G06T2211/421
摘要： A system for optical imaging of a thick specimen that permits rapid acquisition of data necessary for tomographic reconstruction of the three-dimensional (3D) image. One method involves the scanning of the focal plane of an imaging system and integrating the range of focal planes onto a detector. The focal plane of an optical imaging system is scanned along the axis perpendicular to said plane through the thickness of a specimen during a single detector exposure. Secondly, methods for reducing light scatter when using illumination point sources are presented. Both approaches yield shadowgrams. This process is repeated from multiple perspectives, either in series using a single illumination/detection subsystem, or in parallel using several illumination/detection subsystems. A set of pseudo-projections is generated, which are input to a three dimensional tomographic image reconstruction algorithm.
摘要翻译：一种用于光学成像厚样本的系统，其允许快速获取三维（3D）图像的层析成像重建所需的数据。一种方法涉及扫描成像系统的焦平面并将焦平面的范围集成到检测器上。在单个检测器曝光期间，光学成像系统的焦平面沿着垂直于所述平面的轴线扫描样本的厚度。其次，提出了使用照明点源时减少光散射的方法。两种方法产生阴影图。该过程从多个角度重复，使用单个照明/检测子系统串联使用，或者使用几个照明/检测子系统并行重复。生成一组伪投影，其被输入到三维断层图像重建算法。

6. 发明授权

US06522775B2 Apparatus and method for imaging small objects in a flow stream using optical tomography 有权
公开(公告)号：US06522775B2
公开(公告)日：2003-02-18
申请号：US09927151
申请日：2001-08-10
申请人： Alan C. Nelson
发明人： Alan C. Nelson
IPC分类号： G06K900
CPC分类号： G06T11/006 , G01N15/147 , G01N21/05 , G01N23/046 , G01N2021/0346 , G01N2223/419
摘要： A flow optical tomography system includes a flow cytometer, and at least one reconstruction cylinder positioned around a capillary tube. A photon source and a photon sensor work together with a pulse height analyzer to provide a first trigger point for the beginning of an object or cell, and a second trigger point for the end of the cell. The trigger signal is received by the reconstruction cylinder. The reconstruction cylinder includes optical point sources having a selectable emission wavelength, disposed in a geometric pattern around the cylinder perpendicular to and concentric with the capillary tube axis that facilitate the acquisition of transmitted, attenuated projection images of the flowing cells. The sensors also collect projections of fluorescence emitted from tagged molecular probes associated with nuclear and/or cytoplasmic structures or cell membranes. The projections are algorithmically processed to provide three dimensional information about the cells and their disease state.

7. 发明授权

US5799101A Method and apparatus for highly efficient computer aided screening 失效
标题翻译：高效计算机辅助筛选的方法和装置
公开(公告)号：US5799101A
公开(公告)日：1998-08-25
申请号：US897392
申请日：1997-07-21
申请人： Shih-Jong J. Lee , Seho Oh , Stanley F. Patten , Alan C. Nelson , Larry A. Nelson
发明人： Shih-Jong J. Lee , Seho Oh , Stanley F. Patten , Alan C. Nelson , Larry A. Nelson
IPC分类号： G06K9/00 , G06K9/68 , G01N33/48
CPC分类号： G06K9/6282 , G06K9/00127 , Y10S128/922
摘要： A computer aided biological specimen screener is responsive to a priori information about biological specimens. An automated slide classifier scans a slide specimen and generates a set of scores. The classification which results from this set of scores depends on a priori information concerning the patient, such as patient age and prior health history and diagnosis. Using the patient information and an appropriate score, the specimen is classified. A normal threshold used for classification is changed over a wide range depending on the specificity appropriate to a particular patient risk category. The sensitivity of the classification is automatically maximized for a predetermined normal specificity.
摘要翻译：计算机辅助生物样本筛选器响应关于生物样本的先验信息。自动滑块分类器扫描幻灯片样本并生成一组分数。由该分数得出的分类取决于患者的先验信息，例如患者年龄和以前的健康史和诊断。使用患者信息和适当的分数，将样本分类。用于分类的正常阈值根据对特定患者风险类别的特异性而在宽范围内变化。对于预定的正常特异性，分类的灵敏度自动最大化。

8. 发明授权

US07907765B2 Focal plane tracking for optical microtomography 有权
标题翻译：光学显微镜的焦平面跟踪
公开(公告)号：US07907765B2
公开(公告)日：2011-03-15
申请号：US11532648
申请日：2006-09-18
申请人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
发明人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , G01N15/147 , G01N15/1475
摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.
摘要翻译：一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据用于跟踪感兴趣的对象。

9. 发明申请

US20100322494A1 Focal Plane Tracking for Optical Microtomography 有权
标题翻译：光学显微镜的焦平面跟踪
公开(公告)号：US20100322494A1
公开(公告)日：2010-12-23
申请号：US11532648
申请日：2006-09-18
申请人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
发明人： Mark E. Fauver , Eric J. Seibel , Michael G. Meyer , Alan C. Nelson , J. Richard Rahn , Thomas Neumann , Roger H. Johnson
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , G01N15/147 , G01N15/1475
摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.
摘要翻译：一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据用于跟踪感兴趣的对象。

10. 发明授权

US07542597B2 Method for correction of relative object-detector motion between successive views 有权
标题翻译：在连续视图之间校正相对物体检测器运动的方法
公开(公告)号：US07542597B2
公开(公告)日：2009-06-02
申请号：US11558593
申请日：2006-11-10
申请人： John Richard Rahn , Alan C. Nelson
发明人： John Richard Rahn , Alan C. Nelson
IPC分类号： G06K9/00 , G06K9/40 , G06K9/64 , G06K9/32
CPC分类号： G02B21/26 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2021/0346 , G01N2021/1787 , G01N2201/0813 , G01N2223/612 , G02B21/365 , G06T11/005 , G06T11/006 , G06T2211/412 , G06T2211/421
摘要： An apparatus and method for correction of relative object-detector motion between successive views during optical tomographic imaging in three dimensions. An object of interest is illuminated to produce an image. A lateral offset correction value is determined for the image. An axial offset correction value is determined for the image. The lateral offset correction value and the axial offset correction value are applied to the image to produce a corrected file image.
摘要翻译：一种用于在三维尺度下在光学层析成像期间校正连续视图之间的相对物体检测器运动的装置和方法。感兴趣的对象被照亮以产生图像。确定图像的横向偏移校正值。为图像确定轴向偏移校正值。将横向偏移校正值和轴向偏移校正值应用于图像以产生校正的文件图像。

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