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    • 2. 发明授权
    • Variable-motion optical tomography of small objects
    • 小物体的可变运动光学层析成像
    • US07197355B2
    • 2007-03-27
    • US10126026
    • 2002-04-19
    • Alan C. Nelson
    • Alan C. Nelson
    • A61B5/05
    • G01N15/1475G01N15/147G01N21/4795G01N2015/1006G01N2015/1075G01N2015/1445G01N2201/0813G01N2223/612G06T11/006G06T2211/421
    • Motion of an object of interest, such as a cell, has a variable velocity that can be varied on a cell-by-cell basis. Cell velocity is controlled in one example by packing cells into a capillary tube, or any other linear substrate that provides optically equivalent 360 degree viewing access, so that the cells are stationary within the capillary tube, but the capillary tube is translated and rotated mechanically through a variable motion optical tomography reconstruction cylinder. The capillary tube motion may advantageously be controlled in a start-and-stop fashion and translated and rotated at any velocity for any motion interval, under the control of a computer program. As such, there are several configurations of the optical tomography system that take advantage of this controlled motion capability. Additionally, the use of polarization filters and phase plates to reduce light scatter and diffraction background noise is described.
    • 感兴趣对象(诸如单元)的运动具有可以逐个细胞的变化的可变速度。 在一个实例中,通过将细胞包装到毛细管或提供光学等效的360度观察通道的任何其它线性基质中,使细胞在毛细管内是固定的,但毛细管被平移并机械地旋转 可变运动光学层析成像圆筒。 在计算机程序的控制下,毛细管运动可以有利地以起始和停止的方式被控制并且以任何运动间隔的任何速度平移和旋转。 因此,存在利用该受控运动能力的光学层析成像系统的几种配置。 另外,描述了使用偏振滤光器和相位板来减少光散射和衍射背景噪声。
    • 6. 发明授权
    • Depolarized light scattering array apparatus and method of using same
    • 去极化光散射阵列装置及其使用方法
    • US06157449A
    • 2000-12-05
    • US174986
    • 1998-10-19
    • Damian A. Hajduk
    • Damian A. Hajduk
    • C40B40/18C40B60/14G01J4/04G01N21/21G01J4/00
    • G01N21/21B01J2219/00286B01J2219/00315B01J2219/00585B01J2219/00659B01J2219/00707B01J2219/0072B01J2219/00745C40B40/18C40B60/14G01J4/04G01N2201/0813
    • A method and apparatus for characterizing and scanning an array of material samples in a combinatorial library in parallel is disclosed. The apparatus includes a sample block having a plurality of regions for containing the material samples, a polarized light source to illuminate the materials, an analyzer having a polarization direction oriented 90.degree. relative to the polarization direction of the polarized light source so as to filter out light intensities having the same polarization direction as the incident light beams from the light source after illuminating the material samples, and a detector for analyzing changes in the intensity of the light beams. In one aspect, the light source in combination with a polarizer, includes a plurality of light beams to simultaneously illuminate the entire array of materials with linearly polarized light such that the characterization can be performed quickly. In another aspect, the materials in the sample block are subjected to different environmental conditions wherein the detector analyzes the array as a function of those environmental conditions.
    • 公开了一种用于在并联的组合库中表征和扫描材料样品阵列的方法和装置。 该装置包括具有用于容纳材料样品的多个区域的样品块,照射材料的偏振光源,具有相对于偏振光源的偏振方向取向90°的偏振方向的分析器,以便滤出 在照射材料样品之后,具有与来自光源的入射光束相同的偏振方向的光强度,以及用于分析光束强度变化的检测器。 在一个方面,与偏振器组合的光源包括多个光束,以同时以线性偏振光照射整个材料阵列,使得可以快速执行表征。 在另一方面,样品块中的材料经受不同的环境条件,其中检测器根据这些环境条件分析阵列。