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1. 发明申请

US20070154559A1 Nanoparticle compositions of water-soluble drugs for oral administration and preparation methods thereof 有权
标题翻译：用于口服给药的水溶性药物的纳米颗粒组合物及其制备方法
公开(公告)号：US20070154559A1
公开(公告)日：2007-07-05
申请号：US10584449
申请日：2004-12-24
申请人： Chaul-Min Pai , Mi Hong Min , Jun Hwang , Kyung Mi Cho
发明人： Chaul-Min Pai , Mi Hong Min , Jun Hwang , Kyung Mi Cho
IPC分类号： A61K38/28 , A61K31/727 , A61K38/18 , A61K8/31 , A61K38/21 , A61K38/27 , A61K38/23 , A61K31/66 , A61K31/545 , A61K9/14
CPC分类号： A61K9/5123 , A61K9/08 , A61K9/146 , A61K9/5146 , A61K9/5192 , A61K31/545 , A61K31/66 , A61K31/727 , A61K38/1816 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/31 , A61K47/32 , A61K47/34 , A61K47/44
摘要： The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1˜30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5˜80 weight % of a lipid, 0.5˜80 weight % of a polymer, and 1˜80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05˜3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.
摘要翻译：本发明涉及含有粒径为500nm以下的纳米粒子的口服给药组合物，其含有0.1〜30重量％的水溶性药物和抗衡离子物质的复合物，其中带电的水溶性药物与抗衡离子物质，0.5〜80重量％的脂质，0.5〜80重量％的聚合物和1〜80重量％的乳化剂结合，其中所述脂质和所述聚合物的重量比在范围为1：0.05〜3，及其制备方法。本发明的组合物在口服给药时具有高的胃肠吸收速率，并且在纳米颗粒中具有高的药物截留速率，并且对脂肪酶也是稳定的。

2. 发明申请

US20130052264A1 CONTROLLED-RELEASE PHARMACEUTICAL COMPOSITION INCLUDING TAMSULOSIN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND ORAL FORMULATION INCLUDING THE SAME 审中-公开
公开(公告)号：US20130052264A1
公开(公告)日：2013-02-28
申请号：US13695814
申请日：2011-04-27
申请人： Ho-Jin Chung , Sang-Yeob Park , Chaul-Min Pai
发明人： Ho-Jin Chung , Sang-Yeob Park , Chaul-Min Pai
IPC分类号： A61K9/58 , A61K9/32 , A61P13/02 , A61K9/08 , A61K31/18 , A61K9/14 , A61K9/16
CPC分类号： A61K31/18 , A61K9/5073 , A61K9/5078 , A61K9/5084
摘要： A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time. Furthermore, this composition can shield the bitter taste of the active ingredient even when exposed to the inside of the mouth, thus increasing the therapeutic effects for patients upon oral administration.

3. 发明授权

US06319518B1 Colon selective drug delivery composition 失效
标题翻译：结肠选择性药物输送组合物
公开(公告)号：US06319518B1
公开(公告)日：2001-11-20
申请号：US08919957
申请日：1997-08-29
申请人： Seung-Seo Lee , Sung-Bum La , Chang-Baeg Lim , Sujung Lee , Bo-Youn Seo , Chaul-Min Pai
发明人： Seung-Seo Lee , Sung-Bum La , Chang-Baeg Lim , Sujung Lee , Bo-Youn Seo , Chaul-Min Pai
IPC分类号： A61K922
CPC分类号： A61K9/4816 , A61K9/286 , A61K9/5036
摘要： A composition comprising gelatin and a polysaccharide which is degradable by a colonic enzyme and, optionally, with an aldehyde and/or a polyvalent metal ion and/or an additional polysaccharide, which is not degraded or disintegrated in the upper gastrointestinal tract, thereby rendering the active substance loaded therein to be selectively delivered to the colon and to be effectively released in the colon.
摘要翻译：一种包含明胶和多糖的组合物，其可以通过结肠酶和任选的醛和/或多价金属离子和/或另外的多糖降解，其在上胃肠道中不会降解或分解，从而使载入其中的活性物质被选择性地递送到结肠并且有效地释放在结肠中。

4. 发明授权

US5948020A Implantable bioresorbable membrane and method for the preparation thereof 失效
标题翻译：植入式生物可吸收膜及其制备方法
公开(公告)号：US5948020A
公开(公告)日：1999-09-07
申请号：US765021
申请日：1997-12-26
申请人： Seok-Joon Yoon , Guw-Dong Yeo , You-Chan Kim , Min-Hyo Seo , Chaul-Min Pai , Jong-Pyoung Jung , Seung-Jin Lee
发明人： Seok-Joon Yoon , Guw-Dong Yeo , You-Chan Kim , Min-Hyo Seo , Chaul-Min Pai , Jong-Pyoung Jung , Seung-Jin Lee
IPC分类号： A61K9/00 , A61L15/64 , A61L27/00 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61F2/02
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/606
摘要： An implantable bioresorbable membrane for the separation and regeneration of tissue in a defect site and augmentation of tissues surrounding other implants comprises: (a) porous bioresorbable polymer matrix made of a bioresorbable polymer selected from the group consisting of polylactic acid, poly(lactic-co-glycolic acid), polycarprolactone, polyparadioxanone, polytrimethylene carbonate and a mixture thereof; and (b) a reinforcing fabric made of bioresorbable fibers embedded in said matrix, and is produced by preparing a fabric as a support from bioresorbable fibrous materials, coating the fabric with a solution containing a bioresorbable polymer and a pore forming agent, and treating the coated fabric to generate pores.
摘要翻译：用于分离和再生缺损部位中的组织并增加包围其他植入物的组织的可植入生物再吸收膜包括：（a）由生物可再吸收聚合物制成的多孔生物可再吸收聚合物基质，所述生物可再吸收聚合物选自聚乳酸，聚乳酸乙醇酸），聚己内酯，聚对二恶烷酮，聚三亚甲基碳酸酯及其混合物; 和（b）由嵌入所述基质中的可生物再吸收的纤维制成的增强织物，并且通过由生物可再吸收的纤维材料制备作为支持物的织物制备，用含有生物可再吸收聚合物和成孔剂的溶液涂布织物，涂层织物产生毛孔。

5. 发明申请

US20120076838A1 POORLY SOLUBLE DRUG CONTAINING MICROSPHERE WITH IMPROVED BIOAVAILABILTY AND METHOD OF PREPARING THE SAME 审中-公开
标题翻译：具有改善生物利用度的含有微生物的不溶性溶剂及其制备方法
公开(公告)号：US20120076838A1
公开(公告)日：2012-03-29
申请号：US13322549
申请日：2010-05-27
申请人： Kyung-Hee Kim , Hyun-Ki Lee , Jun- Seok Hwang , Su-long Hwang , Chaul-Min Pai
发明人： Kyung-Hee Kim , Hyun-Ki Lee , Jun- Seok Hwang , Su-long Hwang , Chaul-Min Pai
IPC分类号： A61K9/14 , A61K31/519 , A61K31/343 , A61K31/216 , A61K31/55 , A61K31/593 , A61K31/4184 , A61K31/7048 , A61K31/522 , A61K31/52
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1652 , A61K31/522
摘要： A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.
摘要翻译：提供了具有改善的生物利用度的含有微溶性微球的药物，包含其的口服制剂及其制备方法，其中所述难溶性药物微球体是固体分散体，其中难溶性药物分散在水溶性聚合物载体以非结晶形式通过喷雾干燥，从而提高难溶性药物的生物利用度。

6. 发明授权

US06322805B1 Biodegradable polymeric micelle-type drug composition and method for the preparation thereof 有权
标题翻译：可生物降解聚合胶束型药物组合物及其制备方法
公开(公告)号：US06322805B1
公开(公告)日：2001-11-27
申请号：US09547545
申请日：2000-04-12
申请人： Sung-Chul Kim , Eun-Ok Chang , In-Suk Song , Chaul-Min Pai
发明人： Sung-Chul Kim , Eun-Ok Chang , In-Suk Song , Chaul-Min Pai
IPC分类号： A61F200
CPC分类号： A61K47/34 , A61K9/1075
摘要： A biodegradable polymeric drug carrier micelle composition capable of solubilizing a hydrophobic drug in a hydrophilic environment comprises a biodegradable polymeric drug carrier micelle and a hydrophobic drug wherein the drug is physically trapped within and not covalently bonded to the polymeric drug carrier micelle. The drug carrying micelle is capable of dissolving in water to form a solution thereof, and the drug carrier comprises an amphiphilic block copolymer having a hydrophilic poly(alkylene oxide) component, and a biodegradable hydrophobic polymer component selected from the group consisting of poly(lactic acid), poly(glycoloc acid), poly(lactic-co-glycolic acid), poly(&egr;-caprolactone), a derivative thereof and a mixture thereof. Preferably the amphiphilic block copolymer has a molecular weight in a range of about 1430 to about 6000 Daltons and the hydrophilic component content is in a range of about 50 wt % to about 70 wt % based on the total weight of the block copolymer.
摘要翻译：能够将疏水性药物溶解在亲水环境中的可生物降解的聚合物药物载体胶束组合物包括可生物降解的聚合物药物载体胶束和疏水性药物，其中所述药物被物理地俘获并且不共价键合到聚合物药物载体胶束上。载药胶束能够溶解在水中以形成其溶液，药物载体包括具有亲水性聚（环氧烷）组分的两亲性嵌段共聚物和选自聚（乳酸）的生物可降解的疏水性聚合物组分酸），聚（糖醇酸），聚（乳酸 - 共 - 乙醇酸），聚（ε-己内酯），其衍生物及其混合物。优选地，两亲性嵌段共聚物的分子量在约1430至约6000道尔顿范围内，并且基于嵌段共聚物的总重量，亲水组分含量在约50重量％至约70重量％的范围内。

7. 发明授权

US06193994B1 Locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof 失效
标题翻译：局部给药，可生物降解和持续释放的牙周炎药物组合物及其制备方法
公开(公告)号：US06193994B1
公开(公告)日：2001-02-27
申请号：US09180480
申请日：1999-03-04
申请人： Jae-Yong Lee , Min-Hyo Seo , In-Ja Choi , Jee-Hyang Kim , Chaul-Min Pai
发明人： Jae-Yong Lee , Min-Hyo Seo , In-Ja Choi , Jee-Hyang Kim , Chaul-Min Pai
IPC分类号： A61L1528
CPC分类号： A61K9/7007 , A61K9/0063 , Y10S514/953
摘要： This invention relates to locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof, which can show continuous drug effect for a long time by controlling the release time and by making the drug remain in the periodontal pocket for a prolonged time. The composition is prepared by i) making a microsphere containing the physiologically active substance, ii) making the mixture of the microspheres and water-soluble polymer such as polysaccharides iii) making the mixture into the form of film or strip or/and iv) coating the film or strip with a cation aqueous solution such as calcium and barium. The present pharmaceutical composition can be easily administered using forceps, has minimized side effects and maximizes the effect by releasing the active substance at the minimum dose, and make the patients feel comfortable.
摘要翻译：本发明涉及用于牙周炎的局部可施用的，可生物降解的和持续释放的药物组合物及其制备方法，其可以通过控制释放时间并通过使药物保留在牙周袋中长时间显示持续的药物作用时间。该组合物通过以下步骤制备：i）制备含有生理活性物质的微球体，ii）制备微球体和水溶性聚合物如多糖的混合物，iii）使混合物成膜或条状或/和iv）涂层该膜或条带具有阳离子水溶液如钙和钡。本药物组合物可以使用镊子容易地施用，具有最小化的副作用并且通过以最小剂量释放活性物质来最大化效果，并且使患者感到舒适。

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