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1. 发明申请

US20100261983A1 IMPLANTABLE DEVICES FOR DYNAMIC MONITORING OF PHYSIOLOGICAL AND BIOLOGICAL PROPERTIES OF TUMORS 有权
标题翻译：用于动态监测肿瘤生理和生物学特性的可植入装置
公开(公告)号：US20100261983A1
公开(公告)日：2010-10-14
申请号：US12823521
申请日：2010-06-25
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译：配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。

2. 发明授权

US07756568B2 Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权
标题翻译：用于动态监测肿瘤的生理和生物学特性的方法，系统和相关的可植入装置
公开(公告)号：US07756568B2
公开(公告)日：2010-07-13
申请号：US11148608
申请日：2005-06-09
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/07
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译：配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。

3. 发明授权

US07010340B2 Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权
公开(公告)号：US07010340B2
公开(公告)日：2006-03-07
申请号：US10078310
申请日：2002-02-18
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/07
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.

4. 发明授权

US09662049B2 Methods and systems for monitoring patients undergoing treatment for cancer 有权
公开(公告)号：US09662049B2
公开(公告)日：2017-05-30
申请号：US12823598
申请日：2010-06-25
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/1486 , A61B5/1495 , G06F19/00 , A61N5/10
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information.

5. 发明授权

US08380290B2 Implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权
标题翻译：用于动态监测肿瘤生理和生物学特性的植入式装置
公开(公告)号：US08380290B2
公开(公告)日：2013-02-19
申请号：US12823521
申请日：2010-06-25
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/07
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译：配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。

6. 发明授权

US07171252B1 Methods, computer program products, and devices for calibrating chronically tissue implanted sensors using chronically tissue 失效
标题翻译：方法，计算机程序产品和用于使用长期组织校准长期组织植入传感器的装置
公开(公告)号：US07171252B1
公开(公告)日：2007-01-30
申请号：US10089483
申请日：2000-03-29
申请人： Charles W. Scarantino , H. Troy Nagle , Chang-Soo Kim , Stefan Ufer , Jason Fiering , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Chang-Soo Kim , Stefan Ufer , Jason Fiering , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B5/05 , A61B5/07 , A61B6/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Calibration of in vivo oxygen and pH sensor systems can be performed by generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode and determining a level of the constituent element in the tissue via the in vivo sensor electrode. Accordingly, accurate monitoring of tissue can be achieved while reducing the need to calibrate the in vivo sensor systems using invasive procedures. Related electrode assemblies are also discussed.
摘要翻译：体内氧和pH传感器系统的校准可以通过经由体内产生电极生成靠近体内传感器电极的环境的构成元件，并且经由体内传感器电极确定组织中的构成元件的水平来进行。因此，可以在减少使用侵入性程序校准体内传感器系统的需要的同时，实现对组织的准确监测。还讨论了相关电极组件。

7. 发明申请

US20160080384A1 METHOD AND APPARATUS FOR DNA-BASED AUTHENTICATION SYSTEM 审中-公开
标题翻译：基于DNA的认证系统的方法与装置
公开(公告)号：US20160080384A1
公开(公告)日：2016-03-17
申请号：US14857764
申请日：2015-09-17
申请人： Bahram Ghaffarzadeh Kermani
发明人： Bahram Ghaffarzadeh Kermani
IPC分类号： H04L29/06 , G06F19/24 , G06F19/22
CPC分类号： H04L63/0861 , G16B30/00
摘要： Techniques for biochemcally-enabled security/authentication mechanisms are described herein. In an example embodiment, a security system receives a biological sample from a key. The biological sample includes a set of deoxyribonucleic acid (DNA) oligos that represent a code assigned to the key. The set of DNA oligos is sequenced to obtain a set of read sequences. The set of read sequences is then filtered to identify a set of filtered sequences. The set of filtered sequences is matched to sets of expected sequences, where the sets of expected sequences are assigned to respective keys issued for the security system. Access to a resource is then granted or denied based on whether the set of filtered sequences matches with any set from the sets of expected sequences.
摘要翻译：本文描述了用于生物化学启用的安全/认证机制的技术。在示例实施例中，安全系统从密钥接收生物样本。生物样品包括一组代表分配给钥匙的代码的脱氧核糖核酸（DNA）寡核苷酸。对DNA寡聚体进行测序以获得一组读序列。然后对该组读取序列进行过滤以识别一组经过滤的序列。滤波序列的集合与期望序列的集合匹配，其中预期序列的集合被分配给为安全系统发出的相应密钥。根据该组滤波序列是否与来自预期序列集的任何集合相匹配，然后授予或拒绝对资源的访问。

8. 发明申请

US20130059740A1 Sequencing Small Amounts of Complex Nucleic Acids 审中-公开
标题翻译：测序小量的复杂核酸
公开(公告)号：US20130059740A1
公开(公告)日：2013-03-07
申请号：US13448279
申请日：2012-04-16
申请人： Radoje Drmanac , Brock A. Peters , Bahram Ghaffarzadeh Kermani
发明人： Radoje Drmanac , Brock A. Peters , Bahram Ghaffarzadeh Kermani
IPC分类号： C40B20/00 , C40B20/04
CPC分类号： G16B30/00
摘要： The present invention provides methods and compositions for sequencing small amounts of complex nucleic acids such as human genomes and for analyzing the resulting sequence information in order to reduce sequencing errors and perform haplotype phasing, for example.
摘要翻译：本发明提供了用于测序少量复合核酸如人类基因组的方法和组合物，并且用于分析所得序列信息以减少测序误差并进行例如单倍型定相。

9. 发明申请

US20100324775A1 Vehicle interaction communication system 审中-公开
标题翻译：车辆交互通信系统
公开(公告)号：US20100324775A1
公开(公告)日：2010-12-23
申请号：US12081095
申请日：2008-04-10
申请人： Bahram Ghaffarzadeh Kermani , Scott Wayne McLellan , Steven DeArmond Curtin
发明人： Bahram Ghaffarzadeh Kermani , Scott Wayne McLellan , Steven DeArmond Curtin
IPC分类号： G08G1/09 , G06F7/00
CPC分类号： G08G1/096725 , B60K31/0058 , B60K2370/191 , B60W40/04 , G07C5/008 , G08G1/096741 , G08G1/096775 , G08G1/096783 , G08G1/163
摘要： The information available to a driver of a vehicle is greatly expanded using wireless communications (e.g., using Bluetooth wireless communication devices). In one embodiment, information regarding an adjacent vehicle such as a brake light, a turn light, speed, distance, direction, etc., is transmitted from one vehicle to a nearby or adjacent other vehicle. The received information is used in any appropriate manner, such as causing the receiving vehicle to change vehicle speed or brake, to turn to avoid a collision, etc. In a second embodiment, roadside wireless transceivers collect information regarding passing vehicles, and central database is compiled relating to a traffic conditions. The traffic condition information can be passed back to the passing vehicles for appropriate use, e.g., causing the driver to slow down, or even causing a navigation device in the receiving vehicle to manually prompt for or automatically recalculate a best route to an intended destination. In yet another embodiment, broadcast transmitters can be established at signs and other significant locations transmitting information to passing vehicles. The broadcast information may be as simple as indicating the existence of the sign, or depending upon the range of the particular wireless transmitter, the existence of a particular sign, bump in road, curve, etc., can be forewarned far in advance of when the driver will actually see the relevant object. Alternatively, the broadcast information may be quite detailed, e.g., containing a detailed itemization and directions to a large number of gas stations, restaurants, etc., reachable from a particular exit from a highway.
摘要翻译：使用无线通信（例如，使用蓝牙无线通信设备）大大扩展了车辆驾驶员可用的信息。在一个实施例中，关于诸如刹车灯，转向灯，速度，距离，方向等的相邻车辆的信息从一个车辆传输到附近或相邻的其他车辆。接收到的信息以任何适当的方式使用，例如使接收车辆改变车辆速度或制动器，以避免碰撞等。在第二实施例中，路边无线收发器收集关于经过车辆的信息，并且中央数据库是汇编与交通情况有关。交通状况信息可以被传回给经过的车辆以供适当使用，例如使驾驶员减速，或甚至导致接收车辆中的导航装置手动提示或自动地重新计算到预定目的地的最佳路线。在另一个实施例中，广播发射机可以在向通过的车辆发送信息的符号和其他重要位置处建立。广播信息可以简单地指示符号的存在，或者取决于特定无线发射机的范围，特定符号的存在，道路，曲线等中的凸起，可以在何时预先警告司机会实际看到相关对象。或者，广播信息可以是非常详细的，例如，包含详细的分项和向来自高速公路的特定出口可到达的大量加油站，餐馆等的方向。

10. 发明授权

US07799527B2 Systems and methods for automated quality control of polymer synthesis 有权
标题翻译：聚合物合成自动化质量控制的系统和方法
公开(公告)号：US07799527B2
公开(公告)日：2010-09-21
申请号：US11173952
申请日：2005-07-01
申请人： Nels A. Olson , Bahram Ghaffarzadeh Kermani , Hongji Ren , Theo Kotseroglou
发明人： Nels A. Olson , Bahram Ghaffarzadeh Kermani , Hongji Ren , Theo Kotseroglou
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/02 , A61K38/00 , C07K1/00
CPC分类号： C40B99/00 , B01J2219/00693
摘要： The invention provides systems and methods for evaluating synthetic reactions such as polymer synthesis reactions. Evaluation of a synthetic reaction product can be based on a quantitative measure of synthesis such as coupling efficiency or yield, and various parameters determined from a separation record obtained for the synthetic reaction product. The invention further provides methods for evaluating a separation method based on various parameters determined from a separation record. The invention can be used to select an appropriate treatment for a synthetic reaction product such as a separation treatment or treatments related to further processing for the desired product. The methods are particularly useful for automated selection of treatments for synthetic reaction products.
摘要翻译：本发明提供用于评价合成反应如聚合物合成反应的系统和方法。合成反应产物的评估可以基于合成的定量测量，例如偶合效率或产率，以及由合成反应产物获得的分离记录确定的各种参数。本发明还提供了基于从分离记录确定的各种参数来评估分离方法的方法。本发明可用于选择合成反应产物的合适处理，例如分离处理或与所需产物的进一步加工有关的处理。该方法对于自动选择合成反应产物的处理特别有用。

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