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1. 发明授权

US4766114A Tricyclic compound called 5-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydro-dibenzo (c,f) (1,2)thiazepin-11-yl)-amino) pentanoic acid 失效
标题翻译：称为5 - （（3-氯-6-甲基-5,5-二氧代-6,11-二氢 - 二苯并（c，f）（1,2）硫杂-11-基） - 氨基）戊酸的三环化合物
公开(公告)号：US4766114A
公开(公告)日：1988-08-23
申请号：US17237
申请日：1987-02-20
申请人： Charles Malen , Jean C. Poignant
发明人： Charles Malen , Jean C. Poignant
IPC分类号： A61K31/00 , A61P25/24 , A61P25/26 , C07D281/02 , A61K31/55
CPC分类号： C07D281/02
摘要： The invention concerns 5-[(3-chloro-6-methyl-5,5-dioxo-6,11-dihydro-dibenzo (c,f) (1,2) thiazepin-11-yl)-amino] pentanoic acid.Medicament.
摘要翻译：本发明涉及5 - [（3-氯-6-甲基-5,5-二氧代-6,11-二氢 - 二苯并（c，f）（1,2）硫氮杂-11-基） - 氨基]戊酸。药物

2. 发明授权

US4459306A Tricyclic ethers, their process of preparation and their use as medicines 失效
标题翻译：三环醚，其制备过程及其作为药物的使用
公开(公告)号：US4459306A
公开(公告)日：1984-07-10
申请号：US251052
申请日：1981-04-06
申请人： Charles Malen , Jean-Claude Poignant
发明人： Charles Malen , Jean-Claude Poignant
IPC分类号： A61K31/335 , A61K31/357 , A61K31/39 , A61K31/395 , A61K31/40 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D321/10 , C07D327/02
CPC分类号： C07D321/10 , C07D327/02
摘要： This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.
摘要翻译：本发明涉及新的三环醚，其药学上可接受的加成盐和旋光异构体。本文所述的化合物可用作治疗抑郁症和焦虑症中的精神药物。还包括制备所述化合物的方法，包括它们的药物组合物和通过施用这些药物组合物来治疗人或动物的方法。

3. 发明授权

US4496557A Tricyclic ethers, their preparation and the pharmaceutical compositions containing them 失效
标题翻译：三环醚，它们的制备和含有它们的药物组合物
公开(公告)号：US4496557A
公开(公告)日：1985-01-29
申请号：US408451
申请日：1982-08-16
申请人： Charles Malen , Jean-Claude Poignant
发明人： Charles Malen , Jean-Claude Poignant
IPC分类号： A61K31/00 , A61P25/20 , C07D267/18 , C07D311/80 , C07D313/12 , A61K31/33 , A61K31/335
CPC分类号： C07D313/12 , C07D267/18 , C07D311/80
摘要： Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group,A represents a methylene group, a direct bond or an imino--NR.sub.3 -- group in which R.sub.3 is a hydrogen atom or a lower alkyl or lower alkanoyl groupR.sub.1 and R.sub.2 identical or different, each represents a hydrogen atom or a lower alkyl group, or together with the nitrogen atom to which they are attached they form a pyrrolidino, piperidino or methyl-4 piperazine group, andn represents an integer from 1 to 3, in their racemic or optical isomeric forms, as well as their salts of addition with a therapeutically compatible mineral or organic acid.These compounds are useful as antidepressants.
摘要翻译：相应于下列通式的化合物：其中X和Y相同或不同，表示氢或卤素原子，低级烷基，低级烷氧基或三氟甲基，A表示亚甲基，直接键或其中R 3为氢原子或低级烷基或低级烷酰基的亚氨基-NR 3 - 基团，R 1和R 2相同或不同，各自表示氢原子或低级烷基，或与氮原子一起附着它们形成吡咯烷子基，哌啶子基或甲基-4-哌嗪基团，n表示1至3的整数，以其外消旋或旋光异构体形式，以及其与治疗相容的矿物或有机酸的加成盐。这些化合物可用作抗抑郁药。

4. 发明授权

US4378366A 2-[Trifluoroethylamine]oxazolines 失效
标题翻译： 2- [三氟乙胺]恶唑啉
公开(公告)号：US4378366A
公开(公告)日：1983-03-29
申请号：US295255
申请日：1981-08-24
申请人： Charles Malen , Pierre Roger , Michel Laubie
发明人： Charles Malen , Pierre Roger , Michel Laubie
IPC分类号： C07D243/04 , A61K31/415 , A61K31/42 , A61K31/421 , A61P9/12 , C07C45/00 , C07C49/167 , C07C49/327 , C07D233/48 , C07D239/10 , C07D239/14 , C07D263/28 , C07D277/18 , C07D263/16
CPC分类号： C07D277/18 , C07C45/004 , C07C49/167 , C07C49/327 , C07D233/48 , C07D239/14 , C07D263/28
摘要： This invention relates to trifluorethylamines and to a process for producing the same.These trifluorethylamines are substituted on the nitrogen atom with a lower alkyl or a cyclo lower alkyl radical.They are endowed with interesting pharmacological properties.
摘要翻译：本发明涉及三芴乙胺及其制备方法。这些三氟乙胺在氮原子上被低级烷基或环低级烷基取代。他们具有有趣的药理性质。

5. 发明授权

US4092423A Alkoxy anilides and pharmaceutical compositions 失效
标题翻译：烷氧基苯胺和药物组合物
公开(公告)号：US4092423A
公开(公告)日：1978-05-30
申请号：US723684
申请日：1976-09-16
申请人： Charles Malen , Pierre Roger , Jean-Claude Poignant , Xavier Pascaud
发明人： Charles Malen , Pierre Roger , Jean-Claude Poignant , Xavier Pascaud
IPC分类号： C07D207/08 , C07D211/34 , C07D211/60 , C07D295/15 , C07D207/04 , A61K31/40
CPC分类号： C07D295/15 , C07D207/08 , C07D211/34 , C07D211/60
摘要： This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.
摘要翻译：本发明涉及具有被氨基低级烷基羧酸残基取代的氨基的邻烷氧基苯胺，以及它们的生理上相容的酸加成盐及其光学活性异构体。

6. 发明授权

US3960891A Thiochroman compounds 失效
标题翻译：硫氰化合物
公开(公告)号：US3960891A
公开(公告)日：1976-06-01
申请号：US130010
申请日：1971-03-31
申请人： Charles Malen , Michel Laubie
发明人： Charles Malen , Michel Laubie
IPC分类号： C07D335/04 , C07D335/06 , C08J9/32
CPC分类号： C07D335/06 , C08J9/32
摘要： (3-amino-2-hydroxy propyloxy) thiochromans of the formula ##SPC1##Wherein A is hydrogen or halogen, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 is lower alkyl or cyclo lower alkyl.These compounds possess cardiovascular properties and may be used as blockers of cardiac .beta. adrenergic receptors.
摘要翻译：（3-氨基-2-羟基丙氧基）二氢苯并噻喃，式WHEREIN A是氢或卤素，R 1是氢或低级烷基，R 2是低级烷基或环低级烷基。

7. 发明授权

US5192775A New aminomethylpiperidine compounds 失效
标题翻译：新的氨基哌啶化合物
公开(公告)号：US5192775A
公开(公告)日：1993-03-09
申请号：US661494
申请日：1991-02-26
申请人： Charles Malen , Guillaume de Nanteuil , Francis Colpaert
发明人： Charles Malen , Guillaume de Nanteuil , Francis Colpaert
IPC分类号： A61K31/35 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61P9/00 , A61P9/12 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D235/30 , C07D263/58 , C07D277/82 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D401/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention relates to compounds of general formula (I). ##STR1## in which X represents an atom of sulfur or oxygen, or a substituted or unsubstituted amino group;R represents a hydrogen atom or any one of groups A, B, C, D, E, F, or G;R' represents a hydrogen atom, an alkyl group or any one of groups A, B, C, D, E or F, with R'=H when R=G;or R and R' form, with the nitrogen atom to which they are attached, an optionally substituted piperazine ring. Medicaments.
摘要翻译：本发明涉及通式（I）的化合物。（I）其中X表示硫或氧原子，或取代或未取代的氨基; R代表氢原子或A，B，C，D，E，F或G组之一; R'表示氢原子，烷基或基团A，B，C，D，E或F中的任一个，当R = G时，R'= H; 或R和R'与它们所连接的氮原子一起形成任选取代的哌嗪环。药剂

8. 发明授权

US5030646A Novel tricyclic indole compound 失效
公开(公告)号：US5030646A
公开(公告)日：1991-07-09
申请号：US446034
申请日：1989-12-05
申请人： Charles Malen , Jean-Michel Lacoste , Michel Laubie
发明人： Charles Malen , Jean-Michel Lacoste , Michel Laubie
IPC分类号： A61K31/40 , A61P1/08 , A61P9/00 , A61P25/04 , A61P25/20 , A61P25/28 , A61P43/00 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or alternatively a lower alkyl group optionally substituted with one or more halogen atoms,X denotes a hydrogen atom, a linear or branched lower alkyl group or a group SO.sub.2 E in which E denotes a linear or branched lower alkyl group or an aryl group optionally substituted with a linear or branched lower alkyl group,T denotes a hydrogen atom or a lower alkyl group,R.sub.3 denotes a hydrogen atom or a linear or branched lower alkyl group or an aryl group optionally substituted with one or more linear or branched lower alkyl groups,n and m, which may be identical or different, each denote 0 or 1,R.sub.1 and R.sub.2, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group,or alternatively,R.sup.1 and R.sup.2 form, together with the nitrogen atom to which they are linked, a saturated or unsaturated, mono- or bicyclic nitrogenous heterocyclic system, each ring being 5- or 6-membered and optionally comprising one or two other hetero atoms selected from nitrogen, oxygen or sulfur, and optionally substituted with one or more linear or branched lower alkyl or alkoxy groups or with an aryl group which is itself optionally substituted with one or more lower alkyl, lower alkoxy or trifluoromethyl groups or alternatively one or more halogen atoms,or alternatively,R.sup.1 denotes a group ##STR2## in which R.sub.4, R.sub.5 and R.sub.6, which may be identical or different, each denote a hydrogen atom or a linear or branched lower alkyl group, or alternatively R.sub.4 forms with R.sub.5 a bridge (CH.sub.2).sub.p, p being between 2 and 4, or alternatively R.sub.1 denotes a dibenzo[a,d]cyclohept-5-yl group and R.sub.2 denotes a hydrogen atom, where appropriate, their isomers and also their addition salts with a pharmaceutically acceptable acid. Medicinal products.

9. 发明授权

US5494934A Guanidine compounds 失效
标题翻译：胍化合物
公开(公告)号：US5494934A
公开(公告)日：1996-02-27
申请号：US787374
申请日：1991-11-04
申请人： Charles Malen , Jean-Michel Lacoste , Guillaume de Nanteuil
发明人： Charles Malen , Jean-Michel Lacoste , Guillaume de Nanteuil
IPC分类号： A61K31/155 , A61K31/415 , A61K31/495 , A61P3/04 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P11/00 , A61P25/24 , A61P25/26 , C07C279/06 , C07C279/08 , C07C281/16 , C07C281/18 , C07D233/48 , C07D233/50 , C07D233/52 , C07D239/14 , C07D239/18
CPC分类号： C07C281/18 , C07C281/16 , C07D233/48 , C07D233/52 , C07C2101/02
摘要： A compound of formula (I): ##STR1## in which: R.sub.1 represents substituted or unsubstituted phenyl or (C.sub.3 -C.sub.7) cycloalkyl,R.sub.2 represents trifluoromethyl or (C.sub.3 -C.sub.4) cycloalkyl,A represents --CH.sub.2 --, --CH.dbd.N--, .dbd.N-- or --NH--,R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl or, with the nitrogen atoms to which they are attached, form a 5- or 6-membered heterocycle,R represents either hydrogen in the case where A=--CH.sub.2 --, --CH.dbd.N-- or --NH--, or a bond of the group A when the latter is equal to .dbd.N--,its enantiomers and epimers as well as its addition salts with a pharmaceutically acceptable acid.Medicine products.
摘要翻译：式（I）化合物：其中：R 1表示取代或未取代的苯基或（C 3 -C 7）环烷基，R 2表示三氟甲基或（C 3 -C 4）环烷基，A表示-CH 2 - ， - CH = N，= N-或-NH-，R 3和R 4可以相同或不同，表示氢或直链或支链（C1-C6）烷基，或与它们相连的氮原子形成5 - 或6-元杂环，当A = -CH 2 - ， - CH = N-或-NH-的情况下，R表示氢，或者当后者等于= N-时A基团的键，其对映异构体和差向异构体以及其与药学上可接受的酸的加成盐。医药产品。

10. 发明授权

US5254590A Acylaminophenol compounds 失效
标题翻译：酰氨基苯酚化合物
公开(公告)号：US5254590A
公开(公告)日：1993-10-19
申请号：US847599
申请日：1992-03-05
申请人： Charles Malen , Jean-Michel Lacoste , Jean-Paul Vilaine , Albert Lenaers
发明人： Charles Malen , Jean-Michel Lacoste , Jean-Paul Vilaine , Albert Lenaers
IPC分类号： A61K31/165 , A61P3/06 , A61P9/10 , C07C231/14 , C07C233/25 , C07C233/26 , C07C233/27 , C07C233/60 , A01N37/22 , A01N37/18
CPC分类号： C07C233/26 , C07C233/25 , C07C233/27 , C07C2101/08
摘要： The invention relates to the compounds of formula (I): ##STR1## in which R represents higher alkyl, 1-(higher alkyl)lower cycloalkyl-1-yl or higher alkenyl comprising one or more double bonds, and eitherR.sub.3 represents hydroxyl,R.sub.1 and R.sub.2, which are different, represent hydrogen or lower alkyl,R.sub.4 and R.sub.5, which are identical or different, represent lower alkyl or alkoxy, orR.sub.1 and R.sub.4 represent hydroxyl andR.sub.2, R.sub.3 and R.sub.5, which are identical or different, represent lower alkyl or alkoxy,their isomers as well as their salts, and a method for treating an animal or human living body afflicted with dylipidemias or atherosclerosis.
摘要翻译：本发明涉及式（I）化合物：其中R表示高级烷基，1-（高级烷基）低级环烷基-1-基或含有一个或多个双键的更高级链烯基，R3或R3 表示羟基，不同的R 1和R 2表示氢或低级烷基，R 4和R 5相同或不同，表示低级烷基或烷氧基，或者R 1和R 4表示羟基，R 2，R 3和R 5是相同或不同的，代表低级烷基或烷氧基，它们的异构体及其盐，以及用于治疗患有血脂异常或动脉粥样硬化的动物或人类活体的方法。

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