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    • 10. 发明授权
    • Nitrosourea derivatives, process for their preparation and medicaments
containing them
    • 亚硝基脲衍生物,其制备方法和含有它们的药物
    • US4902791A
    • 1990-02-20
    • US181760
    • 1988-04-14
    • Pierre RogerPatrick ChoayClaude MonneretJean-Paul FournierAlain Martin
    • Pierre RogerPatrick ChoayClaude MonneretJean-Paul FournierAlain Martin
    • C07C271/06C07H13/12
    • C07H13/12C07C271/06Y10S514/908
    • The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them.The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an --NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an --NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R" can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R" represents hydrogen, and R' and R" cannot be simultaneously hydrogen atoms.These compounds present an antitumor activity. No drawing.
    • 本发明涉及亚硝基脲衍生物,其制备方法和含有它们的药物组合物。 本发明的亚硝基脲衍生物对应于下式(I):其中:R可以表示氢原子或1〜30个碳原子的烷基,X表示羟基或-NR1R2基,Y表示 表示氢原子,羟基或-NR'1R'2基团,其中R1和/或R'1各自表示氢原子或基团,Hal表示卤素,R2和/或R' 2可以各自表示氢原子或含有1至6个碳原子的烷基,R'和R“可以表示氢或OH,条件是至少X表示,其中R1表示或Y表示< IMAGE>,其中R'1表示,并且条件是R'表示氢或R“表示氢,并且R'和R”不能同时为氢原子。 这些化合物具有抗肿瘤活性。 没画