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1. 发明授权

US09102521B2 Nanosensors and related technologies 有权
标题翻译：纳米传感器及相关技术
公开(公告)号：US09102521B2
公开(公告)日：2015-08-11
申请号：US12308207
申请日：2007-06-11
申请人： Charles M. Lieber , Ying Fang , Fernando Patolsky
发明人： Charles M. Lieber , Ying Fang , Fernando Patolsky
IPC分类号： B82Y30/00 , B82Y10/00 , C12Q1/68 , G01N27/414 , H01L51/00
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between an analyte and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances.
摘要翻译：本发明一般涉及用于确定怀疑存在于样品中的核酸或其它分析物的纳米级线器件和方法。例如，纳米级线器件可用于检测核酸内的单碱基错配（例如，通过确定缔合和/或解离速率）。在一方面，可以在分析物和相对于纳米尺度线固定的结合对象之间确定诸如结合常数，缔合速率和/或解离速率的动力学信息。在一些情况下，纳米尺寸线包括包含金属 - 半导体化合物的第一部分和不包括金属 - 半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米尺度线的至少第二部分是固定的，并且纳米级线的第二部分的尺寸可以在一些情况下被最小化和/或控制。

2. 发明申请

US20100087013A1 Nanosensors and related technologies 有权
标题翻译：纳米传感器及相关技术
公开(公告)号：US20100087013A1
公开(公告)日：2010-04-08
申请号：US12308207
申请日：2007-06-11
申请人： Charles M. Lieber , Ying Fang , Fernando Patolsky
发明人： Charles M. Lieber , Ying Fang , Fernando Patolsky
IPC分类号： G01N33/551 , H01L21/38 , G01N33/553
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.
摘要翻译：本发明通常涉及纳米技术和亚微电子电路，以及相关的方法和装置，例如纳米级线器件和用于确定疑似存在于样品中的核酸或其他分析物的方法（例如，它们的存在和/或动态信息），例如在单分子水平。例如，在一些情况下可以使用纳米级线器件来检测核酸内的单碱基错配（例如，通过确定缔合和/或解离速率）。在一个方面，可以在核酸或其他分析物与相对于纳米尺度线固定的结合对象之间确定动力学信息，例如结合常数，缔合速率和/或解离速率。在一些情况下，纳米尺寸线包括包含金属 - 半导体化合物的第一部分和不包括金属 - 半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米尺度线的至少第二部分是固定的，并且纳米级线的第二部分的尺寸可以在一些情况下被最小化和/或控制。尺寸大于纳米尺寸的制品和装置也包括在某些实施方案中。本发明的其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制造和/或使用这种纳米级线的方法等。

3. 发明申请

US20100112546A1 NANOSCALE SENSORS 有权
标题翻译：纳米传感器
公开(公告)号：US20100112546A1
公开(公告)日：2010-05-06
申请号：US12536269
申请日：2009-08-05
申请人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
发明人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
IPC分类号： C12Q1/70 , H01L29/66 , C07K17/14 , C07H21/00
CPC分类号： A61B5/14546 , A61B5/415 , A61B5/418 , A61B2018/00875 , A61B2562/0285 , C12Q1/6825 , C12Q1/6834 , G01N33/54353 , G01N33/6854 , G01N2333/96455 , C12Q2565/607 , C12Q2563/155 , C12Q2563/125
摘要： Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire. In another aspect, the invention provides systems and methods for attaching entities such as nucleic acids, receptors such as gangliosides, or surfactants to a nanoscale wire, for example, using aldehyde-producing reactions or hydrophobic interactions. In some aspects, certain systems and methods of the present invention may be used to determine an analyte suspected to be present in a sample, for example, a toxin, a virus, or a small molecule. Systems and methods of using such nanoscale wires are disclosed in other aspects of the invention, for example, within a microarray. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high-throughput screening), and the like.
摘要翻译：本发明的各个方面通常涉及用于确定疑似存在于样品中的分析物的纳米级线器件和方法，以及相对于纳米尺寸线固定诸如反应实体的实体的系统和方法。在一个方面，可以相对于纳米级线固定核酸，例如DNA，并且在一些情况下，从纳米线生长。在某些实施方案中，核酸可与诸如其他核酸，蛋白质等的实体相互作用，并且在一些情况下，这种相互作用可以是可逆的。例如，可以使诸如端粒酶之类的酶与相对于纳米尺度线固定的DNA结合。端粒酶可以延长DNA的长度，例如通过与游离的脱氧核苷酸三磷酸酯在溶液中反应; 此外，可以例如使用核酸和纳米线之间的电场相互作用来确定核酸的各种性质。在另一方面，本发明提供了用于将实体（例如核酸，诸如神经节苷脂或受体表面活性剂等受体）附着到纳米线上的系统和方法，例如使用醛产生反应或疏水相互作用。在一些方面，本发明的某些系统和方法可用于确定疑似存在于样品中的分析物，例如毒素，病毒或小分子。在本发明的其他方面，例如在微阵列内公开了使用这种纳米线的系统和方法。本发明的另外其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制备和/或使用官能化的纳米线（例如在药物筛选或高通量筛选中）的方法，以及喜欢。

4. 发明授权

US08232584B2 Nanoscale sensors 有权
标题翻译：纳米级传感器
公开(公告)号：US08232584B2
公开(公告)日：2012-07-31
申请号：US12536269
申请日：2009-08-05
申请人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
发明人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
IPC分类号： G01N27/403 , G01N33/566
CPC分类号： A61B5/14546 , A61B5/415 , A61B5/418 , A61B2018/00875 , A61B2562/0285 , C12Q1/6825 , C12Q1/6834 , G01N33/54353 , G01N33/6854 , G01N2333/96455 , C12Q2565/607 , C12Q2563/155 , C12Q2563/125
摘要： Various aspects of the invention relate to nanoscale wire devices and methods of use for detecting analytes. In one aspect, the invention relates to a nanoscale electrical sensor array device, comprising at least one n-doped semiconductor nanoscale wire and at least one p-doped semiconductor nanoscale wire, each having a reaction entity immobilized thereon. Binding of an analyte to the immobilized reaction entity causes a detectable change in the electrical property of the nanoscale wire. In some embodiments, the reaction entity can be a nucleic acid that may interact with other nucleic acids, proteins, etc. In a specific embodiment, the nucleic acid may interact with an enzyme such as telomerase, which can extend the nucleic acid. In other embodiments, the analyte to be detected can be a toxin, virus or small molecule. Systems and methods of using such nanoscale devices are also disclosed, for example, within a microarray.
摘要翻译：本发明的各个方面涉及用于检测分析物的纳米级线器件和使用的方法。一方面，本发明涉及一种纳米级电传感器阵列器件，其包括至少一个n掺杂半导体纳米线和至少一个p掺杂的半导体纳米线，每条导线固定有反应实体。分析物与固定的反应物质的结合导致纳米尺度电线的电性能的可检测的变化。在一些实施方案中，反应实体可以是可以与其他核酸，蛋白质等相互作用的核酸。在一个具体实施方案中，核酸可以与诸如端粒酶的酶相互作用，其可以延伸核酸。在其他实施方案中，待检测的分析物可以是毒素，病毒或小分子。使用这种纳米级器件的系统和方法也例如在微阵列内公开。

5. 发明申请

US20100227382A1 Nanoscale sensors 审中-公开
标题翻译：纳米级传感器
公开(公告)号：US20100227382A1
公开(公告)日：2010-09-09
申请号：US11501466
申请日：2006-08-09
申请人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
发明人： Charles M. Lieber , Fernando Patolsky , Gengfeng Zheng
IPC分类号： C12M1/34 , G01N30/00
CPC分类号： A61B5/14546 , A61B5/415 , A61B5/418 , A61B2018/00875 , A61B2562/0285 , C12Q1/6825 , C12Q1/6834 , G01N33/54353 , G01N33/6854 , G01N2333/96455 , C12Q2565/607 , C12Q2563/155 , C12Q2563/125
摘要： Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire. In another aspect, the invention provides systems and methods for attaching entities such as nucleic acids, receptors such as gangliosides, or surfactants to a nanoscale wire, for example, using aldehyde-producing reactions or hydrophobic interactions. In some aspects, certain systems and methods of the present invention may be used to determine an analyte suspected to be present in a sample, for example, a toxin, a virus, or a small molecule. Systems and methods of using such nanoscale wires are disclosed in other aspects of the invention, for example, within a microarray. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high-throughput screening), and the like.
摘要翻译：本发明的各个方面通常涉及用于确定疑似存在于样品中的分析物的纳米级线器件和方法，以及相对于纳米尺寸线固定诸如反应实体的实体的系统和方法。在一个方面，可以相对于纳米级线固定核酸，例如DNA，并且在一些情况下，从纳米线生长。在某些实施方案中，核酸可与诸如其他核酸，蛋白质等的实体相互作用，并且在一些情况下，这种相互作用可以是可逆的。例如，可以使诸如端粒酶之类的酶与相对于纳米尺度线固定的DNA结合。端粒酶可以延长DNA的长度，例如通过与游离的脱氧核苷酸三磷酸酯在溶液中反应; 此外，可以例如使用核酸和纳米线之间的电场相互作用来确定核酸的各种性质。在另一方面，本发明提供了用于将实体（例如核酸，诸如神经节苷脂或受体表面活性剂等受体）附着到纳米线上的系统和方法，例如使用醛产生反应或疏水相互作用。在一些方面，本发明的某些系统和方法可用于确定疑似存在于样品中的分析物，例如毒素，病毒或小分子。在本发明的其他方面，例如在微阵列内公开了使用这种纳米线的系统和方法。本发明的另外其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制备和/或使用官能化的纳米线（例如在药物筛选或高通量筛选中）的方法，以及喜欢。

6. 发明申请

US20090299213A1 Nanobioelectronics 审中-公开
标题翻译：纳米电子学
公开(公告)号：US20090299213A1
公开(公告)日：2009-12-03
申请号：US12225142
申请日：2007-03-15
申请人： Fernando Patolsky , Brian P. Timko , Guihua Yu , Charles M. Lieber
发明人： Fernando Patolsky , Brian P. Timko , Guihua Yu , Charles M. Lieber
IPC分类号： A61B5/05 , H01L29/66
CPC分类号： G01N33/5058 , B82Y10/00 , H01L29/0665 , H01L29/0673 , H01L29/1606
摘要： The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and/or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine. Also provided in other aspects of the invention are methods for making and using such devices, kits for using the same, and the like.
摘要翻译：本发明通常涉及纳米电子学，并且在一些情况下涉及包括纳米电子元件（例如纳米管和/或纳米线）以及生物组分（诸如神经元）的电路。在一个方面，诸如神经元的细胞被定位成与一个或多个纳米尺度线电连通。纳米线可用于刺激细胞，和/或确定细胞的电气状态。可以将多于一个的纳米级导线定位成与电池电连通，例如在电池的不同区域中。然而，纳米级线可以被定位成使得它们相对靠近在一起，例如间隔开不超过约200nm。纳米线可以设置在例如电极之间的基板上，并且可以使用诸如聚赖氨酸之类的细胞粘附因子将细胞粘附到基底上。在本发明的其他方面中还提供了制造和使用这种装置的方法，用于使用它们的试剂盒等。

7. 发明授权

US09063053B2 Functionalized nanostructures for detecting nitro-containing compounds 有权
标题翻译：用于检测含硝基化合物的官能化纳米结构
公开(公告)号：US09063053B2
公开(公告)日：2015-06-23
申请号：US13703056
申请日：2011-06-06
申请人： Fernando Patolsky , Yoni Engel , Roey Elnathan
发明人： Fernando Patolsky , Yoni Engel , Roey Elnathan
IPC分类号： G01N27/00 , G01N33/22 , G01N27/414 , G01N33/00
CPC分类号： G01N33/0057 , G01N27/00 , G01N27/4146 , G01N33/227 , Y10T436/17 , Y10T436/173076
摘要： Devices, methods and systems for detecting nitro-containing compounds such as TNT, which utilize semiconductor nanostructures modified by a functional moiety that interacts with the nitro-containing compound, are disclosed. The functional moiety is attached to the nanostructures and is being such that upon contacting a sample that contains the nitro-containing compound, the nanostructure exhibits a detectable change in an electrical property, which is indicative of the presence and/or amount of the nitro-containing compound in the sample. Electronic noses for generating recognition patterns of various nitro-containing compounds, made of a plurality of nanostructures modified by versatile functional moieties are also disclosed. The devices, methods and systems are suitable for detecting nitro-containing compounds in both liquid and gaseous states and for detecting a concentration of a nitro-containing compound such as TNT as low as attomolar concentrations.
摘要翻译：公开了用于检测含氮化合物如TNT的装置，方法和系统，其利用由与含硝基化合物相互作用的功能部分修饰的半导体纳米结构。功能部分连接到纳米结构上，并且使得当接触含有含硝基化合物的样品时，纳米结构显示出电性能的可检测变化，其表示硝基的化合物的存在和/或量，样品中含有的化合物。还公开了用于产生由通用功能部分修饰的多个纳米结构制成的各种含硝基化合物的识别图案的电子鼻。装置，方法和系统适用于检测液态和气态两者中的含硝基化合物，并且用于检测含氮化合物如TNT的浓度低至极限浓度。

8. 发明申请

US20130115705A1 FUNCTIONALIZED NANOSTRUCTURES FOR DETECTING NITRO-CONTAINING COMPOUNDS 有权
标题翻译：用于检测含有硝基化合物的功能性纳米结构
公开(公告)号：US20130115705A1
公开(公告)日：2013-05-09
申请号：US13703056
申请日：2011-06-06
申请人： Fernando Patolsky , Yoni Engel , Roey Elnathan
发明人： Fernando Patolsky , Yoni Engel , Roey Elnathan
IPC分类号： G01N27/00
CPC分类号： G01N33/0057 , G01N27/00 , G01N27/4146 , G01N33/227 , Y10T436/17 , Y10T436/173076
摘要： Devices, methods and systems for detecting nitro-containing compounds such as TNT, which utilize semiconductor nanostructures modified by a functional moiety that interacts with the nitro-containing compound, are disclosed. The functional moiety is attached to the nanostructures and is being such that upon contacting a sample that contains the nitro-containing compound, the nanostructure exhibits a detectable change in an electrical property, which is indicative of the presence and/or amount of the nitro-containing compound in the sample. Electronic noses for generating recognition patterns of various nitro-containing compounds, comprising a plurality of nanostructures modified by versatile functional moieties are also disclosed. The devices, methods and systems are suitable for detecting nitro-containing compounds in both liquid and gaseous states and for detecting a concentration of a nitro-containing compound such as TNT as low as attomolar concentrations.
摘要翻译：公开了用于检测含氮化合物如TNT的装置，方法和系统，其利用由与含硝基化合物相互作用的功能部分修饰的半导体纳米结构。功能部分连接到纳米结构上，并且使得当接触含有含硝基化合物的样品时，纳米结构显示出电性能的可检测变化，其表示硝基的化合物的存在和/或量，样品中含有的化合物。还公开了用于产生各种含硝基化合物的识别图案的电子鼻，其包含由通用功能部分修饰的多个纳米结构。装置，方法和系统适用于检测液态和气态两者中的含硝基化合物，并且用于检测含氮化合物如TNT的浓度低至极限浓度。

9. 发明申请

US20120148799A1 ALIGNED NANOARRAY AND METHOD FOR FABRICATING THE SAME 有权
标题翻译：对准的纳米级及其制备方法
公开(公告)号：US20120148799A1
公开(公告)日：2012-06-14
申请号：US13390719
申请日：2010-08-11
申请人： Fernando Patolsky , Tamir Ducobni , Alexander Pevzner , Yoni Engel , Roey Elnathan , Moshit Ben-Ishai
发明人： Fernando Patolsky , Tamir Ducobni , Alexander Pevzner , Yoni Engel , Roey Elnathan , Moshit Ben-Ishai
IPC分类号： B32B3/00 , B05C11/02 , H05K3/02 , B05D1/12 , B82Y30/00
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L21/67092 , H01L29/0673 , Y10T29/49155 , Y10T428/24355
摘要： An elongated nanostructure is formed on a planar surface of a substrate such that the nanostructure is oriented generally perpendicularly to the surface. The nanostructure is then felled onto the surface such that it is oriented generally parallel to the surface.
摘要翻译：在衬底的平坦表面上形成细长的纳米结构，使得纳米结构大致垂直于表面定向。然后将纳米结构挤压到表面上，使得其大致平行于表面定向。

10. 发明授权

US09598785B2 Nanostructures and process of preparing same 有权
公开(公告)号：US09598785B2
公开(公告)日：2017-03-21
申请号：US13063205
申请日：2009-09-10
申请人： Fernando Patolsky , Roey Elnathan , Raisa Kantaev
发明人： Fernando Patolsky , Roey Elnathan , Raisa Kantaev
IPC分类号： A61B5/055 , C25D1/00 , B82Y15/00 , B82Y30/00 , C25D5/10 , C25D5/18 , C25D13/04 , C25D11/04
CPC分类号： C25D1/006 , B01J2219/005 , B01J2219/00504 , B01J2219/00547 , B82Y15/00 , B82Y30/00 , C25D5/10 , C25D5/18 , C25D11/04 , C25D13/04 , Y10T29/49826 , Y10T428/10 , Y10T428/12493 , Y10T428/12528 , Y10T428/12542 , Y10T428/12556 , Y10T428/12826 , Y10T428/12868 , Y10T428/12889 , Y10T428/2913 , Y10T428/298
摘要： A process of preparing a plurality of nanostructures, each being composed of at least one target material is disclosed. The process comprises sequentially electrodepositing a first material and the at least one target material into pores of a porous membrane having a nanometric pore diameter, to thereby obtain within the pores nanometric rods, each of the nanometric rods having a plurality of segments where any two adjacent segments are made of different materials. The process further comprises and etching the membrane and the first material, thereby obtaining the nanostructures.

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