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1. 发明申请

US20100327847A1 High-Resolution Molecular Sensor 有权
标题翻译：高分辨率分子传感器
公开(公告)号：US20100327847A1
公开(公告)日：2010-12-30
申请号：US12677573
申请日：2008-09-12
申请人： Charles M. Leiber , Qihua Xiong , Ping Xie , Ying Fang
发明人： Charles M. Leiber , Qihua Xiong , Ping Xie , Ying Fang
IPC分类号： G01N27/00 , H01L29/772
CPC分类号： G01N33/48721 , B82Y15/00 , G01N27/4145 , H01L29/1606
摘要： A solid state molecular sensor having an aperture extending through a thickness of a sensing region is configured with a sensing region thickness that corresponds to the characteristic extent of at least a component of a molecular species to be translocated through the aperture. A change in an electrical characteristic of the sensing region is measured during the molecular species translocation. The sensor can be configured as a field effect transistor molecular sensor. The sensing region can be a region of graphene including an aperture extending through a thickness of the graphene.
摘要翻译：具有延伸穿过感测区域的厚度的孔的固态分子传感器配置有感测区域厚度，该感测区域厚度对应于待通过孔径移位的分子种类的至少一个成分的特征程度。在分子物质易位期间测量感测区域的电特性的变化。传感器可以配置为场效应晶体管分子传感器。感测区域可以是石墨烯的区域，其包括延伸穿过石墨烯厚度的孔。

2. 发明授权

US08698481B2 High-resolution molecular sensor 有权
标题翻译：高分辨率分子传感器
公开(公告)号：US08698481B2
公开(公告)日：2014-04-15
申请号：US12677573
申请日：2008-09-12
申请人： Charles M. Lieber , Qihua Xiong , Ping Xie , Ying Fang
发明人： Charles M. Lieber , Qihua Xiong , Ping Xie , Ying Fang
IPC分类号： G01N27/00
CPC分类号： G01N33/48721 , B82Y15/00 , G01N27/4145 , H01L29/1606
摘要： A solid state molecular sensor having an aperture extending through a thickness of a sensing region is configured with a sensing region thickness that corresponds to the characteristic extent of at least a component of a molecular species to be translocated through the aperture. A change in an electrical characteristic of the sensing region is measured during the molecular species translocation. The sensor can be configured as a field effect transistor molecular sensor. The sensing region can be a region of graphene including an aperture extending through a thickness of the graphene.
摘要翻译：具有延伸穿过感测区域的厚度的孔的固态分子传感器配置有感测区域厚度，该感测区域厚度对应于待通过孔径移位的分子种类的至少一个成分的特征程度。在分子物质易位期间测量感测区域的电特性的变化。传感器可以配置为场效应晶体管分子传感器。感测区域可以是石墨烯的区域，其包括延伸穿过石墨烯厚度的孔。

3. 发明申请

US20120040335A1 Identification of Porcine Reproductive and Respiratory Syndrome Virus 审中-公开
标题翻译：猪繁殖与呼吸综合征病毒鉴定
公开(公告)号：US20120040335A1
公开(公告)日：2012-02-16
申请号：US13131592
申请日：2009-11-25
申请人： Ying Fang , Elizabeth M. Brown , Craig Welbon , Eric A. Nelson
发明人： Ying Fang , Elizabeth M. Brown , Craig Welbon , Eric A. Nelson
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , C12N2770/10022 , G01N33/56983 , G01N2333/08
摘要： An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for the detection and/or differentiation of serum antibodies directed against Type 1 and/or Type 2 PRRSV utilizing PRRSV nsp7 as an antigen, and provides a diagnostic method for the detection of PRRSV infection, epidemiological surveys, and outbreak investigations. The invention may be used either alone or as a follow-up assay to determine the true status of unexpected positive results that may occur using other assays, such as the IDEXX HERDCHEK PRRS ELISA.
摘要翻译：酶联免疫吸附测定（ELISA）基于猪繁殖和呼吸综合征病毒（PRRSV）的非结构蛋白7（nsp7），并且提供针对1型（欧洲）和 2型（北美）PRRSV。本发明提供了使用PRRSV nsp7作为抗原的针对1型和/或2型PRRSV的血清抗体的检测和/或分化的血清学测定，并提供了用于检测PRRSV感染，流行病学调查和爆发的诊断方法调查。本发明可以单独使用或作为随访测定来确定可能使用其它测定法（例如IDEXX HERDCHEK PRRS ELISA）发生的意想不到的阳性结果的真实状态。

4. 发明授权

US07401258B1 Circuit for and method of accessing instruction data written to a memory 有权
标题翻译：访问写入存储器的指令数据的电路和方法
公开(公告)号：US07401258B1
公开(公告)日：2008-07-15
申请号：US10956599
申请日：2004-09-30
申请人： Ying Fang , Mehul R. Vashi
发明人： Ying Fang , Mehul R. Vashi
IPC分类号： G06F11/00
CPC分类号： G06F11/36
摘要： According to one embodiment of the invention, a method of accessing instruction data from a memory comprises steps of specifying a predetermined address of a memory for storing instruction data; writing instruction data to the predetermined address in the memory; reading the instruction data from the predetermined address after the step of writing instruction data; and determining whether the instruction data is valid. According to another embodiment of the invention, a method describes a method of accessing instruction data from a memory by way of first and second data buses. According to a further embodiment, instruction data read back from the memory is multiplexed to a memory controller. A circuit for accessing instruction data written to a memory is also described.
摘要翻译：根据本发明的一个实施例，一种从存储器访问指令数据的方法包括以下步骤：指定用于存储指令数据的存储器的预定地址; 将指令数据写入存储器中的预定地址; 在写入指令数据的步骤之后从预定地址读取指令数据; 以及确定所述指令数据是否有效。根据本发明的另一实施例，一种方法描述了一种通过第一和第二数据总线从存储器访问指令数据的方法。根据另一实施例，从存储器读回的指令数据被复用到存储器控制器。还描述了用于访问写入存储器的指令数据的电路。

5. 发明申请

US20070264623A1 Nanosensors 审中-公开
标题翻译：纳米传感器
公开(公告)号：US20070264623A1
公开(公告)日：2007-11-15
申请号：US11629722
申请日：2005-06-15
申请人： Wayne Wang , Chuo Chen , Keng-Hui Lin , Ying Fang , Charles Lieber
发明人： Wayne Wang , Chuo Chen , Keng-Hui Lin , Ying Fang , Charles Lieber
IPC分类号： C12Q1/00 , C12M1/40 , G01N27/00 , G01N33/53
CPC分类号： B82Y15/00 , G01N27/4146 , G01N33/54373
摘要： The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding assay including a nanoscale wire to a sample containing a species able to interact with the retain entity to produce a product, where the sample also contains or is suspected of containing a second species able to interact with the reaction entity to prevent production of the product resulting from interaction of the first species and the reaction entity. Based upon determination of production of the product, determination of the second species in the sample can be made. In one set of embodiments, nanoscale wires can be used that have been functionalized at their surface, and/or in close proximity to their surface, for example, by immobilizing a protein or an enzyme relative to the nanoscale wire. Functionalization may permit interaction of the nanoscale wire with various analytes, and such interaction may induce a determinable change in a property of the nanoscale wire. Determination of two or more analytes, o one analyte and the suspected presence of another analyte can involve, for example, binding species to a protein or an enzyme immobilized relative to the nanoscale wire. Other aspects of the invention include assays, sensors, detectors, and/or other devices that include functionalized nanoscale wires, methods of making and/or using functionalized nanoscale wires (for example, in drug screening or high throughput screening) and the like.
摘要翻译：本发明一般涉及用于确定疑似存在于样品中的分析物的纳米尺度丝，特别是关于确定含有或怀疑含有两种或多种分析物的样品的信息。例如，本发明可涉及竞争性的，无竞争性的或非竞争性的结合测定，其包括纳米尺度的丝线，其含有能够与保留实体相互作用以产生产品的样品，其中样品还含有或怀疑含有能够与反应实体相互作用以防止由第一种和反应实体的相互作用产生的产物的第二种。基于产品生产的确定，可以确定样品中的第二种。在一组实施方案中，可以使用在其表面和/或其表面附近功能化的纳米线，例如通过相对于纳米线固定蛋白质或酶。功能化可以允许纳米尺度线与各种分析物的相互作用，并且这种相互作用可以诱导纳米尺度线的性质的可确定的变化。测定两种或更多种分析物，一种分析物和怀疑存在另一种分析物可涉及例如将物质结合到相对于纳米尺度线固定的蛋白质或酶。本发明的其它方面包括测定，传感器，检测器和/或包括功能化的纳米线的其它器件，制造和/或使用官能化的纳米线（例如，在药物筛选或高通量筛选）等的方法。

6. 发明申请

US20100136047A1 RECOMBINANT NORTH AMERICAN TYPE 1 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND METHODS OF USE 有权
标题翻译：重组北美1型PORCINE生殖和呼吸综合征病毒及其使用方法
公开(公告)号：US20100136047A1
公开(公告)日：2010-06-03
申请号：US12145231
申请日：2008-06-24
申请人： Ying Fang , Eric A. Nelson , Jane Hennings
发明人： Ying Fang , Eric A. Nelson , Jane Hennings
IPC分类号： A61K39/12 , A61P31/14 , C12N7/01 , C12Q1/70
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061
摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of vaccinated animals from those naturally infected with wild-type virus. Using a cDNA infectious clone of North American Type 1 PRRSV, a recombinant green fluorescent protein (GFP) tagged PRRSV has been made, containing deletion of an immunogenic epitope, ES4, in the nsp2 region. GFP and ES4 epitope-based ELISAs compliment the marker identification.
摘要翻译：猪繁殖与呼吸综合征病毒（PRRSV）是全球猪肉行业的主要问题。在疫苗中包含标记将允许接种动物与野生型病毒天然感染的动物进行诊断分化。使用北美1型PRRSV的cDNA感染性克隆，已经制备了重组绿色荧光蛋白（GFP）标记的PRRSV，其在nsp2区域中含有免疫原性表位ES4的缺失。 GFP和ES4基于表位的ELISA证明了标记鉴定。

7. 发明申请

US20100087013A1 Nanosensors and related technologies 有权
标题翻译：纳米传感器及相关技术
公开(公告)号：US20100087013A1
公开(公告)日：2010-04-08
申请号：US12308207
申请日：2007-06-11
申请人： Charles M. Lieber , Ying Fang , Fernando Patolsky
发明人： Charles M. Lieber , Ying Fang , Fernando Patolsky
IPC分类号： G01N33/551 , H01L21/38 , G01N33/553
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.
摘要翻译：本发明通常涉及纳米技术和亚微电子电路，以及相关的方法和装置，例如纳米级线器件和用于确定疑似存在于样品中的核酸或其他分析物的方法（例如，它们的存在和/或动态信息），例如在单分子水平。例如，在一些情况下可以使用纳米级线器件来检测核酸内的单碱基错配（例如，通过确定缔合和/或解离速率）。在一个方面，可以在核酸或其他分析物与相对于纳米尺度线固定的结合对象之间确定动力学信息，例如结合常数，缔合速率和/或解离速率。在一些情况下，纳米尺寸线包括包含金属 - 半导体化合物的第一部分和不包括金属 - 半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米尺度线的至少第二部分是固定的，并且纳米级线的第二部分的尺寸可以在一些情况下被最小化和/或控制。尺寸大于纳米尺寸的制品和装置也包括在某些实施方案中。本发明的其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制造和/或使用这种纳米级线的方法等。

8. 发明授权

US11077685B2 Aligning a carriage within a printing device 有权
公开(公告)号：US11077685B2
公开(公告)日：2021-08-03
申请号：US16093476
申请日：2016-07-29
申请人： Hewlett-Packard Development Company, L.P. , Xin-Ling Wu , Ying Fang , Wei-Fei Chang , Qiang Tang
发明人： Xin-Ling Wu , Ying Fang , Wei-Fei Chang , Qiang Tang
IPC分类号： B41J25/00
摘要： A printing device (100, 200) may include a carriage (101, 201) to hold an integrated printhead (103, 203) in the printing device; a manifold latch (105, 205) to connect the integrated printhead and an ink tank connector in a locked position; and a controller (109, 209) to align the carriage within the printing device based on a level of health of the integrated printhead and a latching position of the manifold latch. Furthermore, a non-transitory computer readable medium and a printing method are disclosed.

9. 发明授权

US09102521B2 Nanosensors and related technologies 有权
标题翻译：纳米传感器及相关技术
公开(公告)号：US09102521B2
公开(公告)日：2015-08-11
申请号：US12308207
申请日：2007-06-11
申请人： Charles M. Lieber , Ying Fang , Fernando Patolsky
发明人： Charles M. Lieber , Ying Fang , Fernando Patolsky
IPC分类号： B82Y30/00 , B82Y10/00 , C12Q1/68 , G01N27/414 , H01L51/00
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between an analyte and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances.
摘要翻译：本发明一般涉及用于确定怀疑存在于样品中的核酸或其它分析物的纳米级线器件和方法。例如，纳米级线器件可用于检测核酸内的单碱基错配（例如，通过确定缔合和/或解离速率）。在一方面，可以在分析物和相对于纳米尺度线固定的结合对象之间确定诸如结合常数，缔合速率和/或解离速率的动力学信息。在一些情况下，纳米尺寸线包括包含金属 - 半导体化合物的第一部分和不包括金属 - 半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米尺度线的至少第二部分是固定的，并且纳米级线的第二部分的尺寸可以在一些情况下被最小化和/或控制。

10. 发明申请

US20130210654A1 Multiplex Immune Effector Molecule Assay 审中-公开
标题翻译：多重免疫效应分子测定
公开(公告)号：US20130210654A1
公开(公告)日：2013-08-15
申请号：US13703025
申请日：2011-06-09
申请人： Jane Christopher-Hennings , Steven Lawson , Eric Nelson , Ying Fang , Joan K. Lunney
发明人： Jane Christopher-Hennings , Steven Lawson , Eric Nelson , Ying Fang , Joan K. Lunney
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/54306 , G01N33/6863 , G01N33/6866
摘要： Methods for detecting at least seven cytokines in a porcine biological sample are provided. Also provided are multiplex assay kits that allow for the detection and quantification of the cytokines in a single reaction mixture. Use of the methods and kits for diagnosis, prognosis, and monitoring of immunity is also contemplated.
摘要翻译：提供了检测猪生物样品中至少七种细胞因子的方法。还提供了允许在单个反应混合物中检测和定量细胞因子的多重测定试剂盒。还考虑使用用于诊断，预后和免疫监测的方法和试剂盒。

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