专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050227921A1 Inhibition of FGF signaling 有权
标题翻译：抑制FGF信号传导
公开(公告)号：US20050227921A1
公开(公告)日：2005-10-13
申请号：US11057390
申请日：2005-02-11
申请人： Charles Emerson , Xingbin Ai
发明人： Charles Emerson , Xingbin Ai
IPC分类号： A61K38/18 , A61K38/46
CPC分类号： A61K38/465 , A61K31/727 , C12Y301/06
摘要： Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
摘要翻译：描述了用于抑制FGF信号传导的方法和组合物。本发明的方法包括使FGF反应性细胞与外源硫酸肝素硫酸酯6-O硫酸酯酶（Sulf1）以有效修饰内源硫酸乙酰肝素的量接触，从而抑制FGF信号传导。本发明的方法还包括使FGF应答细胞与外源性Sulf1修饰化合物接触，所述外源性Sulf1修饰化合物的特征在于能够降低FGF2或FGF4与FGFR1的结合。还提供了包含外源性Sulf1-修饰化合物的组合物以与本发明的方法结合使用。

2. 发明申请

US20070212712A1 Methods for identifying modulators of hedgehog autoprocessing 审中-公开
标题翻译：鉴定刺猬自动加工调节剂的方法
公开(公告)号：US20070212712A1
公开(公告)日：2007-09-13
申请号：US11634300
申请日：2006-12-05
申请人： Xingbin Ai , Charles Emerson , Henry Paulus
发明人： Xingbin Ai , Charles Emerson , Henry Paulus
IPC分类号： C12Q1/68 , C12Q1/66 , C12Q1/37 , C07F9/80
CPC分类号： G01N33/542 , C12Q1/37 , C12Q1/66 , G01N33/5008 , G01N33/5011 , G01N33/582 , G01N33/6872 , G01N2500/00
摘要： The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.
摘要翻译：本发明涉及使用可用于体内和高通量体外系统的方法筛选Hedgehog肽自动加工调节剂的方法。本发明还涉及通过本发明的方法鉴定的用于调节Hh自动加工的试剂，特别是涉及至少部分地由于Hh自动加工的失调而引起的疾病和疾病的治疗。

3. 发明授权

US07968527B2 Inhibition of FGF signaling 有权
标题翻译：抑制FGF信号传导
公开(公告)号：US07968527B2
公开(公告)日：2011-06-28
申请号：US11057390
申请日：2005-02-11
申请人： Charles P. Emerson, Jr. , Xingbin Ai
发明人： Charles P. Emerson, Jr. , Xingbin Ai
IPC分类号： C12N5/00 , C12N9/14 , A61K31/727 , A61K38/00
CPC分类号： A61K38/465 , A61K31/727 , C12Y301/06
摘要： Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
摘要翻译：描述了用于抑制FGF信号传导的方法和组合物。本发明的方法包括使FGF反应性细胞与外源硫酸肝素硫酸酯6-O硫酸酯酶（Sulf1）以有效修饰内源硫酸乙酰肝素的量接触，从而抑制FGF信号传导。本发明的方法还包括使FGF应答细胞与外源性Sulf1修饰化合物接触，所述外源性Sulf1修饰化合物的特征在于能够降低FGF2或FGF4与FGFR1的结合。还提供了包含外源性Sulf1-修饰化合物的组合物以与本发明的方法结合使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式