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1. 发明授权

US07553832B2 Methods and compositions for specific inhibition of protein splicing by small molecules 失效
标题翻译：通过小分子特异性抑制蛋白质剪接的方法和组合物
公开(公告)号：US07553832B2
公开(公告)日：2009-06-30
申请号：US11338383
申请日：2006-01-24
申请人： Henry Paulus
发明人： Henry Paulus
IPC分类号： A61K31/33 , C07K2/00 , C07K14/00
CPC分类号： A61K31/095 , A61K31/275 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/401 , A61K31/433 , A61K31/53
摘要： The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.
摘要翻译：本发明涉及组合物（即本文举例说明的各种有机小分子）和抑制蛋白质剪接的方法，特别涉及抑制含内蛋白的蛋白质的蛋白质自动切片。此外，本发明涉及本发明的蛋白质剪接抑制剂用于治疗各种疾病（包括但不限于结核病）的用途。此外，本发明提供了具有药物样特征的蛋白质剪接的小分子抑制剂的第一例。

2. 发明申请

US20060217381A1 Methods and compostions for specific inhibition of protein splicing by small molecules 失效
标题翻译：用于特异性抑制小分子蛋白质剪接的方法和组合
公开(公告)号：US20060217381A1
公开(公告)日：2006-09-28
申请号：US11338383
申请日：2006-01-24
申请人： Henry Paulus
发明人： Henry Paulus
IPC分类号： A61K31/53 , A61K31/433 , A61K31/401 , A61K31/381 , A61K31/34 , A61K31/275 , A61K31/36
CPC分类号： A61K31/095 , A61K31/275 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/401 , A61K31/433 , A61K31/53
摘要： The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.
摘要翻译：本发明涉及组合物（即本文举例说明的各种有机小分子）和抑制蛋白质剪接的方法，特别涉及抑制含内蛋白的蛋白质的蛋白质自动切片。此外，本发明涉及本发明的蛋白质剪接抑制剂用于治疗各种疾病（包括但不限于结核病）的用途。此外，本发明提供了具有药物样特征的蛋白质剪接的小分子抑制剂的第一例。

3. 发明授权

US6140091A Anti-idiotype vaccines to elicit catalytic antibodies 失效
标题翻译：抗独特型疫苗引发催化抗体
公开(公告)号：US6140091A
公开(公告)日：2000-10-31
申请号：US102451
申请日：1998-06-22
申请人： Victor Raso , Henry Paulus
发明人： Victor Raso , Henry Paulus
IPC分类号： C07K16/42 , C12N9/00
CPC分类号： C07K16/4208
摘要： Disclosed are methods for the production of second generation catalytic antibodies. The disclosed methods offer a variety of advantages relative to prior art techniques. For example, the methods of the present invention do not require prior identification of the active site of an enzyme, the activity of which is desired in the catalytic antibody. Additionally, the disclosed methods enable the production of antibodies which catalyze chemical reactions which do not occur in nature.
摘要翻译：公开了用于生产第二代催化抗体的方法。所公开的方法相对于现有技术提供了各种优点。例如，本发明的方法不需要事先确定酶的活性位点，其活性在催化抗体中是期望的。此外，所公开的方法使得能够产生催化在自然界中不发生的化学反应的抗体。

4. 发明授权

US06858775B1 Method for generating split, non-transferable genes that are able to express an active protein product 有权
标题翻译：用于产生能够表达活性蛋白质产物的分裂的，不可转移的基因的方法
公开(公告)号：US06858775B1
公开(公告)日：2005-02-22
申请号：US09936588
申请日：2000-05-23
申请人： Ming-Qun Xu , Thomas C. Evans , Sriharsa Pradhan , Donald G. Comb , Henry Paulus , Luo Sun , Lixin Chen , Inca Ghosh
发明人： Ming-Qun Xu , Thomas C. Evans , Sriharsa Pradhan , Donald G. Comb , Henry Paulus , Luo Sun , Lixin Chen , Inca Ghosh
IPC分类号： C07K14/435 , C12N9/10 , C12N9/12 , C12N9/88 , C12N15/10 , C12N15/62 , C12N15/82 , C12P21/02 , A01H1/00
CPC分类号： C12N9/1029 , C07K14/43595 , C07K2319/00 , C07K2319/055 , C07K2319/06 , C07K2319/08 , C07K2319/09 , C07K2319/32 , C07K2319/75 , C07K2319/92 , C12N9/1092 , C12N9/1252 , C12N9/88 , C12N15/10 , C12N15/62 , C12N15/8214 , C12N15/8216 , C12N15/8241 , C12N15/8242 , C12N15/8257 , C12N15/8275 , C12N15/8278 , C12P21/02
摘要： A new type of transgene system is disclosed which allows efficient protein expression in a target host such as a plant, but avoids the undesirable result of the migration of the transgene into related host system and/or to the environment via the pollen. The methods described herein may also be applied to the expression of virtually any protein of interest (e.g. a toxic protein) in eukaryotic (yeast, insect, mammalian cells, etc.) and prokaryotic (E. coli, etc.) organisms.
摘要翻译：公开了一种新型的转基因系统，其允许在靶宿主如植物中有效的蛋白质表达，但避免了通过花粉将转基因迁移到相关宿主系统和/或环境中的不期望的结果。本文所述的方法也可应用于真核生物（酵母，昆虫，哺乳动物细胞等）和原核（大肠杆菌等）生物中几乎任何目标蛋白质（例如毒性蛋白质）的表达。

5. 发明申请

US20070212712A1 Methods for identifying modulators of hedgehog autoprocessing 审中-公开
标题翻译：鉴定刺猬自动加工调节剂的方法
公开(公告)号：US20070212712A1
公开(公告)日：2007-09-13
申请号：US11634300
申请日：2006-12-05
申请人： Xingbin Ai , Charles Emerson , Henry Paulus
发明人： Xingbin Ai , Charles Emerson , Henry Paulus
IPC分类号： C12Q1/68 , C12Q1/66 , C12Q1/37 , C07F9/80
CPC分类号： G01N33/542 , C12Q1/37 , C12Q1/66 , G01N33/5008 , G01N33/5011 , G01N33/582 , G01N33/6872 , G01N2500/00
摘要： The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.
摘要翻译：本发明涉及使用可用于体内和高通量体外系统的方法筛选Hedgehog肽自动加工调节剂的方法。本发明还涉及通过本发明的方法鉴定的用于调节Hh自动加工的试剂，特别是涉及至少部分地由于Hh自动加工的失调而引起的疾病和疾病的治疗。

6. 发明授权

US08183449B2 Tunable clarinet barrel 有权
标题翻译：可调单簧管桶
公开(公告)号：US08183449B2
公开(公告)日：2012-05-22
申请号：US12990504
申请日：2009-04-29
申请人： Henry Paulus , Matthias Schuler
发明人： Henry Paulus , Matthias Schuler
IPC分类号： G10D9/00
CPC分类号： G10D7/066
摘要： The present invention relates to a tuneable clarinet barrel joint (1) for arrangement between the mouthpiece and the upper joint of a (Eb, D, C, A or Bb) clarinet, with a longitudinal axis (L) and a bore (100) which runs in the longitudinal axis (L), whereby the clarinet barrel joint (1) is comprised of an upper part (2) and a lower part (3), which are arranged for connection in the longitudinal axis (L), and provided with a set collar (4) for the connection of the upper part (2) and the lower part (3), by means of which the distance between the upper part (2) and the lower part (3) is adjustable, characterized in that the set collar (4) is connected to both the upper part (2) and the lower part (3) by means of screw threads (6, 7), whereby the said screw threads (6, 7) are pitched with opposing directions of rotation.
摘要翻译：本发明涉及一种用于配置在具有纵向轴线（L）和孔（100）的（Eb，D，C，A或Bb）单簧管的接口和上接头之间的可调单簧管筒接头（1）其中纵向轴线（L）延伸，由此单簧管筒形接头（1）由上部（2）和下部（3）组成，它们设置成在纵向轴线（L）上连接，具有用于上部（2）和下部（3）的连接的固定套环（4），借助于该上部（2）和下部（3）的上部（2）和下部（3）之间的距离是可调节的，其特征在于所述套圈（4）通过螺纹（6,7）与上部（2）和下部（3）连接，由此所述螺纹（6,7）以相对的方向的旋转。

7. 发明申请

US20110146473A1 TUNABLE CLARINET BARREL 有权
公开(公告)号：US20110146473A1
公开(公告)日：2011-06-23
申请号：US12990504
申请日：2009-04-29
申请人： Henry Paulus , Matthias Schuler
发明人： Henry Paulus , Matthias Schuler
IPC分类号： G10D7/06
CPC分类号： G10D7/066
摘要： The present invention relates to a tuneable clarinet barrel joint (1) for arrangement between the mouthpiece and the upper joint of a (Eb, D, C, A or Bb) clarinet, with a longitudinal axis (L) and a bore (100) which runs in the longitudinal axis (L), whereby the clarinet barrel joint (1) is comprised of an upper part (2) and a lower part (3), which are arranged for connection in the longitudinal axis (L), and provided with a set collar (4) for the connection of the upper part (2) and the lower part (3), by means of which the distance between the upper part (2) and the lower part (3) is adjustable, characterized in that the set collar (4) is connected to both the upper part (2) and the lower part (3) by means of screw threads (6, 7), whereby the said screw threads (6, 7) are pitched with opposing directions of rotation.
摘要翻译：本发明涉及一种用于配置在具有纵向轴线（L）和孔（100）的（Eb，D，C，A或Bb）单簧管的接口和上接头之间的可调单簧管筒接头（1）其中纵向轴线（L）延伸，由此单簧管筒形接头（1）由上部（2）和下部（3）组成，它们设置成在纵向轴线（L）上连接，具有用于上部（2）和下部（3）的连接的固定套环（4），借助于该上部（2）和下部（3）的上部（2）和下部（3）之间的距离是可调节的，其特征在于所述套圈（4）通过螺纹（6,7）与上部（2）和下部（3）连接，由此所述螺纹（6,7）以相对的方向的旋转。

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