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    • 1. 发明授权
    • Cream composition for skin care
    • 护肤霜组合物
    • US06372236B1
    • 2002-04-16
    • US09691446
    • 2000-10-18
    • Chang Seo ParkJin Wook KimJee Hean Jeong
    • Chang Seo ParkJin Wook KimJee Hean Jeong
    • A61K700
    • A61K8/68A61K8/553A61K8/63A61K8/92A61Q19/08Y10S514/844
    • Disclosed are compositions for skin care and their medicinal uses. The compositions are identical in lipid constituents and structural properties to that of human stratum corneum. They comprise the major constituents for the lipid lamellar of the stratum corneum, including ceramides, cholesterol and fatty acids, the major constituents for epidermal cell membranes, including phospholipids, and physiologically active substances, including phytosphingosine and its derivatives. Without causing side effects, the cream composition for skin care is of much better skin penetration and water-retention capacity than are conventional compositions comprised of ceramide and other components in forms different from those of human skin. In addition to providing inhibitory activity against skin microorganisms, the cream composition brings about an improvement in the wrinkle condition of the skin, so that it can be applied to cosmetics. Also, it can be used as a medicinal material for the therapeutic treatment of inflammation, such as thermic erythema caused by IR and/or UV light.
    • 公开了用于皮肤护理及其药用用途的组合物。 组合物的脂质成分和结构特性与人角质层的组成相同。 它们包括角质层的脂质层的主要成分,包括神经酰胺,胆固醇和脂肪酸,表皮细胞膜(包括磷脂)和生理活性物质(包括植物鞘氨醇及其衍生物)的主要成分。 不引起副作用的皮肤护理用霜组合物比由神经酰胺和其他与人皮肤不同形式的组分组成的常规组合物具有更好的皮肤渗透和保水能力。 除了提供对皮肤微生物的抑制活性之外,奶油组合物还能使皮肤的皱纹状况得到改善,从而可以应用于化妆品。 此外,它可以用作用于治疗炎症的药物,例如由IR和/或UV光引起的热红斑。
    • 2. 发明授权
    • Method for preparing aqueous phytosphingosine solution
    • 水溶性鞘氨醇溶液的制备方法
    • US06403111B1
    • 2002-06-11
    • US09691469
    • 2000-10-18
    • Chang Seo ParkJin Wook KimJee Hean Jeong
    • Chang Seo ParkJin Wook KimJee Hean Jeong
    • A61K3578
    • A61K8/97A61K8/68A61Q19/00Y10S514/844
    • Disclosed is a method for preparing an aqueous phytosphingosine solution containing as much as 5-10 weight % of phytosphingosine without using any solvents other than water. A high content of phytosphingosine is dissolved in water and lactic acid with the help of a willow bark extract. In addition to being clear, the aqueous phytosphingosine solution is able to recover damaged skin with activity against bacteria and inflammation. Also, when being applied for cosmetics, the aqueous phytosphingosine solution allows them to contain as much as 1-2 weight % of phytosphingosine by virtue of its high content of phytosphingosine. Further, the phytosphingosine solution is greatly improved in compatibility with cosmetic components so that it can be readily applied for aqueous cosmetics such as skin lotions, essence lotions, aqueous pack products, body essence compositions, etc., for which phytosphingosine has not yet been applied, thus far. Thus, the phytosphingosine solution of the present invention gives a great contribution to the functional improvement of aqueous cosmetics.
    • 公开了一种在不使用水以外的任何溶剂的情况下制备含有多达5-10重量%的植物鞘氨醇的水溶性植物鞘氨醇溶液的方法。 借助柳树皮提取物,将高含量的植物鞘氨醇溶于水和乳酸。 除了清楚,植物水溶液能够恢复损伤的皮肤,具有抵抗细菌和炎症的活性。 另外,当用于化妆品时,由于植物鞘氨醇含量高,植物水溶液使得它们能含有1-2重量%的植物鞘氨醇。 此外,植物鞘氨醇溶液与化妆品组分的相容性大大提高,因此其可以容易地用于尚未应用植物鞘氨醇的水性化妆品如皮肤洗剂,精华液,水性包装产品,身体精华组合物等 , 迄今。 因此,本发明的植物鞘氨醇溶液对水性化妆品的功能改善有很大的贡献。