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1. 发明申请

US20090270939A1 DEVICE AND METHOD FOR DETECTING ATRIAL FIBRILLATION 有权
标题翻译：用于检测椎间孔纤维化的装置和方法
公开(公告)号：US20090270939A1
公开(公告)日：2009-10-29
申请号：US12207388
申请日：2008-09-09
申请人： Cem Shaquer , Jong Gill , Fujian Qu
发明人： Cem Shaquer , Jong Gill , Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61B5/046
摘要： Detection of atrial fibrillation involves detecting a plurality of ventricular events and obtaining a series of probabilities of AF, each corresponding to a probability of AF for a different beat window having a plurality of ventricular events. AF onset is detected when one or each of a plurality of consecutive AF probabilities satisfies an AF trigger threshold. AF termination is detected when one or each of a plurality of consecutive AF probabilities does not satisfy the AF trigger threshold. Upon detection of AF onset, ventricular events are processed to detect for a sudden onset of irregularity of the ventricular events. AF onset is confirmed when sudden onset is detected and overturned when sudden onset is not detected.
摘要翻译：心房颤动的检测涉及检测多个心室事件并获得一系列AF概率，每个概率对应于具有多个心室事件的不同节拍窗口的AF概率。当多个连续AF概率中的一个或每个满足AF触发阈值时，检测AF起始。当多个连续AF概率中的一个或每个不满足AF触发阈值时，检测到AF终止。在检测到AF发作时，处理心室事件以检测心室事件突然发作不规则。当发现突然发作并且突然发现未被检测到翻转时，确定AF发作。

2. 发明授权

US08121675B2 Device and method for detecting atrial fibrillation 有权
标题翻译：用于检测房颤的装置和方法
公开(公告)号：US08121675B2
公开(公告)日：2012-02-21
申请号：US12207388
申请日：2008-09-09
申请人： Cem Shaquer , Jong Gill , Fujian Qu
发明人： Cem Shaquer , Jong Gill , Fujian Qu
IPC分类号： A61B5/04
CPC分类号： A61B5/046
摘要： Detection of atrial fibrillation involves detecting a plurality of ventricular events and obtaining a series of probabilities of AF, each corresponding to a probability of AF for a different beat window having a plurality of ventricular events. AF onset is detected when one or each of a plurality of consecutive AF probabilities satisfies an AF trigger threshold. AF termination is detected when one or each of a plurality of consecutive AF probabilities does not satisfy the AF trigger threshold. Upon detection of AF onset, ventricular events are processed to detect for a sudden onset of irregularity of the ventricular events. AF onset is confirmed when sudden onset is detected and overturned when sudden onset is not detected.
摘要翻译：心房颤动的检测涉及检测多个心室事件并获得一系列AF概率，每个概率对应于具有多个心室事件的不同节拍窗口的AF概率。当多个连续AF概率中的一个或每个满足AF触发阈值时，检测AF起始。当多个连续AF概率中的一个或每个不满足AF触发阈值时，检测到AF终止。在检测到AF发作时，处理心室事件以检测心室事件突然发作不规则。当发现突然发作并且突然发现未被检测到翻转时，确定AF发作。

3. 发明授权

US08989852B2 Systems and methods for use by implantable medical devices for detecting and discriminating stroke and cardiac ischemia using electrocardiac signals 有权
标题翻译：使用可植入医疗器械用于使用心电信号检测和鉴别中风和心脏缺血的系统和方法
公开(公告)号：US08989852B2
公开(公告)日：2015-03-24
申请号：US13207307
申请日：2011-08-10
申请人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh G. Farazi , Euljoon Park
发明人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh G. Farazi , Euljoon Park
IPC分类号： A61B5/0452 , A61B5/0468 , A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61N1/37 , A61B5/024 , A61B5/0295
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/0205 , A61B5/02158 , A61B5/02405 , A61B5/0295 , A61B5/0422 , A61B5/4839 , A61N1/3702
摘要： Techniques are provided for detecting and distinguishing stroke and cardiac ischemia based on electrocardiac signals. In one example, the device senses atrial and ventricular signals within the patient along a set of unipolar sensing vectors and identifies certain morphological features within the signals such as PR intervals, ST intervals, QT intervals, T-waves, etc. The device detects changes, if any, within the morphological features such as significant shifts in ST interval elevation or an inversion in T-wave shape, which are indicative of stroke or cardiac ischemia. By selectively comparing changes detected along different unipolar sensing vectors, the device distinguishes or discriminates stroke from cardiac ischemia within the patient. The discrimination may be corroborated using various physiological and hemodynamic parameters. In some examples, the device further identifies the location of the ischemia within the heart. In still other examples, the device detects cardiac ischemia occurring during stroke.
摘要翻译：提供了用于基于心电信号检测和区分中风和心脏缺血的技术。在一个示例中，该装置沿着一组单极感测向量感测患者内的心房和心室信号，并且识别信号内的某些形态特征，例如PR间隔，ST间隔，QT间隔，T波等。该装置检测变化（如果有的话）在形态学特征之中，例如ST间隔升高的显着变化或T波形的反转，其指示中风或心脏缺血。通过选择性地比较沿着不同的单极性感测向量检测的变化，该装置区分或区分患者体内的心脏缺血的中风。可以使用各种生理和血液动力学参数来确认辨别。在一些实例中，该装置还识别心脏内局部缺血的位置。在另外的例子中，该装置检测在中风期间发生的心脏缺血。

4. 发明申请

US20130041274A1 SYSTEMS AND METHODS FOR USE BY IMPLANTABLE MEDICAL DEVICES FOR DETECTING AND DISCRIMINATING STROKE AND CARDIAC ISCHEMIA USING ELECTROCARDIAC SIGNALS 有权
标题翻译：用于通过电刺激信号检测和鉴别卒中和心脏病的植入式医疗设备使用的系统和方法
公开(公告)号：US20130041274A1
公开(公告)日：2013-02-14
申请号：US13207307
申请日：2011-08-10
申请人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
发明人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/0205 , A61B5/02158 , A61B5/02405 , A61B5/0295 , A61B5/0422 , A61B5/4839 , A61N1/3702
摘要： Techniques are provided for detecting and distinguishing stroke and cardiac ischemia based on electrocardiac signals. In one example, the device senses atrial and ventricular signals within the patient along a set of unipolar sensing vectors and identifies certain morphological features within the signals such as PR intervals, ST intervals, QT intervals, T-waves, etc. The device detects changes, if any, within the morphological features such as significant shifts in ST interval elevation or an inversion in T-wave shape, which are indicative of stroke or cardiac ischemia. By selectively comparing changes detected along different unipolar sensing vectors, the device distinguishes or discriminates stroke from cardiac ischemia within the patient. The discrimination may be corroborated using various physiological and hemodynamic parameters. In some examples, the device further identifies the location of the ischemia within the heart. In still other examples, the device detects cardiac ischemia occurring during stroke.
摘要翻译：提供了用于基于心电信号检测和区分中风和心脏缺血的技术。在一个示例中，该装置沿着一组单极感测向量感测患者内的心房和心室信号，并且识别信号内的某些形态特征，例如PR间隔，ST间隔，QT间隔，T波等。该装置检测变化（如果有的话）在形态学特征之中，例如ST间期升高的显着变化或T波形的反转，其指示中风或心脏缺血。通过选择性地比较沿着不同的单极性感测向量检测的变化，该装置区分或区分患者体内的心脏缺血的中风。可以使用各种生理和血液动力学参数来确认辨别。在一些实例中，该装置还识别心脏内局部缺血的位置。在另外的例子中，该装置检测在中风期间发生的心脏缺血。

5. 发明授权

US08670820B2 Near field-based systems and methods for assessing impedance and admittance for use with an implantable medical device 有权
标题翻译：用于评估用于可植入医疗设备的阻抗和导纳的近场系统和方法
公开(公告)号：US08670820B2
公开(公告)日：2014-03-11
申请号：US12853130
申请日：2010-08-09
申请人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah , Andreas Blomqvist
发明人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah , Andreas Blomqvist
IPC分类号： A61B5/053
CPC分类号： A61B5/0538 , A61B5/02028 , A61B5/029 , A61B5/4878 , A61B5/686 , A61B7/00 , A61B2562/0219
摘要： A new model is provided for understanding and exploiting impedance or admittance values measured by implantable medical devices, such as pacemakers or cardiac resynchronization devices (CRTs.) The device measures impedance along vectors extending through tissues of the patient between various pairs of electrodes. The device then converts the vector-based impedance measurements into near-field individual electrode-based impedance values. This is accomplished, in at least some examples, by converting the vector-based impedance measurements into a set of linear equations to be solved while ignoring far-field contributions to the impedance measurements. The device solves the linear equations to determine the near-field impedance values for the individual electrodes, which are representative of the impedance of tissues in the vicinity of the electrodes. The device then performs or controls various device functions based on the near-field values, such as analyzing selected near-field values to detect heart failure or pulmonary edema.
摘要翻译：提供了一种新型号，用于了解和利用可植入医疗设备（例如起搏器或心脏再同步装置（CRT））测量的阻抗或导纳值。该装置测量沿着延伸穿过患者组织的不同对电极之间的阻力。然后，器件将基于矢量的阻抗测量值转换为近场单独的基于电极的阻抗值。这在至少一些示例中是通过将基于矢量的阻抗测量值转换成待解决的一组线性方程而实现的，同时忽略对阻抗测量的远场贡献。该装置解决了线性方程来确定各个电极的近场阻抗值，其代表电极附近的组织的阻抗。然后，设备基于近场值执行或控制各种设备功能，例如分析所选的近场值以检测心脏衰竭或肺水肿。

6. 发明授权

US08457727B2 Monitoring variation patterns in physiological parameters associated with myocardial instability 有权
标题翻译：监测与心肌不稳定相关的生理参数变化模式
公开(公告)号：US08457727B2
公开(公告)日：2013-06-04
申请号：US12340352
申请日：2008-12-19
申请人： Fujian Qu
发明人： Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61N1/365
摘要： A method of analyzing myocardial instability includes obtaining a physiological parameter representative of myocardial behavior over a set of cardiac cycles and determining reversal points in the physiological parameter over the set of cardiac cycles. The method also includes identifying myocardial instability based on the reversal points in the physiological parameter. A reversal point may correspond to a value of the physiological parameter, during a current cardiac cycle, that exceeds or is less than the values of the physiological parameter during prior and subsequent cardiac cycles. Optionally, the method includes calculating differences between values of the physiological parameter for consecutive cardiac cycles and detecting the reversal points when a current difference exceeds or is less than differences for prior and subsequent cardiac cycles.
摘要翻译：分析心肌不稳定性的方法包括获得代表一组心脏周期的心肌行为的生理参数，并且确定心脏周期集合中生理参数中的反转点。该方法还包括基于生理参数中的反转点识别心肌不稳定性。反转点可以对应于在当前心动周期期间超过或小于在先前和随后的心动周期中的生理参数的值的生理参数的值。可选地，该方法包括计算连续心脏周期的生理参数的值之间的差异，并且当电流差异超过或小于先前和随后的心动周期的差异时检测反转点。

7. 发明授权

US08401627B1 Methods and systems for monitoring heart instabilities 有权
标题翻译：监测心脏不稳定的方法和系统
公开(公告)号：US08401627B1
公开(公告)日：2013-03-19
申请号：US11848631
申请日：2007-08-31
申请人： Taraneh Ghaffari Farazi , Fujian Qu
发明人： Taraneh Ghaffari Farazi , Fujian Qu
IPC分类号： A61N1/362
CPC分类号： A61N1/3702 , A61N1/36592
摘要： Systems and method for assessing a patient's myocardial electrical stability by pacing a patient's heart using a pacing sequence that includes at least two different types of pacing pulses. The pacing rate used is preferably only slightly above the patient's intrinsic heart rate. A degree of alternans, in a signal (e.g., IEGM or ECG) that is indicative of cardiac activity in response to the pacing sequence, is determined. The degree of alternans can be determined by comparing portions of the signal that are indicative of cardiac activity in response to the first type of pacing pulses to portions of the signal that are indicative of cardiac activity in response to the second type of pacing pulses. The patient's myocardial electrical stability is assessed based on the determined degree of alternans.
摘要翻译：通过使用包括至少两种不同类型的起搏脉冲的起搏序列来对患者的心脏进行起搏来评估患者的心肌电稳定性的系统和方法。起搏率优选仅略高于患者的内在心率。确定在响应于起搏序列指示心脏活动的信号（例如，IEGM或ECG）中的交替量的程度。可以通过将响应于第一类型的起搏脉冲的指示心脏活动的部分的信号的部分与响应于第二类型的起搏脉冲的指示心脏活动的信号的部分进行比较来确定交替的程度。基于确定的交替量程度评估患者的心肌电稳定性。

8. 发明授权

US08255043B2 Methods and systems for analyzing T-wave alternans 有权
标题翻译：分析T波交替的方法和系统
公开(公告)号：US08255043B2
公开(公告)日：2012-08-28
申请号：US12456628
申请日：2009-06-18
申请人： Fujian Qu , Riddhi Shah
发明人： Fujian Qu , Riddhi Shah
IPC分类号： A61B5/0452
CPC分类号： A61B5/0472 , A61B5/0452 , A61B5/0456 , A61N1/37
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therein, that can detect T-wave alternans and analyze the detected alternans to provide information regarding cardiac instabilities and predict impending arrhythmias.
摘要翻译：本发明的实施例涉及可植入系统及其中使用的方法，其可以检测T波交替并且分析检测到的交替物以提供关于心脏不稳定性的信息并预测即将发生的心律失常。

9. 发明授权

US08135468B2 Systems and methods for estimating left atrial pressure (LAP) in patients with acute mitral valve regurgitation for use by an implantable medical device 有权
标题翻译：用于估计急性二尖瓣反流患者的左心房压力（LAP）的系统和方法，用于可植入医疗器械
公开(公告)号：US08135468B2
公开(公告)日：2012-03-13
申请号：US12853157
申请日：2010-08-09
申请人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah
发明人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61B5/0215 , A61B5/02158 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/37235 , A61N1/37258 , A61N1/3962
摘要： Various techniques are provided for use with an implantable medical device for estimating cardiac pressure within a patient based on admittance (or related electrical values such as impedance or conductance) that takes into account the presence of acute MR within the patient. Briefly, the device detects an indication of acute MR, if occurring within the patient. The device also applies electrical fields to tissues of the patient and measures electrical parameters influenced by the electrical field, such as admittance, impedance or conductance. The device then estimates cardiac pressure within the patient based on the measured electrical parameter and the indication of acute MR. In one example, different linear correlation functions are used to convert admittance values to left atrial pressure (LAP) values depending upon the presence or absence of acute MR within the patient.
摘要翻译：提供了与植入式医疗装置一起使用的各种技术，其基于考虑到患者内急性MR的存在的导纳（或相关的电气值，例如阻抗或电导）来估计患者内的心脏压力。简而言之，如果在患者体内发生，则该装置检测到急性MR的指示。该装置还对患者的组织施加电场并测量受电场影响的电参数，例如导纳，阻抗或电导。然后，该装置基于测量的电参数和急性MR的指示来估计患者内的心脏压力。在一个示例中，不同的线性相关函数用于根据患者内存在或不存在急性MR将导纳值转换为左心房压（LAP）值。

10. 发明申请

US20120035681A1 SYSTEMS AND METHODS FOR ESTIMATING LEFT ATRIAL PRESSURE (LAP) IN PATIENTS WITH ACUTE MITRAL VALVE REGURGITATION FOR USE BY AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于通过可植入医疗器械使用急性麻药阀注射患者的左心室压力（LAP）的系统和方法
公开(公告)号：US20120035681A1
公开(公告)日：2012-02-09
申请号：US12853157
申请日：2010-08-09
申请人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah
发明人： Dan E. Gutfinger , Fujian Qu , Alex Soriano , Ryan Rooke , Yelena Nabutovsky , Riddhi Shah
IPC分类号： A61N1/36
CPC分类号： A61N1/36585 , A61B5/0215 , A61B5/02158 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/37235 , A61N1/37258 , A61N1/3962
摘要： Various techniques are provided for use with an implantable medical device for estimating cardiac pressure within a patient based on admittance (or related electrical values such as impedance or conductance) that takes into account the presence of acute MR within the patient. Briefly, the device detects an indication of acute MR, if occurring within the patient. The device also applies electrical fields to tissues of the patient and measures electrical parameters influenced by the electrical field, such as admittance, impedance or conductance. The device then estimates cardiac pressure within the patient based on the measured electrical parameter and the indication of acute MR. In one example, different linear correlation functions are used to convert admittance values to left atrial pressure (LAP) values depending upon the presence or absence of acute MR within the patient.
摘要翻译：提供了与植入式医疗装置一起使用的各种技术，其基于考虑到患者内急性MR的存在的导纳（或相关的电气值，例如阻抗或电导）来估计患者内的心脏压力。简而言之，如果在患者体内发生，则该装置检测到急性MR的指示。该装置还对患者的组织施加电场并测量受电场影响的电参数，例如导纳，阻抗或电导。然后，该装置基于测量的电参数和急性MR的指示来估计患者内的心脏压力。在一个示例中，不同的线性相关函数用于根据患者内存在或不存在急性MR将导纳值转换为左心房压（LAP）值。

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