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1. 发明申请

US20050112349A1 Polymeric nanofibers for tissue engineering and drug delivery 失效
标题翻译：用于组织工程和药物递送的聚合物纳米纤维
公开(公告)号：US20050112349A1
公开(公告)日：2005-05-26
申请号：US10938493
申请日：2004-09-10
申请人： Cato Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry Allcock , Jared Bender , Paul Brown , Yaser Greish
发明人： Cato Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry Allcock , Jared Bender , Paul Brown , Yaser Greish
IPC分类号： A61L27/18 , A61L27/50 , A61L31/10 , D04H3/00
CPC分类号： A61L27/50 , A61L27/18 , A61L31/10 , Y10T428/1369 , Y10T428/249924 , Y10T428/2913 , C08L85/02
摘要： Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.
摘要翻译：已经开发了可用于各种医疗和其他应用的聚合物纳米纤维，例如过滤装置，医疗假体，用于组织工程的支架，伤口敷料，受控药物递送系统，化妆品皮肤面罩和防护服。这些可以由不可降解或可降解的各种不同聚合物中的任何一种形成。在以下实施例中证明的优选实施方案中，纳米纤维由可生物降解和不可生物降解的聚磷腈，它们与其它聚磷腈或与有机，无机/有机金属聚合物的共混物以及具有纳米尺寸颗粒如羟基磷灰石的聚磷腈的复合纳米纤维形成。

2. 发明申请

US20060263279A1 Adjustable path sublimator system and related method of use 审中-公开
标题翻译：可调式升华器系统及相关使用方法
公开(公告)号：US20060263279A1
公开(公告)日：2006-11-23
申请号：US11416504
申请日：2006-04-27
申请人： Cato Laurencin , Swaminathan Sethuraman , Subhabrata Bhattacharyya , William Shoup
发明人： Cato Laurencin , Swaminathan Sethuraman , Subhabrata Bhattacharyya , William Shoup
IPC分类号： B01D7/00
CPC分类号： B01D7/00 , B01D7/02
摘要： A sublimator device is designed where the distance between the sublimation surface and the bottom of the device to be adjusted depending on the amount of substance in the bottom of the device and the rate of sublimation without stopping the process. The device has a threaded connector on the top that allows the condenser to be advanced or receded without stopping the sublimation process. Different embodiments of the sublimator device are disclosed and indications for the use of these devices during the sublimation process are discussed.
摘要翻译：设计升华装置，其中升华表面和装置的底部之间的距离将根据装置底部物质的量和升华速率而调整，而不停止该过程。该设备在顶部具有螺纹连接器，允许冷凝器前进或后退，而不停止升华过程。公开了升华装置的不同实施例，并且讨论了在升华过程中使用这些装置的指示。

3. 发明授权

US6077916A Biodegradable mixtures of polyphoshazene and other polymers 失效
标题翻译：可聚降解的聚苯乙烯和其他聚合物的混合物
公开(公告)号：US6077916A
公开(公告)日：2000-06-20
申请号：US90374
申请日：1998-06-04
申请人： Cato Laurencin , Harry Allcock , Sobrasua Ibim , Archel Ambrosio , Michael Kwon
发明人： Cato Laurencin , Harry Allcock , Sobrasua Ibim , Archel Ambrosio , Michael Kwon
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30 , A61K9/20 , A61L27/26 , C08G79/02 , C08L85/02 , C08F283/00
CPC分类号： C08L85/02 , A61L27/26 , C08G79/025 , A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61K9/2031 , A61K9/204 , Y10S525/903 , Y10S525/937 , Y10S525/938
摘要： Biodegradable polymeric compositions are provided, wherein biodegradable polyphosphazenes are combined with at least one other polymer, either in the form of a blend, a semi-interpenetrating network (semi-IPN), or an interpenetrating network IPN. The side groups and composition of the polyphosphazenes are used to determine the properties of the compositions, for example, the rate and extent of degradation, and mechanical properties. These are useful in biomedical applications, including controlled drug delivery and tissue regeneration, and environmental applications. In the most preferred embodiment, as demonstrated by the examples, the polyphosphazenes contain hydrophobic side groups, such as p-methylphenoxy and other aromatic groups, and groups which impart hydrolytic instability, such as amino acid alkyl esters, and degrade by surface erosion. A preferred example is ethyl glycinato-substituted polyphosphazene (PPHOS) with p-methylphenoxy as co-substituent. These are blended with other polymers, such as PLGA, which have desirable mechanical properties but which degrade by bulk erosion, so that the blend degrades by surface erosion. For the biomedical applications, FDA approved polymers, such as polymers of lactic and glycolic acids and their copolymers, are preferred. Methods for making these compositions also are provided.
摘要翻译：提供了可生物降解的聚合物组合物，其中可生物降解的聚磷腈与至少一种其它聚合物（混合物，半互穿网络（半IPN）或互穿网络IPN）的形式组合。聚磷腈的侧基和组成用于确定组合物的性质，例如降解的速率和程度以及机械性能。这些可用于生物医学应用，包括受控药物递送和组织再生以及环境应用。在最优选的实施方案中，如实施例所证明的，聚磷腈含有疏水侧基如对甲基苯氧基和其它芳族基团，以及赋予水解不稳定性的基团，例如氨基酸烷基酯，并通过表面侵蚀降解。优选的实例是具有对甲基苯氧基作为共取代基的甘氨酰胺取代的聚磷腈（PPHOS）。这些与其它聚合物（例如PLGA）共混，其具有期望的机械性能但通过体积腐蚀而降解，使得共混物由于表面侵蚀而降解。对于生物医学应用，FDA批准的聚合物，如乳酸和乙醇酸的聚合物及其共聚物是优选的。还提供了制备这些组合物的方法。

4. 发明申请

US20050100581A1 Polymeric bioresorbable composites containing an amorphous calcium phosphate polymer ceramic for bone repair and replacement 失效
标题翻译：含有无定形磷酸钙聚合物陶瓷用于骨修复和置换的聚合物生物可再吸收复合材料
公开(公告)号：US20050100581A1
公开(公告)日：2005-05-12
申请号：US10469617
申请日：2002-03-14
申请人： Cato Laurencin , Archel Ambrosio , Janmeet Sahota
发明人： Cato Laurencin , Archel Ambrosio , Janmeet Sahota
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/46 , A61L27/50
CPC分类号： A61L27/50 , A61F2/28 , A61F2002/30062 , A61F2002/30968 , A61F2210/0004 , A61F2310/00293 , A61L27/46 , Y10S977/70
摘要： A bioresorbable composite of a non-crystalline calcium phosphate ceramic synthesized within an encapsulating microspheres of bioresorbable polymeric material for use in bone repair and replacement is provided. Also provides are methods for producing these composites as well as porous, 3-dimensional scaffold produced by sintering together microspheres of this bioresorbable composite.
摘要翻译：提供了在用于骨修复和置换的生物再吸收聚合物材料的包封微球体内合成的非结晶磷酸钙陶瓷的生物可吸收复合材料。还提供了用于生产这些复合材料的方法以及通过将该生物可吸收复合材料的微球烧结在一起而制备的多孔的3维支架。

5. 发明申请

US20070250165A1 Muscle-Polymer Constructs for Bone Tissue Engineering 审中-公开
标题翻译：用于骨组织工程的肌肉聚合物构建体
公开(公告)号：US20070250165A1
公开(公告)日：2007-10-25
申请号：US11766166
申请日：2007-06-21
申请人： Cato Laurencin , Helen Lu , Michelle Kofron , Saadiq El-Amin , Mohamed Attawia
发明人： Cato Laurencin , Helen Lu , Michelle Kofron , Saadiq El-Amin , Mohamed Attawia
IPC分类号： A61F2/28
CPC分类号： A61L27/3847 , A61F2002/2817 , A61F2002/2835 , A61K35/12 , A61L27/227 , A61L27/3608 , A61L27/365 , A61L2430/02 , C12N5/0068 , C12N5/0654 , C12N2501/155 , C12N2506/1323 , C12N2533/40
摘要： Bone grafting materials containing a polymer scaffold loaded with bone morphogenetic proteins and populated with muscle cells induced by the bone morphogenetic proteins to exhibit an osteoblastic phenotype and to synthesize bone tissue are provided. Also provided are methods for using these polymer scaffolds in bone grafting procedures.
摘要翻译：提供了含有装载有骨形态发生蛋白的聚合物支架和由骨形态发生蛋白诱导的肌肉细胞展示成骨细胞表型并合成骨组织的骨移植材料。还提供了在骨移植过程中使用这些聚合物支架的方法。

6. 发明申请

US20070231900A1 Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof 有权
标题翻译：生物相容性，可生物降解的聚合物为基础，比组织工程的水支架轻于或轻度，以及其制备和使用方法
公开(公告)号：US20070231900A1
公开(公告)日：2007-10-04
申请号：US11755254
申请日：2007-05-30
申请人： Cato Laurencin , Solomon Pollack , Elliot Levine , Edward Botchwey , Helen Lu , Mohammed Khan
发明人： Cato Laurencin , Solomon Pollack , Elliot Levine , Edward Botchwey , Helen Lu , Mohammed Khan
IPC分类号： C12N5/00
CPC分类号： A61L27/3847 , A61K35/12 , A61L27/3895 , C12N5/0075 , C12N2533/40
摘要： Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.
摘要翻译：提供用于组织工程的支架，其由生物相容性，可生物降解的聚合物为基础，比水微载体轻或轻，并且设计用于在旋转生物反应器中体外细胞培养。还提供了用于制备和使用这些支架作为组织工程装置的方法。

7. 发明授权

US5866155A Methods for using microsphere polymers in bone replacement matrices and composition produced thereby 失效
标题翻译：在骨置换基质中使用微球聚合物的方法和由此制备的组合物
公开(公告)号：US5866155A
公开(公告)日：1999-02-02
申请号：US749772
申请日：1996-11-20
申请人： Cato Laurencin , Mark Borden
发明人： Cato Laurencin , Mark Borden
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/46 , A61L27/56 , A61K9/50 , B01J13/02 , B32B5/16
CPC分类号： A61L27/46 , A61F2/28 , A61L27/56 , A61F2/30767 , A61F2/3094 , A61F2002/2835 , A61F2002/30062 , A61F2002/30957 , A61F2002/30968 , A61F2210/0004 , A61F2310/00796 , A61L2430/02 , Y10T428/2985
摘要： Methods for producing matrices useful in bone graft onlay and inlay procedures are provided. Compositions prepared by these methods are also provided.
摘要翻译：提供了可用于骨移植物镶嵌和镶嵌过程的基质的制备方法。还提供了通过这些方法制备的组合物。

8. 发明申请

US20070233242A1 Ligament and Tendon Replacement Constructs and Methods for Production and Use Thereof 有权
标题翻译：韧带和肌腱替代构造及其生产和使用方法
公开(公告)号：US20070233242A1
公开(公告)日：2007-10-04
申请号：US11753889
申请日：2007-05-25
申请人： Cato Laurencin , Frank Ko , James Cooper , Helen Lu , Mohammed Attawia
发明人： Cato Laurencin , Frank Ko , James Cooper , Helen Lu , Mohammed Attawia
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/38 , A61F2/40 , A61F2210/0004 , A61F2230/0006 , A61F2230/0019 , A61L27/18 , A61L27/56 , A61L27/58 , A61L2430/10
摘要： Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.
摘要翻译：提供了可降解的，基于聚合物纤维的三维编织支架，用作韧带和腱修复，重建和替换中的接枝材料。还提供了制备这些支架的方法。

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