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1. 发明授权

US07131957B2 Safety device for a blood treatment machine and a method of increasing the safety of a blood treatment machine 有权
标题翻译：用于血液处理机的安全装置和增加血液处理机的安全性的方法
公开(公告)号：US07131957B2
公开(公告)日：2006-11-07
申请号：US10860196
申请日：2004-06-03
申请人： Carsten Müller , Christoph Bardorz
发明人： Carsten Müller , Christoph Bardorz
IPC分类号： A61M37/00 , A61M1/14 , C02F1/44 , A61M1/34 , A61M1/10
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/3403 , A61M2205/18 , A61M2205/3331 , A61M2205/50 , A61M2205/702 , A61M2205/705 , A61M2205/707
摘要： A device and method for increasing the safety of an extracorporeal blood treatment machine are based on monitoring transmembrane pressure. The transmembrane pressure measured by a measuring device during the treatment is compared with an upper limit transmembrane pressure L1 and a lower limit transmembrane pressure L2 which define a monitoring window. If the transmembrane pressure is outside this monitoring window, an alarm is triggered by an alarm device. The monitoring window is shifted as a function of the ultrafiltration rate. To determine the window limits, the transmembrane pressure is established after a change in the ultrafiltration rate is calculated. Thereafter, the window limits are determined on the basis of the expected transmembrane pressure.
摘要翻译：用于提高体外血液处理机的安全性的装置和方法基于监测跨膜压力。将在处理期间由测量装置测量的跨膜压力与限定监测窗口的上限跨膜压力L 1和下限跨膜压力L 2 2进行比较。如果跨膜压力超出该监控窗口，报警器将触发报警。监控窗口作为超滤速率的函数移动。为了确定窗口限制，在计算超滤速率的变化之后建立跨膜压力。此后，根据预期的跨膜压力确定窗口限制。

2. 发明授权

US06767333B1 Safety device for a blood treatment machine and a method of increasing the safety of a blood treatment machine 有权
公开(公告)号：US06767333B1
公开(公告)日：2004-07-27
申请号：US09649213
申请日：2000-08-28
申请人： Carsten Müller , Christoph Bardorz
发明人： Carsten Müller , Christoph Bardorz
IPC分类号： A61M3700
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/3403 , A61M2205/18 , A61M2205/3331 , A61M2205/50 , A61M2205/702 , A61M2205/705 , A61M2205/707
摘要： A device and method for increasing the safety of an extracorporeal blood treatment machine are based on monitoring transmembrane pressure. The transmembrane pressure measured by a measuring device during the treatment is compared with an upper limit transmembrane pressure L1 and a lower limit transmembrane pressure L2 which define a monitoring window. If the transmembrane pressure is outside this monitoring window, an alarm is triggered by an alarm device. The monitoring window is shifted as a function of the ultrafiltration rate. To determine the window limits, the transmembrane pressure is established after a change in the ultrafiltration rate is calculated. Thereafter, the window limits are determined on the basis of the expected transmembrane pressure.

3. 发明授权

US06860866B1 Method of determining the efficiency of a dialyzer of a dialysis machine and a dialysis machine for carrying out this method 有权
标题翻译：确定透析机和透析机的透析器效率的方法
公开(公告)号：US06860866B1
公开(公告)日：2005-03-01
申请号：US09599334
申请日：2000-06-22
申请人： Thomas Graf , Christoph Bardorz , Malte Gross , Rainer Goldau
发明人： Thomas Graf , Christoph Bardorz , Malte Gross , Rainer Goldau
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , B01D61/28 , B01D61/34 , A61M37/00 , A61B5/00 , B01D35/00 , B01D63/00 , C02F1/44
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/50
摘要： A method and a device for determining the efficiency of a dialyzer of a dialysis machine during a dialysis treatment wherein the dialyzer is divided by a semipermeable membrane into a blood chamber and a dialysis fluid chamber and wherein the blood flows at a predetermined flow rate through the blood chamber and dialysis fluid flows at a predetermined flow rate through the dialysis fluid chamber. In use, the dialysance or clearance for a predetermined dialysis fluid flow rate and/or blood flow rate is measured, and then the dialysance or clearance for any dialysis fluid flow rate and blood flow rate is calculated.
摘要翻译：一种用于在透析治疗期间确定透析机的透析器的效率的方法和装置，其中透析器被半透膜分成血液室和透析液室，并且其中血液以预定的流速通过血液室和透析液以预定的流速流过透析液室。在使用中，测量预定透析液流速和/或血流速度的透析或间隙，然后计算任何透析流体流速和血流速度的透析或间隙。

4. 发明申请

US20130144139A1 METHOD AND DEVICE FOR DETERMINING A BLOOD CONSTITUENT 有权
标题翻译：用于确定血液组成的方法和装置
公开(公告)号：US20130144139A1
公开(公告)日：2013-06-06
申请号：US13685198
申请日：2012-11-26
申请人： Wei Zhang , Christoph Bardorz , Carsten Mueller , Elke Schulte
发明人： Wei Zhang , Christoph Bardorz , Carsten Mueller , Elke Schulte
IPC分类号： A61B5/145
CPC分类号： A61B5/14525 , A61B5/14557 , A61M1/3609 , A61M2205/3313 , G01N21/53 , G01N21/85
摘要： A method and device for determining the concentration of blood constituents, in particular haemoglobin, in a hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, and an extracorporeal blood treatment apparatus with a device for determining the concentration of a blood constituent, are based on the correction of the influence of the blood flow rate of the blood flowing through the hose line on the determination of the concentration of the blood constituent. The device comprises a computing and evaluation unit configured such that a correction factor is ascertained for the influence of the blood flow rate on the determination of the concentration of the blood constituent. The concentration of the blood constituent is then determined based on a relationship describing the dependence of the concentration of the blood constituent on the intensity of the decoupled electromagnetic radiation, taking account of the correction factor.
摘要翻译：一种用于确定体外血液处理装置的体外血液回路的软管管线中的血液成分浓度特别是血红蛋白的浓度的方法和装置，以及具有用于测定血液成分浓度的装置的体外血液处理装置，基于通过软管线流动的血液的血流速度对血液成分浓度的确定的影响的校正。该装置包括计算和评估单元，其被配置为使得针对血液流量对血液成分浓度的确定的影响确定校正因子。然后考虑校正因子，基于描述血液成分的浓度对解耦电磁辐射的强度的依赖性的关系来确定血液成分的浓度。

5. 发明申请

US20130033697A1 DEVICE FOR DETERMINING A CONCENTRATION OF A CONSTITUENT OF BLOOD IN A HOSE LINE 有权
标题翻译：用于确定软管线中血液浓度浓度的装置
公开(公告)号：US20130033697A1
公开(公告)日：2013-02-07
申请号：US13554145
申请日：2012-07-20
申请人： Wei Zhang , Elke Schulte , Martin Kaiser , Carsten Mueller , Tom Klein , Stefan Zerle , Christoph Bardorz , Stefan Stuehler
发明人： Wei Zhang , Elke Schulte , Martin Kaiser , Carsten Mueller , Tom Klein , Stefan Zerle , Christoph Bardorz , Stefan Stuehler
IPC分类号： G01N33/49 , G01N27/00
CPC分类号： G01N33/49 , A61B5/14557 , A61M1/367 , A61M2205/14 , A61M2205/3306 , A61M2230/20 , G01N21/05 , G01N21/31 , G01N2021/0378 , G01N2021/3144
摘要： A device for determining the concentration of a constituent of blood in a hose line, in particular in the hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, includes a clamping unit having an actuation mechanism configured to apply a clamping force such that first and second receiving elements are moved towards one another from a first position releasing the hose line into a second position clamping the hose line, in which the drive of the actuation mechanism takes place with an electric motor, and a monitoring unit configured to detect a hose line inserted into the receiving elements. A method for detecting a hose line in a clamping unit of a device for determining the concentration of a blood constituent in the hose line is also described. Automation of the measurement of the blood parameters is thus possible.
摘要翻译：一种用于确定软管管线中的血液成分浓度的装置，特别是在体外血液处理设备的体外血液回路的软管管线中的装置，包括具有致动机构的夹紧单元，该致动机构构造成施加夹紧力，使得第一和第二接收元件从第一位置朝向彼此移动，从而将软管线释放到夹紧软管线的第二位置，在该第二位置中，使用电动机进行致动机构的驱动;以及监视单元，软管线插入接收元件。还描述了用于检测用于确定软管管线中的血液成分浓度的装置的夹持单元中的软管线的方法。因此血液参数测量的自动化是可能的。

6. 发明授权

US08858486B2 Method and arrangement for determining the recirculation in a fistula or the cardiopulmonary recirculation, and a blood treatment device comprising a device for determining the fistula recirculation or the cardiopulmonary recirculation part 有权
标题翻译：用于确定瘘管或心肺再循环中的再循环的方法和装置，以及包括用于确定瘘再循环或心肺再循环部分的装置的血液处理装置
公开(公告)号：US08858486B2
公开(公告)日：2014-10-14
申请号：US12744281
申请日：2008-11-22
申请人： Wei Zhang , Elke Schulte , Christoph Bardorz
发明人： Wei Zhang , Elke Schulte , Christoph Bardorz
IPC分类号： A61M37/00 , A61M1/36 , A61M1/16
CPC分类号： A61M1/16 , A61M1/1617 , A61M1/3658 , A61M2205/13
摘要： A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.
摘要翻译：公开了一种用于在体外血液处理期间确定瘘管和/或心肺再循环部分中的再循环的方法，其中待治疗的血液通过半透膜分离的透析器的血室在体外血液回路中流动进入血液室和液体室，并且透析液体在透析液体路径中流过透析器的透析液体室。还公开了一种用于确定瘘管和/或心肺再循环部分中的再循环的装置，以及包括这种装置的血液处理装置。该方法和装置基于以下事实：对于彼此不同的两个血液流速，确定瘘再循环和心肺再循环部分的总和，即总再循环。然后从两次血流速率的再循环中确定瘘再循环和/或心肺再循环部分。

7. 发明授权

US08792089B2 Device for determining a concentration of a constituent of blood in a hose line 有权
标题翻译：用于确定软管管线中血液成分浓度的装置
公开(公告)号：US08792089B2
公开(公告)日：2014-07-29
申请号：US13554145
申请日：2012-07-20
申请人： Wei Zhang , Elke Schulte , Martin Kaiser , Carsten Mueller , Tom Klein , Stefan Zerle , Christoph Bardorz , Stefan Stuehler
发明人： Wei Zhang , Elke Schulte , Martin Kaiser , Carsten Mueller , Tom Klein , Stefan Zerle , Christoph Bardorz , Stefan Stuehler
IPC分类号： G01N33/48
CPC分类号： G01N33/49 , A61B5/14557 , A61M1/367 , A61M2205/14 , A61M2205/3306 , A61M2230/20 , G01N21/05 , G01N21/31 , G01N2021/0378 , G01N2021/3144
摘要： A device for determining the concentration of a constituent of blood in a hose line, in particular in the hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, includes a clamping unit having an actuation mechanism configured to apply a clamping force such that first and second receiving elements are moved towards one another from a first position releasing the hose line into a second position clamping the hose line, in which the drive of the actuation mechanism takes place with an electric motor, and a monitoring unit configured to detect a hose line inserted into the receiving elements. A method for detecting a hose line in a clamping unit of a device for determining the concentration of a blood constituent in the hose line is also described. Automation of the measurement of the blood parameters is thus possible.
摘要翻译：一种用于确定软管管线中的血液成分浓度的装置，特别是在体外血液处理设备的体外血液回路的软管管线中的装置，包括具有致动机构的夹紧单元，该致动机构构造成施加夹紧力，使得第一和第二接收元件从第一位置朝向彼此移动，从而将软管线释放到夹紧软管线的第二位置，其中致动机构的驱动通过电动机进行，以及监视单元，其被配置为检测软管线插入接收元件。还描述了用于检测用于确定软管管线中的血液成分浓度的装置的夹持单元中的软管线的方法。因此血液参数测量的自动化是可能的。

8. 发明申请

US20110004141A1 METHOD AND ARRANGEMENT FOR DETERMINING THE RECIRCULATION IN A FISTULA OR THE CARDIOPULMONARY RECIRCULATION, AND A BLOOD TREATMENT DEVICE COMPRISING A DEVICE FOR DETERMINING THE FISTULA RECIRCULATION OR THE CARDIOPULMONARY RECIRCULATION PART 有权
标题翻译：用于确定模型或心脏重建中的再循环的方法和装置，以及包含用于确定模块再循环或心脏重建部分的装置的血液处理装置
公开(公告)号：US20110004141A1
公开(公告)日：2011-01-06
申请号：US12744281
申请日：2007-11-22
申请人： Wei Zhang , Elke Schulte , Christoph Bardorz
发明人： Wei Zhang , Elke Schulte , Christoph Bardorz
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/16 , A61M1/1617 , A61M1/3658 , A61M2205/13
摘要： A method for determining the recirculation in a fistula and/or the cardiopulmonary recirculation part during an extracorporeal blood treatment is disclosed, where the blood to be treated flows in an extracorporeal blood circuit through a blood chamber of a dialyzer split by a semi-permeable membrane into the blood chamber and a liquid chamber, and dialysis liquid flows in a dialysis liquid path through the dialysis liquid chamber of the dialyzer. A device for determining the recirculation in a fistula and/or the cardio-pulmonary recirculation part, and a blood treatment device including such a device are also disclosed. The method and device are based on the fact that the sum of the fistula recirculation and the cardiopulmonary recirculation part, i.e. the total recirculation, is determined for two blood flow rates which differ from each other. The fistula recirculation and/or the cardiopulmonary recirculation part are then determined from the recirculation for the two blood flow rates.
摘要翻译：公开了一种用于在体外血液处理期间确定瘘管和/或心肺再循环部分中的再循环的方法，其中待治疗的血液通过半透膜分离的透析器的血室在体外血液回路中流动进入血液室和液体室，并且透析液体在透析液体路径中流过透析器的透析液体室。还公开了一种用于确定瘘管和/或心肺再循环部分中的再循环的装置，以及包括这种装置的血液处理装置。该方法和装置基于以下事实：对于彼此不同的两个血液流速，确定瘘再循环和心肺再循环部分的总和，即总再循环。然后从两次血流速率的再循环中确定瘘再循环和/或心肺再循环部分。

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