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1. 发明申请

US20160040124A1 ADAPTED LEPIDOPTERAN INSECT CELLS FOR THE PRODUCTION OF RECOMBINANT PROTEINS 有权
标题翻译：适应的LEPIDOPTERAN INSEC细胞用于生产重组蛋白
公开(公告)号：US20160040124A1
公开(公告)日：2016-02-11
申请号：US14775154
申请日：2014-03-13
申请人： Carrie L. BALLIET , James M. WAGNER , Shyamsundar SUBRAMANIAN , David PAJEROWSKI , Danilo CASIMIRO , Jessica FLYNN , Jennifer GALLI , Patrick MCHUGH , Dawn HALL , Christopher DANIELS , Jennifer GIRARD , MERCK SHARP & DOHME CORP.
发明人： James M. Wagner , Shyamsundar Subramanian , David Pajerowski , Danilo Casimiro , John Balliet (DECEASED) , Jessica Flynn , Jennifer Galli , Patrick McHugh , Dawn Hall , Christopher Daniels , Jennifer Girard
IPC分类号： C12N5/07 , C12P21/00 , C07K14/005 , C12N7/00
CPC分类号： C12N5/0601 , C07K14/005 , C12N7/00 , C12N2500/60 , C12N2511/00 , C12N2770/36151 , C12P21/00
摘要： The present invention relates to the use of increased culture pH, relative to standard insect cell culture conditions, during baculovirus infection of lepidopteran insect cells to enable production of recombinant chikungunya (CHIKV) virus like particles (VLPs). The invention further relates to adapted insect cell lines derived from insect cells such as Sf21, which can grow robustly at elevated culture pH, the use of said cell lines to recombinantly produce pH sensitive proteins in the correct conformation and increase expression of recombinant proteins relative to standard insect cell lines. In some embodiments of the invention, the cells are useful for recombinant production of CHIKV VLPs. The invention also relates to a method for the production of a pH-adapted lepidopteran insect cell line. In some embodiments of said method, the cell line is produced and/or maintained in reduced phosphate serum-free insect cell media.
摘要翻译：本发明涉及在鳞翅目昆虫细胞杆状病毒感染期间相对于标准昆虫细胞培养条件增加培养物pH的用途，以使得能够生产重组基孔肯雅（CHIKV）病毒样颗粒（VLP）。本发明还涉及衍生自昆虫细胞如Sf21的适应性昆虫细胞系，其可以在升高的培养pH下强壮生长，使用所述细胞系以正确构象重组产生pH敏感蛋白并增加重组蛋白相对于标准昆虫细胞系。在本发明的一些实施方案中，所述细胞可用于重组生产CHIKV VLP。本发明还涉及一种用于生产pH适应的鳞翅目昆虫细胞系的方法。在所述方法的一些实施方案中，产生和/或维持细胞系在减少的无磷酸血清无血清昆虫细胞培养基中。

2. 发明申请

US20180308172A1 COMPUTERIZED SYSTEM FOR LARGE-SCALE INVESTMENT CLUB, QUALIFYING FOR REGULATORY EXEMPTION 审中-公开
公开(公告)号：US20180308172A1
公开(公告)日：2018-10-25
申请号：US15494756
申请日：2017-04-24
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： G06Q40/06 , G06Q40/00
CPC分类号： G06Q40/06 , G06Q40/10
摘要： A system to manage a large-scale investment club with at least 1,000 members includes a module to receive investment actions from members; a module to make group investment decisions based on member voting; a module to track and store investment value of the investment club; a module to penalize members who are passive in managing club investments; and an interface for information retrieval, using a computing device, to display member benefits in the investment club.

3. 发明申请

US20080075118A1 Methods and apparatuses for managing resources within a virtual room 有权
标题翻译：用于管理虚拟房间内的资源的方法和装置
公开(公告)号：US20080075118A1
公开(公告)日：2008-03-27
申请号：US11549562
申请日：2006-10-13
申请人： David Knight , Christopher Daniels , Steffen Matt
发明人： David Knight , Christopher Daniels , Steffen Matt
IPC分类号： H04J3/24
CPC分类号： H04L12/1822 , H04L51/04
摘要： In one embodiment, the methods and apparatuses display a list configured to represent a plurality of virtual rooms; identify a selected participant device associated with a selected virtual room from the plurality of virtual rooms wherein the selected participant device is a member of the selected virtual room; selectively display content associated with the selected virtual room to the selected participant device; and notify the selected participant device of a change to the content associated with the selected virtual room.
摘要翻译：在一个实施例中，方法和装置显示配置为表示多个虚拟房间的列表; 从所述多个虚拟房间中识别与所选择的虚拟房间相关联的所选参与者设备，其中所选择的参与者设备是所选虚拟房间的成员; 选择性地将与所选虚拟房间相关联的内容显示给所选择的参与者设备并通知所选择的参与者设备对与所选虚拟房间相关联的内容的改变。

4. 发明申请

US20160223426A1 APPARATUS AND METHOD FOR QUANTIFYING FLUID LOSS IN A CLOSED SYSTEM 有权
标题翻译：在封闭系统中定量流体损失的装置和方法
公开(公告)号：US20160223426A1
公开(公告)日：2016-08-04
申请号：US15013212
申请日：2016-02-02
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： G01M3/28
CPC分类号： G01M3/2853
摘要： In various embodiments, the present invention provides an improved apparatus and method for quantification of fluid loss from a nominally closed system using a pressure decay with mass point leak rate analysis methodology, which avoids the need for repetitive testing due to test configuration incompatibilities and allows for real time analysis and test control based upon desired results. The novel apparatus and methods of the present invention utilize a control system to maintain a desired pressure differential across the test article throughout the test by automatically raising or lowering the downstream pressure as the fluid leaks through the test article. In various embodiments, the apparatus and method of the present invention improves the efficiency of existing test methods by shortening otherwise long test durations, right-sizing the amount of data collected, providing quantifiable and controllable measurement uncertainty, reducing statistical variance, and eliminating post-process data analysis.
摘要翻译：在各种实施例中，本发明提供了一种改进的装置和方法，用于使用具有质点泄漏率分析方法的压力衰减从标称闭合系统定量流体损失，其避免了由于测试配置不兼容性而需要重复测试，并允许基于所需结果的实时分析和测试控制。本发明的新型设备和方法利用一种控制系统，在整个测试过程中，通过在流体通过测试物品泄漏时自动升高或降低下游压力，在整个测试物品上保持期望的压力差。在各种实施例中，本发明的装置和方法通过缩短长时间的测试持续时间来缩短现有测试方法的效率，对收集的数据量进行调整，提供量化和可控测量不确定性，减少统计学差异，过程数据分析。

5. 发明授权

US08645463B2 Methods and apparatuses for managing resources within a virtual room 有权
标题翻译：用于管理虚拟房间内的资源的方法和装置
公开(公告)号：US08645463B2
公开(公告)日：2014-02-04
申请号：US11549562
申请日：2006-10-13
申请人： David Knight , Christopher Daniels , Steffen Matt
发明人： David Knight , Christopher Daniels , Steffen Matt
IPC分类号： G06F15/16
CPC分类号： H04L12/1822 , H04L51/04
摘要： In one embodiment, the methods and apparatuses display a list configured to represent a plurality of virtual rooms; identify a selected participant device associated with a selected virtual room from the plurality of virtual rooms wherein the selected participant device is a member of the selected virtual room; selectively display content associated with the selected virtual room to the selected participant device; and notify the selected participant device of a change to the content associated with the selected virtual room.
摘要翻译：在一个实施例中，方法和装置显示配置为表示多个虚拟房间的列表; 从所述多个虚拟房间中识别与所选择的虚拟房间相关联的所选参与者设备，其中所选择的参与者设备是所选虚拟房间的成员; 选择性地将与所选虚拟房间相关联的内容显示给所选择的参与者设备; 并通知所选择的参与者设备对与所选虚拟房间相关联的内容的改变。

6. 发明申请

US20230050881A1 Systems and/or Methods for Funding and Developing Social Internet Businesses 有权
公开(公告)号：US20230050881A1
公开(公告)日：2023-02-16
申请号：US17732360
申请日：2022-04-28
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： G06Q40/04
摘要： Certain exemplary embodiments can provide a method, which comprises creating a stockholder table. The stockholder table created and maintained on a machine-readable medium. The method comprises automatically detecting registration for, and use of, a subscription service accessed via the Internet by a user. The method comprises, responsive to detected registration for, and use of, the subscription service, automatically changing the stockholder table to add the user as a shareholder of the subscription service.

7. 发明授权

US09578909B2 Jacket garment for tandem vehicle passenger safety 有权
标题翻译：夹克服装，用于串联车辆乘客安全
公开(公告)号：US09578909B2
公开(公告)日：2017-02-28
申请号：US14261424
申请日：2014-04-25
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： A41D27/20 , A41D1/02 , A41D27/02 , A41D13/00 , A41F9/00
CPC分类号： A41D27/20 , A41D1/02 , A41D13/0007 , A41D27/02 , A41F9/005
摘要： A novel jacket garment worn by the driver of a tandem vehicle, such as a motorcycle, intended for rear passenger safety is disclosed. The novel garment comprises an outer shell, an inner lining, and an internal frame structure. The internal frame structure comprises a ribbing nexus comprising horizontal and vertical members. Novel features include handgrips disposed inside front pockets and connected to the internal frame structure. In some embodiments, the internal frame structure comprises elastic members. Pocket-borne handgrips may be attached to elastic members so that when engaged by a rear tandem passenger, the internal frame structure is tightened against the tandem vehicle driver's body to provide stain relief and additional stabilization of the jacket as a passenger safety device.
摘要翻译：公开了一种用于后排乘客安全的诸如摩托车的串联车辆的驾驶员佩戴的新颖的夹克服。该新颖服装包括外壳，内衬和内框架结构。内部框架结构包括包括水平和垂直构件的肋状结构。新颖的功能包括配置在前袋内部并连接到内部框架结构的把手。在一些实施例中，内部框架结构包括弹性构件。口袋式手柄可以附接到弹性构件，使得当由后排的乘客接合时，内部框架结构被紧固在串联车辆驾驶员身上，以提供防污染和附加的作为乘客安全装置的护套的稳定性。

8. 发明申请

US20150305420A1 Jacket Garment for Tandem Vehicle Passenger Safety 审中-公开
标题翻译：串联车辆乘客安全衣服
公开(公告)号：US20150305420A1
公开(公告)日：2015-10-29
申请号：US14261424
申请日：2014-04-25
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： A41D27/20 , A41D27/02 , A41D1/02
CPC分类号： A41D27/20 , A41D1/02 , A41D13/0007 , A41D27/02 , A41F9/005
摘要： A novel jacket garment worn by the driver of a tandem vehicle, such as a motorcycle, intended for rear passenger safety is disclosed. The novel garment comprises an outer shell, an inner lining, and an internal frame structure. The internal frame structure comprises a ribbing nexus comprising horizontal and vertical members. Novel features include handgrips disposed inside front pockets and connected to the internal frame structure. In some embodiments, the internal frame structure comprises elastic members. Pocket-borne handgrips may be attached to elastic members so that when engaged by a rear tandem passenger, the internal frame structure is tightened against the tandem vehicle driver's body to provide stain relief and additional stabilization of the jacket as a passenger safety device.
摘要翻译：公开了一种用于后排乘客安全的诸如摩托车的串联车辆的驾驶员佩戴的新颖的夹克服。该新颖服装包括外壳，内衬和内框架结构。内部框架结构包括包括水平和垂直构件的肋状结构。新颖的功能包括配置在前袋内部并连接到内部框架结构的把手。在一些实施例中，内部框架结构包括弹性构件。口袋式手柄可以附接到弹性构件，使得当由后排的乘客接合时，内部框架结构被紧固在串联车辆驾驶员身上，以提供防污染和附加的作为乘客安全装置的护套的稳定性。

9. 发明申请

US20080001361A1 SEAL WITH INTEGRATED SHROUD FOR ANDROGENOUS DOCKING AND BERTHING IN CONTAMINATED ENVIRONMENTS 有权
标题翻译：密封用于污染环境中的积极破坏和破坏
公开(公告)号：US20080001361A1
公开(公告)日：2008-01-03
申请号：US11758337
申请日：2007-06-05
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： F16J15/02 , B64G1/64
CPC分类号： F16J15/027 , B64G1/646
摘要： The present invention is directed to a specially configured seal system which provides a barrier to gas leakage flow between a pressurized module and its external environment. The seal includes a shroud covering which protects the sealing interface from its environment when not in use, and retracts to expose the sealing interface when mated. The seal system is constructed and arranged to mate with a seal of identical construction and arrangement or to mate with a flat surface.
摘要翻译：本发明涉及一种特别配置的密封系统，其提供加压模块与其外部环境之间的气体泄漏流动的障碍。密封件包括一个护罩罩，当不使用密封界面时，保护密封界面免受其环境的影响，并且当密封接合部分配合时缩回以露出密封界面。密封系统构造和布置成与具有相同构造和布置的密封件配合或与平坦表面配合。

10. 发明授权

US09958353B2 Apparatus and method for quantifying fluid loss in a closed system 有权
公开(公告)号：US09958353B2
公开(公告)日：2018-05-01
申请号：US15013212
申请日：2016-02-02
申请人： Christopher Daniels
发明人： Christopher Daniels
IPC分类号： G01M3/28 , F16J15/32
CPC分类号： G01M3/2853
摘要： In various embodiments, the present invention provides an improved apparatus and method for quantification of fluid loss from a nominally closed system using a pressure decay with mass point leak rate analysis methodology, which avoids the need for repetitive testing due to test configuration incompatibilities and allows for real time analysis and test control based upon desired results. The novel apparatus and methods of the present invention utilize a control system to maintain a desired pressure differential across the test article throughout the test by automatically raising or lowering the downstream pressure as the fluid leaks through the test article. In various embodiments, the apparatus and method of the present invention improves the efficiency of existing test methods by shortening otherwise long test durations, right-sizing the amount of data collected, providing quantifiable and controllable measurement uncertainty, reducing statistical variance, and eliminating post-process data analysis.

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