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1. 发明申请

US20070202008A1 Systems and methods of lipoprotein size fraction assaying 审中-公开
$Systems and methods of lipoprotein size fraction assaying$
标题翻译：脂蛋白大小分数测定的系统和方法
公开(公告)号：US20070202008A1
公开(公告)日：2007-08-30
申请号：US11364267
申请日：2006-02-28
申请人： Carol Schembri , May Tom-Moy
发明人： Carol Schembri , May Tom-Moy
IPC分类号： G01N21/00
CPC分类号： G01N33/92 , G01N33/48721 , G01N33/5438
摘要： Systems and methods for nanopore flow cells are provided.
摘要翻译：提供了纳米孔流动池的系统和方法。

2. 发明授权

US06586232B2 Substrate preparation for chemical-species-specific binding 失效
公开(公告)号：US06586232B2
公开(公告)日：2003-07-01
申请号：US09814360
申请日：2001-03-21
申请人： May Tom-Moy , Carl Alan Myerholtz
发明人： May Tom-Moy , Carl Alan Myerholtz
IPC分类号： C12Q168
CPC分类号： G01N33/54373 , G01N29/022 , G01N33/54353 , G01N33/552 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0427 , Y10S436/827
摘要： A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of the biosensor, while the biotinylated layer can be added by the user. This two-phase method of chemically modifying the measurement surface significantly reduces the user time required to customize the measurement surface to render it capable of binding selected compounds. An organosilane coupling agent attached to the surface provides sites to which avidin is bound. Avidin acts as a universal receptor of biotinylated compounds with specific binding affinities. Biotinylated antibodies or other biotinylated compounds are added and bind to the immobilized avidin. Surface adsorption is reduced by washing the modified surface with biotin to block potential sites of weak bond formation, electrostatic and hydrophobic interactions.

3. 发明授权

US06235488B1 Surface preparation for chemical-specific binding 失效
标题翻译：化学特异性结合的表面处理
公开(公告)号：US06235488B1
公开(公告)日：2001-05-22
申请号：US07876804
申请日：1992-04-29
申请人： May Tom-Moy , Carl Alan Myerholtz
发明人： May Tom-Moy , Carl Alan Myerholtz
IPC分类号： G01N3353
CPC分类号： G01N33/54373 , G01N29/022 , G01N33/54353 , G01N33/552 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0427 , Y10S436/827
摘要： A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of the biosensor, while the biotinylated layer can be added by the user. This two-phase method of chemically modifying the measurement surface significantly reduces the user time required to customize the measurement surface to render it capable of binding selected compounds. An organosilane coupling agent attached to the surface provides sites to which avidin is bound. Avidin acts as a universal receptor of biotinylated compounds with specific binding affinities. Biotinylated antibodies or other biotinylated compounds are added and bind to the immobilized avidin. Surface adsorption is reduced by washing the modified surface with biotin to block potential sites of weak bond formation, electrostatic and hydrophobic interactions.
摘要翻译：质量生物传感器使用中间抗生物素蛋白层来促进生物素化抗体与生物传感器的测量表面的结合。生物传感器的制造商可以添加亲和素层，而生物素化层可以由用户添加。这种化学修饰测量表面的两相方法显着地减少了定制测量表面以使其能够结合所选化合物所需的用户时间。附着在表面上的有机硅烷偶联剂提供结合抗生物素蛋白的位点。亲和素作为具有特异性结合亲和力的生物素化化合物的通用受体。加入生物素化抗体或其他生物素化化合物并结合固定的抗生物素蛋白。通过用生物素洗涤修饰的表面来减少表面吸附以阻断弱键形成，静电和疏水相互作用的潜在位点。

4. 发明授权

US07488607B2 Electronically readable microarray with electronic addressing function 失效
标题翻译：具有电子寻址功能的电子可读微阵列
公开(公告)号：US07488607B2
公开(公告)日：2009-02-10
申请号：US10676707
申请日：2003-09-30
申请人： May Tom-Moy , Carl Myerholtz , August Hidalgo , William McAllister
发明人： May Tom-Moy , Carl Myerholtz , August Hidalgo , William McAllister
IPC分类号： G01N33/551 , G01N33/553
CPC分类号： C12Q1/6825 , C12Q1/6837 , Y10S435/973 , Y10S436/806 , Y10S436/809 , Y10S436/815 , Y10S436/817 , C12Q2565/607
摘要： Methods and apparatus for electronically addressing and interrogating microarrays are disclosed. The described microarrays include a plurality of features disposed on a substrate. Each of the features has a first electrode disposed on the substrate, a second electrode disposed on the substrate, and a probe disposed between the first electrode and second electrode. The substrate also includes addressing circuitry in operable relation to the features. Method of using the microarrays are also described.
摘要翻译：公开了用于电子寻址和询问微阵列的方法和装置。所描述的微阵列包括设置在基板上的多个特征。每个特征具有设置在基板上的第一电极，设置在基板上的第二电极和设置在第一电极和第二电极之间的探针。衬底还包括与特征可操作的寻址电路。还描述了使用微阵列的方法。

5. 发明申请

US20060105461A1 Nanopore analysis system 审中-公开
标题翻译：纳米分析系统
公开(公告)号：US20060105461A1
公开(公告)日：2006-05-18
申请号：US10971966
申请日：2004-10-22
申请人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
发明人： May Tom-Moy , Reid Brennen , Arthur Schleifer , Hongfeng Yin , Tom Goor , James Young , Richard Pittaro
IPC分类号： G01N35/00
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , Y10T436/11 , C12Q2565/631
摘要： Nanopore analysis systems, methods of preparing nanopore analysis systems, and methods of automating the analysis of samples using nanopore analysis systems, are provided.
摘要翻译：提供纳米孔分析系统，制备纳米孔分析系统的方法以及使用纳米孔分析系统自动分析样品的方法。

6. 发明申请

US20050255515A1 Biomolecular sensors and detection methods utilizing photoinduced charge separation 审中-公开
标题翻译：生物分子传感器和利用光诱导电荷分离的检测方法
公开(公告)号：US20050255515A1
公开(公告)日：2005-11-17
申请号：US11153000
申请日：2005-06-14
申请人： Daniel Roitman , May Tom-Moy , Seiji Inaoka , Robert Ach
发明人： Daniel Roitman , May Tom-Moy , Seiji Inaoka , Robert Ach
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/54373
摘要： The invention provides methods and sensors for detecting target biological molecules. Biosensors feature photoactivatable charge separation moieties capable of generating electron-hole pairs upon photoinduction. Photoinduced charge carriers participate in redox reactions that are detectable, for example, by optical, chemical, or electronic means.
摘要翻译：本发明提供了用于检测靶生物分子的方法和传感器。生物传感器具有能够在光诱导时产生电子 - 空穴对的可光活化的电荷分离部分。光诱导电荷载体参与例如通过光学，化学或电子手段可检测的氧化还原反应。

7. 发明申请

US20050069905A1 Detection of molecular binding events 审中-公开
标题翻译：检测分子结合事件
公开(公告)号：US20050069905A1
公开(公告)日：2005-03-31
申请号：US10676957
申请日：2003-09-30
申请人： Carl Myerholtz , May Tom-Moy , August Hidalgo , William McAllister
发明人： Carl Myerholtz , May Tom-Moy , August Hidalgo , William McAllister
IPC分类号： C12Q1/68 , G01N33/543 , C12M1/34
CPC分类号： G01N33/5438 , C12Q1/6825
摘要： A device for electronic detection of a target includes a probe, e.g. an oligonucleotide, attached to a pad of resistive material, wherein the pad is adjacent a first electrode and also is adjacent a second electrode. In use, the probe is contacted with a sample containing the target, e.g. a target nucleic acid, under conditions and for a time sufficient to allow target to bind the probe. An enhancement reaction is then applied to result in a change in an observable property of the device. The observable property is then monitored using measurement apparatus operably associated with the device. Typically, multiple devices will be present on an array of devices, allowing multiplex analysis of multiple different targets using a single array of devices.
摘要翻译：用于电子检测靶的装置包括探针，例如。附着到电阻材料焊盘的寡核苷酸，其中所述焊盘与第一电极相邻并且还邻近第二电极。在使用中，探针与含有靶标的样品接触。在足以允许靶结合探针的条件下和足够时间的靶核酸。然后应用增强反应以导致装置的可观察性质的变化。然后使用与装置可操作地相关联的测量装置监测可观察的性质。通常，多个设备将存在于设备阵列上，允许使用单个阵列阵列对多个不同目标进行多路复用分析。

8. 发明授权

US5229301A Mass biosensor method with quantified sensor renewal 失效
标题翻译：大量生物传感器方法与定量传感器更新
公开(公告)号：US5229301A
公开(公告)日：1993-07-20
申请号：US711786
申请日：1991-06-07
申请人： Darlene J. Spira-Solomon , May Tom-Moy , Carl A. Myerholtz
发明人： Darlene J. Spira-Solomon , May Tom-Moy , Carl A. Myerholtz
IPC分类号： G01N21/64 , G01N21/76 , G01N33/543
CPC分类号： G01N33/54373 , Y10S436/80 , Y10S436/805
摘要： A mass biosensor method provides enhanced quantification of analyte concentrations in a sample. In a direct approach, an analyte is derivatized to form an analyte chelate and then specifically bound to a sensor. In an indirect approach, a complement of the analyte is derivatized to form a complement chelate which is then bound to a sensor. In a direct/indirect hybrid approach, an analog of the analyte is derivatized to form an analog chelate that is bound to a sensor in competition with the sample analyte. In all three approaches, mass measurements taken as the ligand chelate attaches to the sensor permit the concentration of the analyte in the sample to be calculated. Once measurement is completed, a dissociation treatment is applied to dissociate the derivatized species from the sensor so that the sensor can be reused. The effects of the dissociation treatment can be monitored using phosphorescence detection. The results obtained during monitoring can be compared with a predetermined threshold to ensure complete dissociation while avoiding alteration of the sensor surface. This procedure permits precision renewal of a sensor to maximize the number of times a sensor can be used. Moreover, this method allows quantification to be performed using the same sensor and coating in place during calibration, minimizing systematic errors and enhancing quantification accuracy.

9. 发明申请

US20050136408A1 Methods and systems for characterizing a polymer 审中-公开
标题翻译：表征聚合物的方法和系统
公开(公告)号：US20050136408A1
公开(公告)日：2005-06-23
申请号：US10741119
申请日：2003-12-19
申请人： May Tom-Moy , Richard Pittaro , Carl Myerholtz
发明人： May Tom-Moy , Richard Pittaro , Carl Myerholtz
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6874 , C12Q1/6816 , G01N33/48721 , C12Q2565/631 , C12Q2563/155
摘要： Methods and systems for characterizing a polymer in a sample are provided. In the subject methods, a sample that includes a polymer labeled with at least one nanoparticle is contacted with a nanopore under conditions so that the polymer translocates through the nanopore. A signal is read from the nanopore to characterize the translocated polymer. The subject systems include a nanopore device and a polymer that is labeled with at least one nanoparticle. Also provided is programming stored on a computer-readable medium for use in practicing the subject methods. Kits for use in practicing the subject methods are also provided.
摘要翻译：提供了用于表征样品中聚合物的方法和系统。在本发明方法中，包括用至少一种纳米颗粒标记的聚合物的样品在纳米孔的条件下与纳米孔接触，使得聚合物转移通过纳米孔。从纳米孔读取信号以表征易位聚合物。主题系统包括纳米孔装置和用至少一个纳米颗粒标记的聚合物。还提供存储在计算机可读介质上的程序，用于实践主题方法。还提供了用于实践主题方法的套件。

10. 发明授权

US6077674A Method of producing oligonucleotide arrays with features of high purity 有权
标题翻译：制备高纯度特征的寡核苷酸阵列的方法
公开(公告)号：US6077674A
公开(公告)日：2000-06-20
申请号：US428332
申请日：1999-10-27
申请人： Arthur Schleifer , May Tom-Moy
发明人： Arthur Schleifer , May Tom-Moy
IPC分类号： C07H21/00 , C12N15/10 , C40B40/06 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07H21/00 , C12N15/1006 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , C40B40/06
摘要： A method of making full-length oligonucleotide arrays provides for the purification of pre-synthesized full-length oligonucleotides from shorter length oligonucleotides and other impurities at the same time the oligonucleotides are deposited on the array. A synthesized mixture that includes desired full-length oligonucleotides and some capped shorter length or "failed" oligonucleotide sequences, is reacted with a linking agent to add a linking group on to the free-end of the full-length oligonucleotides but not the shorter-length oligonucleotides. The resulting mixture is deposited on an array without first separately purifying the mixture to remove the unwanted shorter-length oligonucleotides. After deposition, unbound material, including the shorter length oligonucleotide sequences and other impurities, is removed.
摘要翻译：制备全长寡核苷酸阵列的方法提供了从短长度寡核苷酸和其它杂质纯化预合成的全长寡核苷酸，同时寡核苷酸沉积在阵列上。将包含所需全长寡核苷酸和某些封端较短长度或“失败”寡核苷酸序列的合成混合物与连接剂反应以在全长寡核苷酸的自由端添加连接基团，长度寡核苷酸。将所得混合物沉积在阵列上，而无需首先分别纯化混合物以除去不想要的较短长度的寡核苷酸。沉积后，去除未结合的材料，包括较短长度的寡核苷酸序列和其他杂质。

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