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1. 发明授权

US06886568B2 Method for fabricating cell-containing implants 失效
标题翻译：含细胞植入物的方法
公开(公告)号：US06886568B2
公开(公告)日：2005-05-03
申请号：US09825632
申请日：2001-04-04
申请人： Carmelita G. Frondoza , David J. Fink , David S. Hungerford , Alan H. Shikani
发明人： Carmelita G. Frondoza , David J. Fink , David S. Hungerford , Alan H. Shikani
IPC分类号： A61F2/08 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/12 , A61K47/36 , A61L27/38 , C08B15/00 , C08B33/00 , C08B37/00 , C08B37/02 , C08H1/00 , C08J3/12 , C12N5/00 , C12N5/077 , A61B19/00
CPC分类号： A61L27/3817 , A61F2/08 , A61K9/0019 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , A61L27/3633 , A61L27/3895 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： Disclosed is a method of growing cells on biodegradable microcarrier particles and more specifically growing chondrocytes for an extended period of time until they aggregate. These aggregated cells can be injected directly or shaped for implantation into the body. In another embodiment of this invention, the cell microcarrier aggregates are grown in a mold that is shaped to conform to the geometry of the desired body part to be replaced. An apparatus for shaping the aggregated cells is disclosed. The aggregated cells can be supplied in a kit.
摘要翻译：公开了一种在可生物降解的微载体颗粒上生长细胞的方法，并且更具体地说是长时间培养软骨细胞，直到它们聚集。这些聚集的细胞可以直接注射或成形为植入体内。在本发明的另一个实施方案中，细胞微载体聚集体在模具中生长，所述模具被成形为符合待更换的所需身体部位的几何形状。公开了一种用于整形聚集单元的装置。聚集的细胞可以在试剂盒中提供。

2. 发明授权

US06662805B2 Method for composite cell-based implants 失效
标题翻译：基于复合细胞的植入物的方法
公开(公告)号：US06662805B2
公开(公告)日：2003-12-16
申请号：US09922909
申请日：2001-08-06
申请人： Carmelita G. Frondoza , David S. Hungerford , Alan H. Shikani , Abraham J. Domb , David J. Fink , Leonard Bloom
发明人： Carmelita G. Frondoza , David S. Hungerford , Alan H. Shikani , Abraham J. Domb , David J. Fink , Leonard Bloom
IPC分类号： A61B1900
CPC分类号： A61L27/3817 , A61F2/08 , A61K9/0024 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , A61L27/3633 , A61L27/3641 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/3852 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： This invention is a method for the implantation of a combination of cells or cell-microcarrier aggregates wherein one component comprises a solid implantable construct and a second component comprises an injectable formulation. For example, in one embodiment, the solid implant may be first implanted to fill the majority of the cavity receiving the implant, and then cells or cell-microcarrier aggregates in an injectable format, with or without the addition of gelling materials to promote rapid gelling in situ, may be injected into spaces surrounding the solid implant in order to secure the solid implant in the site and/or to promote rapid adherence and/or integration of the solid implant to surrounding tissues. Also contemplated in this embodiment is that the cellular composition of the injectable component may differ from that of the solid component. For example, the solid implant may result from the culturing of chondrocytes on microcarriers or scaffolds, thereby resulting in an implant having cartilage-like properties, whereas the injectable cells or aggregates may result from the culturing of stem cells, resulting thereby in cells capable of producing cells of a chondrogenic, fibroblastic, myoblastic or osteoblastic phenotype. In this example, cells in the injectable aggregates may promote the fixation to or rapid integration of the solid cartilage implant into surrounding cartilage, connective tissue, muscle or bone, respectively.
摘要翻译：本发明是用于植入细胞或细胞 - 微载体聚集体的组合的方法，其中一个组分包含固体可植入构建体，第二组分包含可注射制剂。例如，在一个实施例中，可以首先植入固体植入物以填充接收植入物的空腔的大部分，然后填充可注射形式的细胞或细胞 - 微载体聚集体，伴随或不添加胶凝材料以促进快速凝胶化原位可以被注入到固体植入物周围的空间中，以便将固体植入物固定在部位中和/或促进固体植入物与周围组织的快速粘附和/或整合。在该实施方案中也考虑到可注射组分的细胞组成可能不同于固体组分。例如，固体植入物可以由微载体或支架上的软骨细胞的培养产生，从而导致具有软骨样特性的植入物，而可注射细胞或聚集体可能是由培养干细胞导致的，从而导致能够产生软骨形成，成纤维细胞，成肌细胞或成骨细胞表型的细胞。在该实施例中，可注射聚集体中的细胞可以促进将固体软骨植入物固定或者快速整合到周围软骨，结缔组织，肌肉或骨骼中。

3. 发明授权

US06637437B1 Cell-culture and polymer constructs 失效
标题翻译：细胞培养和聚合物构建体
公开(公告)号：US06637437B1
公开(公告)日：2003-10-28
申请号：US09712662
申请日：2000-11-14
申请人： David S. Hungerford , Carmelita G. Frondoza , Alan H. Shikani , Abraham J. Domb
发明人： David S. Hungerford , Carmelita G. Frondoza , Alan H. Shikani , Abraham J. Domb
IPC分类号： A61B1900
CPC分类号： A61L27/3817 , A61F2/08 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： The invention is directed to the culture of cells, and particularly chondrocytes for purpose of tissue replacement. The cells are cultured on polymer constructs. Integren expression is used as a measure of chondrocyte viability. Chondrocytes are obtained from the knee, nose and ankle cartilage. Mechanical strain is used to propagate chondrocytes, chitosan and arabinogalactanchitosan are used as scaffolds. Progenitor, pluripotential, stem and mesenchymal cells are operative in this invention.
摘要翻译：本发明涉及细胞的培养，特别是用于组织置换的软骨细胞。细胞在聚合物构建体上培养。 Integren表达被用作软骨细胞活力的量度。软骨细胞从膝盖，鼻子和脚踝软骨获得。机械菌株用于繁殖软骨细胞，壳聚糖和阿拉伯半乳聚糖壳聚糖用作支架。祖细胞，多能性，干细胞和间充质细胞在本发明中是可操作的。

4. 发明授权

US06378527B1 Cell-culture and polymer constructs 失效
公开(公告)号：US06378527B1
公开(公告)日：2002-04-30
申请号：US09275319
申请日：1999-03-24
申请人： David S. Hungerford , Carmelita G. Frondoza , Afshin Sohrabi , Alan H. Shikani , Abraham J. Domb
发明人： David S. Hungerford , Carmelita G. Frondoza , Afshin Sohrabi , Alan H. Shikani , Abraham J. Domb
IPC分类号： A61B1900
CPC分类号： A61L27/3817 , A61F2/08 , A61F2/30756 , A61K9/1652 , A61K9/5036 , A61K35/12 , A61K47/36 , A61L27/3852 , A61L27/3895 , C08B15/005 , C08B33/00 , C08B37/00 , C08B37/0021 , C08B37/006 , C08H1/00 , C08J3/12 , C08J2305/08 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N2500/02 , C12N2531/00 , C12N2533/70 , C12N2533/72
摘要： Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the chondrocytes from the carrier. Cells can also be grown on chitosan microcarriers to be used for implantation. In addition, cells can be grown on polysaccharide polymers to be used as implant devices. Various polymers serve as scaffolds for cells to be used for implantation. The polymers can be used for cell culture as well as for preparing scaffolds useful for tissue replacement such as cartilage tissue.

5. 发明授权

US5358534A Femoral component for a hip prosthesis 失效
标题翻译：髋关节假体的股骨部件
公开(公告)号：US5358534A
公开(公告)日：1994-10-25
申请号：US055426
申请日：1993-04-29
申请人： Michael W. Dudasik , Anthony K. Hedley , David S. Hungerford , Matthew P. Poggie
发明人： Michael W. Dudasik , Anthony K. Hedley , David S. Hungerford , Matthew P. Poggie
IPC分类号： A61F2/32 , A61B17/16 , A61B17/17 , A61F2/00 , A61F2/30 , A61F2/36
CPC分类号： A61F2/3662 , A61B17/175 , A61F2/30942 , A61B17/1659 , A61F2/36 , A61F2/367 , A61F2/3672 , A61F2/3676 , A61F2002/30112 , A61F2002/30113 , A61F2002/30138 , A61F2002/30205 , A61F2002/30945 , A61F2002/30952 , A61F2002/3625 , A61F2002/365 , A61F2230/0004 , A61F2230/0006 , A61F2230/0017 , A61F2230/0067
摘要： A femoral component for a hip prosthesis has a distal portion defining a central longitudinal axis. The component has a generally conically shaped mid-shaft portion and a proximal portion with a shape based on the reamer and a shaped chisel used by the surgeon to prepare the proximal metaphysis and medullary canal. The proximal portion is shaped in a manner wherein a cross-section taken perpendicular to the central axis has a medial side formed as a first circular arc, a corner of the cross-section formed by the posterior and lateral sides as a second circular arc with a center on the central axis. The posterior side is arcuate and concave and tangent to the first and second circular arcs, with the anterior side being arcuate and convex.
摘要翻译：用于髋关节假体的股骨部件具有限定中心纵向轴线的远端部分。该部件具有大致圆锥形的中轴部分和具有基于铰刀的形状的近端部分和外科医生用于制备近端干ysis端和髓质管的成形凿子。近端部分的形状是垂直于中心轴线截取的横截面具有形成为第一圆弧的内侧，由后侧和侧面形成的横截面的角部为第二圆弧，中心轴的中心。后侧是弧形和凹入并且与第一和第二圆弧相切，前侧是弓形和凸形的。

6. 发明授权

US06530927B2 Bone cutting and breaking apparatus, and miniaturized cutting head 失效
公开(公告)号：US06530927B2
公开(公告)日：2003-03-11
申请号：US09784211
申请日：2001-02-16
申请人： John H. Staehlin , David S. Hungerford , Dror Paley , Charles Bartish , John Garmon , Dana Mcpherson
发明人： John H. Staehlin , David S. Hungerford , Dror Paley , Charles Bartish , John Garmon , Dana Mcpherson
IPC分类号： A61B1732
CPC分类号： A61B17/1668 , A61B17/147 , A61B17/1657
摘要： The present invention includes an apparatus and method for cutting a bone including a cutting assembly having a cutting blade, a cutting guide for guiding the shape of the cut in the bone, and a power source for powering the cutting blade. The cutting blade is moveable radially to vary the depth of the cut in the bone, and the cutting blade is capable of cutting around the circumference of the bone as well as in a longitudinal direction along the bone. A powered bone breaking device for completing the breaking of the weakened bone is also disclosed. A miniaturized version of the bone cutting apparatus can be used to cut out sections of a femur head from inside a femur body.

7. 发明授权

US06488686B2 Bone cutting and breaking apparatus, and miniaturized cutting head 失效
标题翻译：骨切割装置和小型切割头
公开(公告)号：US06488686B2
公开(公告)日：2002-12-03
申请号：US09784177
申请日：2001-02-16
申请人： John H. Staehlin , David S. Hungerford
发明人： John H. Staehlin , David S. Hungerford
IPC分类号： A61B1732
CPC分类号： A61B17/1668 , A61B17/147 , A61B17/1657
摘要： The present invention includes an apparatus and method for cutting a bone including a cutting assembly having a cutting blade, a cutting guide for guiding the shape of the cut in the bone, and a power source for powering the cutting blade. The cutting blade is moveable radially to vary the depth of the cut in the bone, and the cutting blade is capable of cutting around the circumference of the bone as well as in a longitudinal direction along the bone. A powered bone breaking device for completing the breaking of the weakened bone is also disclosed. A miniaturized version of the bone cutting apparatus can be used to cut out sections of a femur head from inside a femur body.
摘要翻译：本发明包括一种用于切割骨骼的装置和方法，包括具有切割刀片的切割组件，用于引导骨头中切割形状的切割引导件和用于为切割刀片供电的电源。切割刀片可径向移动以改变骨中切口的深度，并且切割刀片能够围绕骨的周边以及沿着骨的纵向方向切割。还公开了一种用于完成弱化骨的断裂的动力骨断裂装置。骨切割装置的小型化可用于从股骨内部切割股骨头部分。

8. 发明授权

US06309394B1 Bone cutting and breaking apparatus, and miniaturized cutting head 失效
标题翻译：骨切割装置和小型切割头
公开(公告)号：US06309394B1
公开(公告)日：2001-10-30
申请号：US09377403
申请日：1999-08-20
申请人： John H. Staehlin , David S. Hungerford , Dror Paley , Charles Bartish , John Garmon , Dana Mcpherson
发明人： John H. Staehlin , David S. Hungerford , Dror Paley , Charles Bartish , John Garmon , Dana Mcpherson
IPC分类号： A61B1700
CPC分类号： A61B17/1668 , A61B17/147 , A61B17/1657
摘要： The present invention includes an apparatus and method for cutting a bone including a cutting assembly having a cutting blade, a cutting guide for guiding the shape of the cut in the bone, and a power source for powering the cutting blade. The cutting blade is moveable radially to vary the depth of the cut in the bone, and the cutting blade is capable of cutting around the circumference of the bone as well as in a longitudinal direction along the bone. A powered bone breaking device for completing the breaking of the weakened bone is also disclosed. A miniaturized version of the bone cutting apparatus can be used to cut out sections of a femur head from inside a femur body.
摘要翻译：本发明包括一种用于切割骨骼的装置和方法，包括具有切割刀片的切割组件，用于引导骨头中切割形状的切割引导件和用于为切割刀片供电的电源。切割刀片可径向移动以改变骨中切口的深度，并且切割刀片能够围绕骨的周边以及沿着骨的纵向方向切割。还公开了一种用于完成弱化骨的断裂的动力骨断裂装置。骨切割装置的小型化可用于从股骨内部切割股骨头部分。

9. 发明授权

US4653488A Prosthetic knee implantation 失效
公开(公告)号：US4653488A
公开(公告)日：1987-03-31
申请号：US799630
申请日：1985-11-19
申请人： Robert V. Kenna , David S. Hungerford , Kenneth A. Krackow
发明人： Robert V. Kenna , David S. Hungerford , Kenneth A. Krackow
IPC分类号： A61B17/15 , A61F5/04
CPC分类号： A61B17/154 , A61B17/155 , A61B17/157
摘要： A prosthetic knee is implanted after cutting the femor and tibia in the proper manner with the aid of instruments which include axial alignment guides and a series of cutting jigs.

10. 发明授权

US4646729A Prosthetic knee implantation 失效
公开(公告)号：US4646729A
公开(公告)日：1987-03-03
申请号：US811020
申请日：1985-12-19
申请人： Robert V. Kenna , David S. Hungerford , Kenneth A. Krackow
发明人： Robert V. Kenna , David S. Hungerford , Kenneth A. Krackow
IPC分类号： A61B17/15 , A61F5/04
CPC分类号： A61B17/154 , A61B17/155 , A61B17/157
摘要： A prosthetic knee is implanted after cutting the femor and tibia in the proper manner with the aid of instruments which include axial alignment guides and a series of cutting jigs.

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