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1. 发明授权

US06562867B2 Carbamate compounds for use in preventing or treating bipolar disorder 有权
标题翻译：用于预防或治疗双相情感障碍的氨基甲酸酯化合物
公开(公告)号：US06562867B2
公开(公告)日：2003-05-13
申请号：US10081766
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman , Yong Moon Choi , Robert Gordon
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman , Yong Moon Choi , Robert Gordon
IPC分类号： A61K3127
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗双相情感障碍的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一至五个选自下列的卤素原子取代：由氟，氯，溴和碘组成; 并且R 1和R 2独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

2. 发明申请

US20110152362A1 METHODS OF TREATING EPILEPTOGENESIS AND EPILEPSY 审中-公开
标题翻译：治疗肾上腺皮质功能异常的方法
公开(公告)号：US20110152362A1
公开(公告)日：2011-06-23
申请号：US11940710
申请日：2007-11-15
申请人： Yong Moon CHOI , Robert Gordon , Gerald P. Novak , Carlos R. Plata-Salaman , Roy E. Twyman , H. Steve White , Boyu Zhao
发明人： Yong Moon CHOI , Robert Gordon , Gerald P. Novak , Carlos R. Plata-Salaman , Roy E. Twyman , H. Steve White , Boyu Zhao
IPC分类号： A61K31/27 , A61P25/08
CPC分类号： A61K45/06 , A61K31/27 , A61K31/325 , A61K2300/00
摘要： This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及在受试者中预防，治疗，逆转，抑制或阻止癫痫和癫痫发生的方法，其包括向有需要的受试者施用治疗有效量的选自式（I）和式 II）或其药学上可接受的盐或酯：其中苯基在X上被一至五个选自氟，氯，溴和碘的卤素原子取代; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

3. 发明授权

US07122576B2 Carbamate compounds for use in preventing or treating bipolar disorder 失效
标题翻译：用于预防或治疗双相情感障碍的氨基甲酸酯化合物
公开(公告)号：US07122576B2
公开(公告)日：2006-10-17
申请号：US10081606
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman , Yong Moon Choi , Robert Gordon
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman , Yong Moon Choi , Robert Gordon
IPC分类号： A01N47/10 , A61K31/27
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) or enantiomeric mixture wherein one enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1–C4 alkyl; wherein C1–C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1–C4 alkyl, C1–C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗双相性精神障碍的方法，包括向有需要的受试者施用治疗有效量的式（I）的对映异构体或其对映体混合物，其中式（I）的一个对映异构体占优势：其中苯基被取代在X处具有选自氟，氯，溴和碘的一至五个卤素原子; 且R 1，R 2，R 3和R 4各自独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基的取代基取代， C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

4. 发明授权

US06541513B2 Carbamate compounds for use in preventing or treating psychotic disorders 有权
标题翻译：用于预防或治疗精神病的氨基甲酸酯化合物
公开(公告)号：US06541513B2
公开(公告)日：2003-04-01
申请号：US10081761
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K3127
CPC分类号： A61K31/325
摘要： This invention is directed to a method for preventing or treating psychotic disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种用于预防或治疗精神病的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X 具有选自氟，氯，溴和碘的一至五个卤素原子; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

5. 发明授权

US06815464B2 Carbamate compounds for use in the treatment of pain 失效
标题翻译：用于治疗疼痛的氨基甲酸酯化合物
公开(公告)号：US06815464B2
公开(公告)日：2004-11-09
申请号：US10081943
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K3127
CPC分类号： A61K31/27
摘要： This invention is directed to a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种治疗疼痛的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X与一至五个选自氟，氯，溴和碘的卤素原子; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

6. 发明授权

US07078436B2 Carbamate compounds for use in preventing or treating anxiety disorders 失效
标题翻译：用于预防或治疗焦虑症的氨基甲酸酯化合物
公开(公告)号：US07078436B2
公开(公告)日：2006-07-18
申请号：US10081713
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K31/27
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗焦虑症的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X 具有选自氟，氯，溴和碘的一至五个卤素原子; 和R 1，R 2，R 3，R 4，R 5和/或和R 6和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 6烷基的取代基取代， C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

7. 发明授权

US06589985B2 Carbamate compounds for use in preventing or treating movement disorders 失效
标题翻译：用于预防或治疗运动障碍的氨基甲酸酯化合物
公开(公告)号：US06589985B2
公开(公告)日：2003-07-08
申请号：US10081501
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K3127
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating movement disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗运动障碍的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基被X取代具有选自氟，氯，溴和碘的一至五个卤素原子; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

8. 发明申请

US20090234003A1 CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING ANXIETY DISORDERS 审中-公开
标题翻译：碳酸盐化合物用于预防或治疗恶心病
公开(公告)号：US20090234003A1
公开(公告)日：2009-09-17
申请号：US12475815
申请日：2009-06-01
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K31/27 , A61P25/00
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗焦虑症的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X 具有选自氟，氯，溴和碘的一至五个卤素原子; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

9. 发明申请

US20090005442A1 CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于预防或治疗神经损伤性疾病的碳酸盐化合物
公开(公告)号：US20090005442A1
公开(公告)日：2009-01-01
申请号：US12207816
申请日：2008-09-10
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K31/27 , A61P25/00
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating neurodegenerative disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗神经变性疾病的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X 具有选自氟，氯，溴和碘的一至五个卤素原子; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

10. 发明申请

US20090105334A1 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
标题翻译：用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物
公开(公告)号：US20090105334A1
公开(公告)日：2009-04-23
申请号：US11442445
申请日：2006-05-26
申请人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
发明人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
IPC分类号： A61K31/27 , A61P25/06
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

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