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1. 发明授权

US06794187B2 Mass1 gene, a target for anticonvulsant drug development 失效
标题翻译： Mass1基因，抗惊厥药物开发的目标
公开(公告)号：US06794187B2
公开(公告)日：2004-09-21
申请号：US10220587
申请日：2002-09-03
申请人： Louis J. Ptacek , H. Steve White , Ying-Hui Fu , Shana Skradski
发明人： Louis J. Ptacek , H. Steve White , Ying-Hui Fu , Shana Skradski
IPC分类号： C12N516
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , C12N2517/02
摘要： The present invention relates to a novel gene which is associated with audiogenic seizures in mice. The gene is known as the Monogenic Audiogenic Seizure-susceptible gene or mass1. The product of the mass1 gene is designated MASS1. Nucleic acid molecules that encode for MASS1 have been identified and purified. The sequence of murine mass1 can be found at SEQ ID NO: 1, and the sequence of human mass1 can be found at SEQ ID NO: 3. Mammalian genes encoding a MASS1 protein are also provided. The invention also provides recombinant vectors comprising nucleic acid molecules that code for a MASS1 protein. These vectors can be plasmids. In certain embodiments, the vectors are prokaryotic or eukaryotic expression vectors. The nucleic acid coding for MASS1 can be linked to a heterologous promoter. The invention also relates to transgenic animals in which one or both alleles of the endogenous mass1 gene is mutated.
摘要翻译：本发明涉及与小鼠中的听觉发作相关的新基因。该基因被称为单因子感觉性发作敏感基因或质量1。 mass1基因的产物命名为MASS1。编码MASS1的核酸分子已被鉴定和纯化。鼠群1的序列可以在SEQ ID NO：1中找到，并且人质粒1的序列可以在SEQ ID NO：3中找到。还提供了编码MASS1蛋白的哺乳动物基因。本发明还提供了包含编码MASS1蛋白的核酸分子的重组载体。这些载体可以是质粒。在某些实施方案中，载体是原核或真核表达载体。编码MASS1的核酸可以与异源启动子连接。本发明还涉及转基因动物，其中内源mass1基因的一个或两个等位基因被突变。

2. 发明申请

US20130324467A1 NEUROPEPTIDE ANALOGS, COMPOSITIONS, AND METHODS FOR TREATING PAIN 审中-公开
标题翻译：神经元模拟物，组合物和治疗疼痛的方法
公开(公告)号：US20130324467A1
公开(公告)日：2013-12-05
申请号：US13994675
申请日：2011-12-14
申请人： H. Steve White , Brian Donald Klein , Cameron Spencer Metcalf , Daniel Ryan McDougle , Erika Adkins Scholl , Misty Danielle Smith , Grzegorz Bulaj , Liuyin Zhang
发明人： H. Steve White , Brian Donald Klein , Cameron Spencer Metcalf , Daniel Ryan McDougle , Erika Adkins Scholl , Misty Danielle Smith , Grzegorz Bulaj , Liuyin Zhang
IPC分类号： C07K14/575 , C07K7/08 , C07K14/655
CPC分类号： A61K38/10 , A61K38/2271 , A61K38/31 , A61K47/60 , C07K7/083 , C07K14/57545 , C07K14/655
摘要： Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.
摘要翻译：神经肽类似物和包含神经肽类似物的组合物在本文中描述。还提供了产生和使用包含一种或多种神经肽类似物的神经肽类似物和组合物的方法。

3. 发明授权

US08435940B2 Methods and compositions related to improving properties of pharmacological agents targeting nervous system 有权
公开(公告)号：US08435940B2
公开(公告)日：2013-05-07
申请号：US12160035
申请日：2007-01-05
申请人： Grzegorz Bulaj , H. Steve White
发明人： Grzegorz Bulaj , H. Steve White
IPC分类号： A01N37/18 , C07K1/00
CPC分类号： C07K14/47 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K7/23 , C07K14/575 , C07K14/57545 , C07K14/6555 , C07K14/665 , C07K2319/01
摘要： Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.

4. 发明申请

US20110152362A1 METHODS OF TREATING EPILEPTOGENESIS AND EPILEPSY 审中-公开
标题翻译：治疗肾上腺皮质功能异常的方法
公开(公告)号：US20110152362A1
公开(公告)日：2011-06-23
申请号：US11940710
申请日：2007-11-15
申请人： Yong Moon CHOI , Robert Gordon , Gerald P. Novak , Carlos R. Plata-Salaman , Roy E. Twyman , H. Steve White , Boyu Zhao
发明人： Yong Moon CHOI , Robert Gordon , Gerald P. Novak , Carlos R. Plata-Salaman , Roy E. Twyman , H. Steve White , Boyu Zhao
IPC分类号： A61K31/27 , A61P25/08
CPC分类号： A61K45/06 , A61K31/27 , A61K31/325 , A61K2300/00
摘要： This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及在受试者中预防，治疗，逆转，抑制或阻止癫痫和癫痫发生的方法，其包括向有需要的受试者施用治疗有效量的选自式（I）和式 II）或其药学上可接受的盐或酯：其中苯基在X上被一至五个选自氟，氯，溴和碘的卤素原子取代; 并且，R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

5. 发明申请

US20090281031A1 Methods and Compositions Related to Improving Properties of Pharmacological Agents Targeting Nervous System 有权
标题翻译：与改善针对神经系统的药理学特性相关的方法和组合
公开(公告)号：US20090281031A1
公开(公告)日：2009-11-12
申请号：US12160035
申请日：2007-01-05
申请人： Grzegorz Bulaj , H. Steve White
发明人： Grzegorz Bulaj , H. Steve White
IPC分类号： A61K38/17 , C07K14/435 , C12N15/85 , A61P25/08 , A61P29/00 , A61P35/00 , A61P25/00 , A61P25/24 , A61P25/28
CPC分类号： C07K14/47 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K7/23 , C07K14/575 , C07K14/57545 , C07K14/6555 , C07K14/665 , C07K2319/01
摘要： Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.
摘要翻译：公开了与改善靶向神经系统的生物活性化合物的药理学性质相关的组合物和方法。

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