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1. 发明申请

US20050033230A1 Prefillable intradermal delivery device with hidden needle and passive shielding 审中-公开
标题翻译：具有隐蔽针头和被动屏蔽的可预充皮内输送装置
公开(公告)号：US20050033230A1
公开(公告)日：2005-02-10
申请号：US10474603
申请日：2002-02-15
申请人： Paul Alchas , Carlos Guillermo , David DeSalvo , Lucio Giambattista
发明人： Paul Alchas , Carlos Guillermo , David DeSalvo , Lucio Giambattista
IPC分类号： A61M5/32 , A61M5/46 , A61M5/00
CPC分类号： A61M5/326 , A61M5/46 , A61M2005/3247 , A61M2005/3267
摘要： An intradermal needle assembly (10) for injecting a substance into the skin of an animal is disclosed. A hub (16) is attachable to a container (12) storing the substance. A needle (18) is supported by the hub (16) and has a forward tip (20) extending away from the hub (16). A limiter (22) surrounds the needle (18) and extends away from the hub (16) toward the forward tip (20) of the needle (18). The limiter (22) includes a generally flat skin engaging surface (24) extending in a plane generally perpendicular to an axis of the needle (18) and is adapted to be received against the skin (26) to administer an intradermal injection. The limiter (22) is movable between a first position (28), wherein the skin engaging surface (24) shields the needle (18), and a second position (30), wherein the forward tip (20) extends beyond the skin (26) upon depressing the skin engaging surface (24) against the skin (26).
摘要翻译：公开了一种用于将物质注入动物皮肤的皮内针组件（10）。轮毂（16）可附着到容纳物质的容器（12）上。针（18）由轮毂（16）支撑并且具有远离轮毂（16）延伸的前尖部（20）。限制器（22）围绕针（18）并且朝向针（18）的前尖部（20）远离轮毂（16）延伸。限制器（22）包括在大致垂直于针（18）的轴线的平面中延伸的大致平坦的皮肤接合表面（24），并且适于被接收抵靠皮肤（26）以进行皮内注射。限制器（22）可在第一位置（28）和第二位置（30）之间移动，其中皮肤接合表面（24）屏蔽针（18）和第二位置（30），其中前尖端（20）延伸超过皮肤在将皮肤接合表面（24）压靠皮肤（26）的同时，

2. 发明授权

US08460245B2 Device for delivering a medicament 有权
标题翻译：用于递送药物的装置
公开(公告)号：US08460245B2
公开(公告)日：2013-06-11
申请号：US12666963
申请日：2008-07-19
申请人： Carlos Guillermo , Lucio Giambattista , David DeSalvo
发明人： Carlos Guillermo , Lucio Giambattista , David DeSalvo
IPC分类号： A61M5/20 , A61M5/315
CPC分类号： A61M5/2033 , A61M5/31515 , A61M5/3155 , A61M5/31563 , A61M5/31591 , A61M5/326 , A61M5/46 , A61M2005/2013 , F16F1/027 , F16F1/10
摘要： A device for delivery of medicament, which device comprises an elongated housing; a container (4) mounted within said housing and adapted to contain liquid medicament; a stopper slidably arranged within said container; and actuating means comprising a resilient member (60), a driving means (50) having one end connected to the stopper and a second end being operably connected to the resilient member, retaining means (40) for releasably retaining said driving means in a first position where said resilient member has an accumulated energy, and activating means operably connected to said retaining means for releasing said driving means to a second position, upon actively operation by an user, such that said accumulated energy is transferred to the driving means for driving the stopper a predetermined distance within the container whereby the medicament within said container i delivered characterized in that the resilient member is a variable force spring adapted for generating a predetermined sequence of at least two different force profiles during the medicament delivery.
摘要翻译：一种用于递送药物的装置，该装置包括细长的壳体; 安装在所述壳体内并适于容纳液体药物的容器（4）; 可滑动地布置在所述容器内的止动件; 以及致动装置，包括弹性构件（60），驱动装置（50），其一端连接到止动件，第二端可操作地连接到弹性构件，保持装置（40）用于将所述驱动装置可释放地保持在第一位置，其中所述弹性构件具有积聚的能量;以及启动装置，可操作地连接到所述保持装置，用于在用户主动操作时将所述驱动装置释放到第二位置，使得所述累积的能量被传递到驱动装置，以驱动在容器内止动预定距离，由此所述容器内的药物被输送，其特征在于，所述弹性构件是适于在药物输送期间产生至少两个不同力分布的预定顺序的可变力弹簧。

3. 发明申请

US20050283115A1 Pen needle and safety shield system 有权
标题翻译：笔针和安全屏蔽系统
公开(公告)号：US20050283115A1
公开(公告)日：2005-12-22
申请号：US11006497
申请日：2004-12-07
申请人： Lucio Giambattista , David DeSalvo
发明人： Lucio Giambattista , David DeSalvo
IPC分类号： A61D7/00 , A61M5/24 , A61M5/31 , A61M5/32 , A61M5/34 , A61M5/00
CPC分类号： A61M5/3202 , A61D7/00 , A61M5/24 , A61M5/3205 , A61M5/326 , A61M5/3271 , A61M5/347 , A61M2005/3104 , A61M2005/3247 , A61M2005/3267 , A61M2205/583 , A61M2205/6081
摘要： A safety shield system for a needle cannula of a pen needle injector or similar device, wherein the safety shield may be retracted from a first position enclosing the needle to a second position exposing the needle for injection. The safety shield system permits retraction of the safety shield during use, but extends the shield enclosing the needle in a locked position following use. The shield system is utilized with a pen needle injector having a double ended needle cannula mounted in a hub received on the open end of the pen needle injector. The assembly is disposed of by removing the assembly and needle cannula hub and storing the assembly in the cup-shaped cap enclosing the exposed end of the needle cannula within the cap. The cap includes internal radial ribs preventing retraction of the shield prior to removing the cap preventing inadvertently piercing the cap during assembly.
摘要翻译：一种用于笔针注射器或类似装置的针插管的安全屏蔽系统，其中所述安全护罩可以从包围所述针的第一位置缩回到露出所述注射针的第二位置。安全屏蔽系统允许在使用期间收回安全护罩，但在使用后将包围针的屏蔽件延伸到锁定位置。屏蔽系统与具有安装在接收在笔针注射器的开口端上的毂中的双端针插管的笔式针注射器一起使用。通过移除组件和针插管毂并将组件存储在包围针套管暴露端在杯盖内的杯状帽中来处理组件。盖子包括内部径向肋，防止在拆卸盖子之前收回护罩，防止在组装过程中无意中刺穿盖子。

4. 发明授权

US06793646B1 Pen style injector with automated substance combining feature 有权
标题翻译：笔式注射器具有自动化物质组合功能
公开(公告)号：US06793646B1
公开(公告)日：2004-09-21
申请号：US09958125
申请日：2002-01-18
申请人： Lucio Giambattista , David DeSalvo
发明人： Lucio Giambattista , David DeSalvo
IPC分类号： A61M3700
CPC分类号： A61M5/284 , A61M5/2066 , A61M5/3146 , A61M5/315
摘要： A pen-style injector (20) includes an automated mover (70) that completes a combination of two substances such as a reconstitution process to reconstitute a lyophilized medicament prior to making an injection. The automated mover (70) is preloaded selectively released to automatically reconstitute the medicament at a controlled rate. The illustrated embodiment includes a mechanical spring (70) that provides the necessary movement of components within the injector (20) to complete the automated reconstitution process. The injector also has safety features (100) to prevent an injection prior to completing the automated combination of the substances.
摘要翻译：笔式注射器（20）包括完成两种物质的组合的自动移动器（70），例如在进行注射之前重构冻干药物的重建过程。自动移动器（70）被预先选择性地释放，以便以受控的速率自动重构药物。所示实施例包括机械弹簧（70），其提供喷射器（20）内部件的必要运动，以完成自动重建过程。注射器还具有在完成物质的自动组合之前防止注射的安全特征（100）。

5. 发明申请

US20100249721A1 Device for Delivering a Medicament 有权
标题翻译：提供药物的设备
公开(公告)号：US20100249721A1
公开(公告)日：2010-09-30
申请号：US12666963
申请日：2008-07-19
申请人： Carlos E. Guillermo , Lucio Giambattista , David DeSalvo
发明人： Carlos E. Guillermo , Lucio Giambattista , David DeSalvo
IPC分类号： A61M5/00
CPC分类号： A61M5/2033 , A61M5/31515 , A61M5/3155 , A61M5/31563 , A61M5/31591 , A61M5/326 , A61M5/46 , A61M2005/2013 , F16F1/027 , F16F1/10
摘要： A device for delivery of medicament, which device comprises an elongated housing; a container (4) mounted within said housing and adapted to contain liquid medicament; a stopper slidably arranged within said container; and actuating means comprising a resilient member (60), a driving means (50) having one end connected to the stopper and a second end being operably connected to the resilient member, retaining means (40) for releasably retaining said driving means in a first position where said resilient member has an accumulated energy, and activating means operably connected to said retaining means for releasing said driving means to a second position, upon actively operation by an user, such that said accumulated energy is transferred to the driving means for driving the stopper a predetermined distance within the container whereby the medicament within said container i delivered characterized in that the resilient member is a variable force spring adapted for generating a predetermined sequence of at least two different force profiles during the medicament delivery.
摘要翻译：一种用于递送药物的装置，该装置包括细长的壳体; 安装在所述壳体内并适于容纳液体药物的容器（4）; 可滑动地布置在所述容器内的止动件; 以及致动装置，包括弹性构件（60），驱动装置（50），其一端连接到止动件，第二端可操作地连接到弹性构件，保持装置（40）用于将所述驱动装置可释放地保持在第一位置，其中所述弹性构件具有积聚的能量;以及启动装置，可操作地连接到所述保持装置，用于在用户主动操作时将所述驱动装置释放到第二位置，使得所述累积的能量被传递到驱动装置，以驱动在容器内止动预定距离，由此所述容器内的药物被输送，其特征在于，所述弹性构件是适于在药物输送期间产生至少两个不同力分布的预定顺序的可变力弹簧。

6. 发明申请

US20050038392A1 Medication delivery pen assembly with needle locking safety shield 有权
标题翻译：药物输送笔组件带针锁安全护罩
公开(公告)号：US20050038392A1
公开(公告)日：2005-02-17
申请号：US10638729
申请日：2003-08-11
申请人： David DeSalvo
发明人： David DeSalvo
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M5/3243 , A61M2005/3247
摘要： A medication delivery pen assembly having a pen body and a needle assembly with a hub connected to the pen body, a needle cannula extending through the hub with a distal end sharpened for insertion into a patient, and a shield having a tubular portion telescopingly disposed about at least a portion of the hub. The tubular portion includes an internal surface, at least one projection extending inwardly from the internal surface, and the hub having at least one externally extending projection. The shield is axially displaceable relatively along the hub distally from a first position, where the distal end of the needle cannula is exposed, to a second position, where the distal end of the needle cannula is enclosed by the shield. Upon the shield being displaced to the second position, the at least one projection on the hub is deflectibly urged passed the at least one projection on the tubular portion so that subsequent distal-to-proximal movement of the shield relative to the hub is hindered by interengagement of the projections. The needle cannula may be directly affixed to the pen body with the hub being formed unitarily with, rigidly affixed to, or removably affixed to the pen body.
摘要翻译：一种药物输送笔组件，其具有笔体和具有连接到笔体的毂的针组件，穿过毂延伸的针插管，其具有被锐化以插入患者体内的远端，以及屏蔽罩，其具有可伸缩地布置在其周围的管状部分轮毂的至少一部分。管状部分包括内表面，从内表面向内延伸的至少一个突起，并且毂具有至少一个外部延伸的突出部。护罩相对地沿着轮毂轴向移位，其中第一位置（其中针插管的远端暴露）到第二位置，其中针插管的远端被护罩包围。当护罩移动到第二位置时，轮毂上的至少一个突起被偏转地推动通过管状部分上的至少一个突起，使得屏蔽件相对于毂的随后的远离近侧运动受到预测的相互联系。针管可以直接固定到笔体上，其中毂被整体地形成，刚性地固定到或者可拆卸地固定到笔体上。

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