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1. 发明申请

US20090318454A1 NOVEL ANTIOXIDANTS AND METHODS OF TREATMENT 审中-公开
标题翻译：新型抗氧化剂和治疗方法
公开(公告)号：US20090318454A1
公开(公告)日：2009-12-24
申请号：US12410133
申请日：2009-03-24
申请人： Carl P. Weiner , Peter Swaan , Jeffrey Aube , Abhijit Ray
发明人： Carl P. Weiner , Peter Swaan , Jeffrey Aube , Abhijit Ray
IPC分类号： A61K31/53 , C07C251/60 , A61K31/195 , C07D253/065
CPC分类号： C07C291/04 , C07C323/41 , C07C323/59 , C07C2602/08 , C07D207/34 , C07D209/14 , C07D211/94 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/14 , C07D217/26 , C07D231/56 , C07D235/14 , C07D237/24 , C07D237/28 , C07D239/28 , C07D239/72 , C07D241/24 , C07D241/44 , C07D241/46 , C07D251/04 , C07D253/04 , C07D253/07 , C07D261/20 , C07D263/56 , C07D273/01 , C07D275/04 , C07D307/68 , C07D333/38 , C07D333/58 , C07D333/72 , C07D475/14
摘要： Formula 1 is an antioxidant compound, wherein R, R1, or D is an antioxidant substituent; R and D are each independently selected from hydrogen or groups containing cysteine, thiols, disulfides, amino acids, amines, amides, or carboxylic acids; when one of R or D is hydrogen, the other includes a thiol, disulfide, or carboxylic acid; A is CO, SO, SO2, or C═S; E is one or more ring groups which are aromatic, carbocyclic, and/or heterocyclic 5, 6 and 7 membered rings being mono, bi, tri, tetra, penta, hexa, hepta or octa cyclic fused rings that are substituted or unsubstituted, each heterocyclic ring can include hetero atoms chosen from to O, S, N, Se, or P; each R1 is at a para, meta, and/or ortho position; n is 1, 2, 3, 4, or 5 for each ring; and each R1 is hydrogen or an antioxidant substituent.
摘要翻译：式1是抗氧化剂化合物，其中R，R 1或D是抗氧化剂取代基; R和D各自独立地选自氢或含有半胱氨酸，硫醇，二硫化物，氨基酸，胺，酰胺或羧酸的基团; 当R或D中的一个是氢时，另一个包括硫醇，二硫键或羧酸; A是CO，SO，SO2或C-S; E是一个或多个环基，其是芳族，碳环和/或杂环的5,6和7元环，其是取代或未取代的单，双，三，四，五，六，七或八环稠合环，每个杂环可以包括选自O，S，N，Se或P的杂原子; 每个R1位于对位，间位和/或邻位; 每个环的n为1,2,3,4或5; 并且每个R 1是氢或抗氧化剂取代基。

2. 发明授权

US08710261B2 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases 失效
公开(公告)号：US08710261B2
公开(公告)日：2014-04-29
申请号：US11816836
申请日：2006-02-21
申请人： Venkata P. Palle , Viswajanani Jitendra Sattigeri , Manoj Kumar Khera , Sreedhara Rao Voleti , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata P. Palle , Viswajanani Jitendra Sattigeri , Manoj Kumar Khera , Sreedhara Rao Voleti , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： C07D253/08 , C07D239/54 , C07D239/64 , C07D239/96 , C07D249/18 , C07D209/48 , C07D209/12 , C07D237/32 , C07D401/10 , C07D403/10 , C07D471/04 , A61K31/53 , A61P19/02 , A61P11/06 , C07D213/64 , C07D265/28 , C07D211/88 , C07D207/40 , C07D263/58
CPC分类号： C07D253/04 , C07C59/54 , C07C233/51 , C07C271/22 , C07C311/19 , C07D209/18 , C07D209/46 , C07D209/48 , C07D211/88 , C07D221/20 , C07D237/32 , C07D239/54 , C07D239/96 , C07D253/08 , C07D263/58 , C07D265/36 , C07D401/06 , C07D401/10 , C07D403/10 , C07D409/10
摘要： The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rχ, —NHC(═O)OR4, —NHSO2R4, C(═Y)NR4R5, C(═O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C═O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(═O)NR4R5, O-acyl, NH2, NR4R5, —NHC(═Y)R4, —NHC(═Y)NR5Rx, —NHC(═O)OR4, —NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

3. 发明申请

US20100113371A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds 审中-公开
标题翻译：戊糖单糖衍生物作为抗炎化合物
公开(公告)号：US20100113371A9
公开(公告)日：2010-05-06
申请号：US11722573
申请日：2005-12-22
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
IPC分类号： A61K31/7008 , C07H15/04 , A61P29/00 , C07H15/12
CPC分类号： C07H3/02 , C07H15/02 , C07H15/18 , C07H15/26
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法疾病

4. 发明授权

US07629812B2 Switching circuits and methods for programmable logic devices 失效
标题翻译：用于可编程逻辑器件的开关电路和方法
公开(公告)号：US07629812B2
公开(公告)日：2009-12-08
申请号：US11888977
申请日：2007-08-03
申请人： Damodar R. Thummalapally , Abhijit Ray
发明人： Damodar R. Thummalapally , Abhijit Ray
IPC分类号： H03K19/173
CPC分类号： H01L27/11803 , H01L27/098 , H01L29/808 , H03K19/17736 , H03K19/1778
摘要： A switching circuit can have a plurality of first signal lines of a programmable logic device, a plurality of second signal lines of the programmable logic device, and a plurality of switch elements. Each switch element can selectively couple one first signal line to a second signal line and include one or more switch junction field effect transistors (JFETs) having a first control gate separated from a second control gate by a channel region.
摘要翻译：开关电路可以具有可编程逻辑器件的多条第一信号线，可编程逻辑器件的多条第二信号线以及多个开关元件。每个开关元件可选择性地将一个第一信号线耦合到第二信号线，并且包括具有通过沟道区与第二控制栅极分离的第一控制栅极的一个或多个开关结场效应晶体管（JFET）。

5. 发明申请

US20090018174A1 MACROLIDES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：防腐剂作为抗炎剂
公开(公告)号：US20090018174A1
公开(公告)日：2009-01-15
申请号：US12093041
申请日：2006-11-08
申请人： Pradip Kumar Bhatnagar , Anjan Chakrabarti , Biswajit Das , Malini Bajpai , Abhijit Ray
发明人： Pradip Kumar Bhatnagar , Anjan Chakrabarti , Biswajit Das , Malini Bajpai , Abhijit Ray
IPC分类号： A61K31/365 , A61K31/424
CPC分类号： A61K31/7048
摘要： Provided herein are macrolide derivatives that can be useful in treating or preventing inflammatory diseases. Also provided are pharmaceutical compositions comprising one or more macrolide derivatives optionally together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixtures thereof, as well as methods for treating or preventing inflammatory diseases.
摘要翻译：本文提供可用于治疗或预防炎性疾病的大环内酯衍生物。还提供药物组合物，其包含一种或多种大环内酯衍生物，任选与一种或多种药学上可接受的载体，赋形剂，稀释剂或其混合物，以及治疗或预防炎性疾病的方法。

6. 发明申请

US20080312285A1 Substituted Indazoles as Inhibitors of Phosphodiesterase Type-Iv 失效
标题翻译：取代的吲唑作为类型的磷酸二酯酶的抑制剂
公开(公告)号：US20080312285A1
公开(公告)日：2008-12-18
申请号：US12065819
申请日：2006-08-30
申请人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/4439 , C07D413/10 , A61K31/422 , A61K31/4245 , A61P11/06 , C07D413/14 , A61P31/18
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia)
摘要翻译：本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。式（Ia）

7. 发明申请

US20080215372A1 Device and Method for Continuity of Care in a Health Care Environment 审中-公开
标题翻译：在医疗保健环境中保持关怀的设备和方法
公开(公告)号：US20080215372A1
公开(公告)日：2008-09-04
申请号：US12041637
申请日：2008-03-03
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： G06F19/00
CPC分类号： G06Q50/24 , G16H10/65
摘要： The present invention is directed to a method and device for ensuring patient continuity of care. One aspect of the present method includes providing to a patient a hand-held portable device that has at least a portion of the patient's medical record stored thereon. The patient can then carry the hand-held portable device on his person for access of the information thereon whenever necessary or desired.
摘要翻译：本发明涉及一种用于确保患者的护理连续性的方法和装置。本方法的一个方面包括向患者提供具有存储在其上的患者医疗记录的至少一部分的手持便携式设备。然后，病人随身携带手持式便携式设备，以便在需要或期望的情况下存取其上的信息。

8. 发明申请

US20070287673A1 MONOSACCHARIDE DERIVATIVES 失效
标题翻译：单糖衍生物
公开(公告)号：US20070287673A1
公开(公告)日：2007-12-13
申请号：US11755164
申请日：2007-05-30
申请人： Ashwani Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
发明人： Ashwani Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Rajkumar Shirumalla
IPC分类号： A61K31/7008
CPC分类号： C07H13/12 , C07H9/04
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

9. 发明授权

US07027548B1 Delay settings for a wide-range, high-precision delay-locked loop and a delay locked loop implementation using these settings 失效
标题翻译：使用这些设置可实现宽范围，高精度延迟锁定环和延迟锁定环实现的延迟设置
公开(公告)号：US07027548B1
公开(公告)日：2006-04-11
申请号：US09873016
申请日：2001-05-30
申请人： Chaitanya Palusa , Abhijit Ray
发明人： Chaitanya Palusa , Abhijit Ray
IPC分类号： H03D3/24
CPC分类号： H03L7/0812 , H03D13/004 , H03L7/0891 , H03L7/091 , H03L7/10
摘要： A delay-locked-loop (DLL) that has increased precision and a wide range of operation is formed by utilizing a chain of delay blocks to add or subtract a discreet amount of delay, and a voltage-controlled delay line (VCDL) to add or subtract a smaller amount of delay. The delay blocks allow the delayed clock signal to get close to the reference clock signal, while the VCDL allows the delayed clock signal to lock onto the reference clock signal.
摘要翻译：通过利用一系列延迟块来增加或减少一定的延迟量来形成具有增加的精度和较宽的操作范围的延迟锁定环（DLL），以及电压控制的延迟线（VCDL）来添加或减去较小的延迟量。延迟块允许延迟的时钟信号接近参考时钟信号，而VCDL允许延迟的时钟信号锁定到参考时钟信号。

10. 发明授权

US06956040B2 Oxazolidinone piperazinyl derivatives as potential antimicrobials 失效
标题翻译：恶唑烷酮哌嗪衍生物作为潜在的抗菌药物
公开(公告)号：US06956040B2
公开(公告)日：2005-10-18
申请号：US10051784
申请日：2002-01-17
申请人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
发明人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
IPC分类号： C07D413/12 , C07D413/14 , A61K31/496 , A61P31/04
CPC分类号： C07D413/12
摘要： The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I with the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基哌嗪基恶唑烷酮，例如具有式I结构的具有变量的定义的那些，以及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

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