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1. 发明申请

US20090318454A1 NOVEL ANTIOXIDANTS AND METHODS OF TREATMENT 审中-公开
标题翻译：新型抗氧化剂和治疗方法
公开(公告)号：US20090318454A1
公开(公告)日：2009-12-24
申请号：US12410133
申请日：2009-03-24
申请人： Carl P. Weiner , Peter Swaan , Jeffrey Aube , Abhijit Ray
发明人： Carl P. Weiner , Peter Swaan , Jeffrey Aube , Abhijit Ray
IPC分类号： A61K31/53 , C07C251/60 , A61K31/195 , C07D253/065
CPC分类号： C07C291/04 , C07C323/41 , C07C323/59 , C07C2602/08 , C07D207/34 , C07D209/14 , C07D211/94 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/14 , C07D217/26 , C07D231/56 , C07D235/14 , C07D237/24 , C07D237/28 , C07D239/28 , C07D239/72 , C07D241/24 , C07D241/44 , C07D241/46 , C07D251/04 , C07D253/04 , C07D253/07 , C07D261/20 , C07D263/56 , C07D273/01 , C07D275/04 , C07D307/68 , C07D333/38 , C07D333/58 , C07D333/72 , C07D475/14
摘要： Formula 1 is an antioxidant compound, wherein R, R1, or D is an antioxidant substituent; R and D are each independently selected from hydrogen or groups containing cysteine, thiols, disulfides, amino acids, amines, amides, or carboxylic acids; when one of R or D is hydrogen, the other includes a thiol, disulfide, or carboxylic acid; A is CO, SO, SO2, or C═S; E is one or more ring groups which are aromatic, carbocyclic, and/or heterocyclic 5, 6 and 7 membered rings being mono, bi, tri, tetra, penta, hexa, hepta or octa cyclic fused rings that are substituted or unsubstituted, each heterocyclic ring can include hetero atoms chosen from to O, S, N, Se, or P; each R1 is at a para, meta, and/or ortho position; n is 1, 2, 3, 4, or 5 for each ring; and each R1 is hydrogen or an antioxidant substituent.
摘要翻译：式1是抗氧化剂化合物，其中R，R 1或D是抗氧化剂取代基; R和D各自独立地选自氢或含有半胱氨酸，硫醇，二硫化物，氨基酸，胺，酰胺或羧酸的基团; 当R或D中的一个是氢时，另一个包括硫醇，二硫键或羧酸; A是CO，SO，SO2或C-S; E是一个或多个环基，其是芳族，碳环和/或杂环的5,6和7元环，其是取代或未取代的单，双，三，四，五，六，七或八环稠合环，每个杂环可以包括选自O，S，N，Se或P的杂原子; 每个R1位于对位，间位和/或邻位; 每个环的n为1,2,3,4或5; 并且每个R 1是氢或抗氧化剂取代基。

2. 发明授权

US08420666B2 Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
标题翻译：吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US08420666B2
公开(公告)日：2013-04-16
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： C07D513/02 , C07D515/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

3. 发明申请

US20100168197A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：US20100168197A1
公开(公告)日：2010-07-01
申请号：US12528987
申请日：2008-02-27
申请人： Naresh Kumar , Jaskiran Kaur , Shelly Aeron , Abhijit Ray , Suman Gupta , Shivani Malhotra , Raj Kumar Shirumalla
发明人： Naresh Kumar , Jaskiran Kaur , Shelly Aeron , Abhijit Ray , Suman Gupta , Shivani Malhotra , Raj Kumar Shirumalla
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D235/08 , C07D233/54 , C07D409/06
摘要： This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

4. 发明授权

US07741882B1 Current-limited output buffer 失效
标题翻译：限流输出缓冲器
公开(公告)号：US07741882B1
公开(公告)日：2010-06-22
申请号：US12173405
申请日：2008-07-15
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： H03K3/00
CPC分类号： H03K19/018521
摘要： An output buffer circuit includes a first output transistor having a source terminal connected to a voltage supply and a drain terminal connected to an output node. The first output transistor is capable of coupling the output node to the voltage supply when the input signal is at a high voltage in the input voltage range. The circuit also includes a second output transistor having a drain terminal connected to the output node and a source terminal connected to ground. The second output transistor is capable of coupling the output node to ground when the input signal is at a low voltage in the input voltage range. The circuit further includes a current-limiting circuit coupled to a gate terminal of the first output transistor and capable of limiting a current flowing through the gate terminal when the first output transistor is turned on. The output node outputs an output signal in an output voltage range, wherein a high voltage of the output voltage range exceeds the high voltage of the input voltage range.
摘要翻译：输出缓冲电路包括具有连接到电压源的源极端子和连接到输出节点的漏极端子的第一输出晶体管。当输入信号在输入电压范围内处于高电压时，第一输出晶体管能够将输出节点耦合到电压源。电路还包括具有连接到输出节点的漏极端子和连接到地的源极端子的第二输出晶体管。当输入信号在输入电压范围内处于低电压时，第二输出晶体管能够将输出节点耦合到地。电路还包括限流电路，其耦合到第一输出晶体管的栅极端子，并且当第一输出晶体管导通时能够限制流过栅极端子的电流。输出节点输出输出电压范围内的输出信号，其中输出电压范围的高电压超过输入电压范围的高电压。

5. 发明授权

US07674811B2 5-lipoxygenase inhibitors 失效
标题翻译： 5-脂氧合酶抑制剂
公开(公告)号：US07674811B2
公开(公告)日：2010-03-09
申请号：US11685892
申请日：2007-03-14
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Raj Kumar
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Raj Kumar
IPC分类号： C07D249/08 , A61K31/4196
CPC分类号： C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.
摘要翻译：本发明涉及5-脂氧合酶抑制剂。本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性皮炎，过敏性鼻炎，其他炎症和自身免疫性疾病。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

6. 发明申请

US20090221566A1 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
标题翻译：磷酸酯酶类型IV的抑制剂
公开(公告)号：US20090221566A1
公开(公告)日：2009-09-03
申请号：US12090790
申请日：2006-10-05
申请人： Venkata P. Palle , Sarala Balachandran , Sarika Ramnani , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata P. Palle , Sarala Balachandran , Sarika Ramnani , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/537 , C07D265/02 , A61K31/535 , A61P25/00 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10
CPC分类号： C07D265/02
摘要： The present invention relates to oxazine derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CMS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及恶嗪衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。本文公开的化合物可用于治疗CMS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。

7. 发明申请

US20090054519A1 DERIVATIVES OF MONOSACCHARIDES AS 5-LIPOXYGENASE INHIBITORS 审中-公开
标题翻译：单赖类药物作为5-LIPOXYGENASE抑制剂的衍生物
公开(公告)号：US20090054519A1
公开(公告)日：2009-02-26
申请号：US11996407
申请日：2006-07-20
申请人： Abhijit Ray , Raj Kumar Shirumalla , Kasim Mookhtiar , Viswajanani J. Sattigeri , Venkata Palle , Mohammad Salman
发明人： Abhijit Ray , Raj Kumar Shirumalla , Kasim Mookhtiar , Viswajanani J. Sattigeri , Venkata Palle , Mohammad Salman
IPC分类号： A61K31/36 , A61P43/00
CPC分类号： A61K31/70
摘要： The present invention relates to the use of derivatives of monosaccharides as 5-lipoxygenase inhibitor.
摘要翻译：本发明涉及单糖衍生物作为5-脂氧合酶抑制剂的用途。

8. 发明授权

US07468366B2 Cytotoxic agents 有权
标题翻译：细胞毒剂
公开(公告)号：US07468366B2
公开(公告)日：2008-12-23
申请号：US11954380
申请日：2007-12-12
申请人： Edmond J. LaVoie , Alexander L. Ruchelman , Sudhir K. Singh , Abhijit Ray , Leroy F. Liu
发明人： Edmond J. LaVoie , Alexander L. Ruchelman , Sudhir K. Singh , Abhijit Ray , Leroy F. Liu
IPC分类号： C07D491/147 , C07D491/22 , A61K31/4738 , A61K31/4985 , A61K31/5025 , A61P35/00
CPC分类号： C07D491/14 , C07D491/147 , C07D491/22 , C12N5/0693 , C12N2501/06 , C12N2501/999
摘要： The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
摘要翻译：本发明提供本发明化合物，其包含本发明化合物的药物组合物，用于制备本发明化合物的方法，用于制备本发明化合物的中间体，以及用于治疗癌症和其它拓扑异构酶介导的病症的治疗方法。

9. 发明申请

US20080300196A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20080300196A1
公开(公告)日：2008-12-04
申请号：US11866542
申请日：2007-10-03
申请人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
发明人： Ashwani Kumar Verma , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Rajkumar Shirumalla , Abhijit Ray
IPC分类号： A61K31/7052 , C07H17/02 , A61K31/70 , A61P9/00 , A61P37/00 , A61P35/00 , A61P29/00 , C07H15/00
CPC分类号： C07H3/02 , C07H9/04 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。

10. 发明授权

US07319105B2 Cytotoxic agents 有权
公开(公告)号：US07319105B2
公开(公告)日：2008-01-15
申请号：US10846936
申请日：2004-05-14
申请人： Edmond J. LaVoie , Alexander L. Ruchelman , Sudhir K. Singh , Abhijit Ray , Leroy F. Liu
发明人： Edmond J. LaVoie , Alexander L. Ruchelman , Sudhir K. Singh , Abhijit Ray , Leroy F. Liu
IPC分类号： C07D491/22 , A61K31/4741 , A61K31/4355 , A61P35/00 , C07D491/147 , C07D491/153 , C07D237/26 , A61K31/5025
CPC分类号： C07D491/14 , C07D491/147 , C07D491/22 , C12N5/0693 , C12N2501/06 , C12N2501/999
摘要： The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.

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