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1. 发明申请

US20080188939A1 Allograft tissue purification process for cleaning bone 审中-公开
标题翻译：用于清洁骨的同种异体移植组织净化过程
公开(公告)号：US20080188939A1
公开(公告)日：2008-08-07
申请号：US12072152
申请日：2008-02-25
申请人： Carl Alexander DePaula , Devin Joshua Mahony , Moon Hae Sunwoo , Arthur A. Gertzman
发明人： Carl Alexander DePaula , Devin Joshua Mahony , Moon Hae Sunwoo , Arthur A. Gertzman
IPC分类号： A61F2/28 , A61L2/025
CPC分类号： A61L27/365 , A61F2/4644 , A61F2002/2835 , A61F2002/4646 , A61L2/0011 , A61L2/0088 , A61L27/3608 , A61L27/3683 , A61L2430/02
摘要： A method for producing a cleaned bone graft with osteoinductivity above 2.0 suitable for transplantation into a human. The first step is sonicating a bone graft in a nonionic detergent in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. and for a time period ranging from 15 minutes to 2 hours effective to produce a cleaned bone graft essentially free from bone marrow. The bone graft is sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to remove the detergent producing a cleaned bone graft. The bone graft is then sonicated in hydrogen peroxide in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. for a time period ranging from 10 minutes to about 2 hours effective to retain osteoinductivity of the bone graft and again sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to produce a cleaned bone graft. The final step is sonicating the bone graft in an alcohol at a temperature ranging from 33° C. to 37° C. for 30 minutes to 2 hours, all of the steps being effective to reduce any initially present viruses at least two logs and bacteria at least ten logs and the bone graft is finally sonicated in purified water to remove the alcohol.
摘要翻译：一种生物活性高于2.0的清洁骨移植物的方法，适用于人类移植。第一步是将超声波清洗机中的非离子洗涤剂中的骨移植物在约33℃至约37℃的温度范围内超声处理15分钟至2小时的时间段，以有效地产生清洁的骨骼移植物基本上不含骨髓。将骨移植物在超声波清洗器中的纯净水中在约33℃至约37℃的温度范围内超声处理多次以除去产生清洁的骨移植物的洗涤剂。然后将骨移植物在超声波清洗器中在约33℃至约37℃的温度范围内在过氧化氢中超声处理10分钟至约2小时的时间段，从而有效地保持骨移植物的骨诱导性，在超声波清洗机中，在约33℃至约37℃的温度范围内，再次在净化水中超声处理多次以产生清洁的骨移植物。最后一步是在33℃至37℃的温度范围内将骨移植物超声处理30分钟至2小时，所有步骤均有效地减少任何最初存在的病毒至少两个原木和细菌将至少十个原木和骨移植物最终在纯化水中超声处理以除去醇。

2. 发明申请

US20100112543A1 PROCESSING SOFT TISSUE, METHODS AND COMPOSITIONS RELATED THERETO 审中-公开
标题翻译：加工软组织，方法和组合物相关
公开(公告)号：US20100112543A1
公开(公告)日：2010-05-06
申请号：US12534613
申请日：2009-08-03
申请人： Manh-Dan NGO , Arthur Gertzman , Michael Kawas , Katherine G. Truncale , Moon Hae Sunwoo , Alison Lee , Richard Seeman , Carl Alexander DePaula , Jeffrey S. Cartmell , David J. Gocke , Carina Syring , Rudiger von Versen
发明人： Manh-Dan NGO , Arthur Gertzman , Michael Kawas , Katherine G. Truncale , Moon Hae Sunwoo , Alison Lee , Richard Seeman , Carl Alexander DePaula , Jeffrey S. Cartmell , David J. Gocke , Carina Syring , Rudiger von Versen
IPC分类号： A01N1/02 , C12N5/071 , A01N1/00
CPC分类号： A61K35/34 , A61K35/36
摘要： In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor, including a living human donor, and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In other embodiments, the present invention relates to a process for treating a decellularized soft tissue by freezing the same at a plurality of decreasing temperatures at atmosphere or higher such that there is formation of ice crystals having a size greater than 2.0 and lyophilizing the soft tissue under vacuum to remove the water to less than 6% forming a porous matrix.
摘要翻译：在某些实施方案中，本发明涉及一种制备从人供体（包括活的人供体）中除去的皮肤并除去细胞组分并在消毒组织时形成具有主要组分胶原和弹性蛋白的脱细胞基质的方法。在其它实施方案中，本发明涉及一种通过在大气压或更高的多个降低的温度下将其冷冻来处理脱细胞的软组织的方法，使得形成具有大于2.0的尺寸的冰晶并冻干软组织在真空下将水除去至少于6％，形成多孔基体。

3. 发明授权

US08288344B2 Ceramic composition for filling bone defects 有权
标题翻译：用于填充骨缺损的陶瓷组合物
公开(公告)号：US08288344B2
公开(公告)日：2012-10-16
申请号：US11724255
申请日：2007-03-15
申请人： Carl Alexander DePaula
发明人： Carl Alexander DePaula
IPC分类号： A61P19/08 , A61K38/00 , C07K14/475 , C12N5/071
CPC分类号： A61L27/46 , A61K9/0024 , A61L27/3847 , A61L27/446 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/414 , A61L2300/622 , A61L2300/802 , A61L2430/02 , C08L71/02
摘要： The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.
摘要翻译：本发明涉及一种用于应用于含水载体溶液中的生物活性玻璃颗粒的骨缺损部位的无菌成形植入物组合物，生物活性玻璃颗粒以约68％至约76％的浓度加入到粘性载体中（ w / w），载体包含范围为24％至32％（w / w）的甘油和聚乙二醇的混合物，甘油与聚乙二醇的比例为约45:55至约65:35。

4. 发明申请

US20080226688A1 Ceramic composition for filling bone defects 有权
标题翻译：用于填充骨缺损的陶瓷组合物
公开(公告)号：US20080226688A1
公开(公告)日：2008-09-18
申请号：US11724255
申请日：2007-03-15
申请人： Carl Alexander DePaula
发明人： Carl Alexander DePaula
IPC分类号： A61L27/32 , A61K9/00 , A61L27/54
CPC分类号： A61L27/46 , A61K9/0024 , A61L27/3847 , A61L27/446 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/414 , A61L2300/622 , A61L2300/802 , A61L2430/02 , C08L71/02
摘要： The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.
摘要翻译：本发明涉及一种用于应用于含水载体溶液中的生物活性玻璃颗粒的骨缺损部位的无菌成形植入物组合物，生物活性玻璃颗粒以约68％至约76％的浓度加入到粘性载体中（ w / w），载体包含范围为24％至32％（w / w）的甘油和聚乙二醇的混合物，甘油与聚乙二醇的比例为约45:55至约65:35。

5. 发明申请

US20130011446A1 CERAMIC COMPOSITION FOR FILLING BONE DEFECTS 审中-公开
标题翻译：用于填充骨缺损的陶瓷组合物
公开(公告)号：US20130011446A1
公开(公告)日：2013-01-10
申请号：US13614369
申请日：2012-09-13
申请人： Carl Alexander DePaula
发明人： Carl Alexander DePaula
IPC分类号： A61K33/42 , A61K35/12 , A61K35/14 , A61K35/18 , A61P19/08 , A61K35/16 , A61K38/48 , A61K38/44 , A61K38/46 , A61K9/00 , A61K35/28
CPC分类号： A61L27/46 , A61K9/0024 , A61L27/3847 , A61L27/446 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/414 , A61L2300/622 , A61L2300/802 , A61L2430/02 , C08L71/02
摘要： The invention is directed toward a sterile formable implant composition for application to a bone defect site comprising bioactive glass particles in an aqueous carrier solution, the bioactive glass particles being added to a viscous carrier at a concentration ranging from about 68% to about 76% (w/w), the carrier comprising a mixture of glycerol and polyethylene glycol ranging from 24% to 32% (w/w) with the ratio of glycerol to polyethylene glycol ranging from about 45:55 to about 65:35.
摘要翻译：本发明涉及一种用于应用于含水载体溶液中的生物活性玻璃颗粒的骨缺损部位的无菌成形植入物组合物，生物活性玻璃颗粒以约68％至约76％的浓度加入到粘性载体中（ w / w），载体包含范围为24％至32％（w / w）的甘油和聚乙二醇的混合物，甘油与聚乙二醇的比例为约45:55至约65:35。

6. 发明申请

US20100304487A1 SOFT TISSUE PROCESSING 有权
标题翻译：软组织加工
公开(公告)号：US20100304487A1
公开(公告)日：2010-12-02
申请号：US12772602
申请日：2010-05-03
申请人： Katherine GOMES TRUNCALE , Carl Alexander DePaula , Jeffrey Stuart Cartmell , David J. Gocke , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
发明人： Katherine GOMES TRUNCALE , Carl Alexander DePaula , Jeffrey Stuart Cartmell , David J. Gocke , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
IPC分类号： C12N5/00
CPC分类号： A61K35/35 , A01N1/02 , A01N1/0215 , A61K35/32
摘要： The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps:(1) isolating from a suitable donor a desired soft tissue sample of the biological material;(2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water;(3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same;(4) processing the tissue by cutting the tissue to size and perforating the tissue; and(5) dipping the tissue in 70% ethanol and packaging the tissue.
摘要翻译：本发明是一种制备软组织的方法，例如肌腱，韧带，软骨，筋膜，真皮，人体阀门和人体静脉，用于植入人体中，并去除细胞成分并形成具有主要组分胶原和弹性蛋白同时灭菌的脱细胞基质组织。该方法包括以下步骤：（1）从合适的供体中分离生物材料的所需软组织样品; （2）软组织的处理和脱细胞化，包括视觉缺陷检查，根据组织是筋膜或真皮修整和浸泡洗涤剂中的组织并用无菌水冲洗; （3）在真空中对软组织进行消毒，并根据软组织是真皮或真皮进行冲洗，将组织浸泡在抗生素组合物或过乙酸中; （4）通过切割组织以使组织尺寸和穿孔来处理组织; 和（5）将组织浸入70％乙醇中并包装组织。

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