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1. 发明申请

US20100304487A1 SOFT TISSUE PROCESSING 有权
标题翻译：软组织加工
公开(公告)号：US20100304487A1
公开(公告)日：2010-12-02
申请号：US12772602
申请日：2010-05-03
申请人： Katherine GOMES TRUNCALE , Carl Alexander DePaula , Jeffrey Stuart Cartmell , David J. Gocke , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
发明人： Katherine GOMES TRUNCALE , Carl Alexander DePaula , Jeffrey Stuart Cartmell , David J. Gocke , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
IPC分类号： C12N5/00
CPC分类号： A61K35/35 , A01N1/02 , A01N1/0215 , A61K35/32
摘要： The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps:(1) isolating from a suitable donor a desired soft tissue sample of the biological material;(2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water;(3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same;(4) processing the tissue by cutting the tissue to size and perforating the tissue; and(5) dipping the tissue in 70% ethanol and packaging the tissue.
摘要翻译：本发明是一种制备软组织的方法，例如肌腱，韧带，软骨，筋膜，真皮，人体阀门和人体静脉，用于植入人体中，并去除细胞成分并形成具有主要组分胶原和弹性蛋白同时灭菌的脱细胞基质组织。该方法包括以下步骤：（1）从合适的供体中分离生物材料的所需软组织样品; （2）软组织的处理和脱细胞化，包括视觉缺陷检查，根据组织是筋膜或真皮修整和浸泡洗涤剂中的组织并用无菌水冲洗; （3）在真空中对软组织进行消毒，并根据软组织是真皮或真皮进行冲洗，将组织浸泡在抗生素组合物或过乙酸中; （4）通过切割组织以使组织尺寸和穿孔来处理组织; 和（5）将组织浸入70％乙醇中并包装组织。

2. 发明授权

US07723108B2 Soft tissue processing 有权
标题翻译：软组织加工
公开(公告)号：US07723108B2
公开(公告)日：2010-05-25
申请号：US11375026
申请日：2006-03-15
申请人： Katherine Gomes Truncale , Jeffrey Stuart Cartmell , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
发明人： Katherine Gomes Truncale , Jeffrey Stuart Cartmell , Carina Syring , Rudiger Von Versen , Manh-Dan Ngo
IPC分类号： C12N5/00
CPC分类号： A61K35/35 , A01N1/02 , A01N1/0215 , A61K35/32
摘要： The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.
摘要翻译：本发明是一种制备软组织的方法，例如肌腱，韧带，软骨，筋膜，真皮，人体阀门和人体静脉，用于植入人体中，并去除细胞成分并形成具有主要组分胶原和弹性蛋白同时灭菌的脱细胞基质组织。该方法包括以下步骤：（1）从合适的供体中分离生物材料的所需软组织样品; （2）软组织的处理和脱细胞化，包括视觉缺陷检查，根据组织是筋膜或真皮修整和浸泡洗涤剂中的组织并用无菌水冲洗; （3）在真空中对软组织进行消毒，并根据软组织是真皮或真皮进行冲洗，将组织浸泡在抗生素组合物或过乙酸中; （4）通过切割组织以使组织尺寸和穿孔来处理组织; 和（5）将组织浸入70％乙醇中并包装组织。

3. 发明授权

US08557581B2 Soft tissue processing 有权
标题翻译：软组织加工
公开(公告)号：US08557581B2
公开(公告)日：2013-10-15
申请号：US12772602
申请日：2010-05-03
申请人： Manh-Dan Ngo , Katherine Gomes Truncale , Jeffrey S. Cartmell , Carina Syring , Rudiger Von Versen
发明人： Manh-Dan Ngo , Katherine Gomes Truncale , Jeffrey S. Cartmell , Carina Syring , Rudiger Von Versen
IPC分类号： C12N5/00 , A61K35/32 , A61K35/36
CPC分类号： A61K35/35 , A01N1/02 , A01N1/0215 , A61K35/32
摘要： The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.
摘要翻译：本发明是一种制备软组织的方法，例如肌腱，韧带，软骨，筋膜，真皮，人体阀门和人体静脉，用于植入人体中，并去除细胞成分，并形成具有胶原和弹性蛋白作为主要成分的脱细胞基质同时进行灭菌组织。该方法包括以下步骤：（1）从合适的供体中分离生物材料的所需软组织样品; （2）软组织的处理和脱细胞化，包括视觉缺陷检查，根据组织是筋膜或真皮修整和浸泡洗涤剂中的组织并用无菌水冲洗; （3）在真空中对软组织进行消毒，并根据软组织是真皮或真皮进行冲洗，将组织浸泡在抗生素组合物或过乙酸中; （4）通过切割组织以使组织尺寸和穿孔来处理组织; 和（5）将组织浸入70％乙醇中并包装组织。

4. 发明申请

US20060275377A1 Soft tissue processing 有权
公开(公告)号：US20060275377A1
公开(公告)日：2006-12-07
申请号：US11375026
申请日：2006-03-15
申请人： Katherine Gomes , Carl DePaula , Jeffrey Cartmell , David Gocke , Carina Syring , Rudiger Von Versen
发明人： Katherine Gomes , Carl DePaula , Jeffrey Cartmell , David Gocke , Carina Syring , Rudiger Von Versen
IPC分类号： A61K35/34
CPC分类号： A61K35/35 , A01N1/02 , A01N1/0215 , A61K35/32
摘要： The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.

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