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1. 发明申请

US20070092973A1 Material compositions for sensors for determination of chemical species at trace concentrations and method of using sensors 有权
标题翻译：用于测定微量浓度的化学物质的传感器的材料组成和使用传感器的方法
公开(公告)号：US20070092973A1
公开(公告)日：2007-04-26
申请号：US11259506
申请日：2005-10-26
申请人： Radislav Potyrailo , Timothy Sivavec , Caibin Xiao , Theodore Cecconie , Lamyaa Hassib , Andrew Leach , David Engel
发明人： Radislav Potyrailo , Timothy Sivavec , Caibin Xiao , Theodore Cecconie , Lamyaa Hassib , Andrew Leach , David Engel
IPC分类号： G01N21/00
CPC分类号： G01N31/22 , G01N21/78 , Y10S436/80 , Y10S436/805
摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.
摘要翻译：用传感器膜定量测定样品溶液中化学物质浓度的方法。制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。将该膜暴露于固定量的样品溶液。使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

2. 发明申请

US20070092972A1 Self-contained phosphate sensors and method for using same 审中-公开
标题翻译：独立的磷酸盐传感器及其使用方法
公开(公告)号：US20070092972A1
公开(公告)日：2007-04-26
申请号：US11259712
申请日：2005-10-26
申请人： Caibin Xiao , Timothy Sivavec , David Engel , Andrew Leach
发明人： Caibin Xiao , Timothy Sivavec , David Engel , Andrew Leach
IPC分类号： G01N31/22
CPC分类号： G01N31/22 , G01N21/78 , Y10T436/16
摘要： Embodiments of the invention provide self-contained phosphate sensors with an analyte-specific reagent and a pH-modifier. The analyte-specific reagent includes a molybdenum salt or metal complex and a dye. The self-contained phosphate sensors can be used either in aqueous or non-aqueous solution or as a solid-state device. These self-contained phosphate sensors require no post-addition reagents to determine phosphate concentrations and the phosphate determination test requires a reduced number of procedural steps. Moreover, the self-contained phosphate sensor provides enhanced sensitivity and faster response time. Embodiments of the invention also provide a method for determining phosphate concentrations in a sample. The phosphate concentration in a sample can be quantified using a calibration curve generated by testing samples with known phosphate concentrations.
摘要翻译：本发明的实施方案提供具有分析物特异性试剂和pH-改性剂的自含磷酸盐传感器。分析物特异性试剂包括钼盐或金属络合物和染料。独立的磷酸盐传感器可以在水溶液或非水溶液中使用或作为固态装置使用。这些独立的磷酸盐传感器不需要后加剂来测定磷酸盐浓度，磷酸盐测定测试需要减少数量的程序步骤。此外，独立的磷酸盐传感器提供增强的灵敏度和更快的响应时间。本发明的实施方案还提供了一种测定样品中磷酸盐浓度的方法。可以使用通过测试具有已知磷酸盐浓度的样品产生的校准曲线来量化样品中的磷酸盐浓度。

3. 发明申请

US20070092411A1 Microfluidic devices and methods of making the same 有权
标题翻译：微流体装置及其制作方法
公开(公告)号：US20070092411A1
公开(公告)日：2007-04-26
申请号：US11440278
申请日：2006-05-25
申请人： Andrew Leach , Thomas Dunton , Christopher Goewey , Radislav Potyrailo , Caibin Xiao , Prashant Shrikhande
发明人： Andrew Leach , Thomas Dunton , Christopher Goewey , Radislav Potyrailo , Caibin Xiao , Prashant Shrikhande
IPC分类号： B01L11/00
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： A microfluidic channel is provided. The microfluidic channel includes a first substrate having at least one microfluidic channel pattern. Further, the microfluidic channel includes a porous material disposed on the first substrate and occupying the at least one microfluidic channel pattern.
摘要翻译：提供微流体通道。微流体通道包括具有至少一个微流体通道图案的第一基底。此外，微流体通道包括设置在第一基板上并占据至少一个微流体通道图案的多孔材料。

4. 发明申请

US20070146715A1 SENSOR SYSTEMS FOR QUANTIFICATION OF PHYSICAL PARAMETERS, CHEMICAL AND BIOCHEMICAL VOLATILE AND NONVOLATILE COMPOUNDS IN FLUIDS 审中-公开
标题翻译：用于定量流体中物理参数，化学和生物化学挥发性和非挥发性化合物的传感器系统
公开(公告)号：US20070146715A1
公开(公告)日：2007-06-28
申请号：US11668061
申请日：2007-01-29
申请人： Radislav Potyrailo , Scott Boyette , Caibin Xiao , William Morris , Andrew Leach , Ronald Wroczynski
发明人： Radislav Potyrailo , Scott Boyette , Caibin Xiao , William Morris , Andrew Leach , Ronald Wroczynski
IPC分类号： G01N21/00
CPC分类号： G01N21/5907 , G01N35/00069
摘要： system and method employing a substrate for supporting a highly reproducible sensor array for producing a prerecorded standard response for quantitative analysis of physical, chemical and biochemical parameters are provided. The system includes a substrate for supporting a highly reproducible sensor array, a light source for directing light onto the sensor spot, at least one optical pickup for detecting light transmitted through or reflected from a sensor spot, the transmitted or reflected light being indicative of a concentration of a compound, and an analog-to-digital converter for quantifying an intensity of the detected light.
摘要翻译：提供了使用用于支持高度可重现的传感器阵列的基板的系统和方法，用于产生用于物理，化学和生物化学参数的定量分析的预先记录的标准响应。该系统包括用于支持高度可重现的传感器阵列的基板，用于将光引导到传感器光点上的光源，用于检测透射通过传感器点或从传感器点反射的光的至少一个光学拾取器，所发射或反射的光指示化合物的浓度，以及用于量化检测到的光的强度的模拟 - 数字转换器。

5. 发明申请

US20070092975A1 Methods and systems for delivery of fluidic samples to sensor arrays 有权
标题翻译：将流体样品传送到传感器阵列的方法和系统
公开(公告)号：US20070092975A1
公开(公告)日：2007-04-26
申请号：US11507689
申请日：2006-08-22
申请人： Radislav Potyrailo , Prashant Shrikhande , Scott Boyette , Caibin Xiao , Andrew Leach
发明人： Radislav Potyrailo , Prashant Shrikhande , Scott Boyette , Caibin Xiao , Andrew Leach
IPC分类号： G01N21/77
CPC分类号： G01N21/78 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0642 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0427 , B01L2400/0448 , G01N21/80 , G01N35/00069 , G01N2021/7766 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译：公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。提供输送装置以将计量的样品流体传送到传感器阵列。提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。该方法结合了多变量优化算法来分析多个传感器响应。这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。然后可以使用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

6. 发明申请

US20070092407A1 Optical sensor array system and method for parallel processing of chemical and biochemical information 有权
标题翻译：光学传感器阵列系统和化学和生化信息并行处理方法
公开(公告)号：US20070092407A1
公开(公告)日：2007-04-26
申请号：US11259643
申请日：2005-10-26
申请人： Caibin Xiao , Radislav Potyrailo , William Morris , Scott Boyette , LiJie Yu , Theodore Cecconie , Andrew Leach , Prashant Shrikhande
发明人： Caibin Xiao , Radislav Potyrailo , William Morris , Scott Boyette , LiJie Yu , Theodore Cecconie , Andrew Leach , Prashant Shrikhande
IPC分类号： G01N21/29 , G01N21/41
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译：公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。该方法结合了多变量优化算法来分析多个传感器响应。这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

7. 发明授权

US08647883B2 Material compositions for sensors for determination of chemical species at trace concentrations 有权
标题翻译：用于测定微量浓度的化学物质的传感器的材料组成
公开(公告)号：US08647883B2
公开(公告)日：2014-02-11
申请号：US12880830
申请日：2010-09-13
申请人： Radislav A. Potyrailo , Timothy M. Sivavec , Caibin Xiao , Theodore J. Cecconie , Lamyaa Hassib , Andrew M. Leach , David B. Engel
发明人： Radislav A. Potyrailo , Timothy M. Sivavec , Caibin Xiao , Theodore J. Cecconie , Lamyaa Hassib , Andrew M. Leach , David B. Engel
IPC分类号： G01N21/00
CPC分类号： G01N31/22 , G01N21/78 , Y10S436/80 , Y10S436/805
摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.
摘要翻译：用传感器膜定量测定样品溶液中化学物质浓度的方法。制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。将该膜暴露于固定量的样品溶液。使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

8. 发明申请

US20120160769A1 WATER TREATMENT USING A BIPOLAR MEMBRANE 有权
标题翻译：使用双极膜进行水处理
公开(公告)号：US20120160769A1
公开(公告)日：2012-06-28
申请号：US12977274
申请日：2010-12-23
申请人： Caroline Chihyu Sui , Caibin Xiao , Hai Yang
发明人： Caroline Chihyu Sui , Caibin Xiao , Hai Yang
IPC分类号： C02F1/461 , C02F1/66 , C25B9/10 , C02F1/52
CPC分类号： C02F1/4618 , C02F1/5236 , C02F5/02 , C02F2103/023 , C02F2209/06
摘要： A method of water treatment comprising: providing an electrolysis device comprising an electrolysis vessel; providing feed streams to the first salt water chamber of the vessel, second salt water chamber of the vessel, acidic chamber of the vessel, and alkalic chamber of the vessel, the acidic chamber producing an acidic solution and the alkalic chamber producing an alkalic solution; directing at least a portion of the contents of the first and second salt water chambers into a precipitation tank; directing at least a portion of the alkalic solution into the precipitation tank, thereby increasing the pH in the precipitation tank to produce precipitate; and removing the precipitate from the precipitation tank.
摘要翻译：一种水处理方法，包括：提供包括电解容器的电解装置; 向容器的第一盐水室，容器的第二盐水室，容器的酸性室和容器的碱室提供进料流，产生酸性溶液的酸性室和产生碱溶液的碱室; 将第一和第二盐水室的内容物的至少一部分引导到沉淀池中; 将至少一部分碱性溶液引导到沉淀槽中，从而提高沉淀池中的pH以产生沉淀物; 并从沉淀池中除去沉淀物。

9. 发明授权

US07807473B2 Material compositions for sensors for determination of chemical species at trace concentrations and method of using sensors 有权
标题翻译：用于测定微量浓度的化学物质的传感器的材料组成和使用传感器的方法
公开(公告)号：US07807473B2
公开(公告)日：2010-10-05
申请号：US11259506
申请日：2005-10-26
申请人： Radislav A. Potyrailo , Timothy M. Sivavec , Caibin Xiao , Theodore J. Cecconie , Lamyaa Hassib , Andrew M. Leach , David B. Engel
发明人： Radislav A. Potyrailo , Timothy M. Sivavec , Caibin Xiao , Theodore J. Cecconie , Lamyaa Hassib , Andrew M. Leach , David B. Engel
IPC分类号： G01N21/00
CPC分类号： G01N31/22 , G01N21/78 , Y10S436/80 , Y10S436/805
摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.
摘要翻译：用传感器膜定量测定样品溶液中化学物质浓度的方法。制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。将该膜暴露于固定量的样品溶液。使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

10. 发明授权

US08105552B2 Optical sensor array system for parallel processing of chemical and biochemical information 有权
标题翻译：用于并行处理化学和生物化学信息的光学传感器阵列系统
公开(公告)号：US08105552B2
公开(公告)日：2012-01-31
申请号：US12730550
申请日：2010-03-24
申请人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
发明人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
IPC分类号： B01L3/00 , G01P3/00 , G01N31/00
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译：公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。该方法结合了多变量优化算法来分析多个传感器响应。这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

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