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1. 发明授权

US11896281B2 Cryo-fixation cardiac pacemaker lead extraction device 有权
公开(公告)号：US11896281B2
公开(公告)日：2024-02-13
申请号：US16185577
申请日：2018-11-09
申请人： THE CLEVELAND CLINIC FOUNDATION , CPSI Holdings, LLC
发明人： Oussama Wazni , Marwane Berrada-Sounni , John M. Baust , Kristi K. Snyder
IPC分类号： A61B18/02 , A61N1/05 , A61B17/3205 , A61B18/00
CPC分类号： A61B18/0218 , A61B17/32053 , A61B18/02 , A61N1/0595 , A61B2018/00196 , A61B2018/00202 , A61B2018/00791 , A61B2018/00922 , A61B2018/0212 , A61B2018/0262 , A61N2001/0578
摘要： A cryo-fixation lead extraction device includes a lead extraction catheter having longitudinally spaced proximal and distal catheter ends and an elongate catheter lumen. A liner has longitudinally spaced proximal and distal liner ends and an elongate liner lumen. The liner lumen is configured to selectively accept at least part of a lead being extracted longitudinally therethrough. At least a portion of the liner is located circumferentially within and/or circumferentially surrounding the catheter lumen. At least one cryogen supply line extends longitudinally through at least a portion of the liner lumen. The cryogen supply line is configured to place a cryogen fluid source into fluid communication with the distal liner end. The cryogen supply line is configured to selectively generate a patient tissue cooled zone adjacent the distal catheter end. A method of cryo-fixation lead extraction is also provided.

2. 发明授权

US11129662B2 Ablation probe with deployable sensors 有权
公开(公告)号：US11129662B2
公开(公告)日：2021-09-28
申请号：US16030933
申请日：2018-07-10
申请人： CPSI HOLDINGS LLC
发明人： Marie Molnar-Hammond , John M. Baust
IPC分类号： A61B18/02 , A61B18/14 , A61B17/00 , A61B18/00
摘要： The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.

3. 发明授权

US10054262B2 Pressurized sub-cooled cryogenic system 有权
公开(公告)号：US10054262B2
公开(公告)日：2018-08-21
申请号：US14687449
申请日：2015-04-15
申请人： CPSI Holdings LLC
发明人： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
IPC分类号： F17C1/00 , F17C5/02
CPC分类号： F17C1/00 , A61B18/02 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/0293 , A61B2090/064 , F17C3/00 , F17C5/02 , F17C2201/0109 , F17C2201/032 , F17C2201/056 , F17C2203/0329 , F17C2203/0391 , F17C2203/0643 , F17C2205/0107 , F17C2205/0161 , F17C2205/0367 , F17C2221/011 , F17C2221/012 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2221/035 , F17C2223/0169 , F17C2223/035 , F17C2223/036 , F17C2227/0341 , F17C2227/0353 , F17C2227/0374 , F17C2250/032 , F17C2250/0408 , F17C2250/0439 , F17C2270/02 , F17C2270/0509
摘要： A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.

4. 发明申请

US20160068804A1 CELL SELECTION METHOD 审中-公开
标题翻译：细胞选择方法
公开(公告)号：US20160068804A1
公开(公告)日：2016-03-10
申请号：US14819960
申请日：2015-08-06
申请人： CPSI Holdings LLC
发明人： John M. Baust , John G. Baust , William L. Corwin , Robert G. Van Buskirk
IPC分类号： C12N5/00 , C12N5/0735 , C12N5/074
CPC分类号： C12N5/0081 , A61K31/05 , A61K31/07 , A61K31/34 , A61K31/355 , A61K31/47 , A61K31/593 , C12N5/00 , C12N5/0606 , C12N5/0696 , C12N2500/02 , C12N2500/60 , C12N2502/02 , C12N2502/45 , C12N2523/00 , G01N33/5008
摘要： A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and/or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery. The cell-guard agents are process-matched and cell-matched to protect and/or select particular cells during laboratory and clinical manipulation. The components modulate cell stress and survival pathways.
摘要翻译：已经鉴定出新的一类试剂用作细胞保护剂和/或靶标特异性补充物以增加细胞质量和产量，以及选择靶细胞群体。实验室实验已经证明了在细胞的生物处理中以及选择所需的细胞群体中使用细胞保护剂和/或靶标特异性补充物。在这些研究中已经鉴定了几种潜在的添加剂（天然和合成），包括在细胞模型中有希望应用的维生素D3，NAC，白藜芦醇，salubrinal，AKT和衣霉素（等）。在一个实施方案中，利用低温胁迫方案。在另一个实施方案中，在加工过程中测试其它应激物时，使用常温条件。保持大量细胞培养和/或选择特定细胞群以进行进一步研究和临床应用的方法代表治疗发现中的重要步骤。细胞保护剂在过程匹配和细胞匹配以在实验室和临床操作期间保护和/或选择特定的细胞。组分调节细胞应激和存活途径。

5. 发明授权

US08747397B2 Cryotreatment pellet 有权
标题翻译：冷冻沉淀
公开(公告)号：US08747397B2
公开(公告)日：2014-06-10
申请号：US13683140
申请日：2012-11-21
申请人： CPSI Holdings LLC
发明人： John M. Baust , John G. Baust , Anthony T. Robilotto , Kristi K. Snyder , Robert G. Van Buskirk
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61K9/0024 , A61K9/145 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/513 , A61K31/59 , A61K31/7048 , A61K45/06 , A61M5/44 , A61M37/0069 , A61M2205/3606
摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.
摘要翻译：可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。本文提供的数据显示了这种方法在破坏癌组织中的功效。例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

6. 发明申请

US20130204241A1 DUAL THERMAL ABLATION DEVICE AND METHOD OF USE 有权
标题翻译：双热消除装置及其使用方法
公开(公告)号：US20130204241A1
公开(公告)日：2013-08-08
申请号：US13761673
申请日：2013-02-07
申请人： CPSI HOLDINGS LLC
发明人： John M. Baust
IPC分类号： A61B18/02 , A61B18/08
CPC分类号： A61B18/02 , A61B18/082 , A61B18/10 , A61B18/1477 , A61B2018/00077 , A61B2018/00154 , A61B2018/00577 , A61B2018/00994 , A61B2018/0293 , A61B2018/1869 , A61B2018/2005 , A61N1/403
摘要： The invention is a multi-functional ablation device that encompasses the use of both heat energy and cryogenic energy as integrated into one medical device. In one embodiment, the medical device integrates a heat source such as RF or HIFU in combination with a source of cryogenic energy such that the multi-functional ablation device is a dual thermal ablation device capable of utilizing either energy source alone or in combination.
摘要翻译：本发明是一种多功能消融装置，其包括集成在一个医疗装置中的热能和低温能量的使用。在一个实施例中，医疗设备将诸如RF或HIFU的热源与低温能量源组合，使得多功能消融装置是能够单独或组合地使用能量源的双重热消融装置。

7. 发明公开

US20240216034A1 CRYO-FIXATION CARDIAC PACEMAKER LEAD EXTRACTION DEVICE 审中-公开
公开(公告)号：US20240216034A1
公开(公告)日：2024-07-04
申请号：US18438720
申请日：2024-02-12
申请人： THE CLEVELAND CLINIC FOUNDATION , CPSI Holdings, LLC
发明人： Oussama Wazni , Marwane Berrada-Sounni , John M. Baust , Kristi K. Snyder
IPC分类号： A61B18/02 , A61B17/3205 , A61B18/00 , A61N1/05
CPC分类号： A61B18/0218 , A61B17/32053 , A61B18/02 , A61N1/0595 , A61B2018/00196 , A61B2018/00202 , A61B2018/00791 , A61B2018/00922 , A61B2018/0212 , A61B2018/0262 , A61N2001/0578
摘要： A cryo-fixation lead extraction device includes a lead extraction catheter having longitudinally spaced proximal and distal catheter ends and an elongate catheter lumen. A liner has longitudinally spaced proximal and distal liner ends and an elongate liner lumen. The liner lumen is configured to selectively accept at least part of a lead being extracted longitudinally therethrough. At least a portion of the liner is located circumferentially within and/or circumferentially surrounding the catheter lumen. At least one cryogen supply line extends longitudinally through at least a portion of the liner lumen. The cryogen supply line is configured to place a cryogen fluid source into fluid communication with the distal liner end. The cryogen supply line is configured to selectively generate a patient tissue cooled zone adjacent the distal catheter end. A method of cryo-fixation lead extraction is also provided.

8. 发明授权

US12000536B2 Pressurized sub-cooled cryogenic system and method of use 有权
公开(公告)号：US12000536B2
公开(公告)日：2024-06-04
申请号：US17655369
申请日：2022-03-18
申请人： CPSI Holdings LLC
发明人： John M. Baust , Joshua T. Smith , Anthony T. Robilotto , Jennie F. McKain
IPC分类号： F17C5/00 , A61B18/02 , F17C1/00 , F17C3/00 , F17C5/02 , A61B18/00 , A61B90/00
CPC分类号： F17C1/00 , A61B18/02 , F17C3/00 , F17C5/02 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/0293 , A61B2090/064 , F17C2201/0109 , F17C2201/032 , F17C2201/056 , F17C2203/0329 , F17C2203/0391 , F17C2203/0643 , F17C2205/0107 , F17C2205/0161 , F17C2205/0367 , F17C2221/011 , F17C2221/012 , F17C2221/014 , F17C2221/016 , F17C2221/017 , F17C2221/035 , F17C2223/0169 , F17C2223/035 , F17C2223/036 , F17C2227/0341 , F17C2227/0353 , F17C2227/0374 , F17C2250/032 , F17C2250/0408 , F17C2250/0439 , F17C2270/02 , F17C2270/0509
摘要： A method of generating a pressurized, sub-cooled mixed-phase cryogen is disclosed, including providing a cryogenic system including a reservoir containing a liquid cryogen; and a heat exchange coil immersed in the liquid cryogen, the heat exchange coil having an input end and an output end not immersed in the liquid cryogen; introducing a pressurized gas cryogen to the input end of the heat exchange coil; cooling the pressurized gas cryogen within the heat exchange coil; and collecting the pressurized gas cryogen at an output end of the heat exchange coil.

9. 发明申请

US20210386467A1 ABLATION PROBE WITH DEPLOYABLE SENSORS 有权
公开(公告)号：US20210386467A1
公开(公告)日：2021-12-16
申请号：US17460948
申请日：2021-08-30
申请人： CPSI HOLDINGS LLC
发明人： Marie Molnar-Hammond , John M. Baust
IPC分类号： A61B18/02 , A61B18/14
摘要： The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for controlling deployment and retraction of the deployable assembly.

10. 发明授权

US10918432B2 Endoscopic cryoablation catheter 有权
公开(公告)号：US10918432B2
公开(公告)日：2021-02-16
申请号：US15881441
申请日：2018-01-26
申请人： CPSI HOLDINGS LLC
发明人： John M. Baust
IPC分类号： A61B18/02 , A61M25/00 , A61M25/01 , A61B18/00 , A61B90/00
摘要： A cryoablation device is provided herein which, in an embodiment, includes a catheter shaft; a cryogen return line disposed within the catheter shaft; and a cryogen supply line disposed within the cryogen return line, such that the cryogen supply line, the cryogen return line, and the catheter shaft are all substantially coaxial. A needle tip probe is disposed at a distal end of the cryogen return line. The cryogen supply line extends in a distal direction beyond a distal end of the cryogen return line and into the needle tip probe, and the catheter shaft is axially movable relative to the needle tip probe and the cryogen return line, and the catheter shaft is configured such that the catheter shaft is distally extended over the needle tip probe in an extended position.

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