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1. 发明授权

US10016201B2 Vascular plug 有权
公开(公告)号：US10016201B2
公开(公告)日：2018-07-10
申请号：US14268397
申请日：2014-05-02
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Christina Rauff Hansen
IPC分类号： A61B17/08 , A61B17/12 , A61F2/01
CPC分类号： A61B17/12109 , A61B17/12031 , A61B17/12172 , A61B17/12177 , A61B2017/1205 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0008 , A61F2230/001 , A61F2230/0091 , A61F2230/0095
摘要： A vascular plug has a frame or skeleton which includes a ring of spring material and, attached to the frame, a cover of impervious or porous material. The plug is able to open a cup configuration when in a deployed condition, so as to provide an occlusion barrier to blood flow. The frame can be radially contracted by twisting into a multi-coiled configuration for deployment through an introducer. The vascular plug has a very short deployment length, making it suitable for deployment in precise locations and is also able to expand to a variety of operating diameters, thereby being suitable for a range of vessel sizes.

2. 发明授权

US09788841B2 Implantable medical device with lumen constriction 有权
公开(公告)号：US09788841B2
公开(公告)日：2017-10-17
申请号：US14749060
申请日：2015-06-24
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bödewadt , Christina Rauff Hansen , Erik E. Rasmussen
IPC分类号： A61M29/00 , A61B17/12 , A61F2/01 , A61F2/82 , A61B17/00
CPC分类号： A61B17/12145 , A61B17/12109 , A61B17/12172 , A61B17/12177 , A61B2017/00862 , A61B2017/00867 , A61B2017/12054 , A61F2/01 , A61F2/013 , A61F2/82 , A61F2002/016 , A61F2210/0014 , A61F2210/0076 , A61F2230/001 , A61F2230/0078 , A61F2230/0091
摘要： An implantable medical device includes a support structure which is twistable in a longitudinal direction of the device. A sleeve of filter or occluding material is attached to the ends of the structure. The structure in practice twists on itself in the longitudinal direction, causing the sleeve to twist on itself and as a result to close the lumen through the sleeve. The device provides reliable closure and as a result occlusion of a vessel. It is also able to be delivered over a guide wire. In another embodiment, the support structure includes a wire which coils around the sleeve to constrict the sleeve and as a result to close a lumen of the sleeve.

3. 发明申请

US20160206319A1 CONE EXPANDING COLLAPSIBLE MEDICAL DEVICE 有权
标题翻译： CONE膨胀可折叠医疗器械
公开(公告)号：US20160206319A1
公开(公告)日：2016-07-21
申请号：US14996286
申请日：2016-01-15
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bödewadt , Christina Rauff Hansen
IPC分类号： A61B17/12
CPC分类号： A61B17/12109 , A61B17/12031 , A61B17/12172 , A61B17/12177 , A61B2017/12054 , A61F2/01 , A61F2002/016 , A61F2230/008
摘要： A vascular occluder includes first and second conical members disposed in opposing relation and which have tooth-shaped wide ends. The conical members are coupled to one another by a coupling element, which may be a cannula or rod. The conical members are formed of a membrane which has a thickness which increases towards the narrow ends and decreases towards the toothed elements. The toothed elements are preferably self-supporting within a vessel and avoid folds within the occluder membrane, which may otherwise result in leakage of blood around the device. The device may be provided with a supporting frame which may be at least partially embedded within the membrane. The membrane is preferably made of silicone.
摘要翻译：血管闭塞器包括以相对关系设置并且具有齿形宽端的第一和第二锥形构件。锥形构件通过联接元件彼此联接，联接元件可以是插管或杆。锥形构件由膜形成，该膜具有朝向窄端增加的厚度并朝着齿形元件减小。齿形元件优选在容器内自支撑并且避免封堵器膜内的折叠，否则可能导致血液在装置周围的泄漏。该装置可以设置有可以至少部分地嵌入膜内的支撑框架。膜优选由硅树脂制成。

4. 发明授权

US09795772B2 Endoluminal drug delivery device 有权
公开(公告)号：US09795772B2
公开(公告)日：2017-10-24
申请号：US14724047
申请日：2015-05-28
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Steen Aggerholm , Christina Rauff Hansen , Sean D. Chambers
IPC分类号： A61F2/06 , A61M31/00 , A61M25/10
CPC分类号： A61M31/00 , A61F2230/0067 , A61F2230/0069 , A61F2250/0065 , A61F2250/0067 , A61M2025/105 , A61M2025/1081
摘要： A drug delivery device (10) includes expandable element (12) formed of a braided structure having a body portion (16) and first and second end cones (18, 20). The end cones are attached at their necks (22, 24) to a catheter assembly (14). The expandable element (12) can expand to a vessel contacting configuration, in which the body portion (16) contacts the vessel wall. Bioactive agent (28) covers at least the outer surface of the body portion (16) such that bioactive material can be administered to a vessel wall. The end cones (18, 20) have an open structure allowing unrestricted passage of blood through the device (10) in the deployed configuration, such that blood flow can be maintained during the administration of bioactive agent (28) from the device (10). The expandable element (12) can be radially contracted by extending it in the longitudinal direction, both for deployment endoluminally to the treatment site and also for retrieval following the administration of the bioactive material.

5. 发明授权

US09173659B2 Vascular plug 有权
标题翻译：血管塞
公开(公告)号：US09173659B2
公开(公告)日：2015-11-03
申请号：US13804882
申请日：2013-03-14
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bodewadt , Christina Rauff Hansen
IPC分类号： A61B17/12
CPC分类号： A61B17/12109 , A61B17/12159 , A61B17/12181
摘要： A vascular plug includes a plurality of cells which extend from a front face of the plug towards a distal end of the plug. The cells form at least a periphery of the plug and are in the preferred embodiment closed at their distal ends. The cells may form a central chamber to the plug or may extend across the entirety of the front face of the plug. The cells will fill with blood from the patient's vessel, to inflate the plug and create a barrier to fluid flow. Static blood within the plug will clot over time, creating enhanced occlusion. The plug can also be configured as a vascular filter.
摘要翻译：血管插塞包括多个细胞，其从插塞的前表面朝向插塞的远端延伸。细胞至少形成插塞的周边，并且在优选实施例中在其远端处封闭。电池可以形成到插头的中心室，或者可以延伸穿过插塞的整个前表面。细胞将填充来自患者血管的血液，使塞子膨胀并产生流体流动的屏障。塞子内的静电血液会随着时间的推移而凝结，从而产生增强的闭塞。插头也可以配置为血管过滤器。

6. 发明申请

US20150196301A1 IMPLANTABLE MEDICAL DEVICE WITH FLEXIBLE CONNECTION 审中-公开
标题翻译：具有柔性连接的可植入医疗装置
公开(公告)号：US20150196301A1
公开(公告)日：2015-07-16
申请号：US14593545
申请日：2015-01-09
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bödewadt , Christina Rauff Hansen
IPC分类号： A61B17/12 , A61F2/01
CPC分类号： A61B17/12036 , A61B17/12109 , A61B17/12145 , A61B17/1215 , A61F2/01 , A61F2002/016 , A61F2210/0014 , A61F2230/0023 , A61F2230/0078 , A61F2250/0039
摘要： An implantable medical device includes first and second material capture elements which are disposed in opposing orientations and have their narrow ends facing one another. The first and second material capture elements are connected by a flexible connector, which enables the implantable medical device to curve within a curved vessel of a patient. The flexible connector is either closed or has a lumen passing therethrough and includes a closure element for closing the lumen after deployment of the device within a patient. The structure enables the device to be positioned reliably within a curved vessel and benefits from the advantage of a double-ended device.
摘要翻译：可植入医疗装置包括第一和第二材料捕获元件，它们以相对的方向设置并且其窄端面向彼此。第一和第二材料捕获元件通过柔性连接器连接，这使得可植入医疗装置能够在患者的弯曲容器内弯曲。柔性连接器是封闭的或具有通过其中的内腔，并且包括用于在将装置部署在患者体内之后关闭内腔的闭合元件。该结构使得设备可以可靠地定位在弯曲的容器内并且受益于双端装置的优点。

7. 发明申请

US20140330303A1 VASCULAR PLUG 有权
标题翻译：血管插管
公开(公告)号：US20140330303A1
公开(公告)日：2014-11-06
申请号：US14268397
申请日：2014-05-02
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Christina Rauff Hansen
IPC分类号： A61B17/12 , A61F2/01
CPC分类号： A61B17/12109 , A61B17/12031 , A61B17/12172 , A61B17/12177 , A61B2017/1205 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0008 , A61F2230/001 , A61F2230/0091 , A61F2230/0095
摘要： A vascular plug has a frame or skeleton which includes a ring of spring material and, attached to the frame, a cover of impervious or porous material. The plug is able to open a cup configuration when in a deployed condition, so as to provide an occlusion barrier to blood flow. The frame can be radially contracted by twisting into a multi-coiled configuration for deployment through an introducer. The vascular plug has a very short deployment length, making it suitable for deployment in precise locations and is also able to expand to a variety of operating diameters, thereby being suitable for a range of vessel sizes.
摘要翻译：血管塞具有包括弹簧材料环的框架或骨架，并且附接到框架上的是不透水或多孔材料的盖子。当处于部署状态时，塞子能够打开杯子配置，以便为血液流动提供阻塞屏障。框架可以通过扭转成多卷绕构造而被径向收缩以通过导引器进行展开。血管塞具有非常短的部署长度，使其适合于在精确位置的部署，并且还能够扩展到各种操作直径，从而适用于一定范围的血管尺寸。

8. 发明授权

US10463376B2 Implantable medical device with flexible connection 有权
公开(公告)号：US10463376B2
公开(公告)日：2019-11-05
申请号：US14593545
申请日：2015-01-09
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bödewadt , Christina Rauff Hansen
IPC分类号： A61B17/12 , A61F2/01
摘要： An implantable medical device includes first and second material capture elements which are disposed in opposing orientations and have their narrow ends facing one another. The first and second material capture elements are connected by a flexible connector, which enables the implantable medical device to curve within a curved vessel of a patient. The flexible connector is either closed or has a lumen passing therethrough and includes a closure element for closing the lumen after deployment of the device within a patient. The structure enables the device to be positioned reliably within a curved vessel and benefits from the advantage of a double-ended device.

9. 发明申请

US20160045341A1 ENDOLUMINAL DRUG DELIVERY DEVICE 有权
标题翻译：内膜药物递送装置
公开(公告)号：US20160045341A1
公开(公告)日：2016-02-18
申请号：US14724047
申请日：2015-05-28
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Steen Aggerholm , Christina Rauff Hansen , Sean D. Chambers
IPC分类号： A61F2/844 , A61F2/958 , A61F2/90
CPC分类号： A61M31/00 , A61F2230/0067 , A61F2230/0069 , A61F2250/0065 , A61F2250/0067 , A61M2025/105 , A61M2025/1081
摘要： A drug delivery device (10) includes expandable element (12) formed of a braided structure having a body portion (16) and first and second end cones (18, 20). The end cones are attached at their necks (22, 24) to a catheter assembly (14). The expandable element (12) can expand to a vessel contacting configuration, in which the body portion (16) contacts the vessel wall. Bioactive agent (28) covers at least the outer surface of the body portion (16) such that bioactive material can be administered to a vessel wall. The end cones (18, 20) have an open structure allowing unrestricted passage of blood through the device (10) in the deployed configuration, such that blood flow can be maintained during the administration of bioactive agent (28) from the device (10). The expandable element (12) can be radially contracted by extending it in the longitudinal direction, both for deployment endoluminally to the treatment site and also for retrieval following the administration of the bioactive material.
摘要翻译：药物输送装置（10）包括由具有主体部分（16）和第一和第二端锥体（18,20）的编织结构形成的可膨胀元件（12）。末端锥体在其颈部（22,24）处连接到导管组件（14）。可膨胀元件（12）可以膨胀到容器接触构型，其中主体部分（16）接触血管壁。生物活性剂（28）至少覆盖主体部分（16）的外表面，使得生物活性物质可被施用于血管壁。末端锥体（18,20）具有允许血液在展开构型中不经限制地通过装置（10）的开放结构，使得在从装置（10）施用生物活性剂（28）期间可以维持血液流动，。可膨胀元件（12）可以通过沿纵向方向延伸而被径向收缩，两者用于在内部部署到处理部位并且还用于在施用生物活性材料之后进行回收。

10. 发明申请

US20150313603A1 IMPLANTABLE MEDICAL DEVICE WITH TWISTED ELEMENT 审中-公开
标题翻译：具有双向元件的可植入医疗器械
公开(公告)号：US20150313603A1
公开(公告)日：2015-11-05
申请号：US14700327
申请日：2015-04-30
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Tue Thuren Bödewadt , Christina Rauff Hansen , Kim Møgelvang Jensen , Raimo Urban Jensen , Erik E. Rasmussen
IPC分类号： A61B17/12 , A61F2/90 , A61F2/844
CPC分类号： A61B17/12109 , A61B17/12031 , A61B17/12131 , A61B17/12172 , A61B17/12177 , A61F2/01 , A61F2/844 , A61F2/90 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/001
摘要： A vascular occluder includes a tubular support element and a sleeve of occluding material disposed within the support element. The sleeve is twisted in the support creating a constriction which closes the lumen of the sleeve. The lumen of the sleeve can nevertheless be opened by a guide wire or cannula for over the wire delivery. Once the guide wire or cannula are withdrawn from the sleeve, the sleeve will close again by the action of blood pressure thereon. Blood pressure will act to maintain closing pressure on the sleeve, thereby avoiding or reducing the risk of recanalization.
摘要翻译：血管阻塞器包括管状支撑元件和设置在支撑元件内的阻塞材料的套筒。套筒在支撑件中扭转，形成一个闭合套管内腔的收缩部。然而，套管的内腔仍然可以通过导丝或套管打开以用于导线输送。一旦引导线或插管从套筒中取出，套管将再次通过其上的血压作用而关闭。血压将起到保持袖套上的关闭压力的作用，从而避免或降低再通风险。

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